Stroke Clinical Trials

216 studies are recruiting for stroke in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 6

1. Responses to Backward Walking Training Post-Stroke

   Approximately 15,000 Veterans are hospitalized for stroke each year with new cases costing an estimated $111 million for acute inpatient, $75 million for post-acute inpatient, and $88 million for follow-up care over 6 months post-stroke. The investigators have previously established the effectivene…

   Stage

   Not phased

   Ages

   18 to 90

   Site

   North Florida/South Georgia Veterans Health System, Gainesville, FL, Gainesville, Florida

   Locations

   2 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT04928482 on ClinicalTrials.gov

2. SDOH-Homecare Intervention Focus Team (SHIFT) Trial to Improve Stroke Outcomes

   Primary Goal: To test the hypothesis that among stroke patients 18-75 years with ≥3 SDOH risk factors, SHIFT will improve: (1) functional outcomes as measured by the SIS (Primary Outcome), (2) physiological outcomes as measured by changes in blood pressure and cognition, (secondary outcomes) and (3…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   Columbia University Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT06397937 on ClinicalTrials.gov

3. Telerehabilitation for Aphasia (TERRA)

   Speech-language therapy is generally found to be helpful in the rehabilitation of aphasia. However, not all patients with aphasia have access to adequate treatment to maximize their recovery. The goal of this project is to compare the efficacy of telerehabilitation or Aphasia Remote Therapy (ART) t…

   Stage

   Not phased

   Ages

   21 to 80

   Site

   University of South Carolina Aphasia Lab, Columbia, South Carolina

   Run by

   University of South Carolina

   See if you can join NCT04682223 on ClinicalTrials.gov

4. PostureCheck: A Vision-based Compensatory-posture-detection Tool for Robot-assisted Upper-limb Therapy

   The overall objective of this study is to assess whether robot-assisted upper-limb group rehabilitation can be effectively delivered by using a camera-based system equipped with machine learning algorithms to track the quality of the exercise performance and provide feedback accordingly. To address…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Spaulding Rehabilitation Hospital, Charlestown, Massachusetts

   Run by

   Spaulding Rehabilitation Hospital

   See if you can join NCT04851886 on ClinicalTrials.gov

5. Effects of Exoskeleton-Assisted Gait Training on Functional Rehabilitation Outcomes in Patients With Stroke

   The goal of this study is to determine the efficacy of electromechanical exoskeleton-assisted gait training on rehabilitation functional outcomes in patients with stroke undergoing therapy in an in-patient rehabilitation facility.

   Stage

   Not phased

   Ages

   18 to 90

   Site

   Oklahoma City VA Health Care System, Oklahoma City, Oklahoma

   Run by

   University of Oklahoma

   See if you can join NCT03980457 on ClinicalTrials.gov

6. Virtual Reality-Integrated Propulsion Feedback for Stroke Rehab

   This study evaluates a novel Virtual Reality (VR)-integrated visual feedback system designed to enhance limb propulsion during robot-assisted gait rehabilitation in individuals post-stroke. In collaboration with CUREXO, a rehabilitation robotics company, the system is embedded within the Morning Wa…

   Stage

   Not phased

   Ages

   20 and older

   Site

   University of Texas Medical Branch, Galveston, Texas

   Run by

   The University of Texas Medical Branch, Galveston

   See if you can join NCT07087743 on ClinicalTrials.gov

7. Optimizing Gait Symmetry After Stroke Using Mechanical Constraints and Sensory Feedback

   This single-session study aims to evaluate a novel gait training protocol that integrates mechanical constraints and sensory feedback to enhance paretic leg propulsion in individuals post-stroke. The study will include 15 individuals who have experienced a stroke and 15 healthy adults, each aged 20…

   Stage

   Not phased

   Ages

   20 and older

   Site

   University of Texas Medical Branch, Galveston, Texas

   Run by

   The University of Texas Medical Branch, Galveston

   See if you can join NCT07087769 on ClinicalTrials.gov

8. Neuralert Stroke Monitor Trial

   The Neuralert monitoring system, a non-invasive device worn on each wrist, is designed to provide continuous monitoring and expedited recognition of stroke by identifying asymmetry in the extremities, facilitating patient treatment and improving outcomes. This study is designed to evaluate the safe…

   Stage

   Not phased

   Ages

   22 and older

   Site

   Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   Neuralert Technologies LLC

   See if you can join NCT07362303 on ClinicalTrials.gov

9. EEG Changes and DNA Markers Related to taVNS in Stroke Patients: a Preliminary Study

   In the United States, more than 795,000 people have a stroke every year. Motor impairment after a stroke is common and can be debilitating. To date, there remain few treatments available to help improve motor recovery after a stroke, making this an important area of research. Novel use of neuromodu…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Casa Colina Hospital and Centers for Healthcare, Pomona, California

   Run by

   Casa Colina Hospital and Centers for Healthcare

   See if you can join NCT06226493 on ClinicalTrials.gov

10. Variable Intensive Early Walking Post-Stroke - 2 (VIEWS-2)

    The proposed research will evaluate the individual and combined effects of task-specificity and intensity of rehabilitation interventions on locomotor function, community mobility and quality of life in patients with subacute (1-6 months) post-stroke.

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Rehabilitation Hospital of Indiana, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT05727930 on ClinicalTrials.gov

11. Biomarkers of Reaction To HIIT Exercise

    Stroke survivors with lower limb disability can improve their walking speed with high-intensity interval training (HIIT) rehabilitation therapy. However, some individuals may not respond to HIIT even when fully adherent to the program. To address this, the investigators propose to build a predictiv…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia

    Run by

    VA Office of Research and Development

    See if you can join NCT06059872 on ClinicalTrials.gov

12. Comparing Prism Adaptation Training With and Without TENS to Minimize Unilateral Spatial Neglect

    This study aims to find out if doing two treatments together-Prism Adaptation Therapy (PAT) and Transcutaneous Electrical Nerve Stimulation (TENS)-will help people who have had a stroke pay better attention to one side of their body, better than just doing PAT by itself. In addition to understandin…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Kettering Health NeuroRehab and Balance Center, Centerville, Ohio

    Locations

    2 in total

    Run by

    Kettering Health Network

    See if you can join NCT07157865 on ClinicalTrials.gov

13. Cerebellar Stimulation for Aphasia Rehabilitation

    The optimal site of neuromodulation for post-stroke aphasia has yet to be established. This study will investigate whether multiple sessions of cerebellar transcranial direct current stimulation (tDCS) boosts language therapy in helping people recover from aphasia as well as predict who is likely t…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Johns Hopkins Hospital, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05093673 on ClinicalTrials.gov

14. Minocycline in Stroke Study at Maimonides

    The goal of this study is to determine if Minocycline, when added to standard care, can improve survival and functional outcomes in patients with moderate acute stroke (ischemic or hemorrhagic) aged 18 years and older. The main questions it aims to answer are: 1. Does Minocycline improve *National …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Maimonides Medical Center, Brooklyn, New York

    Run by

    Joyce Chen

    See if you can join NCT07237048 on ClinicalTrials.gov

15. Locomotor Function Following Transcutaneous Electrical Spinal Cord Stimulation in Individuals With Hemiplegic Stroke

    This study has two interventional components, the first is a cross-over design and the second is a randomized control trial. Both will evaluate the effectiveness of transcutaneous (non-invasive) spinal cord stimulation on gait and balance function for individuals with hemiplegia due to stroke.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Shirley Ryan AbilityLab, Chicago, Illinois

    Run by

    Shirley Ryan AbilityLab

    See if you can join NCT05167786 on ClinicalTrials.gov

16. Optimizing the Prehospital Use of Stroke Systems of Care-Reacting to Changing Paradigms-Implementation (OPUS-i)

    This interventional trial will compare a novel prehospital stroke transport algorithm (OPUS-i) to a traditional prehospital stroke transport algorithm to improve outcomes in rural stroke patients by determining the effect of implementing a data-driven prehospital stroke algorithm on time to and end…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cooper University Health, Camden, New Jersey

    Locations

    2 in total

    Run by

    Temple University

    See if you can join NCT06530693 on ClinicalTrials.gov

17. Chronic Transcutaneous Stimulation to Promote Motor Function and Recovery in Individuals With Paralysis or Paresis

    This is an early feasibility trial to determine whether transcutaneous neuromuscular electrical stimulation, with or without transcutaneous spinal cord stimulation, using an investigational neurostimulation device improves functional arm/hand movements in individuals with paralysis or paresis due t…

    Stage

    EARLY_Phase 1

    Ages

    18 to 75

    Site

    Northwell Health's The Feinstein Institute for Medical Research, Manhasset, New York

    Run by

    Northwell Health

    See if you can join NCT04755699 on ClinicalTrials.gov

18. Substrates for Post-Stroke Arm Rehabilitation

    Difficulty moving the arm is very common and a major cause of disability after stroke. Although rehabilitation therapies (i.e., occupational and physical therapy) are the most common treatments used to improve arm motor function, it remains unknown how therapy actually changes brain pathways after …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Laboratory for Translational Neurorecovery, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06998485 on ClinicalTrials.gov

19. FOA on Sit to Stand in Individuals Post Chronic Stroke

    The purpose of this study is to fill some gaps in the literature by examining the effects of focus of attention on motor learning and motor performance of sit to stand in individuals post chronic stroke. This study will investigate whether an internal or external focus of attention can lead to impr…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Western Carolina University, Cullowhee, North Carolina

    Run by

    Western Carolina University

    See if you can join NCT07460804 on ClinicalTrials.gov

20. Locomotor Recovery and Compensation Post-stroke (LRC)

    The proposed research will characterize of the time course of neurological and locomotor recovery as well as development of compensatory strategies throughout sub-acute and chronic phases post stroke. In addition, we will also investigate the extent to which measures of recovery and compensation ar…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Rehabilitation Hospital of Indiana, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT05081713 on ClinicalTrials.gov

21. Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia

    The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke. The main questions this study aims to answer are: 1. Can TMS combined with SLT improve co…

    Stage

    Phase 2

    Ages

    40 to 85

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT06842745 on ClinicalTrials.gov

22. Improving Visual Field Deficits With Noninvasive Brain Stimulation

    This is a randomized, pilot interventional study in participants with visual field deficit (VFD) caused by cortical lesion. Damage to the primary visual cortex (V1) causes a contra-lesional, homonymous loss of conscious vision termed hemianopsia, the loss of one half of the visual field. The goal o…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT05085210 on ClinicalTrials.gov

23. Personalized Transcranial Direct Current Stimulation in Stroke Recovery

    The central objective of this application is to explore the neural substrate of personalized tDCS (ptDCS) and to determine whether the paradigm for each stroke patient can predict the amount of sustained clinical improvement through increased connectivity as measured by a biomarker of plasticity.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Houston Methodist Hospital, Houston, Texas

    Run by

    The Methodist Hospital Research Institute

    See if you can join NCT06286800 on ClinicalTrials.gov

24. Non-invasive VNS in Stroke Recovery

    To evaluate feasibility and effectiveness of non-invasive VNS to enhance stroke recovery

    Stage

    Not phased

    Ages

    18 and older

    Site

    Houston Methodist Research Institute, Houston, Texas

    Run by

    The Methodist Hospital Research Institute

    See if you can join NCT06761404 on ClinicalTrials.gov

25. Myofascial Dysfunction in Post Stroke Shoulder Pain

    Shoulder pain is extremely common after stroke and occurs in 30-70% of patients. The pain may begin as early as one week after stroke, although peak onset and severity occurs around four months, and persists into the chronic stage. Chronic post stroke shoulder pain (PSSP) interferes with motor reco…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Johns Hopkins University, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06718413 on ClinicalTrials.gov