Stroke Clinical Trials

216 studies are recruiting for stroke in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 5

1. Exoskeleton for Balance

   Many people who have experienced a stroke have deficits in their walking balance. The long-term goal of this research is to develop an exoskeleton that can effectively improve walking balance, thus improving functional mobility.

   Stage

   Not phased

   Ages

   21 and older

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT07356011 on ClinicalTrials.gov

2. Cortical Priming to Optimize Gait Rehabilitation in Stroke: a Renewal

   Achieving functional ambulation post stroke continues to be a challenge for stroke survivors, clinicians, and researchers. In the effort to enhance outcomes of motor training, cortical priming using brain stimulation has emerged as a promising adjuvant to conventional rehabilitation. This project f…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Physical Therapy, Chicago, Illinois

   Run by

   University of Illinois at Chicago

   See if you can join NCT04477330 on ClinicalTrials.gov

3. Characterization and Clinical Trial of a Variable Friction Shoe

   More than one million Americans present with foot drop after stroke. As the aging population grows in the United States and across the world, incidence of stroke will grow as age is a key risk factor, thus there will be a need for low-cost, easy-to-use, and scalable solutions to administer proper t…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Shirley Ryan AbilityLab, Chicago, Illinois

   Run by

   Shirley Ryan AbilityLab

   See if you can join NCT06234124 on ClinicalTrials.gov

4. Neurofeedback Intervention for Reading Deficits in Subacute Stroke

   The overall goal of this project is to advance a biologically-based approach to treatment of reading disorders after stroke, which will expand the limits of cognitive rehabilitation. Using a novel brain imaging technique, called real-time functional magnetic resonance imaging (fMRI) neurofeedback c…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Kessler Foundation, West Orange, New Jersey

   Run by

   Kessler Foundation

   See if you can join NCT04875936 on ClinicalTrials.gov

5. Deep Brain Stimulation Motor Ventral Thalamus (VOP/VIM) for Restoration of Speech and Upper-limb Function in People With Subcortical Stroke

   The goal of this study is to verify whether the use of deep brain stimulation can improve motor function of the hand and arm and speech abilities for people following a stroke. Participants will undergo a surgical procedure to implant deep brain stimulation electrode leads. The electrodes will be c…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   University of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   Jorge Gonzalez-Martinez

   See if you can join NCT06303869 on ClinicalTrials.gov

6. Assessment of a Physio-neuro Platform (SynPhNe) for Home-based Retraining of Hand Function in Stroke Survivors

   The goal of this study is to: 1. Assess the usability of the SynPhNe device in a home environment. 2. Evaluate the efficacy of the SynPhNe home use device to improve motor hand function in chronic stroke subjects as compared to standard care alone.

   Stage

   Not phased

   Ages

   21 to 80

   Site

   Spaulding Rehabilitation Hospital, Boston, Massachusetts

   Run by

   Spaulding Rehabilitation Hospital

   See if you can join NCT02896348 on ClinicalTrials.gov

7. Acquired Dyslexia Modeling and Treatment

   This study is a low-risk, early phase 1, multicenter trial to test the use of a computational (neural network) cognitive model of reading to simulate acquired dyslexia and its treatment. The aim is to determine whether there is an advantage to receiving the treatment the model predicts to be advant…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Florida State University, Tallahassee, Florida

   Locations

   3 in total

   Run by

   Rutgers, The State University of New Jersey

   See if you can join NCT07209488 on ClinicalTrials.gov

8. ECoG BMI for Motor and Speech Control

   Test the feasibility of using electrocorticography (ECoG) signals to control complex devices for motor and speech control in adults severely affected by neurological disorders.

   Stage

   Not phased

   Ages

   21 and older

   Site

   University of California San Francisco, San Francisco, California

   Run by

   Karunesh Ganguly

   See if you can join NCT03698149 on ClinicalTrials.gov

9. Increasing the Repertoire of Intermuscular Co-ordination Post Stroke Through EMG-Guided Human-Machine Interaction

   The purposes of this study include: 1. - To identify whether features of aberrant intermuscular coordination patterns can be used to predict motor impairment after stroke. 2. - To test whether muscle synergies are malleable to a non-invasive EMG-guided exercise that induces changes in intermuscular…

   Stage

   Not phased

   Ages

   40 to 75

   Site

   University of Houston, Houston, Texas

   Run by

   University of Houston

   See if you can join NCT06523335 on ClinicalTrials.gov

10. Non-invasive BCI-controlled Assistive Devices

    Injuries affecting the central nervous system may disrupt the cortical pathways to muscles causing loss of motor control. Nevertheless, the brain still exhibits sensorimotor rhythms (SMRs) during movement intents or motor imagery (MI), which is the mental rehearsal of the kinesthetics of a movement…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    The University of Texas at Austin, Austin, Texas

    Run by

    University of Texas at Austin

    See if you can join NCT05183152 on ClinicalTrials.gov

11. HIT-Stroke Trial 2

    People who had a stroke at least 6 months prior and who still have difficulty with walking will each be randomly assigned to receive either moderate or vigorous intensity walking exercise. Both protocols will be performed individually with a physical therapist for 45 minutes, 3x/week for 12 weeks. …

    Stage

    Not phased

    Ages

    30 to 85

    Site

    University of Delaware, Newark, Delaware

    Locations

    3 in total

    Run by

    University of Cincinnati

    See if you can join NCT06268041 on ClinicalTrials.gov

12. Efficacy and Sustainability of a Carepartner-Integrated Telerehabilitation Program for Persons With Stroke

    Stroke is a leading cause of long-term disability. Research has placed little emphasis on integrating care partners (CP) (family members) into the rehabilitation process without increasing negative care partner outcomes. The research team has developed and implemented a novel, web-based care partne…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Emory Rehabilitation Hospital, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT06655402 on ClinicalTrials.gov

13. Improving Participation After Stroke Self-Management-Rehabilitation

    The overall goal of this proposed study is to evaluate the efficacy of a small-group, stroke-specific, self-management program delivered via telehealth to improve self-efficacy, activity performance, and quality of life in individuals with sub-acute stroke.

    Stage

    Not phased

    Ages

    45 to 85

    Site

    University of Missouri, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT06588647 on ClinicalTrials.gov

14. Modulation of Brain Rhythms in Stroke

    The goal of this research study is to examine communication between brain and muscle in individuals with stroke and determine if applying non-invasive brain stimulation to different parts of the brain improves this communication and performance on a hand squeezing task. The investigators will fit p…

    Stage

    Not phased

    Ages

    45 to 80

    Site

    Bondurant Hall, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT07121582 on ClinicalTrials.gov

15. Driver Simulator Training to Improve Driving After Stroke

    One hundred Veteran stroke survivors will participate in both an Active Driver Training intervention and a Control intervention in a fully interactive driving simulator. In addition, all participants will complete pre- and post-intervention driving assessments in the driving simulator to measure dr…

    Stage

    Not phased

    Ages

    40 to 80

    Site

    VA Northern California Health Care System, Mather, CA, Sacramento, California

    Run by

    VA Office of Research and Development

    See if you can join NCT06672107 on ClinicalTrials.gov

16. Robotic Rehabilitation of the Upper Limb in Subacute Stroke

    This multicenter international randomized controlled trial (RCT) evaluates the effectiveness of the Gloreha Sinfonia® robotic exoskeleton for upper limb rehabilitation in individuals with subacute post-stroke paresis. The study aims to determine whether robotic-assisted therapy improves voluntary m…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    IRCCS San Raffaele Roma, Rome, RM

    Locations

    21 in total

    Run by

    IRCCS San Raffaele Roma

    See if you can join NCT06839482 on ClinicalTrials.gov

17. Pharmacogenomics in Stroke: Feasibility of CYP2C19 Testing

    The purpose of this research study is to explore whether genetic testing can offer a personalized and timely approach to assist physicians in making more informed medication decisions for stroke or high-risk transient ischemic attack (TIA) patients during their hospital stay.

    Stage

    Not phased

    Ages

    18 to 89

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06943586 on ClinicalTrials.gov

18. Mirror Speech Entrainment: A Novel Technique for Voice Personalized Speech Entrainment for Nonfluent Aphasia

    The goal of this clinical trial is to test the use of voice personalization through artificial intelligence (AI) voice cloning on speech entrainment tasks to improve language production of persons with aphasia (PWA). The main question the study aims to answer is: - What is the impact of personalize…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of South Florida, Tampa, Florida

    Locations

    2 in total

    Run by

    University of South Florida

    See if you can join NCT06829420 on ClinicalTrials.gov

19. EMPOWER: Effects of Weight Loss and Exercise Post-stroke

    The prevalence of obesity among U.S. adults is ~40% and is projected to climb. It is well documented that obesity is associated with increased levels of disability as well as risk for numerous adverse health-related outcomes; including occurrence of stroke and all-cause mortality. Obesity is highly…

    Stage

    Not phased

    Ages

    35 to 85

    Site

    College of Health Professions, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT05901675 on ClinicalTrials.gov

20. Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)

    The Connect-One Study is an early feasibility study to obtain preliminary device safety information for the Connexus Brain-Computer Interface (BCI). The Connexus BCI is intended to be used as: (1) an assistive communication device to decode imagined language correlates and speech for patients with …

    Stage

    Not phased

    Ages

    22 to 75

    Site

    University of California, Davis, Sacramento, California

    Locations

    3 in total

    Run by

    Paradromics

    See if you can join NCT07357428 on ClinicalTrials.gov

21. MyHand 2: An Active Hand Orthosis for Stroke Patients

    This study is designed to further develop and test the hardware and software components of the MyHand device based on user feedback and results from our pilot study. The goal is to refine the device so that is more effective and easier for stroke patients to use to increase their hand function.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Columbia University Irving Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT04436042 on ClinicalTrials.gov

22. Constraint-Induced Movement Therapy Plus Sensory Components After Stroke

    Constraint-Induced Movement Therapy or CI Therapy is a form of treatment that systematically employs the application of selected behavioral techniques delivered in intensive treatment over consecutive day with the following strategies utilized: behavioral strategies are implemented to improve the u…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT05515237 on ClinicalTrials.gov

23. Balancing Effortful and Errorless Learning in Naming Treatment for Aphasia

    Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interferes with life participation and quality of life. Anomia (i.e., word- finding difficulty) is a primary frustration for people with aphasia. Pic…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Language Rehab and Cognition Lab, Department of Communication Sciences and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT05653440 on ClinicalTrials.gov

24. Pulmonary Embolism and Right-to-Left Shunts

    Every fetus has a small hole in their heart, called a foramen ovale when they are developing in the womb. For most people this hole closes shortly after birth, but it doesn't close completely in 1 out of every 4 people. This is called a "patent" foramen ovale, or PFO. In people with a PFO it is pos…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Tufts Medical Center, Boston, Massachusetts

    Run by

    Tufts Medical Center

    See if you can join NCT07519876 on ClinicalTrials.gov

25. Wearable MCI to Reduce Muscle Co-activation in Acute and Chronic Stroke

    The purpose of the study is to explore the feasibility of using a wearable device, called a myoelectric-computer interface (MCI), to improve arm movement in people who have had a stroke. Impaired arm movement after stroke is caused not just by weakness, but also by impaired coordination between joi…

    Stage

    Not phased

    Ages

    21 and older

    Site

    Northwestern University, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT03401762 on ClinicalTrials.gov