Stroke Clinical Trials

216 studies are recruiting for stroke in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Facilitating Neuroplastic Changes of Acute Stroke Survivors

   This project will develop a wearable rehabilitation robot suitable for in-bed acute stage rehabilitation. It involves robot-guided motor relearning, passive and active motor-sensory rehabilitation early in the acute stage post-stroke including patients who are paralyzed with no motor output. The ea…

   Stage

   Phase 1

   Ages

   30 to 85

   Site

   University of Maryland Baltimore, Baltimore, Maryland

   Locations

   3 in total

   Run by

   University of Maryland, Baltimore

   See if you can join NCT06404268 on ClinicalTrials.gov

2. kTMP-Enhanced Motor Rehabilitation for Chronic Stroke Recovery (KULMINATE) Pilot

   kTMP, kilohertz transcutaneous magnetic perturbations, is a low intensity transcranial magnetic stimulation technique that will be used in this study to promote arm/hand rehabilitation in patients who have been disabled by stroke.

   Stage

   Not phased

   Ages

   18 to 80

   Site

   UCSF Mission Bay- Sandler Neurosciences Center, San Francisco, California

   Run by

   Magnetic Tides

   See if you can join NCT07631078 on ClinicalTrials.gov

3. Pilot/Pivotal Study of DBS+Rehab After Stroke

   The RESTORE Stroke Study will evaluate the safety and effectiveness of DBS+Rehab for treating arm weakness and reduced function after a stroke.

   Stage

   Not phased

   Ages

   21 and older

   Site

   Barrow Neurological Institute (BNI), Phoenix, Arizona

   Locations

   10 in total

   Run by

   Enspire DBS Therapy, Inc.

   See if you can join NCT05701280 on ClinicalTrials.gov

4. Digital Technology-Informed Stroke Rehabilitation

   The goal of this study is to determine the effects of lab and home-based technology guidance during movement training post-stroke. The study will compare movement training informed by lab-based technology to training delivered with technology at home. The main questions it aims to answer are: * How…

   Stage

   Not phased

   Ages

   30 to 85

   Site

   Kennecott Mechanical Engineering Building, Salt Lake City, Utah

   Run by

   University of Utah

   See if you can join NCT07698522 on ClinicalTrials.gov

5. Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

   CAPTIVA-MRI is an observational multimodal MR imaging study that is ancillary to the CAPTIVA trial [a 3-arm, double-blind Phase III trial conducted at approximately 115 StrokeNet sites randomizing patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Alabama Hospital, Birmingham, Alabama

   Locations

   28 in total

   Run by

   Yale University

   See if you can join NCT05907629 on ClinicalTrials.gov

6. Assistance Delivery and Muscle Coordination

   The experiment will be conducted with 15 chronic stroke survivors and 15 control subjects. Subjects will perform extension movements of the index finger of their more-impaired (stroke) or nondominant (control) hand under two different assistance types: end-effector assistance and exotendon assistan…

   Stage

   EARLY_Phase 1

   Ages

   20 to 80

   Site

   Catholic University of America, Washington D.C., District of Columbia

   Run by

   The Catholic University of America

   See if you can join NCT07011173 on ClinicalTrials.gov

7. Mechanisms of Open and Hidden Placebo in Stroke Recovery

   This trial aims to investigate whether placebo in isolation (open and hidden) has a specific neural signature in stroke subjects thus providing a novel mechanism to explain placebo effects that can be used to ultimately enhance stroke rehabilitation therapies.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Spaulding Hospital Cambridge, Cambridge, Massachusetts

   Run by

   Spaulding Rehabilitation Hospital

   See if you can join NCT05832567 on ClinicalTrials.gov

8. Relying on Pharmacotherapy to Improve Motor Gains in Chronic Stroke Survivors

   The goal of this trial is to study if the concomitant administration of Telmisartan, Cilostazol IR (immediate release), and Metformin ER (extended release) can help stroke survivors make greater gains in movement and recovery during robot-assisted arm and hand rehabilitation.

   Stage

   EARLY_Phase 1

   Ages

   21 to 80

   Site

   Spaulding Rehabilitation Hospital, Charlestown, Massachusetts

   Run by

   Spaulding Rehabilitation Hospital

   See if you can join NCT07588932 on ClinicalTrials.gov

9. An Augmented Reality Based System for Neglect Detection, Assessment, and Rehabilitation

   The aim of this phase is to examine the feasibility and acceptability of the Augmented Reality (AR)-based and electroencephalography (EEG)-based neglect detection and rehabilitation tool.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Pittsburgh, Pittsburgh, Pennsylvania

   Locations

   2 in total

   Run by

   University of Pittsburgh

   See if you can join NCT04187131 on ClinicalTrials.gov

10. Language Processing and TMS

    This study will examine the effect of TMS on people with stroke and aphasia as well as healthy individuals.

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Medical College of Wisconsin, Milwaukee, Wisconsin

    Run by

    Medical College of Wisconsin

    See if you can join NCT05425615 on ClinicalTrials.gov

11. At Home Wearable Sensors and Smartphone for Stroke Survivors With Upper Limb Motor Challenges.

    The goal of this clinical trial is to learn if wearable sensor data visualization on smartphones can improve the use of the stroke-affected limb during everyday activities. Chronic stroke survivors (>12 months from onset) ages 18-80 years old with residual upper extremity motor impairments may be e…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Spaulding Rehabilitation Hospital, Motion Analysis Laboratory, Charlestown, Massachusetts

    Run by

    Spaulding Rehabilitation Hospital

    See if you can join NCT06787729 on ClinicalTrials.gov

12. Evaluation of an Advanced Lower Extremity Neuroprostheses

    The purpose of this study is to evaluate a surgically implanted functional electrical stimulation (FES) system to facilitate exercise, standing, stepping and/or balance in people with various degrees of paralysis.

    Stage

    Not phased

    Ages

    21 to 75

    Site

    Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio

    Locations

    2 in total

    Run by

    Case Western Reserve University

    See if you can join NCT00623389 on ClinicalTrials.gov

13. Transcranial Alternating Current Stimulation (tACS) for the Recovery of Phonological Short-Term Memory in Patients With Aphasia After Stroke

    This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical College of Wisconsin, Milwaukee, Wisconsin

    Run by

    Medical College of Wisconsin

    See if you can join NCT06048159 on ClinicalTrials.gov

14. Post-Stroke Aphasia TMS

    The investigator proposes to examine the effects of excitatory transcranial magnetic stimulation (TMS) combined with semantic feature analysis (SFA) language therapy to improve word-finding abilities in stroke survivors with aphasia (SWA).

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical College of Wisconsin, Milwaukee, Wisconsin

    Run by

    Medical College of Wisconsin

    See if you can join NCT06974279 on ClinicalTrials.gov

15. Feasibility of a Remotely Delivered Step Count Intervention in Chronic Stroke

    The goal of this study is to explore the feasibility of a new approach to rehabilitation that focuses on step count. Participants will complete 6 telephone or Zoom-based sessions with an occupational therapist over 6 weeks and use a step count tracker during that time. They will also complete quest…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT07649135 on ClinicalTrials.gov

16. Alternative Therapies for Improving Physical Function in Individuals With Stroke

    Neurological impairment is a devastating disease for patients and their families and a leading cause of adult disability. Traditional rehabilitative therapies can help regain motor function and ameliorate disability. However, health care reimbursed rehabilitation is usually provided for up to 6 mon…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    University of Illinois at Chicago, Chicago, Illinois

    Locations

    2 in total

    Run by

    University of Illinois at Chicago

    See if you can join NCT03869138 on ClinicalTrials.gov

17. Accelerated rTMS vs. Sham for Stroke Apathy

    Apathy is a common set of symptoms seen in many people following a stroke. Apathy occurs when a person has lost motivation, becomes withdrawn, and stops doing things that used to be important to them. Apathy has a large negative impact on a person's quality of life, and can also have a large impact…

    Stage

    Phase 1

    Ages

    40 and older

    Site

    Medical University of South Carolina Brain Stimulation Lab, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07113067 on ClinicalTrials.gov

18. Neuroplasticity Biomarkers in Aphasia

    Patients with stroke frequently suffer from aphasia, a disorder of expressive and/or receptive language, that can lead to serious health consequences, including social isolation, depression, reduced quality of life, and increased caregiver burden. Aphasia recovery varies greatly between individuals…

    Stage

    Not phased

    Ages

    40 to 90

    Site

    UW School of Medicine and Public Health, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT06471127 on ClinicalTrials.gov

19. Reactive Balance Training for Fall Prevention

    The objective of this pilot study is to evaluate and compare the effect of three different perturbation based training devices on the reactive balance control among healthy young adults, healthy older adults, and neurologically impaired stroke individuals. Furthermore, the project aims to determine…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    University of Illinois at Chicago, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT04205279 on ClinicalTrials.gov

20. Measurement Properties of Mechanical Cost of Walking for Individuals With Walking Impairment

    Walking impairment following neurologic injury can increase the energy cost of walking threefold, acting as a functional barrier to independence. The goal of this cross-sectional study is to determine the measurement properties of a novel biomechanical cost of walking measure in chronic stroke capa…

    Stage

    Not phased

    Ages

    30 to 80

    Site

    University of Cincinnati - Digital Futures, Cincinnati, Ohio

    Run by

    University of Cincinnati

    See if you can join NCT07494890 on ClinicalTrials.gov

21. Genetic and Environmental Risk Factors for Hemorrhagic Stroke

    The purpose of this study is to find risk factors for hemorrhagic stroke.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Baptist Health Louisville, Louisville, Kentucky

    Locations

    7 in total

    Run by

    State University of New York at Buffalo

    See if you can join NCT00682695 on ClinicalTrials.gov

22. RESPARK - Brain Q for Chronic Stroke

    This trial tests a promising new intervention to promote post-stroke neural reorganization and functional recovery. The Q Therapeutic (BQ 3.0) is a wearable medical system that produces and delivers non-invasive, extremely-low-intensity and low-frequency, frequency-tuned electromagnetic fields in o…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Brooks Rehabilitation Clinical Research Center, Jacksonville, Florida

    Run by

    University of Florida

    See if you can join NCT07095920 on ClinicalTrials.gov

23. Neurologic Stem Cell Treatment Study

    This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will provide improvement in neurologic function for patients with certain n…

    Stage

    Not phased

    Ages

    18 and older

    Site

    MD Stem Cells, Westport, Connecticut

    Locations

    3 in total

    Run by

    MD Stem Cells

    See if you can join NCT02795052 on ClinicalTrials.gov

24. Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

    The primary objective of this study is to evaluate the effectiveness (prevention of thromboembolic events) and safety (major bleeding) of adding oral anticoagulation (OAC) to background antiplatelet therapy in patients who develop new-onset post-operative atrial fibrillation (POAF) after isolated c…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    CHI St. Vincent, Arkansas, Little Rock, Arkansas

    Locations

    106 in total

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT04045665 on ClinicalTrials.gov

25. Spinal Cord Stimulation Combined With Physical Therapy in Post-Stroke Upper-Limb Motor Hemiparesis

    This study plans to use systems that have been developed by Medtronic to investigate the use of cervical spinal cord stimulation to treat adults with upper limb hemiparesis resulting from a stroke. The spinal cord stimulation (SCS) will be combined with physical training to improve arm and hand mot…

    Stage

    Not phased

    Ages

    22 to 70

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    Marco Capogrosso

    See if you can join NCT07153536 on ClinicalTrials.gov