Stroke Clinical Trials

216 studies are recruiting for stroke in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Low Intensity Focused Ultrasound Stimulation in Stroke Patients - Parameter Optimization

   The goal of this research study is to optimize the parameter of Low-Intensity Focused Ultrasound Stimulation (LIFUS) that is most effective in changing cortical excitability and motor learning skills in patients who suffered a stroke. The researchers hope to answer two questions. * with increasing …

   Stage

   Not phased

   Ages

   21 and older

   Site

   Duke University Hospital, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT07220005 on ClinicalTrials.gov

2. Self-Supervised Constraint-Induced Movement Therapy for Stroke Recovery

   The goal of this clinical trial is to learn how a partially self-supervised constraint-induced movement therapy (sCIMT) program in adults with arm and hand weakness will work after stroke. This study will look at whether the program can help people improve the use of their arm and hand after a stro…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Ohio State University, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT07723300 on ClinicalTrials.gov

3. tACS to Enhance Language Abilities

   The goal of this study is to see if transcranial alternating current stimulation (tACS) can be used to enhance language abilities in people with post-stroke aphasia. Participants will receive real and sham tACS in conjunction with various language tests. Researchers will compare the post-stroke aph…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT06092814 on ClinicalTrials.gov

4. Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials

   VERIFY will validate biomarkers of upper extremity (UE) motor outcome in the acute ischemic stroke window for immediate use in clinical trials, and explore these biomarkers in acute intracerebral hemorrhage. VERIFY will create the first multicenter, large-scale, prospective dataset of clinical, tra…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Birmingham VA Medical Center, Birmingham, Alabama

   Locations

   45 in total

   Run by

   Yale University

   See if you can join NCT05338697 on ClinicalTrials.gov

5. A Digital Intervention for Post-Stroke Depression and Executive Dysfunction

   Individuals with stroke commonly experience both depression and cognitive difficulties. The goal of this study is to evaluate the efficacy of a treatment that combines a digital therapeutic (an iPad-based cognitive training program) with learning cognitive strategies. The hypotheses are that this t…

   Stage

   Phase 2

   Ages

   50 to 79

   Site

   Weill Cornell Medical Center, New York, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT05507138 on ClinicalTrials.gov

6. Neuroplastic Changes Due to an Exercise Intervention That Aid in Lower Limb Recovery After Subcortical Stroke

   This study aims to develop imaging-based biomarkers to assess which chronic stroke participant with lower extremity disability may respond or resist high intensity interval training (HIIT). Previous research suggests that physical exercise training is safe and could help improve the walking speed o…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Emory Rehabilitation Hospital, Atlanta, Georgia

   Locations

   2 in total

   Run by

   Emory University

   See if you can join NCT07663292 on ClinicalTrials.gov

7. Carotid Implants for PreveNtion of STrokE ReCurrEnce From Large Vessel Occlusion in Atrial Fibrillation Patients Treated With Oral Anticoagulation

   Patients with atrial fibrillation (AF) who have had a prior stroke are at very high risk of recurrent ischemic stroke. About 40% of these strokes are due to large emboli which result in large cerebral vessel occlusion (LVO). This randomized control trial aims to address this unmet need by testing w…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mercyhealth Javon Bea Hospital - Riverside, Rockford, Illinois

   Locations

   21 in total

   Run by

   Javelin Medical

   See if you can join NCT05723926 on ClinicalTrials.gov

8. The Beneficial Effects of Naps on Motor Learning

   Background: Memory consolidation is the process by which memories become stable, long-term representations in the brain. Consolidation of a motor skill is dependent upon sleep. Some research shows that daytime naps improve people s motor performance and memory retention. Researchers want to find ou…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Neurological Disorders and Stroke (NINDS)

   See if you can join NCT04312126 on ClinicalTrials.gov

9. Effect of Neural Constraints on Movement in Stroke

   This study investigates the effects of Tizanidine on the voluntary movement controls of the arms of participants who have had a stroke and have not had a stroke by measuring medication-induced changes in upper extremity kinematics, pupillometry, and brain activity. Tizanidine is approved by the U.S…

   Stage

   EARLY_Phase 1

   Ages

   18 to 80

   Site

   Northwestern University, Dept. of PTHMS 645 N Michigan Ave, Suite 1100, Chicago, Illinois

   Run by

   Northwestern University

   See if you can join NCT06666673 on ClinicalTrials.gov

10. Overground Virtual Reality (VR) Gait Rehabilitation for Stroke

    The purpose of this study is to evaluate a new virtual reality (VR)-based rehabilitation program designed to help stroke survivors improve their walking abilities in real-world settings. By comparing immersive VR-assisted overground gait therapy to contemporary non-immersive, treadmill-based VR the…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Indiana University Health, Neurorehabilitation & Robotics, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT07676578 on ClinicalTrials.gov

11. Electrical Stimulation Exercise for Individuals With Lower Limb Paralysis

    The purpose of this research study is to evaluate the effectiveness of an exercise training intervention (24-36 sessions) to improve muscle strength and endurance in the lower limbs of individuals with paralysis. Specifically, surface electrical stimulation or previously implanted stimulator will b…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio

    Run by

    Louis Stokes VA Medical Center

    See if you can join NCT07768761 on ClinicalTrials.gov

12. Safety and Efficacy of NeuroTechR3 System for Upper Extremity Recovery After Stroke

    This research aims to understand the feasibility and effectiveness of using the NeuroTechR3 System to improve upper extremity function after stroke.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brooks Rehabilitation Hospital - Bartram Campus, Jacksonville, Florida

    Run by

    Brooks Rehabilitation

    See if you can join NCT07769281 on ClinicalTrials.gov

13. Combined Exercise and Targeted Therapy for Post-Stroke Reading Deficits

    The goal of the proposed project is to test the effectiveness of a novel hybrid approach to treatment of reading disorders after stroke, in which exercise training will be used in combination with a targeted reading treatment. This approach is expected to increase cerebral circulation and help to r…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Kessler Foundation, West Orange, New Jersey

    Run by

    Kessler Foundation

    See if you can join NCT06213272 on ClinicalTrials.gov

14. Portable MRI for Pediatric Hypoxic Ischemic Brain Injury

    This study will evaluate the sensitivity and specificity of low field portable MRI (pMRI) for detection of hypoxic ischemic brain injuries in pediatric patients compared to clinically obtained neuroimaging to define pediatric diagnostic limitations and to determine the diagnostic capabilities of th…

    Stage

    Not phased

    Ages

    Up to 17

    Site

    Children's Mercy Hospital and Clinics, Kansas City, Missouri

    Run by

    Children's Mercy Hospital Kansas City

    See if you can join NCT07577336 on ClinicalTrials.gov

15. Cognition and Imaging With Tigertriever

    The objective of the COGNITIVE Study is to evaluate whether successful reperfusion with Tigertriever is associated with cognitive benefit.

    Stage

    Not phased

    Ages

    18 to 75

    Site

    University of California, Los Angeles, California

    Locations

    3 in total

    Run by

    Rapid Medical

    See if you can join NCT05531461 on ClinicalTrials.gov

16. Music Listening for Mental Health Recovery After Stroke

    This study aims to explore whether listening to music intentionally can support the mental health of people recovering from a stroke. The question the investigators aim to answer is: Can intentional music listening improve emotional well-being in stroke survivors? And if so, what kinds of changes m…

    Stage

    Not phased

    Ages

    50 to 90

    Site

    New York University, New York, New York

    Run by

    New York University

    See if you can join NCT07127159 on ClinicalTrials.gov

17. Self-Administered Gaming and Exercise at Home (SAGEH)

    This study aims at comparing manual function outcomes between the standard of care and additional self-administered hand therapy after stroke. Strokes are common neurological injuries, and although rates of survival have increased in recent decades, survivors often continue to experience deficienci…

    Stage

    Not phased

    Ages

    21 and older

    Site

    Johns Hopkin, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05929027 on ClinicalTrials.gov

18. TDCS to Improve Post-Stroke Cognitive Impairment

    The investigators will conduct a randomized, double-blinded, sham-controlled trial of approximately 60 patients with minor stroke and post-stroke mild cognitive impairment (psMCI). Participants will be individually randomized on enrollment using a random number generator to treatment with anodal tD…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    Johns Hopkins Bayview Medical Center, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05195398 on ClinicalTrials.gov

19. Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage

    The aim is to compare the rate of hypertensive subjects with ICH who reach SBP target with stability within 60 minutes of enrollment, among patients treated with IV clevidipine with those treated with alternate IV antihypertensive regimen.

    Stage

    Not phased

    Ages

    18 to 100

    Site

    University of California, Irvine, California

    Locations

    20 in total

    Run by

    Zeenat Qureshi Stroke Institute

    See if you can join NCT06402968 on ClinicalTrials.gov

20. Mobile Cognitive Behavioral Therapy for Stroke

    This study aims to assess the feasibility and acceptability of "MAYA", a mobile cognitive behavioral therapy app for anxiety and mood disorders, in adults who have had a stroke.

    Stage

    Not phased

    Ages

    40 to 79

    Site

    Weill Cornell Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT06689878 on ClinicalTrials.gov

21. Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking

    Investigators primary aim is to carry out a two-site, randomized, double-blind, sham-controlled, phase II trial to systematically examine the potential for aerobic exercise (AEx) to enhance the anti-depressant benefits of rTMS in individuals with post-stroke depression (PSD). Investigators propose …

    Stage

    Not phased

    Ages

    21 and older

    Site

    Duke University School of Medicine, Durham, North Carolina

    Locations

    2 in total

    Run by

    Medical University of South Carolina

    See if you can join NCT07050355 on ClinicalTrials.gov

22. GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

    This study will assess the safety and effectiveness of GORE® CARDIOFORM Septal Occluder in a post approval setting and evaluate the quality of operator education and training and transferability of trial experience to a post-market setting.

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Scripps Health La Jolla, La Jolla, California

    Locations

    45 in total

    Run by

    W.L.Gore & Associates

    See if you can join NCT03821129 on ClinicalTrials.gov

23. Examining Relationships Between Musculoskeletal Function Measurements of Movement Efficiency and Nervous System Function After Chronic Stroke

    Stroke remains the leading cause of severe disability, and survivors frequently have incomplete recovery. More than half of older survivors have impaired mobility which contributes to poorer quality-of-life (QoL) and suffering. The annual rate of disability compared to myocardial infarction triples…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California Davis, Sacramento, California

    Run by

    University of California, Davis

    See if you can join NCT07737873 on ClinicalTrials.gov

24. Transcranial Alternating Current Stimulation (tACS) in Aphasia

    This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functions.

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Medical College of Wisconsin, Milwaukee, Wisconsin

    Run by

    Medical College of Wisconsin

    See if you can join NCT04375722 on ClinicalTrials.gov

25. Diagnostic Performance Study of the EMVision Emu™ Brain Scanner in the Detection of Intracranial Hemorrhage in Suspected Stroke Patients

    The purpose of this research is to evaluate a new investigational device for the diagnosis of stroke, the EMVision emu™ Brain Scanner. Stroke is the result of a blood clot stopping the normal flow of blood in the brain (ischaemic stroke) or a breakage in a blood vessel causing bleeding in the brain…

    Stage

    Not phased

    Ages

    22 and older

    Site

    UCLA, Los Angeles, California

    Locations

    8 in total

    Run by

    EMVision Medical Devices Ltd

    See if you can join NCT06999122 on ClinicalTrials.gov