Stroke Clinical Trials

210 studies are recruiting for stroke in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Real-time Personalized Brain State-dependent TMS After Stroke

   Transcranial magnetic stimulation (TMS) interventions could feasibly strengthen residual corticospinal tract (CST) connections and enhance recovery of paretic upper extremity function after stroke. This project will test whether personalized brain state-dependent TMS can activate the residual corti…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Iowa, Iowa City, Iowa

   Run by

   Sara Hussain

   See if you can join NCT06533176 on ClinicalTrials.gov

2. CoMind Early Feasibility Study

   The purpose of this research, which has been determined as non-significant risk by the central IRB overseeing the study, is to obtain information to help further develop a machine (a medical device) to measure the pressure around the brain from the outside (this pressure is called intracranial pres…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Banner University Medical Center, Phoenix, Arizona

   Locations

   17 in total

   Run by

   CoMind Technologies Limited

   See if you can join NCT06368648 on ClinicalTrials.gov

3. Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage

   The aim is to compare the rate of hypertensive subjects with ICH who reach SBP target with stability within 60 minutes of enrollment, among patients treated with IV clevidipine with those treated with alternate IV antihypertensive regimen.

   Stage

   Not phased

   Ages

   18 to 100

   Site

   University of California, Irvine, California

   Locations

   21 in total

   Run by

   Zeenat Qureshi Stroke Institute

   See if you can join NCT06402968 on ClinicalTrials.gov

4. Xeomin® and Gait Related Mobility After Stroke

   The aim of the present pilot study is to evaluate the association between change in gait related mobility in ambulatory male and female adult hemiparetic patients before and 4-6-weeks after Xeomin® injection into the upper limb, using two standardized tests of physical function in outpatient rehabi…

   Stage

   Phase 4

   Ages

   18 to 79

   Site

   Carolinas Rehabilitation, Charlotte, North Carolina

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT04908423 on ClinicalTrials.gov

5. Telerehabilitation In The Home After Stroke

   The purpose of this research study is to evaluate whether telerehabilitation targeting arm movement, when added to usual care, improves arm function and reduces global disability after stroke, compared to usual care alone. Patients with arm weakness due to stroke that happened in the past 90-270 da…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Rancho Los Amigos Research Institute, Downey, California

   Locations

   27 in total

   Run by

   University of California, Los Angeles

   See if you can join NCT06682429 on ClinicalTrials.gov

6. Implementing Transcranial Direct Current Stimulation in a Rehabilitation Setting

   This study looks at whether transcranial Direct Current Stimulation (tDCS) can be effectively implemented in inpatient and outpatient rehabilitation settings during routine speech therapy for people who recently had a stroke and now have aphasia (difficulty speaking or understanding language)

   Stage

   Not phased

   Ages

   18 and older

   Site

   Casa Colina Hospital and Centers for Healthcare, Pomona, California

   Run by

   Casa Colina Hospital and Centers for Healthcare

   See if you can join NCT07535788 on ClinicalTrials.gov

7. Determine the Effect of Targeted High-definition Transcranial Direct Current Stimulation (tDCS) on Reducing Post-stroke Upper Limb Motor Impairments

   Significant motor impairments occur in 80% of individuals after moderate to severe stroke and impact the body side to the lesioned hemisphere. Typical motor impairments involve loss of dexterity with highly prevalent upper limb flexion synergy. Advances in treating flexion synergy impairments have …

   Stage

   Not phased

   Ages

   18 to 90

   Site

   Carle Foundation Hospital, Urbana, Illinois

   Run by

   Carle Foundation Hospital

   See if you can join NCT05479006 on ClinicalTrials.gov

8. Neuromodulation-Enhanced Use of RObotic BALANCE Training to Improve Balance Function in Individuals With Stroke

   Our proposed study, "NEUROBALANCE Stroke,"; aims to evaluate the effectiveness of a combined intervention involving robotic balance training and noninvasive brain stimulation in improving balance function and postural control in individuals with chronic stroke. The study will recruit 45 participant…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   Kessler Foundation, West Orange, New Jersey

   Run by

   Kessler Foundation

   See if you can join NCT07113041 on ClinicalTrials.gov

9. Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosome Intranasal Instillations for Stroke

   This trial will study the safety and efficacy of intranasal instillation of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of Stroke

   Stage

   Phase 1

   Ages

   Any age

   Site

   Prodromos Stem Cell Institute, Naples, Florida

   Locations

   2 in total

   Run by

   The Foundation for Orthopaedics and Regenerative Medicine

   See if you can join NCT05158101 on ClinicalTrials.gov

10. Locomotor Function Following Transcutaneous Electrical Spinal Cord Stimulation in Individuals With Hemiplegic Stroke

    This study has two interventional components, the first is a cross-over design and the second is a randomized control trial. Both will evaluate the effectiveness of transcutaneous (non-invasive) spinal cord stimulation on gait and balance function for individuals with hemiplegia due to stroke.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Shirley Ryan AbilityLab, Chicago, Illinois

    Run by

    Shirley Ryan AbilityLab

    See if you can join NCT05167786 on ClinicalTrials.gov

11. Effect of Neuro20 Functional Electrical Stimulation Suit on Autonomic Function, Muscle Performance, and Gait

    This research aims to understand the effect of the Neuro20 Functional Electrical Stimulation Suit on autonomic nervous system function, muscle performance, and gait after amputation or neurologic injury.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brooks Rehabilitation, Jacksonville, Florida

    Locations

    2 in total

    Run by

    Brooks Rehabilitation

    See if you can join NCT07164846 on ClinicalTrials.gov

12. Wearable Biofeedback for Swallowing Disorders Rehabilitation in Stroke and Parkinson Disease

    Dysphagia, or difficulty swallowing, is a common symptom of many neurological diseases but its treatment is not well established or easily accessible. To start addressing this gap, the researchers developed and validated a cost-effective wearable surface electromyography (sEMG) biofeedback sensor t…

    Stage

    Phase 2

    Ages

    50 to 90

    Site

    University of Illinois Urbana-Champaign, Champaign, Illinois

    Locations

    2 in total

    Run by

    University of Illinois at Urbana-Champaign

    See if you can join NCT06638944 on ClinicalTrials.gov

13. Elite AF IDE Trial (Elite AF)

    The primary objective of this study is to establish the safety and effectiveness of the WATCHMAN Elite Left Atrial Appendage Closure (LAAC) Device for subjects with non-valvular atrial fibrillation who are eligible for anticoagulation therapy to reduce the risk of stroke.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Arrhythmia Research Group, Jonesboro, Arkansas

    Locations

    2 in total

    Run by

    Boston Scientific Corporation

    See if you can join NCT07287436 on ClinicalTrials.gov

14. Overground Virtual Reality (VR) Gait Rehabilitation for Stroke

    The purpose of this study is to evaluate a new virtual reality (VR)-based rehabilitation program designed to help stroke survivors improve their walking abilities in real-world settings. By comparing immersive VR-assisted overground gait therapy to contemporary non-immersive, treadmill-based VR the…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Indiana University Health, Neurorehabilitation & Robotics, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT07676578 on ClinicalTrials.gov

15. Telerehabilitation for Post-Stroke Hand Function

    This pilot randomized controlled trial will evaluate the feasibility and preliminary effects of a home-based, technology-enabled hand telerehabilitation program for adults with chronic stroke. Participants will receive either remotely guided hand training or a standard home exercise program matched…

    Stage

    Not phased

    Ages

    40 to 75

    Site

    Physical Medicine & Rehabilitation 325 E Eisenhower Pkwy Suite 3011, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT07792655 on ClinicalTrials.gov

16. Explore the Effects of Cortical Priming on Visuomotor Stepping Learning in Persons With Chronic Stroke

    This research study aims to understand the relationship between brain stimulation and leg skill learning in both healthy adults and persons with chronic stroke.

    Stage

    Not phased

    Ages

    21 to 90

    Site

    Physical Therapy, University of Texas Medical Branch, Galveston, Texas

    Run by

    The University of Texas Medical Branch, Galveston

    See if you can join NCT06681207 on ClinicalTrials.gov

17. Myofascial Dysfunction in Post Stroke Shoulder Pain

    Shoulder pain is extremely common after stroke and occurs in 30-70% of patients. The pain may begin as early as one week after stroke, although peak onset and severity occurs around four months, and persists into the chronic stage. Chronic post stroke shoulder pain (PSSP) interferes with motor reco…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Johns Hopkins University, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06718413 on ClinicalTrials.gov

18. Efficacy of a Telehealth Delivered Group Lifestyle Balance for People Post Stroke (tGLB-CVA)

    Investigators will conduct a randomized controlled trial (RCT) to assess intervention efficacy of telehealth delivery of the GLB-CVA (tGLB-CVA) compared to a 6-month wait-list control (WLC) in partnership with a diverse group of patient partners and peer mentors.

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Baylor Scott & White Research Institute, Dallas, Texas

    Run by

    Baylor Research Institute

    See if you can join NCT06569121 on ClinicalTrials.gov

19. Cognition and Imaging With Tigertriever

    The objective of the COGNITIVE Study is to evaluate whether successful reperfusion with Tigertriever is associated with cognitive benefit.

    Stage

    Not phased

    Ages

    18 to 75

    Site

    University of California, Los Angeles, California

    Locations

    6 in total

    Run by

    Rapid Medical

    See if you can join NCT05531461 on ClinicalTrials.gov

20. Tele-CE in Severe Stroke

    The goal of this clinical trial is to determine the effects of home-based cross-education on lower limb neuroplasticity in severe stroke. The main questions the investigators aim to answer are: * What are the effects of home-based cross-education on lower limb neuroplasticity? * What are the effect…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Brain Plasticity Lab, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT07652970 on ClinicalTrials.gov

21. EMG-Controlled Game to Retrain Upper Extremity Muscle Activation Patterns Following Stroke

    The purpose of this study is to develop and test if upper limb task practice and muscle activity training improve upper limb function in stroke survivors. Participants will be asked to come to the laboratory 23 times (approximately 3 times a week) over 2.5 months to receive upper limb task practice…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina

    Run by

    VA Office of Research and Development

    See if you can join NCT05628324 on ClinicalTrials.gov

22. Influence of Brain Oscillation-Dependent TMS on Motor Function

    Background: When people have a stroke, they often have difficulty moving their arms and hands. Transcranial magnetic stimulation (TMS) can improve how well people with and without stroke can move their arms and hands. But the effects of TMS are minor, and it doesn t work for everyone. Researchers w…

    Stage

    Not phased

    Ages

    18 to 120

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Neurological Disorders and Stroke (NINDS)

    See if you can join NCT03288220 on ClinicalTrials.gov

23. Effect of Neural Constraints on Movement in Stroke

    This study investigates the effects of Tizanidine on the voluntary movement controls of the arms of participants who have had a stroke and have not had a stroke by measuring medication-induced changes in upper extremity kinematics, pupillometry, and brain activity. Tizanidine is approved by the U.S…

    Stage

    EARLY_Phase 1

    Ages

    18 to 80

    Site

    Northwestern University, Dept. of PTHMS 645 N Michigan Ave, Suite 1100, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT06666673 on ClinicalTrials.gov

24. Improving Measurement and Treatment of Post-stroke Neglect

    This study examines how to best assess and treat post-stroke neglect. This study will examine the preliminary effects of an innovative intervention (repetitive task-specific practice + transcranial direct current stimulation) for individuals with neglect. This study will also determine whether item…

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania

    Run by

    VA Office of Research and Development

    See if you can join NCT03317860 on ClinicalTrials.gov

25. Screening for Social Determinants of Health (SDOH) and Cognitive Function in Individuals With History of Stroke

    Background: Stroke is the fifth leading cause of death in the United States. It is also a leading cause of disability. More than 70% of people who survive strokes have mental impairment or dementia. Medical factors, such as the severity of the stroke, affect whether a person will have mental impair…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Neurological Disorders and Stroke (NINDS)

    See if you can join NCT06615973 on ClinicalTrials.gov