Stroke Clinical Trials

216 studies are recruiting for stroke in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Improving the Collaborative Health of Adult Dyads

   This study tests the efficacy of a dyadic intervention to mitigate the adverse health consequences of adults with pre-existing chronic health conditions and their informal carepartners (IC). Socioeconomically disadvantaged, older, and people from rural regions are more likely burdened with greater …

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of South Carolina, Columbia, South Carolina

   Run by

   University of South Carolina

   See if you can join NCT05370014 on ClinicalTrials.gov

2. Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function

   This study aims to recruit patients already implanted with Deep Brain Stimulation (DBS) for movement disorders to complete tasks assessing parameters of motor output, speech, and swallowing functions, both with and without stimulation. DBS parameters would be adjusted prior to motor testing. Patien…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   University of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   Jorge Gonzalez-Martinez

   See if you can join NCT07056348 on ClinicalTrials.gov

3. Stimulating Specific Brain Areas (VOP/VIM) With Electricity to Improve Movement and Muscle Control

   In this study the investigators aim to enroll patients scheduled to undergo deep brain stimulation (DBS) implantation for movement disorders for intra-operative testing. In addition to standard-of-care surgical procedure to implant deep brain stimulation electrode leads, participants will also be s…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   University of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   Jorge Gonzalez-Martinez

   See if you can join NCT07056361 on ClinicalTrials.gov

4. A Closed Loop Neural Activity Triggered Stroke Rehabilitation Device

   The purpose of this research is to determine if two non-invasive brain stimulation techniques, muscle stimulation of the arm and neuro-stimulation through the tongue, can increase the extent of stroke recovery.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Wisconsin, Madison, Wisconsin

   Run by

   University of Wisconsin, Madison

   See if you can join NCT02098265 on ClinicalTrials.gov

5. Screening for Social Determinants of Health (SDOH) and Cognitive Function in Individuals With History of Stroke

   Background: Stroke is the fifth leading cause of death in the United States. It is also a leading cause of disability. More than 70% of people who survive strokes have mental impairment or dementia. Medical factors, such as the severity of the stroke, affect whether a person will have mental impair…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Neurological Disorders and Stroke (NINDS)

   See if you can join NCT06615973 on ClinicalTrials.gov

6. I-Score: Intensive Stroke Cycling for Optimal Recovery and Economic Value

   Traditional rehabilitation approaches are time and personnel intensive and costly, and leave ~75% of stroke survivors with residual disability. We propose a clinical trial to determine effects of forced aerobic exercise (FE; i.e., mechanically supplemented) in facilitating upper and lower extremity…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Cleveland Clinic, Cleveland, Ohio

   Run by

   The Cleveland Clinic

   See if you can join NCT06585943 on ClinicalTrials.gov

7. Telerehabilitation for Post-Stroke Hand Function

   This pilot randomized controlled trial will evaluate the feasibility and preliminary effects of a home-based, technology-enabled hand telerehabilitation program for adults with chronic stroke. Participants will receive either remotely guided hand training or a standard home exercise program matched…

   Stage

   Not phased

   Ages

   40 to 75

   Site

   Physical Medicine & Rehabilitation 325 E Eisenhower Pkwy Suite 3011, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT07792655 on ClinicalTrials.gov

8. Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)

   This is a Phase 2/3 study evaluating the safety and efficacy of DM199 (rinvecalinase alfa) in treating participants with moderate stroke severity, who present within 24 hours of Acute Ischemic Stroke (AIS) onset due to small and medium vessel occlusions. This study focuses on participants with limi…

   Stage

   Phase 2

   Ages

   18 to 90

   Site

   Gulf Health Hospitals d/b/a Thomas Hospital, Fairhope, Alabama

   Locations

   86 in total

   Run by

   DiaMedica Therapeutics Inc

   See if you can join NCT05065216 on ClinicalTrials.gov

9. Repetitive Transcranial Magnetic Stimulation, a Form of Non-invasive Brain Stimulation, as a Possible Treatment for Post-stroke Fatigue

   This experimental trial is investigating the use of magnetic stimulation of the brain as a possible treatment for post-stroke fatigue in people who have had a stroke more than six months prior to enrolling. Fatigue is a common condition after a stroke and can negatively impact an individual's abili…

   Stage

   Phase 2

   Ages

   34 to 80

   Site

   Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia

   Locations

   2 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT05584124 on ClinicalTrials.gov

10. Effects of Recursive Self-feedback on Speech Production in Aphasia

    The goal of this clinical trial is to test the effects of recursive self-feedback procedures on spontaneous speech production in stroke survivors with impaired speech production (aphasia). The main question it aims to answer is: • To what extent can stroke survivors with aphasia use their self-feed…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Brain and Aphasia Recovery Lab, PCD 1030, Department of Communication Sciences and Disorders, University of South Florida, Tampa, Florida

    Run by

    University of South Florida

    See if you can join NCT06323629 on ClinicalTrials.gov

11. Vision Improvement Through Behavioral Rehabilitation And Neuroplasticity Training

    The VIBRANT (Vision Improvement through Behavioral Rehabilitation And Neuroplasticity Training) study is a prospective, double-blind, crossover design (within-subject) in participants with homonymous hemianopia-a type of visual field loss resulting from damage to the post-chiasmatic visual pathways…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Georgetown University Medical Center, Washington D.C., District of Columbia

    Run by

    Georgetown University

    See if you can join NCT07105358 on ClinicalTrials.gov

12. Home-based Vision Rehabilitation Guided by Brain Imaging

    The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss. Using a prospective, crossover design, BRIGHT combines visu…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Georgetown University Medical Center, Washington D.C., District of Columbia

    Run by

    Georgetown University

    See if you can join NCT07635329 on ClinicalTrials.gov

13. Wearable Biofeedback for Swallowing Disorders Rehabilitation in Stroke and Parkinson Disease

    Dysphagia, or difficulty swallowing, is a common symptom of many neurological diseases but its treatment is not well established or easily accessible. To start addressing this gap, the researchers developed and validated a cost-effective wearable surface electromyography (sEMG) biofeedback sensor t…

    Stage

    Phase 2

    Ages

    50 to 90

    Site

    University of Illinois Urbana-Champaign, Champaign, Illinois

    Locations

    2 in total

    Run by

    University of Illinois at Urbana-Champaign

    See if you can join NCT06638944 on ClinicalTrials.gov

14. Cardiac Rehabilitation of Stroke Survivors (SRP-CROSS)

    This study examines the effectiveness of the cardiac rehabilitation program for stroke patients. The study will examine if patients with stroke, who receive cardiac rehabilitation in addition to their standard of care treatments, demonstrate improved recovery of function. It will also examine if th…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Hackensack Meridian Health - JFK Johnson Rehabilitation Institute, Edison, New Jersey

    Run by

    Hackensack Meridian Health

    See if you can join NCT05651945 on ClinicalTrials.gov

15. Telerehabilitation In The Home After Stroke

    The purpose of this research study is to evaluate whether telerehabilitation targeting arm movement, when added to usual care, improves arm function and reduces global disability after stroke, compared to usual care alone. Patients with arm weakness due to stroke that happened in the past 90-150 da…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Rancho Los Amigos Research Institute, Downey, California

    Locations

    27 in total

    Run by

    University of California, Los Angeles

    See if you can join NCT06682429 on ClinicalTrials.gov

16. Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine

    The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Imple…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Johns Hopkins School of Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05845047 on ClinicalTrials.gov

17. Self-Directed Upper Extremity Gaming in Inpatients With Stroke

    STRIVE uses a camera mounted on the in-room TV and a connected laptop to track arm and hand movements during gameplay via markerless motion capture. No controllers or wearable sensors are required, and patients initiate a session with a single button on the TV remote. Games target clinically releva…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Shirley Ryan AbilityLab, Chicago, Illinois

    Run by

    Milap Sandhu

    See if you can join NCT07806097 on ClinicalTrials.gov

18. Improving Measurement and Treatment of Post-stroke Neglect

    This study examines how to best assess and treat post-stroke neglect. This study will examine the preliminary effects of an innovative intervention (repetitive task-specific practice + transcranial direct current stimulation) for individuals with neglect. This study will also determine whether item…

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania

    Run by

    VA Office of Research and Development

    See if you can join NCT03317860 on ClinicalTrials.gov

19. K01 Impacts of Lingual Endurance Exercise

    The goal of this clinical trial is to learn whether a tongue endurance exercise program can improve swallowing function in adults with dysphagia after a stroke. It also aims to explore how this exercise may affect brain structure and connectivity involved in swallowing. The main questions it aims t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Cincinnati, Cincinnati, Ohio

    Run by

    University of Cincinnati

    See if you can join NCT06072924 on ClinicalTrials.gov

20. CoMind Early Feasibility Study

    The purpose of this research, which has been determined as non-significant risk by the central IRB overseeing the study, is to obtain information to help further develop a machine (a medical device) to measure the pressure around the brain from the outside (this pressure is called intracranial pres…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UC Davis Medical Center, Sacramento, California

    Locations

    16 in total

    Run by

    CoMind Technologies Limited

    See if you can join NCT06368648 on ClinicalTrials.gov

21. Escitalopram and Language Intervention for Subacute Aphasia

    In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute pos…

    Stage

    Phase 2

    Ages

    18 to 99

    Site

    Johns Hopkins School of Medicine, Baltimore, Maryland

    Locations

    3 in total

    Run by

    Johns Hopkins University

    See if you can join NCT03843463 on ClinicalTrials.gov

22. Treatment With Endovascular Intervention for STroke Patients With Existing Disability

    TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a moderate-to-severe disability prior to their stroke.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    35 in total

    Run by

    University of Cincinnati

    See if you can join NCT05911568 on ClinicalTrials.gov

23. Robot Aided Rehabilitation - Intervention

    Sensorimotor impairments following stroke often involve complex pathological changes across multiple joints and multiple degrees of freedom of the arm and hand, thereby rendering them difficult to diagnose and treat. The objective of this study is to evaluate multi-joint neuromechanical impairments…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    University of Maryland, Baltimore, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT02359253 on ClinicalTrials.gov

24. Robot Aided Rehabilitation - Multi-joint Evaluations

    Sensory and motor impairments following stroke can lead to substantial disability involving the arm and hand. The investigator hypothesized that excessive local and cross-coupled stiffness, diminished individuation and proprioceptive acuity will be present among multiple degree of freedom in the up…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    University of Maryland, Baltimore, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT02359812 on ClinicalTrials.gov

25. Influence of Brain Oscillation-Dependent TMS on Motor Function

    Background: When people have a stroke, they often have difficulty moving their arms and hands. Transcranial magnetic stimulation (TMS) can improve how well people with and without stroke can move their arms and hands. But the effects of TMS are minor, and it doesn t work for everyone. Researchers w…

    Stage

    Not phased

    Ages

    18 to 120

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Neurological Disorders and Stroke (NINDS)

    See if you can join NCT03288220 on ClinicalTrials.gov