Obesity Clinical Trials

274 studies are recruiting for obesity in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 9

1. FEAST Perinatal Support Program Intervention

   Latino individuals face an elevated risk of adverse health outcomes during pregnancy, impacting both the birthing parent and the baby with potential long-term chronic health conditions. While promoting a healthy diet during pregnancy is a promising strategy, interventions targeting dietary behavior…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Southern California, Los Angeles, California

   Run by

   University of Southern California

   See if you can join NCT06715787 on ClinicalTrials.gov

2. Insulin Regulation of Lipolysis and Lipolysis Proteins

   These studies will define the abnormalities in the adipocyte proteins that are involved in the failure of insulin to suppress lipolysis normally in humans with upper body obesity and will help discover the mechanism by which pioglitazone, a medication used to treat type 2 diabetes and improve insul…

   Stage

   EARLY_Phase 1

   Ages

   18 to 55

   Site

   Mayo Clinic in Rochester, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT03866408 on ClinicalTrials.gov

3. Behavioral Weight Loss Intervention Utilizing Mobile Health Technology in Hematopoietic Stem Cell Transplant Patients

   Pilot study enrolling obese post HSCT (hematopoietic stem cell transplantation) patients at the hematology/oncology clinic at the Mattel Children's Hospital, University of California, Los Angeles. Parameters include percent over the 95th percentile (%BMIp95), zBMI, fasting metabolic metrics, addict…

   Stage

   Not phased

   Ages

   13 to 30

   Site

   UCLA Mattel Children's Hospital, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT04997473 on ClinicalTrials.gov

4. Interscalene vs Phrenic-sparing Blocks in Obesity and Effect of Maximum Inspiratory Pressure

   The goal of this clinical trial is to learn whether a phrenic-sparing nerve block can lower early breathing problems after shoulder surgery in adults with obesity, and whether a simple breathing-strength test (maximum inspiratory pressure, MIP) helps identify who is at higher risk. The main questio…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of North Carolina Hospitals, Chapel Hill, North Carolina

   Run by

   University of North Carolina, Chapel Hill

   See if you can join NCT07216820 on ClinicalTrials.gov

5. Extracellular Vesicles, Insulin Action, and Exercise

   Extracellular vesicles (EVs) play a role in obesity-induced insulin resistance and likely impact the development of cardiovascular disease. However, little is known on how EVs affect vascular insulin action in people. The purpose of this study is to understand how EVs play a role in type 2 diabetes…

   Stage

   Not phased

   Ages

   30 to 80

   Site

   Institute for Food, Nutrition, and Health, New Brunswick, New Jersey

   Locations

   3 in total

   Run by

   Rutgers, The State University of New Jersey

   See if you can join NCT06546085 on ClinicalTrials.gov

6. Comparing the Efficacy and Safety of the EndoZip System and Apollo ESG in Obese Patients

   evaluation of the EndoZip system procedure compared to the Apollo ESG procedure in obese patients.

   Stage

   Not phased

   Ages

   21 to 65

   Site

   Lenox Hill Hospital | Northwell Health, New York, New York

   Locations

   2 in total

   Run by

   Nitinotes Surgical Ltd.

   See if you can join NCT07090005 on ClinicalTrials.gov

7. TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation

   This is a single center randomized double blind controlled study of patients (BMI ≥ 27 kg/m2) with obesity and Atrial Fibrillation (AFIB) randomized to Tirzepatide vs. placebo. It is expected that the significant weight loss with Tirzepatide will result in improved control, management, symptom seve…

   Stage

   Phase 2

   Ages

   18 to 80

   Site

   Cleveland Clinic, Cleveland, Ohio

   Run by

   The Cleveland Clinic

   See if you can join NCT06802081 on ClinicalTrials.gov

8. Effects of Whole vs. Nonfat Milk Consumption on Body Composition in Children

   This study will evaluate the effects of whole vs. nonfat milk consumption on body composition, cardiometabolic disease risk factors, and dietary quality.

   Stage

   Not phased

   Ages

   9 to 12

   Site

   New Balance Foundation Obesity Prevention Center, Boston, Massachusetts

   Run by

   Boston Children's Hospital

   See if you can join NCT05464186 on ClinicalTrials.gov

9. Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment

   The goal of this study is to learn if a smartwatch that measures activity level and body composition, combined with exercise reminders, can safely improve strength and muscle mass in people who recently started or are planning to start treatment with incretin therapy (liraglutide, semaglutide, tirz…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   Diabetes Research Center, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT07226947 on ClinicalTrials.gov

10. Inspire HER: Inspiring the Heart and Emotions for Radical Health

    Poor heart health puts Black women at risk for a shorter life with more illness than people of any other non-indigenous racial group. We will refine and conduct a randomized, wait-list controlled trial of Inspire HER (a heart health lifestyle intervention for Black women that provides health educat…

    Stage

    Not phased

    Ages

    30 to 79

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06966258 on ClinicalTrials.gov

11. Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population

    This study is being done to better understand whether meal replacements can be an effective tool for weight loss and treatment of elevated blood sugars in people with obesity/overweight and diabetes/pre-diabetes who have a low income.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT05799222 on ClinicalTrials.gov

12. Project SHINE (Sleep Health INitiative for Equity): Culturally Informing a Sleep Extension Intervention for African American Adults

    The proposed research aims to reduce obesity-related health disparities by promoting healthy lifestyle behaviors among African Americans (AAs), given the high disease burdens associated with low physical activity, insufficient sleep, and obesity. There will be two phases to the proposed research. P…

    Stage

    Phase 1

    Ages

    21 to 75

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT06226077 on ClinicalTrials.gov

13. High Fructose Diet, the Gut Microbiome, and Metabolic Health

    Americans commonly consume excess amounts of dietary fructose. Added fructose has been shown to have an adverse impact on metabolic health, including increased insulin resistance and type 2 diabetes (T2D) risk. However, the mechanisms that link dietary fructose and metabolic health are poorly under…

    Stage

    Not phased

    Ages

    25 to 45

    Site

    Mount Sinai Morningside, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06329544 on ClinicalTrials.gov

14. Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers

    In this randomized controlled trial, the investigators will assess the health impacts of optimizing the timing of dietary consumption in nurses and nursing assistants who work night shifts, have a habitual eating window of 14 hours or more, and elevated weight. Participants will be randomized to on…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of California San Diego Altman Clinical and Translational Research Institute, La Jolla, California

    Run by

    Salk Institute for Biological Studies

    See if you can join NCT06891352 on ClinicalTrials.gov

15. Microvascular Dysfunction in Obesity

    Impaired endothelial function is observed in disease states related to obesity, such as atherosclerosis, coronary artery disease, and diabetes. Reactive oxygen species (ROS) production and resultant oxidative stress contribute to the development of these obesity-related diseases. The enzyme NADPH-o…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    Florida State University, Tallahassee, Florida

    Run by

    Florida State University

    See if you can join NCT04087655 on ClinicalTrials.gov

16. Effects of Assisted Robotic vs Laparoscopic Sleeve Gastrectomy

    This will be a prospective, obesity-registry based, single-blind randomized controlled trial with a 1:1 allocation ratio. Specific inclusion criteria are all patients eligible to undergo a Laparoscopic sleeve gastrectomy (LSG) based on the current National Institute of Health (NIH) patient selectio…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    Ricard Corcelles

    See if you can join NCT06425016 on ClinicalTrials.gov

17. Feasibility and Colorectal Benefits of Pulses Supplementation

    Beans are a forgotten staple food that shows promise in improving health. The goal of this study is to look at how bean supplementation affects metabolic and bowel health. In the long-term, the investigators believe this research will lead to a better understanding of the impact of beans on bowel h…

    Stage

    Not phased

    Ages

    30 to 80

    Site

    University of California Davis, Sacramento, California

    Run by

    University of California, Davis

    See if you can join NCT06032104 on ClinicalTrials.gov

18. Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans

    This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study satiety in healthy individuals. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to th…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    McLean Hospital, Belmont, Massachusetts

    Locations

    2 in total

    Run by

    Brigham and Women's Hospital

    See if you can join NCT06105164 on ClinicalTrials.gov

19. Brain Blood Flow and Lactate in Non-obese and Obese Subjects

    Cerebral blood flow (CBF) is essential for maintaining brain health and function, as it ensures delivery oxygen and nutrients necessary to support neuronal activity. Reduced CBF can impair the brain's ability to meet its metabolic demands, leading to deficits in cognitive ability. Impairments in CB…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    University of Missouri, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT06791837 on ClinicalTrials.gov

20. Building Connections

    Building Connections seeks to address health and healthcare inequities in socially vulnerable communities. The project will be conducted in collaboration with clinical practices across Massachusetts, serving a diverse population heavily represented in Community Clinics and Health Centers. The progr…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Disparities Research Unit, Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07091032 on ClinicalTrials.gov

21. Arterial Destiffening Effects of SGLT2 Inhibition in Veterans With Obesity

    The study will assign participants to take either the medication, empagliflozin or a placebo for 12 weeks. The goal of the study is to determine the effects of empagliflozin on arterial health in Veterans with obesity.

    Stage

    Phase 2

    Ages

    30 to 60

    Site

    Harry S. Truman Memorial, Columbia, MO, Columbia, Missouri

    Run by

    VA Office of Research and Development

    See if you can join NCT06745063 on ClinicalTrials.gov

22. Preparing FIM-BCS - A Lifestyle Modification for African-American Breast Cancer Survivors

    Hypertension and obesity are both major risk factors for cardiovascular disease (CVD), a leading cause of death for Black women in the United States. The investigators propose examining the feasibility and acceptability of the 12-week RN-CHeFRx (Real Nourishment and Cooking Healthy Food is Rx) inte…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    University of Illinois Chicago, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT06504914 on ClinicalTrials.gov

23. The Physiology of Human Brown Adipose Tissue

    Brown fat is a type of fat, found in both children and adults, which can produce heat and regulate the body's metabolism and energy use. White fat is the more common type of fat which is used to store extra calories. Understanding more about differences between brown and white fat may allow us to d…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT04352244 on ClinicalTrials.gov

24. Study to Investigate Genetic Causes of Severe Early Childhood Onset Obesity.

    This study aims to investigate genetic causes of early childhood obesity. The investigators will enroll children and adults with severe early onset obesity (BMI > 99th percentile) diagnosed prior to 6 years of age. The investigators will ask questions about the health and eating behavior of the par…

    Stage

    Not phased

    Ages

    Up to 80

    Site

    Columbia University Medical Center, New York, New York

    Locations

    2 in total

    Run by

    Columbia University

    See if you can join NCT01998750 on ClinicalTrials.gov

25. The Weight of Cardiovascular Disease

    The purpose of this study is to evaluate the impact of a cardiometabolic clinic on percent body weight loss, body mass index (BMI), and visceral adiposity distribution in obese adults with cardiovascular disease (CVD) at 12 months.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06053645 on ClinicalTrials.gov