Obesity Clinical Trials in Columbia, Missouri

9 studies are recruiting for obesity in Columbia, Missouri right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes

   Study ASC30-302 (AURORA-2) is a Phase III, global, multicenter, randomized, double-blind, placebo-controlled study to investigate the long-term efficacy, safety, and tolerability of three maintenance doses of once-daily oral ASC30 compared with placebo in participants with obesity or overweight and…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   AURORA-2 Clinical Site, Columbia, Missouri

   Locations

   135 in total

   Run by

   Ascletis Pharma (China) Co., Limited

   See if you can join NCT07743450 on ClinicalTrials.gov

2. Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity

   The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abno…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   University of Missouri School of Medicine, Columbia, Missouri

   Run by

   Bettina Mittendorfer

   See if you can join NCT06335771 on ClinicalTrials.gov

3. Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)

   The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abno…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   University of Missouri School of Medicine, Columbia, Missouri

   Run by

   Bettina Mittendorfer

   See if you can join NCT06571474 on ClinicalTrials.gov

4. Routine Validation and Reproducibility Testing of Laboratory Measures and Research Techniques Used for Metabolism Research (VAL)

   The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research on chronic diseases (obesity, pre-diabetes and type-2 diabetes, dyslip…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   University of Missouri School of Medicine, Columbia, Missouri

   Run by

   Bettina Mittendorfer

   See if you can join NCT06286761 on ClinicalTrials.gov

5. Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

   The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.

   Stage

   EARLY_Phase 1

   Ages

   18 to 45

   Site

   University of Missouri, Columbia, Missouri

   Run by

   University of Missouri-Columbia

   See if you can join NCT05219799 on ClinicalTrials.gov

6. Growth Hormone Resistance of Beta-cells A

   The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a personal history of gestational diabetes (high blood sugar in pregnancy) at the University of Missouri. The aim…

   Stage

   Not phased

   Ages

   18 to 45

   Site

   University of Missouri School of Medicine, Columbia, Missouri

   Run by

   University of Missouri-Columbia

   See if you can join NCT06571487 on ClinicalTrials.gov

7. Growth Hormone Resistance of Beta-cells in People With a Family History of Type 2 Diabetes

   The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a family history of type 2 diabetes at the University of Missouri. Our aim is to advance understanding of how gro…

   Stage

   Not phased

   Ages

   18 to 59

   Site

   University of Missouri School of Medicine, Columbia, Missouri

   Run by

   University of Missouri-Columbia

   See if you can join NCT06571500 on ClinicalTrials.gov

8. Brain Blood Flow and Lactate in Non-obese and Obese Subjects

   Cerebral blood flow (CBF) is essential for maintaining brain health and function, as it ensures delivery oxygen and nutrients necessary to support neuronal activity. Reduced CBF can impair the brain's ability to meet its metabolic demands, leading to deficits in cognitive ability. Impairments in CB…

   Stage

   Not phased

   Ages

   18 to 45

   Site

   University of Missouri, Columbia, Missouri

   Run by

   University of Missouri-Columbia

   See if you can join NCT06791837 on ClinicalTrials.gov

9. Arterial Destiffening Effects of SGLT2 Inhibition in Veterans With Obesity

   The study will assign participants to take either the medication, empagliflozin or a placebo for 12 weeks. The goal of the study is to determine the effects of empagliflozin on arterial health in Veterans with obesity.

   Stage

   Phase 2

   Ages

   30 to 60

   Site

   Harry S. Truman Memorial, Columbia, MO, Columbia, Missouri

   Run by

   VA Office of Research and Development

   See if you can join NCT06745063 on ClinicalTrials.gov