Obesity Clinical Trials

274 studies are recruiting for obesity in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate

   Background: At least 30% of Americans have fatty liver disease. This means that they store too much fat in the liver. At the moment lifestyle changes are the only way to treat this problem. Objective: To test how (1) a low-carbohydrate diet and (2) a supplement called nicotinamide riboside (NR) aff…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT06044935 on ClinicalTrials.gov

2. Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities

   Obesity is a condition where a person has excessive body fat, defined by a body mass index (BMI) of 30 kg/m2 or higher. The goal of this study is to evaluate the effect of various doses of ABBV-295 compared to placebo on reducing body weight at Week 32 in participants with obesity or overweight wit…

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Cahaba Research - Pelham /ID# 282381, Pelham, Alabama

   Locations

   45 in total

   Run by

   AbbVie

   See if you can join NCT07752979 on ClinicalTrials.gov

3. Youth-Onset Type 2 Diabetes and Heart Disease: The Young at Heart Prospective Cohort Study

   Background: Type 2 diabetes is a disease that affects blood sugar levels. Complications can include heart and blood vessel (vascular) diseases. Rates of type 2 diabetes have tripled in children and young adults over the last 40 years. Vascular diseases are also increasing in young people. Objective…

   Stage

   Not phased

   Ages

   12 to 25

   Site

   Children's National Hospital (CNH), Washington D.C., District of Columbia

   Locations

   2 in total

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT06730113 on ClinicalTrials.gov

4. Diabetes and Heart Disease Risk in Blacks

   It is unknown if obesity contributes to the development of heart disease in African American men and women. This study was created to determine whether there is a relationship between sex and body size and the incidence of heart disease in African American men and women. Researchers will attempt to…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT00001853 on ClinicalTrials.gov

5. Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

   Background: - Researchers are interested in studying individuals who have known or suspected metabolic, inflammatory or genetic diseases that may put them at a high risk for heart diseases or diseases of their blood vessels. Depending on the condition being studied, both affected and nonaffected in…

   Stage

   Not phased

   Ages

   1 to 100

   Site

   Hope Center, Washington D.C., District of Columbia

   Locations

   3 in total

   Run by

   National Heart, Lung, and Blood Institute (NHLBI)

   See if you can join NCT01143454 on ClinicalTrials.gov

6. Tailoring Mobile Health Technology to Reduce Obesity and Improve Cardiovascular Health in Resource-Limited Neighborhood Environments

   Background Obesity and physical inactivity contribute substantially to cardiovascular disease risk, diabetes, hypertension, and dyslipidemia. African American women experience disproportionately high rates of obesity and have among the lowest levels of physical activity and greatest sedentary time …

   Stage

   Not phased

   Ages

   21 to 75

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Heart, Lung, and Blood Institute (NHLBI)

   See if you can join NCT03288207 on ClinicalTrials.gov

7. Early Tracking of Childhood Health Determinants (ETCHED) Study

   Background: Children s weight has increased sharply in recent years. This may put them at higher risk for health problems. High blood glucose in a pregnant mother and too much weight gain during pregnancy also may have long-term effects on the child s health. Children who become overweight or obese…

   Stage

   Not phased

   Ages

   0 to 99

   Site

   NIDDK, Phoenix, Phoenix, Arizona

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT03481829 on ClinicalTrials.gov

8. Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

   This trial will examine if maridebart cafraglutide as an adjunct to standard of care will lead to a reduction in heart failure (HF) events such as HF hospitalizations and urgent HF visits, cardiovascular (CV) deaths and improvement in HF symptoms in participants with HF with preserved ejection frac…

   Stage

   Phase 3

   Ages

   18 to 99

   Site

   University of Alabama Saint Vincent's Birmingham, Birmingham, Alabama

   Locations

   657 in total

   Run by

   Amgen

   See if you can join NCT07037459 on ClinicalTrials.gov

9. A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes

   Study ASC30-302 (AURORA-2) is a Phase III, global, multicenter, randomized, double-blind, placebo-controlled study to investigate the long-term efficacy, safety, and tolerability of three maintenance doses of once-daily oral ASC30 compared with placebo in participants with obesity or overweight and…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   AURORA-2 Clinical Site, Phoenix, Arizona

   Locations

   135 in total

   Run by

   Ascletis Pharma (China) Co., Limited

   See if you can join NCT07743450 on ClinicalTrials.gov

10. A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities

    Study ASC30-301 (AURORA-1) is a Phase III, global, multicenter, randomized, double-blind, placebo-controlled study to investigate the long-term efficacy, safety, and tolerability of three maintenance doses of once-daily oral ASC30 compared with placebo in participants with obesity or overweight wit…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    AURORA-1 Clinical Site, Phoenix, Arizona

    Locations

    122 in total

    Run by

    Ascletis Pharma (China) Co., Limited

    See if you can join NCT07743463 on ClinicalTrials.gov

11. Variability In Mixed Meal Tests: Fixed Versus Adjusted to Energy Needs Caloric Dose

    Background: Researchers use mixed meal tolerance tests (MMTTs) to look at how people s bodies respond to eating a meal. However, researchers do not agree on how to decide the number of calories to give in each meal. Some use fixed meals, which are the same size for everyone, and some use adjusted m…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    NIDDK, Phoenix, Phoenix, Arizona

    Run by

    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    See if you can join NCT06223555 on ClinicalTrials.gov

12. Level Up! (The Combined and Independent Effects of Exercise Training and Dietary Enhancement on Cardiometabolic Health in Adolescents With Obesity)

    The goal of this clinical trial is to learn how exercise and diet quality affect the health of adolescents with obesity. The main questions it aims to answer are: * Does exercise improve cardiometabolic health in adolescents with obesity? * Does enriching the diet with fruits and vegetables improve…

    Stage

    Not phased

    Ages

    13 to 17

    Site

    Arkansas Children's Hospital Research Institute, Little Rock, Arkansas

    Locations

    2 in total

    Run by

    Arkansas Children's Hospital Research Institute

    See if you can join NCT06848478 on ClinicalTrials.gov

13. First-in-human Study of the Safety, Tolerability, Pharmacokinetics, and Food Effect of ACCG-2671

    This first-in-human study will evaluate the safety, tolerability, and pharmacokinetics of single and multiple ascending oral doses of ACCG-2671. It will also evaluate the effect of food on the pharmacokinetics, safety, and tolerability of a single dose. Parts 1 and 2 will enroll healthy participant…

    Stage

    Phase 1

    Ages

    25 to 75

    Site

    Research Site, Lake Forest, California

    Locations

    6 in total

    Run by

    Aconcagua Bio, Inc. a wholly owned subsidiary of Structure Therapeutics

    See if you can join NCT07815678 on ClinicalTrials.gov

14. Tirzepatide in Obesity-Driven Endometrial Cancer

    LCCC2415 examines the antiproliferative effect of tirzepatide on the endometrium of endometrial cancer (EC). This is a pre-operative window clinical study. Endometrial biopsy samples from patients before tirzepatide treatment will be compared to their post-intervention hysterectomy specimens. If ar…

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

    Run by

    UNC Lineberger Comprehensive Cancer Center

    See if you can join NCT07065552 on ClinicalTrials.gov

15. AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

    This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with excess body weight and obstructive sleep apnoea not treated with positive airway pressure lose weight and improve sleep apnoea. There are 2 study treatments in this study taken as injections under the s…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Artemis Insitute for Clin Res, San Diego, California

    Locations

    80 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07571005 on ClinicalTrials.gov

16. A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

    This is randomized, double-blind, placebo-controlled study of the long-term efficacy, safety, and tolerability of multiple doses of aleniglipron in participants living with overweight or obesity and T2DM. Participants will be randomized to aleniglipron or placebo for a total of 76 weeks of treatmen…

    Stage

    Phase 3

    Ages

    18 to 79

    Site

    ACCOMPLISH-2 Research Site, Birmingham, Alabama

    Locations

    74 in total

    Run by

    Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

    See if you can join NCT07654374 on ClinicalTrials.gov

17. Spinal Cord Injury Model Systems (SCIMS) - Education Module

    The purpose of this study is to find out if receiving education regarding increased risks of cardiometabolic disease helps subjects understand these risks and how these risks participants' health.

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Baylor Scott & White Institute for Research, Dallas, Texas

    Locations

    3 in total

    Run by

    University of Miami

    See if you can join NCT06003686 on ClinicalTrials.gov

18. How a Single Workout Affects Gut Bugs in Women With Different Fitness Levels and Body Types

    This study aims to elucidate the differences in the gut microbiome functional activity and metabolome in adult premenopausal women with distinctive fitness levels and BMIs (with obesity, w/o obesity). The specific aims are as follows: * Aim 1: To examine the effects of acute aerobic exercise at 60-…

    Stage

    Not phased

    Ages

    21 to 40

    Site

    Milken Institute School of Public Health, The George Washington University, Washington D.C., District of Columbia

    Run by

    George Washington University

    See if you can join NCT06691100 on ClinicalTrials.gov

19. A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.

    The purpose of the study is to assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of AZD1043 following single and multiple ascending doses in healthy adult participants living with overweight and/or obesity, including participants of Japanese and Chinese descent.

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Research Site, Glendale, California

    Locations

    3 in total

    Run by

    AstraZeneca

    See if you can join NCT07511205 on ClinicalTrials.gov

20. A Research Study Investigating How a New Medicine NNC0113-5840 Works in People With Overweight or Obesity

    The purpose of this clinical study is to find out if NNC0113-5840 is safe for treating people with excess body weight. There are 2 study treatments in this study, participants will get either NNC0113-5840 (the product being tested) or Placebo (treatment that has no active medicine in it), Which tre…

    Stage

    Phase 1

    Ages

    18 to 55

    Site

    PAREXEL Glendale/LA EPCU, Glendale, California

    Locations

    2 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07566390 on ClinicalTrials.gov

21. AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

    This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with overweight or obesity, and obstructive sleep apnoea treated with positive airway pressure. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will ei…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Dignity Health, Mercy Gilbert, Gilbert, Arizona

    Locations

    92 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07571109 on ClinicalTrials.gov

22. Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight

    The purpose of this study is to see how oral semaglutide, when taken in lower doses help lowering of body weight in participants with excess body weight when compared to 'dummy' tablets (placebo). Results from this study will help select the most optimal lower dose of oral semaglutide that can be u…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Uni of Alabama at Birmingham, Birmingham, Alabama

    Locations

    62 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07770841 on ClinicalTrials.gov

23. Inflammation, Diabetes, Ethnicity and Obesity Cohort

    Obesity affects over one third of US adults (>72 million, with BMI ≥30 kg/m2), and the proportion of US adults with BMI ≥40 kg/m2 has doubled in the last 20 years. Obesity is associated with increased mortality through its linkage to comorbidities including diabetes, hypertension, dyslipidemia, ost…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    University of California San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT03022682 on ClinicalTrials.gov

24. tDCS With Cognitive Training to Reduce Impulsivity and Weight in Veterans With Obesity

    The purpose of this study is to investigate if transcranial direct current stimulation (tDCS) can increase the effectiveness of cognitive training to reduce impulsivity in individuals with obesity, and to evaluate weight change with these individuals. The long-term goal of this research is to devel…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota

    Run by

    VA Office of Research and Development

    See if you can join NCT05225233 on ClinicalTrials.gov

25. A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

    The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various investigational interventions for chronic weight management with intervention-specific appendices (ISAs). The CWMM establishes entry criteria for newl…

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    The Institute for Liver Health II dba Arizona Clinical Trials - Mesa, Chandler, Arizona

    Locations

    56 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT06143956 on ClinicalTrials.gov