Obesity Clinical Trials

274 studies are recruiting for obesity in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Early Tracking of Childhood Health Determinants (ETCHED) Study

   Background: Children s weight has increased sharply in recent years. This may put them at higher risk for health problems. High blood glucose in a pregnant mother and too much weight gain during pregnancy also may have long-term effects on the child s health. Children who become overweight or obese…

   Stage

   Not phased

   Ages

   0 to 99

   Site

   NIDDK, Phoenix, Phoenix, Arizona

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT03481829 on ClinicalTrials.gov

2. Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change

   Background: In a previous study, participants were lived at the NIH and randomly received either a low-fat or a low-carbohydrate diet for 2 weeks and then switched to the other diet for 2 more weeks. Participants who received the low-carbohydrate diet first lost more body fat at the end of the stud…

   Stage

   Not phased

   Ages

   18 to 50

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT06325722 on ClinicalTrials.gov

3. Comparing the Extent to Which Maridebart Cafraglutide is Made Available in the Body of Participants Living With Overweight or Obesity After Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA)

   The primary purpose of the study is to assess the pharmacokinetics of maridebart cafraglutode after switching from weekly GLP-1RA in participants living with overweight or obesity.

   Stage

   Phase 1

   Ages

   18 to 70

   Site

   Arizona Research Center, Phoenix, Arizona

   Locations

   9 in total

   Run by

   Amgen

   See if you can join NCT07908316 on ClinicalTrials.gov

4. Diabetes and Heart Disease Risk in Blacks

   It is unknown if obesity contributes to the development of heart disease in African American men and women. This study was created to determine whether there is a relationship between sex and body size and the incidence of heart disease in African American men and women. Researchers will attempt to…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT00001853 on ClinicalTrials.gov

5. Children s Growth and Behavior Study

   Background: - Studies show that many factors affect children's eating behavior and health. These include sleep, mood, thinking skills, and genetics. Studying children over time may identify children at higher risk for eating-related health concerns. Objective: - To understand how genes and environm…

   Stage

   Not phased

   Ages

   8 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

   See if you can join NCT02390765 on ClinicalTrials.gov

6. Tailoring Mobile Health Technology to Reduce Obesity and Improve Cardiovascular Health in Resource-Limited Neighborhood Environments

   Background Obesity and physical inactivity contribute substantially to cardiovascular disease risk, diabetes, hypertension, and dyslipidemia. African American women experience disproportionately high rates of obesity and have among the lowest levels of physical activity and greatest sedentary time …

   Stage

   Not phased

   Ages

   21 to 75

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Heart, Lung, and Blood Institute (NHLBI)

   See if you can join NCT03288207 on ClinicalTrials.gov

7. Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

   This trial will examine if maridebart cafraglutide as an adjunct to standard of care will lead to a reduction in heart failure (HF) events such as HF hospitalizations and urgent HF visits, cardiovascular (CV) deaths and improvement in HF symptoms in participants with HF with preserved ejection frac…

   Stage

   Phase 3

   Ages

   18 to 99

   Site

   University of Alabama Saint Vincent's Birmingham, Birmingham, Alabama

   Locations

   686 in total

   Run by

   Amgen

   See if you can join NCT07037459 on ClinicalTrials.gov

8. Vibegron for ENergy Thinking and Resilience in Aging

   This 12-week randomized, double-blind, placebo-controlled trial will test the hypothesis that Vibegron (brand name GEMTESA) can improve energy metabolism, cardiometabolic risk factors, and physical and cognitive function in middle-aged and older adults with obesity.

   Stage

   Phase 3

   Ages

   45 to 75

   Site

   Wake Forest University Health Sciences, Winston-Salem, North Carolina

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT06987383 on ClinicalTrials.gov

9. Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities

   Obesity is a condition where a person has excessive body fat, defined by a body mass index (BMI) of 30 kg/m2 or higher. The goal of this study is to evaluate the effect of various doses of ABBV-295 compared to placebo on reducing body weight at Week 32 in participants with obesity or overweight wit…

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Cahaba Research - Pelham /ID# 282381, Pelham, Alabama

   Locations

   64 in total

   Run by

   AbbVie

   See if you can join NCT07752979 on ClinicalTrials.gov

10. Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

    Background: - Researchers are interested in studying individuals who have known or suspected metabolic, inflammatory or genetic diseases that may put them at a high risk for heart diseases or diseases of their blood vessels. Depending on the condition being studied, both affected and nonaffected in…

    Stage

    Not phased

    Ages

    1 to 100

    Site

    Hope Center, Washington D.C., District of Columbia

    Locations

    3 in total

    Run by

    National Heart, Lung, and Blood Institute (NHLBI)

    See if you can join NCT01143454 on ClinicalTrials.gov

11. Improving Glycemic Control With Electrical Stimulation

    Once written consent is obtained, the participant will be provided with an accelerometer to be worn for 7 days to assess current physical activity levels. Subjects will be provided with a standardized diet (55/15/30% CHO/PRO/FAT) prior to collection of pre-intervention data of insulin sensitivity. …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Texas at El Paso, El Paso, Texas

    Run by

    University of Texas, El Paso

    See if you can join NCT03947697 on ClinicalTrials.gov

12. Arterial Destiffening Effects of SGLT2 Inhibition in Veterans With Obesity

    The study will assign participants to take either the medication, empagliflozin or a placebo for 12 weeks. The goal of the study is to determine the effects of empagliflozin on arterial health in Veterans with obesity.

    Stage

    Phase 2

    Ages

    30 to 60

    Site

    Harry S. Truman Memorial, Columbia, MO, Columbia, Missouri

    Run by

    VA Office of Research and Development

    See if you can join NCT06745063 on ClinicalTrials.gov

13. Weight Loss Through Mayo Clinic Diet

    The purpose of study is to evaluate the efficacy of the Mayo Clinic Diet in clinically significant weight loss (>5%) versus usual care. We also wish to evaluate the feasibility, barriers to completion, and sustainability of this intervention at the 24, and 52-week marks. Lastly, we aim to study the…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06862375 on ClinicalTrials.gov

14. A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

    This is randomized, double-blind, placebo-controlled study of the long-term efficacy, safety, and tolerability of multiple doses of aleniglipron in participants living with overweight or obesity and T2DM. Participants will be randomized to aleniglipron or placebo for a total of 76 weeks of treatmen…

    Stage

    Phase 3

    Ages

    18 to 79

    Site

    ACCOMPLISH-2 Research Site, Birmingham, Alabama

    Locations

    74 in total

    Run by

    Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

    See if you can join NCT07654374 on ClinicalTrials.gov

15. Pharmacotherapy in Conjunction With Lifestyle Counseling for Management of Weight Regain After Bariatric Surgery

    This is a randomized controlled trial employing a Sequential Multiple Assignment Randomized Trial (SMART) design to test whether pharmacotherapy, in conjunction with lifestyle counseling, can reverse weight regain after bariatric surgery.

    Stage

    Phase 4

    Ages

    18 to 70

    Site

    University of California Irvine Medical Center, Orange, California

    Run by

    University of California, Irvine

    See if you can join NCT05975580 on ClinicalTrials.gov

16. Evaluation of the Tolerability of Cagrilintide in Participants Not Tolerating GLP-1-RA Therapies Due to Gastrointestinal Adverse Events

    The purpose of this clinical study is to look at the safety of the medicine Cagrilintide when compared to placebo in people who do not tolerate marketed glucagon-like peptide-1 (GLP-1) therapies and who live with overweight or obesity. Participants will get either Cagrilintide (the treatment being …

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Diablo Clinical Research, Inc., Walnut Creek, California

    Locations

    13 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07607587 on ClinicalTrials.gov

17. ENLIGHT Trial: ESG With Fundal Mucosal Ablation

    The ENLIGHT Trial is a single-center, randomized controlled trial evaluating whether adding fundal mucosal ablation (FMA) to endoscopic sleeve gastroplasty (ESG) improves weight loss and metabolic outcomes in adults with obesity. ESG reduces stomach volume through endoscopic suturing, while FMA use…

    Stage

    Not phased

    Ages

    18 and older

    Site

    West Virginia University, Morgantown, West Virginia

    Run by

    West Virginia University

    See if you can join NCT07792226 on ClinicalTrials.gov

18. PreventT2 Together: Examining the Efficacy of Couple-based Lifestyle Intervention to Prevent Type 2 Diabetes

    Nearly half of adults in the United States have or are at risk of developing type 2 diabetes. The overall goal of this community-engaged research is to examine the efficacy of an innovative couple-based lifestyle intervention to prevent type 2 diabetes that is applicable to a broad range of partner…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Utah, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT06690788 on ClinicalTrials.gov

19. A Novel Digital Tool Clinicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors

    The investigators will conduct a feasibility and pilot efficacy randomized controlled trial to test the usability and user satisfaction of an evidence-based digital health tool the investigators developed for clinicians to use to Prioritize Personalize Prescribe EXercise (P3-EX) to patients with ca…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    Hartford HealthCare, Hartford, Connecticut

    Locations

    3 in total

    Run by

    University of Connecticut

    See if you can join NCT07238556 on ClinicalTrials.gov

20. A Research Study Investigating How Adults With Overweight or Obesity, With or Without Type 2 Diabetes, Tolerate Switching to a New Treatment (Zenagamtide) From Their Current Semaglutide Medication

    The purpose of this clinical study is to find out which zenagamtide dose can be switched to, from maintenance dose of semaglutide in people with overweight or obesity, with or without type 2 diabetes (T2D). All participants will get semaglutide and zenagamtide.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    PAREXEL Glendale/LA EPCU, Glendale, California

    Locations

    2 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07855133 on ClinicalTrials.gov

21. A Research Study Investigating How Adults With Overweight or Obesity, With or Without Type 2 Diabetes, Tolerate Switching to a New Treatment (Zenagamtide) From Their Current Tirzepatide Medication

    The purpose of this clinical study is to find out which zenagamtide dose can be switched to, from maintenance dose of tirzepatide in people with overweight or obesity, with or without type 2 diabetes (T2D). All participants will get tirzepatide and zenagamtide.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    PAREXEL Glendale/LA EPCU, Glendale, California

    Locations

    2 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07868354 on ClinicalTrials.gov

22. Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

    This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced …

    Stage

    Not phased

    Ages

    14 to 18

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06007404 on ClinicalTrials.gov

23. Community Park-Based Programs for Health Promotion: Active Older Adults Prospective Cohort Study

    The Active Older Adults prospective cohort study examines the effects of a park-based fitness program on cardiovascular fitness outcomes for older adults (aged 50 years and older). Duke will perform a secondary analysis of the data collected as part of the Active Older Adults prospective cohort stu…

    Stage

    Not phased

    Ages

    50 to 95

    Site

    Miami-Dade County Parks, Recreation and Open Spaces Department, Miami, Florida

    Run by

    Duke University

    See if you can join NCT06604650 on ClinicalTrials.gov

24. A Study of LY4174794 in Participants With Obesity or Overweight Who Are Otherwise Healthy

    The main purpose of this study is to understand how safe and well-tolerated LY4174794 is in participants with obesity or overweight who are otherwise healthy. Blood tests will be performed to check how much LY4174794 gets into the bloodstream and how long it takes the body to eliminate it. Particip…

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    ICON Early Phase Services, LLC, San Antonio, Texas

    Locations

    3 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07654972 on ClinicalTrials.gov

25. A Study to Learn About Switching to a Monthly Study Medicine Called Berobenatide (PF-08653944) to Help Keep Weight Off in People With Overweight or Obesity

    The purpose of this study is to learn about the safety and effectiveness of berobenatide in adults with overweight or obesity who have already lost weight while taking semaglutide or tirzepatide. The study does not include people with diabetes. Participants will be in the study for about 11 months.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    16 in total

    Run by

    Pfizer

    See if you can join NCT07845500 on ClinicalTrials.gov