Obesity Clinical Trials in Boston, Massachusetts

20 studies are recruiting for obesity in Boston, Massachusetts right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

  1. A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

    The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo in participants with persistent obesity or overweight, with or without type 2 diabetes, and on stable incretin background therapy. Participation in the study will last about 80 weeks.

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Brigham and Women's Hospital Diabetes Program, Boston, Massachusetts
    Locations
    187 in total
    Run by
    Eli Lilly and Company

    See if you can join NCT07392190 on ClinicalTrials.gov

  2. Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

    The primary objective of this trial is to demonstrate that maridebart cafraglutide is superior to placebo when given as an adjunct to standard of care with respect to reducing cardiovascular (CV) morbidity and mortality.

    Stage
    Phase 3
    Ages
    45 to 99
    Site
    Brigham and Womens Hospital, Boston, Massachusetts
    Locations
    783 in total
    Run by
    Amgen

    See if you can join NCT07037433 on ClinicalTrials.gov

  3. Concurrent Laparoscopic Hysterectomy and Weight Loss Surgery in Obese Patients With Endometrial Carcinoma or Endometrial Intraepithelial Neoplasia

    To assess the feasibility of an expedited referral process for the obese endometrial cancer or EIN patient from her gynecologic oncologist to the Brigham Center for Metabolic and Bariatric Surgery (CMBS) in order to undergo concurrent weight loss surgery and hysterectomy within 8 weeks of first app…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Dana-Farber Cancer Institute

    See if you can join NCT04839614 on ClinicalTrials.gov

  4. A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

    The purpose of this pediatric, chronic weight management, Phase 3 Master Protocol (PWMP) is to create a framework to evaluate the safety and efficacy of pharmacologic agents for the treatment of obesity or overweight in pediatric participants.

    Stage
    Phase 3
    Ages
    6 to 17
    Site
    Boston Children's Hospital, Boston, Massachusetts
    Locations
    117 in total
    Run by
    Eli Lilly and Company

    See if you can join NCT06672549 on ClinicalTrials.gov

  5. Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions

    The lack of postpartum primary care coordination is a missed opportunity to increase primary care engagement and manage chronic conditions early in life, especially for the >30% of pregnant people who have or are at risk for these conditions. This study aims to increase postpartum primary care enga…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT06557005 on ClinicalTrials.gov

  6. Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

    Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally. While weight loss through lifestyle modification is the standard treatment, most patients regain weight limiting ultimate improvement in liver disease. On the other end of the spectru…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Pichamol Jirapinyo, MD, MPH

    See if you can join NCT06138821 on ClinicalTrials.gov

  7. Trans-nasal Endoscopy for Bariatric Patients

    This study plans to learn if the EvoEndo Endoscopy system can be used to evaluate, provide and follow up care for upper gastrointestinal tract diseases in the bariatric population. The smallest current scope available for such a technique is an adult transnasal endoscope with a larger diameter, a p…

    Stage
    Not phased
    Ages
    18 to 90
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Run by
    Christopher C. Thompson, MD, MSc

    See if you can join NCT06200961 on ClinicalTrials.gov

  8. Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity

    In adults with obesity seeking treatment, weight loss would ideally be composed almost exclusively of fat mass. However, loss of muscle mass and bone are unintentional consequences of weight loss, which may have negative effects on health by lessening improvements in glucose and insulin levels, red…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT05933499 on ClinicalTrials.gov

  9. Efficacy and Safety of Endoscopic Antral Myotomy as a Novel Weight Loss Procedure

    Gastric myotomy has been performed for several years as a means of addressing chronic stenosis after sleeve gastrectomy and treating gastroparesis. The Pylorus Sparing Antral Myotomy (PSAM) technique has the opposite effect by leaving the pylorus intact and extending the myotomy proximally to the d…

    Stage
    Not phased
    Ages
    18 to 70
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Run by
    Christopher C. Thompson, MD, MSc

    See if you can join NCT05711758 on ClinicalTrials.gov

  10. Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease

    The goal of this observation study is to assess whether endoscopic ultrasound shear wave elastography (EUS-SWE) may be a useful tool for liver fibrosis screening in patients with elevated body mass index and non alcoholic fatty liver disease as compared to other non-invasive screening modalities, w…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Brigham and Women's Hospital

    See if you can join NCT05728697 on ClinicalTrials.gov

  11. Effects of Whole vs. Nonfat Milk Consumption on Body Composition in Children

    This study will evaluate the effects of whole vs. nonfat milk consumption on body composition, cardiometabolic disease risk factors, and dietary quality.

    Stage
    Not phased
    Ages
    9 to 12
    Site
    New Balance Foundation Obesity Prevention Center, Boston, Massachusetts
    Run by
    Boston Children's Hospital

    See if you can join NCT05464186 on ClinicalTrials.gov

  12. Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment

    The goal of this study is to learn if a smartwatch that measures activity level and body composition, combined with exercise reminders, can safely improve strength and muscle mass in people who recently started or are planning to start treatment with incretin therapy (liraglutide, semaglutide, tirz…

    Stage
    Not phased
    Ages
    18 to 99
    Site
    Diabetes Research Center, Boston, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT07226947 on ClinicalTrials.gov

  13. Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population

    This study is being done to better understand whether meal replacements can be an effective tool for weight loss and treatment of elevated blood sugars in people with obesity/overweight and diabetes/pre-diabetes who have a low income.

    Stage
    Not phased
    Ages
    18 to 65
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT05799222 on ClinicalTrials.gov

  14. Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans

    This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study satiety in healthy individuals. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to th…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Brigham and Women's Hospital

    See if you can join NCT06105164 on ClinicalTrials.gov

  15. Building Connections

    Building Connections seeks to address health and healthcare inequities in socially vulnerable communities. The project will be conducted in collaboration with clinical practices across Massachusetts, serving a diverse population heavily represented in Community Clinics and Health Centers. The progr…

    Stage
    Not phased
    Ages
    18 to 75
    Site
    Disparities Research Unit, Massachusetts General Hospital, Boston, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT07091032 on ClinicalTrials.gov

  16. The Physiology of Human Brown Adipose Tissue

    Brown fat is a type of fat, found in both children and adults, which can produce heat and regulate the body's metabolism and energy use. White fat is the more common type of fat which is used to store extra calories. Understanding more about differences between brown and white fat may allow us to d…

    Stage
    Not phased
    Ages
    18 to 75
    Site
    Beth Israel Deaconess Medical Center, Boston, Massachusetts
    Run by
    Beth Israel Deaconess Medical Center

    See if you can join NCT04352244 on ClinicalTrials.gov

  17. Study to Investigate Genetic Causes of Severe Early Childhood Onset Obesity.

    This study aims to investigate genetic causes of early childhood obesity. The investigators will enroll children and adults with severe early onset obesity (BMI > 99th percentile) diagnosed prior to 6 years of age. The investigators will ask questions about the health and eating behavior of the par…

    Stage
    Not phased
    Ages
    Up to 80
    Site
    Boston Children's Hospital, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Columbia University

    See if you can join NCT01998750 on ClinicalTrials.gov

  18. Exercise, Brain Activity, and Weight Maintenance

    This study aims to explore how HIIT influences brain function, neural and molecular pathways related to weight control, setting the stage for future obesity intervention research.

    Stage
    Not phased
    Ages
    18 to 70
    Site
    Joslin Diabetes Center, Boston, Massachusetts
    Run by
    Joslin Diabetes Center

    See if you can join NCT06511310 on ClinicalTrials.gov

  19. International Weight Control Registry

    The IWCR is a global scientific study aimed at better understanding the opportunities and barriers for reducing the prevalence of obesity by collecting information from people who have experience with weight management in their everyday lives. The investigators seek to gather information on a wide …

    Stage
    Not phased
    Ages
    18 and older
    Site
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts
    Locations
    7 in total
    Run by
    Tufts University

    See if you can join NCT04907396 on ClinicalTrials.gov

  20. RESET System Pivotal Trial (Rev F)

    A Randomized, Multi-Center, Pivotal Efficacy and Safety Study Evaluating the RESET System for Glycemic Improvement in Patients with Inadequately Controlled Type 2 Diabetes and Obesity, the STEP-1 Study. A multi-center, double-blinded, randomized, sham-controlled trial to evaluate the safety and eff…

    Stage
    Not phased
    Ages
    22 to 65
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Locations
    7 in total
    Run by
    Morphic Medical Inc.

    See if you can join NCT04101669 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.