Obesity Clinical Trials

274 studies are recruiting for obesity in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies, page 8

1. Ketogenic Diets for Weight Loss Maintenance: Impact on Energy Expenditure and Appetite in Individuals With Obesity

   The goal of this clinical trial is to investigate whether a Ketogenic Diet (KD) can increase Total Energy Expenditure (TEE), while benefiting appetite, during weight loss maintenance in reduced-obese individuals.

   Stage

   Not phased

   Ages

   18 to 65

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT06736028 on ClinicalTrials.gov

2. RemI for Post-Bariatric Surgery Weight Regain

   The goal of this clinical trial is to test the effectiveness of remotely-delivered interventions (utilizing acceptance-based behavioral treatment skills (ABTi)) amongst bariatric surgery populations who are experiencing weight regain postoperatively (> 5% from their lowest postoperative weight and …

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Rush University, Chicago, Illinois

   Locations

   2 in total

   Run by

   Temple University

   See if you can join NCT06292936 on ClinicalTrials.gov

3. Reducing Obesity Using Social Ties Program

   This trial aims to test the feasibility and acceptability of addressing interpersonal barriers to weight-related behavior change. Specifically, the study will test if, by including up to two friends, family members, or co-workers in a lifestyle intervention for weight loss, the person enrolled in t…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Weill Cornell Medicine, New York, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT06335810 on ClinicalTrials.gov

4. Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity

   In adults with obesity seeking treatment, weight loss would ideally be composed almost exclusively of fat mass. However, loss of muscle mass and bone are unintentional consequences of weight loss, which may have negative effects on health by lessening improvements in glucose and insulin levels, red…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT05933499 on ClinicalTrials.gov

5. Probiotic Intervention Study

   The current standard of care for obesity is the optimal management of comorbid conditions such as diabetes and hyperlipidemia, and counseling on diet, weight loss, or increased physical activity programs. However, lifestyle, diet, and behavioral interventions may provide between 7-10% reduction in …

   Stage

   Not phased

   Ages

   18 to 50

   Site

   University of California, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT06030362 on ClinicalTrials.gov

6. Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise

   The purpose of this research study is to study the effects of endurance exercise training on adipose (fat) tissue quality and insulin sensitivity in men and women.

   Stage

   Not phased

   Ages

   18 to 45

   Site

   AdventHealth Translational Research Institute, Orlando, Florida

   Locations

   2 in total

   Run by

   AdventHealth Translational Research Institute

   See if you can join NCT06602141 on ClinicalTrials.gov

7. Efficacy Trial of Healthy Together ("Juntos")

   The purpose of this study is to assess the efficacy of a family-based digital (web and mobile phone-based) program known as Healthy Together ("Juntos") in preventing increases in body mass index and improving moderate-to-vigorous physical activity, diet quality, and percentage body fat among Hispan…

   Stage

   Not phased

   Ages

   12 to 15

   Site

   University of Miami, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT06489262 on ClinicalTrials.gov

8. Fasted vs. Fed State Exercise

   Although many medications exist for both heart disease and obesity, cost, lack of access for all people, side effects and the desire for a more natural solution have left many people seeking lifestyle treatments such as exercise. Scientists know that exercise is highly beneficial for heart health. …

   Stage

   Phase 2

   Ages

   18 to 59

   Site

   Arkansas Colleges of Health Education Research Institure Health and Wellness Center, Fort Smith, Arkansas

   Run by

   Arkansas Colleges of Health Education

   See if you can join NCT07487090 on ClinicalTrials.gov

9. Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects

   All participants will undergo baseline biopsies of subcutaneous abdominal adipose tissue for cellular/molecular profiling via snRNA-seq and metabolic/physiological assessments (insulin sensitivity, glucose tolerance, and β-cell function). Older obese participants will be randomized into three arms:…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Cedars Sinai Medical Center, Los Angeles, California

   Run by

   Cedars-Sinai Medical Center

   See if you can join NCT05653258 on ClinicalTrials.gov

10. Testing an Integrated PTSD and Weight Management Intervention: A Hybrid Type 1 Trial

    Obesity and post-traumatic stress disorder (PTSD) are common among Veterans. PTSD increases risk for obesity, impacting functioning, health, quality of life, and premature mortality. Use of proven treatments for PTSD and obesity in VA is low. Furthermore, Veterans with PTSD lose less weight than th…

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA Puget Sound Health Care System Seattle Division, Seattle, WA, Seattle, Washington

    Run by

    VA Office of Research and Development

    See if you can join NCT07010757 on ClinicalTrials.gov

11. A Clinical Study of Semaglutide Nasal Spray in Overweight or Obese Adults

    The specific aim of this study is to examine the Safety, Tolerability and Pharmacokinetic of Semaglutide Nasal Spray compared with placebo and positive control in Adult Overweight or Obese Participants.

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Frontage Clinical Services, Inc., Secaucus, New Jersey

    Run by

    Shanghai World Leader Pharmaceutical Co., Ltd.

    See if you can join NCT07465965 on ClinicalTrials.gov

12. Predictors of Behavioral Obesity Treatment Outcomes

    Socioceconomically disadvantaged individuals typically have poor outcomes in behavioral weight loss interventions, but the reasons for this are unknown. This project will characterize the mechanisms through which adverse daily experiences and present bias -- a cognitive adaptation to harsh and unpr…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Rush University Medical Center, Chicago, Illinois

    Run by

    Rush University Medical Center

    See if you can join NCT05326477 on ClinicalTrials.gov

13. Brain Outcomes With Lifestyle Change in Down Syndrome

    The goal of this study is to determine if weight loss or changes in dietary intake can help prevent of delay adults with Down syndrome from developing Alzheimer's Disease Adults with Down syndrome without dementia will be randomized to either a weight loss group or a general health education contro…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT05985486 on ClinicalTrials.gov

14. Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder

    The goal of this clinical trial is to identify the specific characteristics (phenotypes) that may be useful to help select the right medication for weight loss, and to study the effect of individualized guided medication in patients with bipolar disorder ages 18-65. The main questions it aims to an…

    Stage

    Phase 4

    Ages

    18 to 65

    Site

    Mayo Clinic, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT07213466 on ClinicalTrials.gov

15. Efficacy and Safety of Endoscopic Antral Myotomy as a Novel Weight Loss Procedure

    Gastric myotomy has been performed for several years as a means of addressing chronic stenosis after sleeve gastrectomy and treating gastroparesis. The Pylorus Sparing Antral Myotomy (PSAM) technique has the opposite effect by leaving the pylorus intact and extending the myotomy proximally to the d…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Christopher C. Thompson, MD, MSc

    See if you can join NCT05711758 on ClinicalTrials.gov

16. Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease

    The goal of this observation study is to assess whether endoscopic ultrasound shear wave elastography (EUS-SWE) may be a useful tool for liver fibrosis screening in patients with elevated body mass index and non alcoholic fatty liver disease as compared to other non-invasive screening modalities, w…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Brigham and Women's Hospital

    See if you can join NCT05728697 on ClinicalTrials.gov

17. Sympathetic Mechanisms in Obesity-Crossover Design

    We will study obese hypertensive subjects in a randomized, crossover study to determine if two weeks sympathetic blockade improves endogenous glucose production. Subjects will be studied on 3 different occasions after two weeks of receiving either placebo, amlodipine (vasodilator arm) or moxonidine…

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT05312892 on ClinicalTrials.gov

18. With Love, Grandma ("Con Cariño, Abuelita") Pilot Study

    The purpose of this study is to assess the feasibility, acceptability, and preliminary effects of a digital (web and mobile-phone-based) program to improve lifestyle behaviors (physical activity, dietary intake) among Hispanic female cancer survivors and adult daughters.

    Stage

    Not phased

    Ages

    21 and older

    Site

    University of Miami, Miami, Florida

    Run by

    University of Miami Sylvester Comprehensive Cancer Center

    See if you can join NCT05721976 on ClinicalTrials.gov

19. WatchWell: Simple and Practical Strategies to Reduce the Negative Health Impact of Sedentary Screen Time

    The purpose of this study is to determine the feasibility, acceptability, efficacy, and participant adherence in using home-based technologies and wearable devices and simple, practical strategies to reduce the negative impact that evening screen time may have on your health.

    Stage

    Not phased

    Ages

    26 and older

    Site

    Arizona State University, Tempe, Arizona

    Run by

    Arizona State University

    See if you can join NCT06963736 on ClinicalTrials.gov

20. Avoid and Resist Strategies for Weight Management

    The proposed randomized controlled trial tests two self-regulatory approaches to improve intentional weight loss and diet quality in individuals with overweight or obesity: (1) an environmental control strategy (AVOID) and (2) an impulse control training strategy (RESIST).

    Stage

    Not phased

    Ages

    14 and older

    Site

    Cedars-Sinai Medical Center, Los Angeles, California

    Run by

    Cedars-Sinai Medical Center

    See if you can join NCT05143931 on ClinicalTrials.gov

21. Concentration of n-3 PUFA Monohydroxylated Derivatives in Adults With Obesity After n-3 PUFA Supplementation.

    The goal of this clinical trial is to learn if daily supplementation with SPM Active® can increase omega 3 polyunsaturated fatty acid derivatives and improve well-being in adults with obesity. The main questions it aims to answer are: Does 2 g/day of SPM Active® for 12 weeks increase plasma levels …

    Stage

    Not phased

    Ages

    45 to 60

    Site

    UNC Nutrition Research Institute, Kannapolis, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06991296 on ClinicalTrials.gov

22. CARBON: UAB Cardiovascular Research Biobank

    The UAB Cardiovascular Research Biobank (CARBON) will be a resource that contains biological materials, such as DNA samples, in addition to health and personal information on a large number of people over time. It will be set up so that it can be used in the future as a resource for researchers und…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT05067231 on ClinicalTrials.gov

23. Biobehavioral Reward Responses Associated With Consumption of Nutritionally Diverse Ultra-Processed Foods

    The changing food environment, with increasingly abundant ultra-processed food (UPF) options, may directly contribute to rising rates of obesity, though it is unknown which ingredients in UPF elevate their reinforcing nature in a way that may lead to overconsumption. The proposed study is the first…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Drexel University, Philadelphia, Pennsylvania

    Run by

    Oregon Research Institute

    See if you can join NCT05437809 on ClinicalTrials.gov

24. Semaglutide for Post-Smoking Cessation Weight Management

    This trial will examine the effect of semaglutide 2.4mg on changes in body weight, body composition, and peripheral and central mechanisms that control appetite, satiety, and food intake in the context of smoking cessation.

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    The University of Texas at Austin, Austin, Texas

    Locations

    2 in total

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT06173778 on ClinicalTrials.gov

25. Optimizing Telehealth-delivery of a Weight Loss Intervention in Older Adults

    This study seeks to answer the fundamental questions of which initial, first-line weight loss intervention should be offered to older adults with obesity and multiple chronic conditions and how to address the high non-response rates observed with most conventional strategies. A sequential, multiple…

    Stage

    Not phased

    Ages

    65 to 85

    Site

    UNC Center for Aging and Health, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06044571 on ClinicalTrials.gov