Obesity Clinical Trials

274 studies are recruiting for obesity in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 7

1. Redefining BMI: The Body, Mind, and Inflammation Trial

   Emerging adulthood (18-25 years of age) is a critical developmental window to promote weight management and cardiometabolic health, particularly for emerging adult women. The primary purpose of this study is to test the preliminary efficacy of the intensive lifestyle intervention for EA women in re…

   Stage

   Not phased

   Ages

   18 to 25

   Site

   Virginia Commonwealth Universtity, Richmond, Virginia

   Run by

   Virginia Commonwealth University

   See if you can join NCT06532747 on ClinicalTrials.gov

2. Stand up for Your Health With a Sit-stand Desk

   More than 84 million - or 1 out of every 3 U.S. adults - have prediabetes, a condition that if not treated often leads to type 2 diabetes within five years. Average medical expenditures among diabetics are about 2.3 times higher than expenditures for people without diabetes. Physical inactivity and…

   Stage

   Not phased

   Ages

   18 to 79

   Site

   Medical College of Wisconsin, Milwaukee, Wisconsin

   Run by

   Medical College of Wisconsin

   See if you can join NCT05585190 on ClinicalTrials.gov

3. A Single and Multiple Ascending Dose Study of HM17321 in Healthy and Obese Participants

   This is a Phase 1 study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of HM17321 after single and multiple ascending doses in healthy and obese participants.

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   Medpace Clinical Pharmacology Unit, Cincinnati, Ohio

   Run by

   Hanmi Pharmaceutical Company Limited

   See if you can join NCT07219589 on ClinicalTrials.gov

4. Determinants of Insulin Sensitivity by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis

   The study aims to investigate the relationship between fasting insulin and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) across various demographic factors, including age, sex, race/ethnicity, BMI, and polycystic ovary syndrome (PCOS) diagnosis. By analyzing these variables, the stud…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Lilli Health, Houston, Texas

   Run by

   Ali Chappell

   See if you can join NCT05950282 on ClinicalTrials.gov

5. Adipocyte-Derived Extracellular Vesicles, Weight Loss, and Endothelial Function

   Changes in adipose tissue biology are now recognized as a key factor underlying the increased risk of metabolic and cardiovascular disease with obesity. Clinical interest in adipocyte-derived extracellular vesicles (Ad-EVs) has intensified due to their potential as circulating biomarkers of adipose…

   Stage

   Not phased

   Ages

   40 and older

   Site

   University of Colorado Boulder Clinical and Translational Research Center (CTRC), Boulder, Colorado

   Run by

   University of Colorado, Boulder

   See if you can join NCT06776081 on ClinicalTrials.gov

6. A Research Study Looking Into How NNC0662-0419 Works With Birth Control Pills and Emptying of the Stomach in Women Not Able to Become Pregnant With Excess Body Weight

   The purpose of this clinical study is to find out if NNC0662-0419 is safe and effective to be taken together with other medicines, like birth control pills, and emptying of the stomach in women not able to become pregnant living with overweight or obesity. There are 3 study treatments in this study…

   Stage

   Phase 1

   Ages

   18 to 64

   Site

   Altasciences Clinical Kansas, Inc., Overland Park, Kansas

   Run by

   Novo Nordisk A/S

   See if you can join NCT07525791 on ClinicalTrials.gov

7. Endoscopic Bariatric Therapies (EBTs): A Retrospective and Prospective Multicenter Registry

   The purpose of this registry study is to collect data through medical chart review and in patient visits on the efficacy and safety of various Endoscopic Bariatric therapies (EBTs). This is a retrospective and prospective, observational, medical chart review study for at least 6 standard of care vi…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   Weill Cornell Medicine, New York, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT04494048 on ClinicalTrials.gov

8. Negative Pressure Wound Therapy in Healing Abdominal Incision in Obese Patients Undergoing Breast Reconstruction Surgery

   This trial studies the safety and how well negative pressure wound therapy works in healing the abdominal incision in obese patients undergoing free flap breast reconstruction surgery. Using negative pressure wound therapy (NPWT) instead of standard dressing (bandages) may improve wound healing at …

   Stage

   Not phased

   Ages

   18 and older

   Site

   M D Anderson Cancer Center, Houston, Texas

   Run by

   M.D. Anderson Cancer Center

   See if you can join NCT04003038 on ClinicalTrials.gov

9. Feasibility of Semaglutide in Advanced Lung Disease

   The goal of this clinical trial is to learn whether semaglutide, an FDA-approved treatment for diabetes and obesity, is feasible and tolerable in patients with advanced lung disease. The main question[s] it aims to answer are: 1. Are patients with advanced lung disease able to tolerate semaglutide …

   Stage

   Phase 1

   Ages

   18 to 80

   Site

   University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT05746039 on ClinicalTrials.gov

10. Health Promotion With Targeted Exercise Intervention for Decreasing Fall Risk and Inactivity in Aging Veterans With Obesity and Signs of Sarcopenia

    Falls are a major health risk for older Veterans, especially those with both obesity and low muscle mass or strength (sarcopenia), which together increase the chances of falling and losing independence. Many older Veterans have difficulty staying active and often lack information about how to safel…

    Stage

    Not phased

    Ages

    55 and older

    Site

    Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore, Maryland

    Run by

    VA Office of Research and Development

    See if you can join NCT07206368 on ClinicalTrials.gov

11. A Research Study on How Well Different Doses of the Medicine UBT251 Help People Living With Overweight or Obesity

    The purpose of this clinical study is to find out if UBT251 is safe and effective for treating people who are living with overweight or obesity. Participants will get either UBT251 (the treatment being tested) or Placebo (a treatment that has no active medicine in it), which treatment participants …

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Altasciences Clinical LA, Inc., Cypress, California

    Locations

    3 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07395687 on ClinicalTrials.gov

12. A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use

    The goal of this study is to measure the effects of using Tradipitant to treat nausea and vomiting induced by GLP-1R agonist use in adults with class I or class II obesity, or adults who are overweight with at least one weight-related condition. The study is placebo-controlled with two treatment ar…

    Stage

    Phase 3

    Ages

    18 to 65

    Site

    Vanda Investigational Site, Los Angeles, California

    Locations

    10 in total

    Run by

    Vanda Pharmaceuticals

    See if you can join NCT07446439 on ClinicalTrials.gov

13. Bone Metabolism in 12-21 Year Olds Undergoing Glucagon Like Peptide (GLP)-1 Receptor Agonist Therapy

    The goal of this clinical trial is to compare bone health markers over 24 months in participants 12 - 21 years of age with obesity who are starting the glucagon-like peptide-1 receptor agonists (GLP-1RAs) as compared to those with similar weight followed by lifestyle management. Participants will: …

    Stage

    Phase 2

    Ages

    12 to 21

    Site

    University of Virginia Medical Center, Charlottesville, Virginia

    Run by

    University of Virginia

    See if you can join NCT06903923 on ClinicalTrials.gov

14. SMARTer Weight Loss Management

    The SMARTer trial will be a three-arm, randomized controlled non-inferiority trial that compares the optimized, adaptive SMARTer intervention, fixed DPP, and Self-Guided (Control). The trial will address whether a scalable, stepped-care intervention can stand up to gold-standard DPP by achieving co…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Florida State University, Tallahassee, Florida

    Run by

    Florida State University

    See if you can join NCT05861973 on ClinicalTrials.gov

15. EMPOWER: Effects of Weight Loss and Exercise Post-stroke

    The prevalence of obesity among U.S. adults is ~40% and is projected to climb. It is well documented that obesity is associated with increased levels of disability as well as risk for numerous adverse health-related outcomes; including occurrence of stroke and all-cause mortality. Obesity is highly…

    Stage

    Not phased

    Ages

    35 to 85

    Site

    College of Health Professions, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT05901675 on ClinicalTrials.gov

16. Family COMIDA (Consumo de Opciones Más Ideales De Alimentos) (Eating More Ideal Food Options)

    The purpose of this study is to determine the most effective family-centered intervention (FCI) for weight loss and obesity prevention in Hispanic families. FCI is a type of program that involves family (such as parents and caregivers) supporting their children to promote healthy habits.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York, New York

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT07144800 on ClinicalTrials.gov

17. Randomized Trial of Healthy Family Foundations

    The goal of this clinical trial is to test whether an adaptation of an evidence-based, couple-based preventive intervention at the transition to parenthood improves reduces obesity risk among infants and parents in military families via improved interparental support and coordination around health …

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Nellis Airforce Base, Nellis Air Force Base, Nevada

    Run by

    Penn State University

    See if you can join NCT05630482 on ClinicalTrials.gov

18. Metabolic Adaptations to Weight Loss With and Without Exercise

    Study Purpose: The combination of caloric restriction and exercise is the most common first-line treatment for obesity-related disorders, yet we know very little about how these two very different treatments work together. A deeper understanding about mechanisms underlying the health benefits of ad…

    Stage

    Not phased

    Ages

    18 to 40

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT05806801 on ClinicalTrials.gov

19. Exercise Training and Fat Metabolism in Postmenopausal Women

    Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to e…

    Stage

    Not phased

    Ages

    50 to 75

    Site

    Florida State University, Tallahassee, Florida

    Run by

    Florida State University

    See if you can join NCT05351476 on ClinicalTrials.gov

20. Dinner Time for Obesity and Prediabetes

    Obesity and its metabolic complications are leading causes of global morbidity and mortality. Evidence is mounting that inappropriate timing of food intake contributes to obesity. Specifically, late eating is associated with greater weight gain and metabolic syndrome. However, the mechanism by whic…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    Johns Hopkins Bayview Medical Center, Baltimore, Maryland

    Locations

    2 in total

    Run by

    Johns Hopkins University

    See if you can join NCT05745441 on ClinicalTrials.gov

21. Regional Lipolysis Insulin Regulation

    Adults who gain most of their excess weight in the abdominal area typically do not respond to insulin in the same way as lean adults. Researchers are trying to understand why fat tissue responds differently in people with different body types.

    Stage

    EARLY_Phase 1

    Ages

    18 to 65

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06392854 on ClinicalTrials.gov

22. Body Composition Related Evaluation of Airway Tone and Hyper-rEactivity Using Oscillometry

    This study will determine if airway resistance to airflow and pressure, measured by Oscillometry, is associated with abnormal findings on methacholine challenge testing and whether these findings are associated with body habitus,

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Rochester Medical Center, Rochester, New York

    Run by

    University of Rochester

    See if you can join NCT07356310 on ClinicalTrials.gov

23. PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis

    Obese individuals have a higher prevalence of nocturnal hypertension and non-dipping blood pressure (BP). These conditions are associated with an increased risk of cardiovascular (CV) events and death. Natriuretic Peptides (NPs) are hormones produced by the heart which directly regulate BP by causi…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT04971720 on ClinicalTrials.gov

24. GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study

    Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes and poor cardiometabolic health. Obese and Black individuals have ~30% …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT05216042 on ClinicalTrials.gov

25. First in Human Study in Subjects With Obesity, But Otherwise Healthy

    This is a First in Human study to evaluate the safety and tolerability of DA-1726 following single and multiple doses in participants with obesity, but otherwise healthy subjects.

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Clinical Pharmacology of Miami, LLC, Miami, Florida

    Run by

    NeuroBo Pharmaceuticals Inc.

    See if you can join NCT06252220 on ClinicalTrials.gov