Obesity Clinical Trials

274 studies are recruiting for obesity in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 6

1. Phenotype-Tailored Lifestyle Intervention for Obesity: A Randomized Trial

   The purpose of this study is to develop an evidence-based precision medicine approach for obesity that enhances weight loss and promotes weight loss maintenance.

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Mayo Clinic, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06770049 on ClinicalTrials.gov

2. Weight Loss Study: Genetics and Response to Naltrexone/Bupropion

   The goal of this clinical trial is to understand if genetic variations are associated with the amount of weight loss with diet and while taking an FDA-approved medication for weight loss. The main question[s] it aims to answer are: * In Aim One, the investigators propose to rigorously test the hypo…

   Stage

   Phase 4

   Ages

   18 to 65

   Site

   Columbia University Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT05919797 on ClinicalTrials.gov

3. EBT Fruit and Vegetable Prescription

   Eating Better Together is a 6-month pilot program that teaches families about healthy eating and activity and provides home deliveries of fresh fruits and vegetables from a local retail partner.

   Stage

   Not phased

   Ages

   4 to 10

   Site

   Cherokee Health Systems, Dameron Avenue Pedatrics, Knoxville, Tennessee

   Locations

   2 in total

   Run by

   The University of Tennessee, Knoxville

   See if you can join NCT05028205 on ClinicalTrials.gov

4. Pharmacotherapy in Conjunction With Lifestyle Counseling for Management of Weight Regain After Bariatric Surgery

   This is a randomized controlled trial employing a Sequential Multiple Assignment Randomized Trial (SMART) design to test whether pharmacotherapy, in conjunction with lifestyle counseling, can reverse weight regain after bariatric surgery.

   Stage

   Phase 4

   Ages

   18 to 70

   Site

   University of California Irvine Medical Center, Orange, California

   Run by

   University of California, Irvine

   See if you can join NCT05975580 on ClinicalTrials.gov

5. A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity

   The purpose of this study is to evaluate the safety and tolerability of single and multiple subcutaneous (SC) doses of MBX 4291 in adults with obesity.

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   MBX Biosciences Investigational Site, Doral, Florida

   Locations

   4 in total

   Run by

   MBX Biosciences

   See if you can join NCT07142707 on ClinicalTrials.gov

6. Increased Dietary Protein Intake During GLP-1 Medication Use (in Middle-aged Women With Overweight/Obesity)

   Middle-aged women with (overweight/)obesity who will begin or have begun GLP-1 medication use will be recruited to complete a 12-week diet intervention study. For 12-weeks, participants will continue to take their GLP-1 medication and may be provided with protein-rich foods to consume every day. Bo…

   Stage

   Not phased

   Ages

   30 to 60

   Site

   Dell Pediatric Research Center, Austin, Texas

   Locations

   2 in total

   Run by

   University of Texas at Austin

   See if you can join NCT07480109 on ClinicalTrials.gov

7. Sisters for Heart Health: A Community Health Worker Initiative for Improving Heart Health in Farmworker Women

   The goal of this hybrid Type 1 effectiveness-implementation trial is to test the extent to which a peer support and community resource navigation intervention improves psychological well-being, addresses non-biologic drivers of health (access to healthcare, supportive services, nutrition, housing s…

   Stage

   Not phased

   Ages

   18 to 50

   Site

   Southern GA - Colquitt County, Ellenton, Georgia

   Run by

   Emory University

   See if you can join NCT07111026 on ClinicalTrials.gov

8. Exercise Effects on Adipose Tissue Structure and Function

   Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise …

   Stage

   Not phased

   Ages

   18 to 40

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT04812314 on ClinicalTrials.gov

9. Resistance Exercise and Incretin Mimetic for Cardiometabolic Health in Survivors of ALL With Obesity

   This is a 28-week, single-arm, open-label phase II clinical trial evaluating the combination of Tirzepatide and remote, supervised, tailored resistance exercise training to achieve weight loss in adult survivors of childhood acute lymphoblastic leukemia (ALL) living with obesity or overweight with …

   Stage

   Phase 2

   Ages

   18 and older

   Site

   St. Jude Children's Research Hospital, Memphis, Tennessee

   Run by

   St. Jude Children's Research Hospital

   See if you can join NCT07228741 on ClinicalTrials.gov

10. Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation

    The research in this VA Merit will examine the effects of obesity and Post-COVID Conditions (PCC) on physical functioning, health-related quality of life, and adipose tissue inflammatory and cellular senescence profiles in older Veterans. Further, it will evaluate whether a weight loss intervention…

    Stage

    Not phased

    Ages

    Up to 80

    Site

    Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore, Maryland

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT05880108 on ClinicalTrials.gov

11. Experimental Approach to Test Predictions of Body Weight Regulation Models

    The regulation of human body weight and fatness is not fully understood. Although some models of regulation have been proposed (set point, dual-intervention point, others), no studies have been designed to test their predictions. In this pilot and feasibility study, the investigators will implement…

    Stage

    Not phased

    Ages

    18 to 40

    Site

    Pennington Biomedical Research Center, Baton Rouge, Louisiana

    Run by

    Pennington Biomedical Research Center

    See if you can join NCT06309576 on ClinicalTrials.gov

12. Optimizing a Mobile Health Platform for Sleep Promotion and Obesity Prevention in Children

    The overall objective of this application is to develop a mobile health platform for the pediatric care setting to promote longer sleep duration for childhood obesity prevention.

    Stage

    Not phased

    Ages

    8 to 12

    Site

    Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

    Run by

    Children's Hospital of Philadelphia

    See if you can join NCT05703347 on ClinicalTrials.gov

13. Conical Forearm and Cylindrical Upper Arm Non-Invasive Blood Pressure (NIBP) Measurements in Pregnant Patients

    The diagnosis of hypertensive disease during pregnancy is predicated on strict blood pressure thresholds: 140/90 on at least two occasions measured four hours apart for both gestational hypertension and preeclampsia. An improvement in diagnostic accuracy of even 5mm Hg would be significant, as refl…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Prentice Women's Hospital, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT06466161 on ClinicalTrials.gov

14. Metabolic Effects of Angiotensin-(1-7)

    The overall purpose of this study is to learn more about the metabolic effects of angiotensin-(1-7) in the insulin resistant state associated with obesity. Pharmacologic approaches to increase angiotensin-(1-7) levels or its actions are currently in development for treatment of metabolic-related di…

    Stage

    Phase 1

    Ages

    18 to 60

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University

    See if you can join NCT02646475 on ClinicalTrials.gov

15. Regional Lipolysis and Adipocyte Lipolysis Protein Stimulation

    Adults who gain most of their excess weight in the abdominal area typically do not respond to factors that "turn on" fat cells the same way as people who don't have excessive weight. Researchers are trying to understand why fat tissue responds differently in people with different body types.

    Stage

    EARLY_Phase 1

    Ages

    18 to 65

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06416969 on ClinicalTrials.gov

16. Impact of Yo-Yo Sleep on Cardiometabolic Health

    The goal of this clinical trial is to test the impact of repeated intermittent short sleep, with short sleep maintained 5 days per week followed by 2 days of prolonged sleep, compared to daily adequate sleep, on energy balance and cardiometabolic risk. A secondary goal of this research is to determ…

    Stage

    Not phased

    Ages

    18 to 49

    Site

    Columbia University Irving Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT05880758 on ClinicalTrials.gov

17. Milk-Tot Study: Impact of Whole Versus Low-fat Milk on Child Health

    In the U.S. it is recommended that children consume whole cow's milk (3.5% fat) from ages 1 to 2 years to support rapid early growth and brain development, and then at age 2 years transition to low-fat (1%) or non-fat milk to reduce saturated fat and calorie intake. To date, few studies have examin…

    Stage

    Not phased

    Ages

    1 to 4

    Site

    Nutrition Policy Institute, University of California Agriculture and Natural Resources, Oakland, California

    Run by

    University of California, Davis

    See if you can join NCT06230510 on ClinicalTrials.gov

18. Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling

    The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of Colorado Anschutz, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT06129110 on ClinicalTrials.gov

19. A Study to See if an iPhone Weight Management App Can Help Promote Weight Loss in Adolescents and Young Adults After a Stem Cell Transplant

    This early phase I trial studies how well a behavioral weight loss intervention consisting of a smartphone application and coaching works for the promotion of weight loss in adolescents and young adults after a stem cell transplant. This study may help researchers learn more about how adolescents a…

    Stage

    Not phased

    Ages

    13 to 30

    Site

    UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California

    Run by

    Jonsson Comprehensive Cancer Center

    See if you can join NCT04453072 on ClinicalTrials.gov

20. Alzheimer"s Imaging Biomarkers in Obesity

    High body fat at midlife, as evidenced by overweight or obese body mass index (BMI), is increasingly understood as a risk factor for Alzheimer's disease. However, the underlying processes and mechanisms that may underlie this risk remains unknown. With this project, the Investigator proposes to cre…

    Stage

    Not phased

    Ages

    40 to 60

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Cyrus A Raji

    See if you can join NCT05077579 on ClinicalTrials.gov

21. Growth Hormone Resistance of Beta-cells A

    The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a personal history of gestational diabetes (high blood sugar in pregnancy) at the University of Missouri. The aim…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    University of Missouri School of Medicine, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT06571487 on ClinicalTrials.gov

22. Growth Hormone Resistance of Beta-cells in People With a Family History of Type 2 Diabetes

    The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a family history of type 2 diabetes at the University of Missouri. Our aim is to advance understanding of how gro…

    Stage

    Not phased

    Ages

    18 to 59

    Site

    University of Missouri School of Medicine, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT06571500 on ClinicalTrials.gov

23. Scalable TELeheaLth Cancer CARe: The STELLAR Program to Treat Cancer Risk Behaviors

    The goal of this clinical trial is to improve cancer patient's health, survival, and quality of life by dispelling risk behaviors for Northwestern Memorial Health Care (NMHC) patients who are cancer survivors. The main question[s] STELLAR aims to answer are: * How best to combine three behavior int…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Northwestern University-Feinberg School of Medicine, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT05687604 on ClinicalTrials.gov

24. Nutrition and Exercise Interventions for Androgen Deprivation Therapy-Induced Obese Frailty in Elderly and Non-Elderly Survivors of Advanced Prostate Cancer

    This trial studies how well nutrition and exercise interventions work in reducing androgen deprivation therapy-induced obese frailty in prostate cancer survivors. Individualized nutrition and exercise advice for prostate cancer patients on androgen deprivation therapy may help to reduce obese frail…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Roswell Park Cancer Institute, Buffalo, New York

    Run by

    Roswell Park Cancer Institute

    See if you can join NCT03880422 on ClinicalTrials.gov

25. Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF

    The overall purpose of this study is to investigate whether pulmonary limitations that increase the oxygen (O2) cost of breathing impact dyspnea on exertion (DOE) and peak exercise capacity in patients with HFpEF and obesity. As per investigator's hypothesis, obesity is likely a significant contrib…

    Stage

    Not phased

    Ages

    55 to 90

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT05723679 on ClinicalTrials.gov