Obesity Clinical Trials

274 studies are recruiting for obesity in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 5

1. Adapting and Testing a Novel Digital Health Tool (PREVENT) to Improve Health Behavior Counseling and Cardiovascular Health in Rural Primary Care Clinics

   The focus on this application is low-income, rural patients, since cardiovascular disease (CVD) prevalence is 40% higher among rural than urban residents. Health behavior counseling and follow-up care are required for patients with an elevated body mass index who have increased risk for CVD. Counse…

   Stage

   Not phased

   Ages

   18 to 64

   Site

   Washington University in St. Louis, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT06063564 on ClinicalTrials.gov

2. Cognitive Strategies for Weight Loss

   The goal of this clinical trial is to compare weight change and other related outcomes associated with three different behavioral weight loss interventions (STANDARD Behavioral, PREVENT, and PROMOTE) in adults with obesity. The main questions it aims to answer are: * Which of the three Internet-del…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Weight Control & Diabetes Research Center, Providence, Rhode Island

   Run by

   The Miriam Hospital

   See if you can join NCT05799846 on ClinicalTrials.gov

3. Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure

   This study aims to determine whether a 6-month multilevel intervention involving problem-solving training, exercise training and support from community health workers is more effective in improving outcomes for individuals with low socioeconomic status, type 2 diabetes, obesity, and early cardiac d…

   Stage

   Not phased

   Ages

   30 to 70

   Site

   Johns Hopkins Center for Health Equity, Baltimore, Maryland

   Locations

   2 in total

   Run by

   Johns Hopkins University

   See if you can join NCT06364644 on ClinicalTrials.gov

4. Physiologic Response to Bariatric Surgery and the Impact of Adjunct Semaglutide in Adolescents

   The study plans to learn more about what happens to the body after bariatric surgery in people 12 to 24 years old. The study aims to understand why people respond differently to bariatric surgery and how to define success beyond weight loss alone. The study also plans to learn more about whether a …

   Stage

   Phase 1

   Ages

   12 to 24

   Site

   Childrens Hospital Colorado, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT06575738 on ClinicalTrials.gov

5. Effect of Ketone Esters on Liver Fat Content and Metabolic Function

   The goal of this clinical trial is to determine whether ingestion of a ketone ester drink helps improve liver health and blood glucose control. Ketones are a type of energy source made by the body during times of weight loss, low carbohydrate intake and starvation. People enrolled in this study wil…

   Stage

   Phase 2

   Ages

   18 to 40

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT07097506 on ClinicalTrials.gov

6. Mechanistic and Clinical Outcomes of a Surgical Innovation Aimed at Minimizing GERD Associated With VSG (INNOVATE-VSG)

   This is a two-site randomized clinical trial aiming to test whether a modified investigational bariatric surgical procedure can improve gastroesophageal reflux disease (GERD) after sleeve gastrectomy.

   Stage

   Not phased

   Ages

   18 to 65

   Site

   University of California, Irvine, Orange, California

   Locations

   2 in total

   Run by

   University of California, Irvine

   See if you can join NCT06783751 on ClinicalTrials.gov

7. Identification of Phenotypic Factors That Predict Success for Weight Loss and Long-term Weight Maintenance

   The Investigational Weight Management Clinic now entitled the Weight Management Program at the University of Michigan was created to identify strategies that will result in cost-effective, long term weight management for overweight and obese individuals. The driving hypothesis of the clinic is that…

   Stage

   Not phased

   Ages

   15 to 75

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT02043457 on ClinicalTrials.gov

8. Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

   This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced …

   Stage

   Not phased

   Ages

   14 to 18

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT06007404 on ClinicalTrials.gov

9. Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions

   The lack of postpartum primary care coordination is a missed opportunity to increase primary care engagement and manage chronic conditions early in life, especially for the >30% of pregnant people who have or are at risk for these conditions. This study aims to increase postpartum primary care enga…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06557005 on ClinicalTrials.gov

10. Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Therapy and Exercise Training in People With Obesity

    The use of glucagon-like peptide receptor agonists (GLP-1 RAs) may have clinically important effects on skeletal muscle mass (SMM), and physical function. The effects of exercise training in conjunction with GLP-1 RA therapy on these outcomes has not been studied. Additionally, most people treated …

    Stage

    Not phased

    Ages

    50 to 75

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT07091500 on ClinicalTrials.gov

11. PRImary Care Strategies for Weight Management (PRISM) Study

    The goal of this clinical trial pilot is to determine the feasibility of an intervention to enhance weight management in patients who have stopped taking anti-obesity/weight management medications in primary care. The main questions it aims to answer are: * Can patients be recruited into the study …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Rush University Medical Center, Chicago, Illinois

    Run by

    Rush University Medical Center

    See if you can join NCT07288294 on ClinicalTrials.gov

12. AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

    The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) …

    Stage

    Phase 3

    Ages

    18 and older

    Site

    South Broward Research LLC, Miramar, Florida

    Locations

    72 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07339423 on ClinicalTrials.gov

13. A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

    The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight and knee osteoarthritis. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the …

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Arizona Research Center, Inc., Phoenix, Arizona

    Locations

    82 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07481630 on ClinicalTrials.gov

14. Effect of Insulin Lowering on Lipogenesis

    The goal of this clinical trial is to compare a one-week course of diazoxide (2 mg/kg per dose x 14 doses) and placebo in people with obesity and insulin resistance (IR) with metabolic dysfunction-associated steatotic liver disease (MASLD). The main question it aims to answer are how mitigation of …

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Columbia University Irving Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT07403604 on ClinicalTrials.gov

15. A Study to Improve Skeletal Muscle in Veterans With HIV

    The Department of Veterans Affairs is the largest single provider of medical care to people with HIV in the United States. The condition of excess lipid within and around muscle, termed myosteatosis, predisposes Veterans to physical function decline, frailty, disability, and cardiometabolic disease…

    Stage

    Not phased

    Ages

    20 to 80

    Site

    Tennessee Valley Healthcare System Nashville Campus, Nashville, TN, Nashville, Tennessee

    Run by

    VA Office of Research and Development

    See if you can join NCT06845046 on ClinicalTrials.gov

16. Respiratory Muscle Training to Improve Cerebrovascular and Immune Function

    Millions of adults in America have too much body fat, resulting in obesity. Obesity is detrimental to health and causes disease. Obesity reduces brain health, which causes the brain to function less effectively. Additionally, a lack of exercise contributes to poorer brain health. Most individuals f…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    Florida State University, Tallahassee, Florida

    Run by

    Florida State University

    See if you can join NCT07406295 on ClinicalTrials.gov

17. MEHMO Natural History and Biomarkers

    This observational natural history study will follow individuals with MEHMO (Mental disability, Epileptic seizure, Hypopituitarism/Hypogenitalism, Microcephaly, Obesity) syndrome or an eIF2-pathway related disorder, who have symptoms such as intellectual delay, seizures, abnormal hormone and blood …

    Stage

    Not phased

    Ages

    0 to 100

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

    See if you can join NCT06019182 on ClinicalTrials.gov

18. Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

    Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally. While weight loss through lifestyle modification is the standard treatment, most patients regain weight limiting ultimate improvement in liver disease. On the other end of the spectru…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Pichamol Jirapinyo, MD, MPH

    See if you can join NCT06138821 on ClinicalTrials.gov

19. Trans-nasal Endoscopy for Bariatric Patients

    This study plans to learn if the EvoEndo Endoscopy system can be used to evaluate, provide and follow up care for upper gastrointestinal tract diseases in the bariatric population. The smallest current scope available for such a technique is an adult transnasal endoscope with a larger diameter, a p…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Christopher C. Thompson, MD, MSc

    See if you can join NCT06200961 on ClinicalTrials.gov

20. Evaluation of the Tolerability of Cagrilintide in Participants Not Tolerating GLP-1-RA Therapies Due to Gastrointestinal Adverse Events

    The purpose of this clinical study is to look at the safety of the medicine Cagrilintide when compared to placebo in people who do not tolerate marketed glucagon-like peptide-1 (GLP-1) therapies and who live with overweight or obesity. Participants will get either Cagrilintide (the treatment being …

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Diablo Clinical Research, Inc., Walnut Creek, California

    Locations

    11 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07607587 on ClinicalTrials.gov

21. The Effects of Strength Training on Muscle Mass and Mental Health in Adults Taking Obesity Medication

    The purpose of this study is to examine the effects of resistance exercise, such as weightlifting, on retention of muscle mass and mental health in individuals taking GLP-1 RAs (an obesity medication). Resistance exercise is focused on increasing the strength of participants' muscles, such as how m…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Physical Activity Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT07652333 on ClinicalTrials.gov

22. Body Composition Outcomes in MS Patients

    Objectives The objective of this project is to generate pilot data substantiating our hypothesis that advanced body composition measurement tools will provide more accurate and clinically relevant data on the outcomes of metabolic surgery (MS) in patients with severe obesity compared to traditional…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Pennington Biomedical Research Center, Baton Rouge, Louisiana

    Locations

    2 in total

    Run by

    Pennington Biomedical Research Center

    See if you can join NCT07530718 on ClinicalTrials.gov

23. Daily Eating Patterns for Total Health Study

    The goal of this randomized controlled trial is to learn how the time of day when calories are eaten affects weight loss in the long-term (12 months). The main aims are to learn: 1. The influence of time-based energy intake goals on longer-term weight loss. 2. The influence of time-based energy int…

    Stage

    Not phased

    Ages

    25 to 60

    Site

    Healthy Eating and Activity Laboratory, Knoxville, Tennessee

    Run by

    The University of Tennessee, Knoxville

    See if you can join NCT06455995 on ClinicalTrials.gov

24. A Study to Investigate Why Overweight People Regain Weight After Losing Weight in a Behavioral Weight Loss Program

    The goal of this clinical trial is to determine the physiological basis for the differences in weight regain among adults (25-59 years old) with obesity following participation in a behavioral weight loss program. Eligible participants will undergo a baseline evaluation after which they will enter …

    Stage

    Not phased

    Ages

    25 to 59

    Site

    Columbia University Irving Medical Center, New York, New York

    Locations

    3 in total

    Run by

    University of Pittsburgh

    See if you can join NCT05748158 on ClinicalTrials.gov

25. Michigan Weight Navigation Program (MiWeigh) Study

    The main purpose of this study is to determine whether people who participate in MiWeigh lose more weight than people who receive information about weight loss strategies and programs. The researchers also want to learn what parts of the program do and do not work and why. If the program is effecti…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT07465341 on ClinicalTrials.gov