Obesity Clinical Trials

274 studies are recruiting for obesity in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 10

1. A Bilingual Virtually-based Intervention (PEDALL) for the Prevention of Weight Gain in Childhood ALL Patients Considering Key Genetic and Sociodemographic Risk Factors

   The purpose of this study is determine the effectiveness of a six-month virtually-delivered dietary education intervention (PEDALL) on the prevention of overweight and obesity (OW/OB) during maintenance chemotherapy in children and adolescents with acute lymphoblastic leukemia (ALL).

   Stage

   Not phased

   Ages

   5 to 21

   Site

   Columbia University Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT05963971 on ClinicalTrials.gov

2. Weight Loss Through Mayo Clinic Diet

   The purpose of study is to evaluate the efficacy of the Mayo Clinic Diet in clinically significant weight loss (>5%) versus usual care. We also wish to evaluate the feasibility, barriers to completion, and sustainability of this intervention at the 24, and 52-week marks. Lastly, we aim to study the…

   Stage

   Not phased

   Ages

   18 to 64

   Site

   Mayo Clinic in Rochester, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06862375 on ClinicalTrials.gov

3. Efficacy of mHealth Apps for Health in a Low-income, Type II Diabetic, Hispanic Population

   The purpose of this study is to determine the effectiveness of mobile health applications in improving health outcomes and the subsequent benefit of improving type II diabetes outcomes in a low socioeconomic Hispanic population. This study will involve a 6-month long commitment where participants w…

   Stage

   Not phased

   Ages

   18 to 64

   Site

   San Diego State University, San Diego, California

   Run by

   San Diego State University

   See if you can join NCT05279729 on ClinicalTrials.gov

4. Efficacy of Using Mobile Health Applications for Health

   The purpose of this study is to determine the effectiveness of mobile health applications in improving health outcomes and type II diabetes outcomes in type 2 diabetics. This study will involve a 6-month long commitment where participants will be expected to weigh themselves every morning, at the s…

   Stage

   Not phased

   Ages

   18 to 64

   Site

   San Diego State University, San Diego, California

   Run by

   San Diego State University

   See if you can join NCT05589155 on ClinicalTrials.gov

5. Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention

   Lower attainment of cardiovascular health (CVH), indicated by the American Heart Association's Life's Simple 7 (LS7; physical activity, diet, cholesterol, blood pressure, body mass index, smoking, glycemia) and Life's Essential 8 (LE8; LS7+sleep) metrics, is a major contributor to Black men having …

   Stage

   Not phased

   Ages

   18 and older

   Site

   The Ohio State University, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT06055036 on ClinicalTrials.gov

6. Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension

   Obesity is a global health concern that is associated with high blood pressure and an increased risk for developing cardiovascular disease. The purpose of this study is to find out if the investigational drug angiotensin-(1-7) can improve cardiovascular health in people with obesity and high blood …

   Stage

   EARLY_Phase 1

   Ages

   18 to 65

   Site

   Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania

   Run by

   Milton S. Hershey Medical Center

   See if you can join NCT06482853 on ClinicalTrials.gov

7. DNA Methylation and Vascular Function

   The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for nonpharmacological preventive/therapeutic interventions such as aerobic exerci…

   Stage

   Not phased

   Ages

   18 to 50

   Site

   University of Illinois at Chicago, Chicago, Illinois

   Run by

   University of Illinois at Chicago

   See if you can join NCT03527420 on ClinicalTrials.gov

8. Circadian Misalignment and Energy Balance

   Preliminary findings from the investigators' lab suggest that circadian misalignment, occurring when meals and sleep are mistimed from one another, alters resting state neuronal processing in areas relevant to food reward and interoception; supporting a role of sleep and meal misalignment, on energ…

   Stage

   Not phased

   Ages

   20 to 49

   Site

   Columbia University Irving Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT03663530 on ClinicalTrials.gov

9. Motivational Wellness Coaching to Reduce Childhood Obesity in Families and Kids

   Primary care settings lack interventions to address the childhood obesity epidemic that are feasible and sustainable without requiring significant resources. The investigators propose to modify and test an intervention shown to lower children's body mass index(BMI) so that it is feasible, sustainab…

   Stage

   Not phased

   Ages

   2 to 8

   Site

   Kaiser Permanente Pasadena, Pasadena, California

   Run by

   Kaiser Permanente

   See if you can join NCT05143697 on ClinicalTrials.gov

10. Exercise, Brain Activity, and Weight Maintenance

    This study aims to explore how HIIT influences brain function, neural and molecular pathways related to weight control, setting the stage for future obesity intervention research.

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Joslin Diabetes Center, Boston, Massachusetts

    Run by

    Joslin Diabetes Center

    See if you can join NCT06511310 on ClinicalTrials.gov

11. Community Park-Based Programs for Health Promotion: Fit2Play Prospective Cohort Study

    The Fit2Play prospective cohort study examines the effects of a park-based youth physical activity afterschool program on youth participant fitness and mental health outcomes. Duke will perform a secondary analysis of the data collected as part of the Fit2Play prospective cohort study run by Miami-…

    Stage

    Not phased

    Ages

    6 to 14

    Site

    Miami-Dade County Parks, Recreation and Open Spaces Department, Miami, Florida

    Run by

    Duke University

    See if you can join NCT06595251 on ClinicalTrials.gov

12. Community Park-Based Programs for Health Promotion: Active Older Adults Prospective Cohort Study

    The Active Older Adults prospective cohort study examines the effects of a park-based fitness program on cardiovascular fitness outcomes for older adults (aged 50 years and older). Duke will perform a secondary analysis of the data collected as part of the Active Older Adults prospective cohort stu…

    Stage

    Not phased

    Ages

    50 to 95

    Site

    Miami-Dade County Parks, Recreation and Open Spaces Department, Miami, Florida

    Run by

    Duke University

    See if you can join NCT06604650 on ClinicalTrials.gov

13. ADAPT Study: Assessing Diet, Appetite and Physiology Throughout Weight Loss Study)

    Behavioral weight loss programs for obesity can result in weight loss and health benefits. However, behavioral weight loss often stops despite efforts to continue losing weight, this can be called an involuntarily weight loss plateau. This study investigates changes in metabolism and/or the brain t…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    University of Washington - South Lake Union, Seattle, Washington

    Locations

    2 in total

    Run by

    University of Washington

    See if you can join NCT06174389 on ClinicalTrials.gov

14. Time Restricted Feeding, Muscle, and Metabolism

    Effective nutrition strategies for combatting and/or preventing obesity still need to be identified. This has been the case despite the numerous and different approaches that have been taken. Potential targets for combatting/preventing obesity have been identified, but long-term solutions have not …

    Stage

    Not phased

    Ages

    25 to 50

    Site

    University of Arkansas, Fayetteville, Arkansas

    Run by

    University of Arkansas, Fayetteville

    See if you can join NCT04949451 on ClinicalTrials.gov

15. Non-interventional Pre-screening Protocol Aims to Evaluate Participants for Potential Trial Eligibility in Future Clinical Trials/Studies Focusing on Metabolic and Psychiatric Health.

    DOVE-MET-COME-100 is a single site prescreening survey study designed to identify adults who may be eligible for future industry-sponsored clinical trials. A physician will oversee the informed consent process, after which participants will be surveyed on demographics, medical history, current heal…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Clindove Research LLC, Brooklyn, New York

    Run by

    Clindove Research LLC

    See if you can join NCT07106879 on ClinicalTrials.gov

16. Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients

    Developed nations worldwide are currently enduring a health crisis, as chronic diseases continue to decrease quality of life and promote additional disease states or even death for much of the population. Rural populations are at a particular disadvantage, as they lack access to health clubs, welln…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    West Virginia School of Osteopathic Medicine, Lewisburg, West Virginia

    Run by

    West Virginia School of Osteopathic Medicine

    See if you can join NCT06049420 on ClinicalTrials.gov

17. Strategies for Implementing a Postpartum Lifestyle Intervention in WIC Clinics

    The primary objective of the STRIVE study is to compare two implementation strategies for Diabetes Prevention Program delivery: an in-person health coach strategy (standard 24 in-person sessions at WIC clinics) vs. a multifaceted technology-assisted health coach implementation strategy (12 in-perso…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana

    Run by

    Tulane University

    See if you can join NCT06116149 on ClinicalTrials.gov

18. HIIT Effects on Cardiometabolic Health

    The primary aim of this randomized clinical trial is to compare the effects of three different HIIT protocols and a control group on cardiometabolic health in young adults with obesity. Participants will be randomly assigned to one of the following three groups, with each having varying work-to-res…

    Stage

    Not phased

    Ages

    18 to 25

    Site

    Women's Building, Syracuse, New York

    Run by

    Syracuse University

    See if you can join NCT05838950 on ClinicalTrials.gov

19. Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)

    This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after cardiac arrest. Investigators have shown that cardiac arrest induces chang…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Maine Medical Center, Portland, Maine

    Run by

    MaineHealth

    See if you can join NCT02664831 on ClinicalTrials.gov

20. Anti Inflammatory Lipid Mediators in Asthma Lipid Anti-Inflammtory Mediators in Asthma

    The main purpose of this Phase 2 double blind, placebo controlled crossover clinical study is to demonstrate the efficacy and safety of CXA-10 in obese adult asthmatics. Obesity induces a chronic systemic inflammatory state characterized by impaired adipokine signaling, pro-inflammatory cytokine re…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT03762395 on ClinicalTrials.gov

21. Supplementing L-citrulline to Overweight Late Asthma oNset Phenotypes

    Patients with obese late onset (after childhood) asthma can have lower FeNO levels, yet be highly symptomatic and poorly responsive to inhaled steroids. This is a common asthma phenotype, particularly among females. This reduction of NO occurs through increased arginase activity and uncoupling of N…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Duke University (Asthma, Allergy and Airway Center), Durham, North Carolina

    Run by

    University of Colorado, Denver

    See if you can join NCT03885245 on ClinicalTrials.gov

22. Mitigating the Pro-inflammatory Phenotype of Obesity

    The purpose of this study is to examine the hypothesize that 4 weeks of sympathetic nerve activity (SNA) inhibition (oral clonidine) will cause a significant reduction in circulating blood concentrations and endothelial cell expression of inflammatory markers (e.g., TNF-α, IL-6). Our study is a pro…

    Stage

    Phase 1

    Ages

    18 to 79

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT04934228 on ClinicalTrials.gov

23. PreventT2 Together: Examining the Efficacy of Couple-based Lifestyle Intervention to Prevent Type 2 Diabetes

    Nearly half of adults in the United States have or are at risk of developing type 2 diabetes. The overall goal of this community-engaged research is to examine the efficacy of an innovative couple-based lifestyle intervention to prevent type 2 diabetes that is applicable to a broad range of partner…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Utah, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT06690788 on ClinicalTrials.gov

24. Brown Adipose Tissue Activity in Response to Semaglutide Administered to Obese Subjects.

    Glucagon like peptide (GLP-1) agonists, such as liraglutide, exenatide, and semaglutide, have been increasingly used as a medication to address the current twin epidemics of diabetes and obesity. Their activities include increasing insulin production by pancreatic beta cells, improving insulin sens…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UCLA Health, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT05419726 on ClinicalTrials.gov

25. Glucagon-Like Peptide-1 Receptor Agonist in ADPKD

    The proposed clinical trial aims to assess if a year of treatment with a glucagon-like peptide 1 receptor agonist, a medication approved for weight management that also improves the body's response to glucose and insulin, can slow kidney growth in adults with autosomal dominant polycystic kidney di…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    University of Colorado - Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT06582875 on ClinicalTrials.gov