Obesity Clinical Trials

274 studies are recruiting for obesity in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 11

1. Thermogenenic Responses to Fasting and Overfeeding in Women

   This study plans to learn more about why menopause increases the risk of weight gain. During and after menopause, women are prone to increased weight gain. The weight gained is primarily body fat, particularly visceral or abdominal body fat. The excess gain in abdominal fat during menopause increas…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   University of Colorado Anschutz Medical Campus, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT06610162 on ClinicalTrials.gov

2. Personalized Responses to Dietary Composition Trial 3

   The PREDICT 3 study will build on previous research in over 2,000 individuals to further refine machine learning models that predict individual responses to foods, with the aim of advancing precision nutrition science and individualized dietary advice. The study incorporates both standardized and c…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Zoe US Inc., Needham, Massachusetts

   Locations

   2 in total

   Run by

   Zoe Global Limited

   See if you can join NCT04735835 on ClinicalTrials.gov

3. Fundus Ablation Registry (Gastric Fundus Mucosal Ablation for Weight Loss)

   The purpose of this study is to construct a multi-site, prospective registry to evaluate the clinical outcomes of patients who have undergone gastric fundus mucosal ablation at True You Weight Loss.

   Stage

   Not phased

   Ages

   18 to 65

   Site

   True You Weight Loss, Cary, North Carolina

   Run by

   True You Weight Loss

   See if you can join NCT06428617 on ClinicalTrials.gov

4. Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism

   The goal of this study is to understand the role of brain glucose transport in individuals with obesity and the association with cerebral hypometabolism and these individuals' response to plasma glucose elevations. The main premise is that obesity leads to reduced brain glucose transport and that w…

   Stage

   Phase 1

   Ages

   18 to 45

   Site

   Biomedical Research Imaging Center Marsico Hall (UNC), Chapel Hill, North Carolina

   Locations

   2 in total

   Run by

   University of North Carolina, Chapel Hill

   See if you can join NCT04328337 on ClinicalTrials.gov

5. A Novel Obesity Prevention Program for High-Risk Infants in Primary Care

   The goal of this clinical trial is to test a responsive parenting obesity prevention program with infants and caregivers of color (e.g., non-White; Hispanic/Latinx) and/or who are economically marginalized (i.e., publicly insured), delivered via Integrated Behavioral Health (IBH) in pediatric prima…

   Stage

   Phase 2

   Ages

   0 and older

   Site

   Hopple Street Neighborhood Health Center, Cincinnati, Ohio

   Run by

   Children's Hospital Medical Center, Cincinnati

   See if you can join NCT06028113 on ClinicalTrials.gov

6. Improving Glycemic Control With Electrical Stimulation

   Once written consent is obtained, the participant will be provided with an accelerometer to be worn for 7 days to assess current physical activity levels. Subjects will be provided with a standardized diet (55/15/30% CHO/PRO/FAT) prior to collection of pre-intervention data of insulin sensitivity. …

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Texas at El Paso, El Paso, Texas

   Run by

   University of Texas, El Paso

   See if you can join NCT03947697 on ClinicalTrials.gov

7. Chronic Widespread Pain After Rapid Weight Loss in Non-Hispanic Black and Hispanic/Latino/a/x Adults

   The goal of this observational study is to learn if surgical weight loss can improve chronic widespread pain in people living with higher BMI who self-identify as Hispanic/Latino ethnicity or non-Hispanic Black based on the United States census racial categories. The main questions the study aims t…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   NYU Steinhardt Arthur J. Nelson Laboratory, New York, New York

   Locations

   3 in total

   Run by

   New York University

   See if you can join NCT06795386 on ClinicalTrials.gov

8. Adrenergic Cholinergic Enteric Measures/Mapping

   Patients seen who had autonomic and enteric profiling (Adrenergic, Cholinergic, Enteric Measures/Mapping=ACEM_ from 2012-2019 at the University of Louisville.

   Stage

   Not phased

   Ages

   10 to 80

   Site

   University of Louisville, Louisville, Kentucky

   Run by

   University of Louisville

   See if you can join NCT04013282 on ClinicalTrials.gov

9. Optimizing an Online Behavioral Weight Loss Intervention and Novel Culturally Tailored Components for Sexual Minority Women

   Obesity disproportionately impacts sexual minority women. Behavioral weight loss programs are the gold standard treatment for mild to moderate obesity. The investigators have developed an online behavioral weight loss program that is effective, low-cost, and highly scalable. However, existing resea…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Weight Control and Diabetes Research Center, Providence, Rhode Island

   Run by

   The Miriam Hospital

   See if you can join NCT05775497 on ClinicalTrials.gov

10. Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance

    This 12-week controlled diet and weight intervention study seeks to define the molecular pathways that link excess body weight to the development of insulin resistance (IR). Blood, adipose and stool are sampled at three timepoints; baseline, peak weight (4 weeks) and post weight loss to monitor cha…

    Stage

    Not phased

    Ages

    35 to 65

    Site

    Stanford University, Stanford, California

    Run by

    Stanford University

    See if you can join NCT05165706 on ClinicalTrials.gov

11. Tirzepatide: Reversal of Lipotoxicity and Adipose Tissue Dysfunction in Humans With Overweight/Obesity

    Obesity, affecting 40% of US adults and costing 173b annually, represents a significant health care burden (1). It is associated with increased risk for multiple chronic diseases including hypertension, type 2 diabetes (T2D), cardiovascular disease, and NAFLD, as well as cancer, osteoarthritis, and…

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    Clinical and Translational Research Unit, Palo Alto, California

    Run by

    Stanford University

    See if you can join NCT05912621 on ClinicalTrials.gov

12. Use of Pulsatile Intravenous FSH to Mitigate Reprometabolic Syndrome

    Hypothesis: The investigators hypothesize that pulsatile FSH intravenous administration to women with obesity will correct the Reprometabolic Syndrome (RMS) luteal deficiency phenotype. Specific Aim: To test the hypothesis that pulsatile IV administration of FSH will rescue the impaired folliculoge…

    Stage

    Phase 1

    Ages

    19 to 37

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT06414096 on ClinicalTrials.gov

13. A Culturally-relevant Micronutrient-dense Plant-rich (mNDPR) Dietary Intervention for Native Americans

    The investigators propose to conduct a randomized controlled trial with a wait-list control to determine efficacy in reducing risk of obesity and related disease in Native American employees of Twin Arrows Casino. Participants will be randomly assigned to the experimental group or the wait-list con…

    Stage

    Not phased

    Ages

    18 and older

    Site

    PRANDIAL Lab, Flagstaff, Arizona

    Run by

    Northern Arizona University

    See if you can join NCT04755062 on ClinicalTrials.gov

14. Transduction of Sympathetic Neural Activity in Human Obesity Without Hypertension

    In addition to chronically elevated MSNA, there is a growing recognition that hypertension in states of insulin resistance and obesity may also be attributed to an increased vascular sensitivity to MSNA (1, 2, 13, 36-38). To study this phenomenon, we quantify vascular sensitivity to MSNA using an i…

    Stage

    Not phased

    Ages

    18 to 79

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT06626113 on ClinicalTrials.gov

15. International Weight Control Registry

    The IWCR is a global scientific study aimed at better understanding the opportunities and barriers for reducing the prevalence of obesity by collecting information from people who have experience with weight management in their everyday lives. The investigators seek to gather information on a wide …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    7 in total

    Run by

    Tufts University

    See if you can join NCT04907396 on ClinicalTrials.gov

16. RESET System Pivotal Trial (Rev F)

    A Randomized, Multi-Center, Pivotal Efficacy and Safety Study Evaluating the RESET System for Glycemic Improvement in Patients with Inadequately Controlled Type 2 Diabetes and Obesity, the STEP-1 Study. A multi-center, double-blinded, randomized, sham-controlled trial to evaluate the safety and eff…

    Stage

    Not phased

    Ages

    22 to 65

    Site

    MedStar Health Research Institute, Washington D.C., District of Columbia

    Locations

    7 in total

    Run by

    Morphic Medical Inc.

    See if you can join NCT04101669 on ClinicalTrials.gov

17. The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults

    This clinical trial aims to learn about the alterations in insulin resistance and metabolic flexibility following a transition to an obesogenic lifestyle in fit young men and women. The main questions it aims to answer are: 1. Does adding excess carbohydrates when transitioning to a sedentary lifes…

    Stage

    Not phased

    Ages

    18 to 30

    Site

    University of New Hampshire Cardiometabolic Research Laboratory, Durham, New Hampshire

    Run by

    University of New Hampshire

    See if you can join NCT05912348 on ClinicalTrials.gov

18. Research Framework Exploring Sleep Health

    This is a digital health study in which participants are recruited to collect sleep and activity data from digital activity trackers. We are also collecting survey/questionnaire data on baseline health and sleep characteristics as well as bi-weekly assessments of sleep quality and mood. Overall, we…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Scripps Research Institute, La Jolla, California

    Run by

    Scripps Translational Science Institute

    See if you can join NCT05197738 on ClinicalTrials.gov

19. Triage Survey for Cardiovascular, Obesity, and Related Endocrine Trial Eligibility

    SWIFT-CORE-101 is a single site survey study designed to assess potential participants' eligibility to screen for industry-sponsored clinical trials. A physician will oversee the informed consent process, after which participants will be surveyed on demographics, medical history, comorbidities, and…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brooklyn Clinical Research, Brooklyn, New York

    Run by

    Brooklyn Clinical Research

    See if you can join NCT06412536 on ClinicalTrials.gov

20. Ablation Registry (Combined Gastric Mucosal Ablation With Endoscopic Sleeve Gastroplasty for Weight Loss)

    The purpose of this study is to construct a multi-site, prospective registry to evaluate the clinical outcomes of patients who have undergone combined gastric mucosal ablation with endoscopic sleeve gastroplasty at True You Weight Loss.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    True You Weight Loss, Atlanta, Georgia

    Locations

    2 in total

    Run by

    True You Weight Loss

    See if you can join NCT06420700 on ClinicalTrials.gov

21. Sleep and Metabolism

    The goal of this study is to uncover sleep and circadian mechanisms contributing to adverse metabolic health. The protocol is a 21 day (7 outpatient days, 14 inpatient days) mechanistic randomized-crossover study designed to identify the impact of chronic sleep restriction and circadian timing, ind…

    Stage

    Not phased

    Ages

    18 to 40

    Site

    Oregon Health & Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT05775627 on ClinicalTrials.gov

22. Endoscopic Sleeve Gastroplasty (ESG) for the Treatment of Obesity

    The purpose of this study is to evaluate endoscopic sleeve gastroplasty (ESG) for the treatment of obesity. The ESG procedure is an U.S. Food and Drug Administration (FDA) approved procedure for the treatment of obesity - patients with a body mass index (BMI) 30-50 kg/m2. This procedure is FDA appr…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Houston Methodist Hospital, Houston, Texas

    Locations

    2 in total

    Run by

    The Methodist Hospital Research Institute

    See if you can join NCT06339320 on ClinicalTrials.gov

23. Pharmacologic Weight Loss as Adjunct Therapy for Ulcerative Colitis in Obese Patients

    Approximately 20-40% of patients with ulcerative colitis (UC) are obese. The investigators have demonstrated that obesity adversely impacts disease course in patients with UC, leading to higher risk of persistently active disease, surgery, hospitalization, and treatment failure, particularly in bio…

    Stage

    Phase 2

    Ages

    18 to 80

    Site

    University of California San Diego, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT04721873 on ClinicalTrials.gov

24. Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics

    The objective of this pilot study is to determine whether obesity and metabolic syndrome are in fact synergistic in relation to airway nitric oxide (NO) biology. To do so, the investigators want to determine how obesity and the metabolic syndrome relate to metabolism in bronchial airway epithelial …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    University of Colorado, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT03215836 on ClinicalTrials.gov