Down Syndrome Clinical Trials

26 studies are recruiting for down syndrome in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)

   The overall objective of this randomized clinical trial is to test the effectiveness of a personalized approach to the surgical treatment of OSA in children with Down syndrome (DS).The estimated prevalence of obstructive sleep apnea (OSA) in children with DS ranges from 45-83%, compared to 1-6% in …

   Stage

   Not phased

   Ages

   2 to 17

   Site

   Colorado Children's Hospital, Aurora, Colorado

   Locations

   7 in total

   Run by

   Oregon Health and Science University

   See if you can join NCT05508971 on ClinicalTrials.gov

2. Specimen Collection From Pregnant Women at Increased Risk for Fetal Aneuploidy

   The specimen collection is designed for the purpose of the development of a noninvasive prenatal test for T21.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Alabama Birmingham, Birmingham, Alabama

   Locations

   14 in total

   Run by

   Sequenom, Inc.

   See if you can join NCT01429389 on ClinicalTrials.gov

3. Endotype DIrected Treatment for OSA in Down Syndrome

   Down syndrome is the most common genetic cause of intellectual disability. People with Down syndrome often have obstructive sleep apnea (OSA), a condition where people have difficulties with breathing while asleep. OSA can lead to poor sleep, worse quality of life, behavior problems and more diffic…

   Stage

   Phase 4

   Ages

   6 and older

   Site

   University of Arizona, Tucson, Arizona

   Locations

   5 in total

   Run by

   University of Arizona

   See if you can join NCT07280468 on ClinicalTrials.gov

4. Modulation of the Immune System in Down Syndrome for Improved Outcomes and Neurodevelopment - 1

   This protocol describes a phase 2, double-blind, randomized, placebo-controlled clinical trial for Janus kinase (JAK) inhibition in Down syndrome (DS). This trial will evaluate the safety and efficacy of a 6-month treatment with the JAK1/3 inhibitor tofacitinib in individuals ages 6-22 (inclusive) …

   Stage

   Phase 2

   Ages

   6 to 22

   Site

   CU Anschutz, Children's Hospital Colorado, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT07598643 on ClinicalTrials.gov

5. A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

   This phase II trial studies the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell acute lymphoblastic leukemia (B-ALL) that has come back (relapsed). Down syndrome patients with relapsed B-ALL are included in this study. Blinatumoma…

   Stage

   Phase 2

   Ages

   1 to 30

   Site

   Children's Hospital of Alabama, Birmingham, Alabama

   Locations

   227 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT04546399 on ClinicalTrials.gov

6. A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

   This study attempts to learn more about the health of persons with Down syndrome after treatment for acute leukemia. Children with Down syndrome are at increased risk for side effects during treatment for acute leukemia, but it is unclear of their risk for long-term effects of cancer treatment. By …

   Stage

   Not phased

   Ages

   6 to 39

   Site

   Children's Hospital of Alabama, Birmingham, Alabama

   Locations

   73 in total

   Run by

   Children's Oncology Group

   See if you can join NCT05702645 on ClinicalTrials.gov

7. Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

   The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK…

   Stage

   Not phased

   Ages

   0 to 20

   Site

   Lucile Packard Children's Hospital, Palo Alto, California

   Locations

   52 in total

   Run by

   Duke University

   See if you can join NCT04278404 on ClinicalTrials.gov

8. Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia

   The researchers are investigating if the Self-Supporting Nasopharyngeal Airway (ssNPA) device can be used in the treatment of obstructive sleep apnea in children with Hypotonic Upper Airway Obstruction (HUAO).

   Stage

   Not phased

   Ages

   3 to 21

   Site

   The University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT05527652 on ClinicalTrials.gov

9. Harness-based Mobility Intervention for Infants With Down Syndrome

   The emergence of crawling and walking is significantly delayed in infants with Down syndrome (DS), but the development of independent mobility provides infants with new opportunities for exploring the environment and interacting with objects and people that are important foundations for early learn…

   Stage

   Not phased

   Ages

   Up to 2

   Site

   Boston University, Boston, Massachusetts

   Run by

   Boston University Charles River Campus

   See if you can join NCT06219863 on ClinicalTrials.gov

10. Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without Thymectomy

    Background: Down syndrome is a genetic disorder that can cause heart defects and other problems in the body. People with Down syndrome are more likely to have infections, autoimmunity, and blood diseases. Some may need surgery to treat congenital heart problems. During this surgery, doctors sometim…

    Stage

    Not phased

    Ages

    1 to 120

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Allergy and Infectious Diseases (NIAID)

    See if you can join NCT07416201 on ClinicalTrials.gov

11. Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition

    Progressive age-related cognitive deficits occurring in both AD and DS have been connected to the degeneration of several neuronal populations, but mechanisms are not fully elucidated. The most consistent neuronal losses throughout the progression of AD are seen in cholinergic neurons where these l…

    Stage

    Phase 2

    Ages

    18 to 55

    Site

    Vanderbilt University Medical Center Clinical Research Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT05231798 on ClinicalTrials.gov

12. How Simplified Language Affects Comprehension and Learning in Young Children With Down Syndrome

    The long-term study goal is to experimentally evaluate the components (and likely active ingredients) of early language interventions for young children with Down syndrome (DS). The overall objective is to determine how single-word and telegraphic simplification affects real-time language processin…

    Stage

    Not phased

    Ages

    2 to 7

    Site

    Michigan State University, East Lansing, Michigan

    Run by

    Michigan State University

    See if you can join NCT06951516 on ClinicalTrials.gov

13. Collaboration for Down Syndrome Progress (CDP)

    The Collaboration for Down Syndrome Progress (CDP) is a long-term study that follows people with Down syndrome of all ages. The goal is to better understand their health, development, and everyday experiences over time. Participants and their caregivers will answer questions, share medical informat…

    Stage

    Not phased

    Ages

    Any age

    Site

    University of Wisconsin-Madison, Madison, Wisconsin

    Locations

    16 in total

    Run by

    RTI International

    See if you can join NCT07625579 on ClinicalTrials.gov

14. Drumming Lessons' Influence on Children With Down Syndrome

    The goal of this clinical trial is to learn if drumming lessons can increase self-control in children with Down syndrome. The main question it aims to answer is whether 2 months of drumming lessons can improve the behavioral control and timing skills in children with Down syndrome. Participants are…

    Stage

    Not phased

    Ages

    7 to 15

    Site

    Vanderbilt University, Nashville, Tennessee

    Run by

    Vanderbilt University

    See if you can join NCT07156318 on ClinicalTrials.gov

15. Trial-Ready Cohort-Down Syndrome (TRC-DS)

    The purpose of the Trial-Ready Cohort - Down Syndrome (TRC-DS) is to enroll 120 healthy adults with Down syndrome (DS), between the ages of 25-55, into a trial ready cohort (TRC), and up to 550 participants in total including co-enrolled in the Alzheimer Biomarkers Consortium - Down Syndrome (ABC-D…

    Stage

    Not phased

    Ages

    25 to 55

    Site

    Barrow Neurological Institute, Phoenix, Arizona

    Locations

    22 in total

    Run by

    University of Southern California

    See if you can join NCT04165109 on ClinicalTrials.gov

16. Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome

    Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with widespread organ dysfunction, including abnormalities in the autonomic nervous system (ANS). The ANS regulates critical functions such as heart rate (HR) and blood pressure (BP), both essential for main…

    Stage

    Phase 3

    Ages

    18 to 50

    Site

    Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT07238465 on ClinicalTrials.gov

17. Patterns of Neurodevelopmental Disorders

    The purpose of this study is to systematically evaluate the results of medical investigations to identify symptom and biological patterns and common etiologies of neurodevelopmental disorders.

    Stage

    Not phased

    Ages

    Any age

    Site

    Rossignol Medical Center, Phoenix, Arizona

    Run by

    Richard Frye

    See if you can join NCT06213090 on ClinicalTrials.gov

18. Gamma Frequency Stimulation in Individuals With Down Syndrome

    Down Syndrome (DS) is characterized by an additional copy of chromosome 21, which also increases risk of Alzheimer's Disease (AD). The investigators' lab found a non-invasive way to remove toxic proteins from the brain in AD mouse models. Remarkably, treated mice also have improved memory on behavi…

    Stage

    Not phased

    Ages

    25 to 65

    Site

    Massachusetts Institute of Technology, Cambridge, Massachusetts

    Run by

    Massachusetts Institute of Technology

    See if you can join NCT05196984 on ClinicalTrials.gov

19. Sleep Intervention and Quality of Life in Down Syndrome

    Aim 1 of the proposed project will be to adapt the virtual Mindfulness-Based Therapy for Insomnia (MBTI) for individuals with Down syndrome (DS). The investigators will work closely with a community advisory board consisting of individuals with DS, their caregivers, and clinicians specializing in D…

    Stage

    Not phased

    Ages

    1 to 30

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06783725 on ClinicalTrials.gov

20. Brain Outcomes With Lifestyle Change in Down Syndrome

    The goal of this study is to determine if weight loss or changes in dietary intake can help prevent of delay adults with Down syndrome from developing Alzheimer's Disease Adults with Down syndrome without dementia will be randomized to either a weight loss group or a general health education contro…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT05985486 on ClinicalTrials.gov

21. Physical Activity and Community EmPOWERment Project

    Purpose: Conduct a wait-list randomized controlled trial (RCT) of an inclusive physical activity program called PACE for adults with intellectual disability (ID) who are not yet showing signs of Alzheimer's Disease (AD)/age-related dementias (ARD). Participants: Participants include 120 adults with…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of North Carolina, Chapel Hill, North Carolina

    Locations

    2 in total

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06740162 on ClinicalTrials.gov

22. Retinal Imaging in Neurodegenerative Disease

    This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Duke University Medical Center, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT03233646 on ClinicalTrials.gov

23. The Human Trisome Project

    The Human Trisome Project will significantly increase the speed of Down syndrome research and the understanding of associated medical conditions. Its biobank will provide de-identified samples to research.

    Stage

    Not phased

    Ages

    0 to 89

    Site

    Linda Crnic Institute for Down Syndrome at the University of Colorado Denver, Denver, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT02864108 on ClinicalTrials.gov

24. Measuring Aided Language Development

    The focus of the current study is to systematically investigate the psychometric properties of a range of aided language measures, which are based on the Graphic Symbol Utterance and Sentence Development Framework (Binger \& Kent-Walsh).

    Stage

    Not phased

    Ages

    3 to 5

    Site

    University of Central Florida - Innovative Center, Orlando, Florida

    Run by

    University of Central Florida

    See if you can join NCT06512168 on ClinicalTrials.gov

25. Down Syndrome Obstructive Sleep Apnea

    The purpose of this study is to assess whether oxygen supplementation during sleep improves working memory and other clinical and patient-reported outcomes among children who have Down Syndrome (DS) with moderate to severe Obstructive Sleep Apnea (OSA).

    Stage

    Phase 2

    Ages

    5 to 18

    Site

    Children's Hospital of Los Angeles, Los Angeles, California

    Locations

    7 in total

    Run by

    Brigham and Women's Hospital

    See if you can join NCT06043440 on ClinicalTrials.gov