Down Syndrome Clinical Trials in Nashville, Tennessee

6 studies are recruiting for down syndrome in Nashville, Tennessee right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

   This phase II trial studies the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell acute lymphoblastic leukemia (B-ALL) that has come back (relapsed). Down syndrome patients with relapsed B-ALL are included in this study. Blinatumoma…

   Stage

   Phase 2

   Ages

   1 to 30

   Site

   The Children's Hospital at TriStar Centennial, Nashville, Tennessee

   Locations

   227 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT04546399 on ClinicalTrials.gov

2. A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

   This study attempts to learn more about the health of persons with Down syndrome after treatment for acute leukemia. Children with Down syndrome are at increased risk for side effects during treatment for acute leukemia, but it is unclear of their risk for long-term effects of cancer treatment. By …

   Stage

   Not phased

   Ages

   6 to 39

   Site

   Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee

   Locations

   73 in total

   Run by

   Children's Oncology Group

   See if you can join NCT05702645 on ClinicalTrials.gov

3. Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

   The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK…

   Stage

   Not phased

   Ages

   0 to 20

   Site

   Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee

   Locations

   52 in total

   Run by

   Duke University

   See if you can join NCT04278404 on ClinicalTrials.gov

4. Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition

   Progressive age-related cognitive deficits occurring in both AD and DS have been connected to the degeneration of several neuronal populations, but mechanisms are not fully elucidated. The most consistent neuronal losses throughout the progression of AD are seen in cholinergic neurons where these l…

   Stage

   Phase 2

   Ages

   18 to 55

   Site

   Vanderbilt University Medical Center Clinical Research Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT05231798 on ClinicalTrials.gov

5. Drumming Lessons' Influence on Children With Down Syndrome

   The goal of this clinical trial is to learn if drumming lessons can increase self-control in children with Down syndrome. The main question it aims to answer is whether 2 months of drumming lessons can improve the behavioral control and timing skills in children with Down syndrome. Participants are…

   Stage

   Not phased

   Ages

   7 to 15

   Site

   Vanderbilt University, Nashville, Tennessee

   Run by

   Vanderbilt University

   See if you can join NCT07156318 on ClinicalTrials.gov

6. Trial-Ready Cohort-Down Syndrome (TRC-DS)

   The purpose of the Trial-Ready Cohort - Down Syndrome (TRC-DS) is to enroll 120 healthy adults with Down syndrome (DS), between the ages of 25-55, into a trial ready cohort (TRC), and up to 550 participants in total including co-enrolled in the Alzheimer Biomarkers Consortium - Down Syndrome (ABC-D…

   Stage

   Not phased

   Ages

   25 to 55

   Site

   Vanderbilt University Medical Center Center for Cognitive Medicine, Nashville, Tennessee

   Locations

   22 in total

   Run by

   University of Southern California

   See if you can join NCT04165109 on ClinicalTrials.gov