Down Syndrome Clinical Trials in Ann Arbor, Michigan

5 studies are recruiting for down syndrome in Ann Arbor, Michigan right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)

   The overall objective of this randomized clinical trial is to test the effectiveness of a personalized approach to the surgical treatment of OSA in children with Down syndrome (DS).The estimated prevalence of obstructive sleep apnea (OSA) in children with DS ranges from 45-83%, compared to 1-6% in …

   Stage

   Not phased

   Ages

   2 to 17

   Site

   University of Michigan, Ann Arbor, Michigan

   Locations

   7 in total

   Run by

   Oregon Health and Science University

   See if you can join NCT05508971 on ClinicalTrials.gov

2. A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

   This phase II trial studies the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell acute lymphoblastic leukemia (B-ALL) that has come back (relapsed). Down syndrome patients with relapsed B-ALL are included in this study. Blinatumoma…

   Stage

   Phase 2

   Ages

   1 to 30

   Site

   C S Mott Children's Hospital, Ann Arbor, Michigan

   Locations

   227 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT04546399 on ClinicalTrials.gov

3. A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

   This study attempts to learn more about the health of persons with Down syndrome after treatment for acute leukemia. Children with Down syndrome are at increased risk for side effects during treatment for acute leukemia, but it is unclear of their risk for long-term effects of cancer treatment. By …

   Stage

   Not phased

   Ages

   6 to 39

   Site

   C S Mott Children's Hospital, Ann Arbor, Michigan

   Locations

   73 in total

   Run by

   Children's Oncology Group

   See if you can join NCT05702645 on ClinicalTrials.gov

4. Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia

   The researchers are investigating if the Self-Supporting Nasopharyngeal Airway (ssNPA) device can be used in the treatment of obstructive sleep apnea in children with Hypotonic Upper Airway Obstruction (HUAO).

   Stage

   Not phased

   Ages

   3 to 21

   Site

   The University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT05527652 on ClinicalTrials.gov

5. Down Syndrome Obstructive Sleep Apnea

   The purpose of this study is to assess whether oxygen supplementation during sleep improves working memory and other clinical and patient-reported outcomes among children who have Down Syndrome (DS) with moderate to severe Obstructive Sleep Apnea (OSA).

   Stage

   Phase 2

   Ages

   5 to 18

   Site

   University of Michigan, Ann Arbor Hospital, Ann Arbor, Michigan

   Locations

   7 in total

   Run by

   Brigham and Women's Hospital

   See if you can join NCT06043440 on ClinicalTrials.gov