Down Syndrome Clinical Trials in Aurora, Colorado

8 studies are recruiting for down syndrome in Aurora, Colorado right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)

   The overall objective of this randomized clinical trial is to test the effectiveness of a personalized approach to the surgical treatment of OSA in children with Down syndrome (DS).The estimated prevalence of obstructive sleep apnea (OSA) in children with DS ranges from 45-83%, compared to 1-6% in …

   Stage

   Not phased

   Ages

   2 to 17

   Site

   Colorado Children's Hospital, Aurora, Colorado

   Locations

   7 in total

   Run by

   Oregon Health and Science University

   See if you can join NCT05508971 on ClinicalTrials.gov

2. Modulation of the Immune System in Down Syndrome for Improved Outcomes and Neurodevelopment - 1

   This protocol describes a phase 2, double-blind, randomized, placebo-controlled clinical trial for Janus kinase (JAK) inhibition in Down syndrome (DS). This trial will evaluate the safety and efficacy of a 6-month treatment with the JAK1/3 inhibitor tofacitinib in individuals ages 6-22 (inclusive) …

   Stage

   Phase 2

   Ages

   6 to 22

   Site

   CU Anschutz, Children's Hospital Colorado, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT07598643 on ClinicalTrials.gov

3. A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

   This phase II trial studies the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell acute lymphoblastic leukemia (B-ALL) that has come back (relapsed). Down syndrome patients with relapsed B-ALL are included in this study. Blinatumoma…

   Stage

   Phase 2

   Ages

   1 to 30

   Site

   Children's Hospital Colorado, Aurora, Colorado

   Locations

   227 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT04546399 on ClinicalTrials.gov

4. Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

   The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK…

   Stage

   Not phased

   Ages

   0 to 20

   Site

   Colorado University Denver, Aurora, Colorado

   Locations

   52 in total

   Run by

   Duke University

   See if you can join NCT04278404 on ClinicalTrials.gov

5. Collaboration for Down Syndrome Progress (CDP)

   The Collaboration for Down Syndrome Progress (CDP) is a long-term study that follows people with Down syndrome of all ages. The goal is to better understand their health, development, and everyday experiences over time. Participants and their caregivers will answer questions, share medical informat…

   Stage

   Not phased

   Ages

   Any age

   Site

   University of Colorado Anschutz Medical Campus, Aurora, Colorado

   Locations

   16 in total

   Run by

   RTI International

   See if you can join NCT07625579 on ClinicalTrials.gov

6. Trial-Ready Cohort-Down Syndrome (TRC-DS)

   The purpose of the Trial-Ready Cohort - Down Syndrome (TRC-DS) is to enroll 120 healthy adults with Down syndrome (DS), between the ages of 25-55, into a trial ready cohort (TRC), and up to 550 participants in total including co-enrolled in the Alzheimer Biomarkers Consortium - Down Syndrome (ABC-D…

   Stage

   Not phased

   Ages

   25 to 55

   Site

   Linda Crnic Institute for Down Syndrome, University of Colorado, Aurora, Colorado

   Locations

   22 in total

   Run by

   University of Southern California

   See if you can join NCT04165109 on ClinicalTrials.gov

7. Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome

   Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with widespread organ dysfunction, including abnormalities in the autonomic nervous system (ANS). The ANS regulates critical functions such as heart rate (HR) and blood pressure (BP), both essential for main…

   Stage

   Phase 3

   Ages

   18 to 50

   Site

   Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT07238465 on ClinicalTrials.gov

8. DS-Connect®: The Down Syndrome Registry

   The goal of this study is to develop a registry for Down syndrome (DS) to facilitate research participation by individuals with Down syndrome. DS-Connect® is an online survey tool designed to collect demographic data and health information from individuals with DS. It is open to all people with Dow…

   Stage

   Not phased

   Ages

   Any age

   Site

   Linda Crnic Institute for Down Syndrome, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT01950624 on ClinicalTrials.gov