Down Syndrome Clinical Trials in Philadelphia, Pennsylvania

5 studies are recruiting for down syndrome in Philadelphia, Pennsylvania right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Endotype DIrected Treatment for OSA in Down Syndrome

   Down syndrome is the most common genetic cause of intellectual disability. People with Down syndrome often have obstructive sleep apnea (OSA), a condition where people have difficulties with breathing while asleep. OSA can lead to poor sleep, worse quality of life, behavior problems and more diffic…

   Stage

   Phase 4

   Ages

   6 and older

   Site

   Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

   Locations

   5 in total

   Run by

   University of Arizona

   See if you can join NCT07280468 on ClinicalTrials.gov

2. A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

   This phase II trial studies the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell acute lymphoblastic leukemia (B-ALL) that has come back (relapsed). Down syndrome patients with relapsed B-ALL are included in this study. Blinatumoma…

   Stage

   Phase 2

   Ages

   1 to 30

   Site

   Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

   Locations

   227 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT04546399 on ClinicalTrials.gov

3. A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

   This study attempts to learn more about the health of persons with Down syndrome after treatment for acute leukemia. Children with Down syndrome are at increased risk for side effects during treatment for acute leukemia, but it is unclear of their risk for long-term effects of cancer treatment. By …

   Stage

   Not phased

   Ages

   6 to 39

   Site

   Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

   Locations

   73 in total

   Run by

   Children's Oncology Group

   See if you can join NCT05702645 on ClinicalTrials.gov

4. Collaboration for Down Syndrome Progress (CDP)

   The Collaboration for Down Syndrome Progress (CDP) is a long-term study that follows people with Down syndrome of all ages. The goal is to better understand their health, development, and everyday experiences over time. Participants and their caregivers will answer questions, share medical informat…

   Stage

   Not phased

   Ages

   Any age

   Site

   The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

   Locations

   16 in total

   Run by

   RTI International

   See if you can join NCT07625579 on ClinicalTrials.gov

5. Down Syndrome Obstructive Sleep Apnea

   The purpose of this study is to assess whether oxygen supplementation during sleep improves working memory and other clinical and patient-reported outcomes among children who have Down Syndrome (DS) with moderate to severe Obstructive Sleep Apnea (OSA).

   Stage

   Phase 2

   Ages

   5 to 18

   Site

   Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

   Locations

   7 in total

   Run by

   Brigham and Women's Hospital

   See if you can join NCT06043440 on ClinicalTrials.gov