HIV Clinical Trials

101 studies are recruiting for hiv in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Inflammation and Depression in People With HIV

   The purpose of this 10-week, double-blind, placebo-controlled study is to determine whether inflammation impacts reward and motor neural circuitry to contribute to depressive symptoms like anhedonia and psychomotor slowing in people with Human Immunodeficiency Virus (HIV) and depression. Sixty male…

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   Grady Memorial Hospital, Atlanta, Georgia

   Locations

   2 in total

   Run by

   Emory University

   See if you can join NCT05849038 on ClinicalTrials.gov

2. GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV

   The goal of this clinical trial is to learn if the drug semaglutide works to reduce alcohol intake among adults living with HIV. The main questions it aims to answer are: 1. Does semaglutide lower the average number of alcoholic beverages participants drink per week? 2. Does semaglutide lower the a…

   Stage

   Phase 2

   Ages

   18 to 89

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT07221214 on ClinicalTrials.gov

3. Gathering Online for Dialogue and Discussion to Enhance Social Support

   The goal of this trial is to test a modified mobile health intervention (with a group component) relative to a mobile health intervention in a two-arm randomized trial with up to 500 young women who are human immunodeficiency virus (HIV)-negative and who misuse alcohol. The expected outcomes are to…

   Stage

   Not phased

   Ages

   18 to 30

   Site

   RTI International, Durham, North Carolina

   Run by

   RTI International

   See if you can join NCT05753683 on ClinicalTrials.gov

4. Implementation Trial to Evaluate a Population Health Combination Intervention to Meet HIV Testing, Linkage, and Viral Suppression Goals in Alabama

   The purpose of this study is to adapt and evaluate a combination intervention that includes: (1) a data-driven approach to directed community-based HIV testing to areas with high need, (2) Project Connect to expedite linkage to care at time of diagnosis, (3) and a Rapid ART (antiretroviral therapy)…

   Stage

   Not phased

   Ages

   13 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT05384145 on ClinicalTrials.gov

5. The Collaborative Care PrTNER Study

   A randomized controlled trial to assess the ability of a Collaborative Care Prevention, Treatment, Navigation, Engagement, Resource (PrTNER) intervention to increase initiation of preexposure prophylaxis (PrEP) (for those at-risk for HIV) and decrease viral load (for those living with HIV) among yo…

   Stage

   Not phased

   Ages

   15 to 29

   Site

   Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

   Locations

   2 in total

   Run by

   Children's Hospital of Philadelphia

   See if you can join NCT06585631 on ClinicalTrials.gov

6. Effectiveness of Relationship Education for Reducing HIV Incidence Among Men Who Have Sex With Men

   The purpose of this study is to upgrade an existing relationship education and HIV prevention program. This program is designed for gay, bisexual, queer, and transgender and non-binary people who partner with cisgender men. This means the program is designed for gay, bisexual and queer men, includi…

   Stage

   Not phased

   Ages

   16 to 34

   Site

   Northwestern University, Chicago, Illinois

   Run by

   Northwestern University

   See if you can join NCT05678556 on ClinicalTrials.gov

7. PrEP Readiness Interventions for Sustained Motivation (PRISM)

   This is a hybrid type I randomized controlled trial to test the effectiveness of contingency management (CM) alone versus CM with motivational interviewing (MI) for optimizing entry or re-entry into the HIV prevention or care continua. A total of 400 participants will be randomized to CM (n = 200) …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Florida International University, Miami, Florida

   Run by

   Florida International University

   See if you can join NCT06637436 on ClinicalTrials.gov

8. A Seek, Test, and Treat Intervention to Reduce Chlamydia Trachomatis Disparities

   This study includes testing for four STIs (chlamydia, gonorrhea, syphilis, and HIV) at no cost. If positive, individual subjects will also be counseled and offered options for treatment for themselves and their sex partners that may include no cost expedited treatment and the option to be rescreene…

   Stage

   Not phased

   Ages

   15 to 26

   Site

   Tulane University Celia Scott Weatherhead School of Public Health and Tropical Medicine, New Orleans, Louisiana

   Run by

   Tulane University

   See if you can join NCT06428643 on ClinicalTrials.gov

9. The Use of Leukapheresis to Support HIV Pathogenesis Studies

   Despite the dramatic improvements that have resulted from combination antiretroviral treatment, long-term efficacy, toxicity, cost, and the requirements for life-long adherence remain as formidable challenges. Also, there is emerging consensus that persistent HIV-associated disease occurs during lo…

   Stage

   Not phased

   Ages

   18 and older

   Site

   San Francisco General Hospital, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT01161199 on ClinicalTrials.gov

10. The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies

    HIV medicines have led to dramatic improvements in health. However, there remains a concern for potential drug toxicities, cost of drugs, and need for life-long treatment. In addition, research has found that health is not completely restored in HIV-infected patients, even if they have been taking …

    Stage

    Not phased

    Ages

    18 to 70

    Site

    San Francisco General Hospital, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT01202305 on ClinicalTrials.gov

11. Effects of Cannabidiol and Tetrahydrocannabinol on Microbiome and Neuroinflammation in HIV

    This study has the potential to contribute to a more complete understanding of the independent and combined effects of cannabis use and HIV on the brain and on inflammation. Such knowledge may inform future strategies for treating brain disease and inflammation. Participants will be randomly assign…

    Stage

    Phase 2

    Ages

    21 to 70

    Site

    HIV Neurobehavioral Research Program (HNRP), San Diego, California

    Run by

    University of California, San Diego

    See if you can join NCT05514899 on ClinicalTrials.gov

12. 1MoreStep: An Intervention to Increase HIV Care Engagement and Reduce Intimate Partner Violence Among Black Women Living With HIV

    This study tests a 5-session cognitive behavioral approach program (herein referred to as the 1MoreStep intervention) to train Black women living with HIV (BWLWHI) and exposed to intimate partner violence (IPV) in the past 2 years (hereafter, BWLWHI) in: 1) cognitive and behavioral skills to access…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Johns Hopkins School of Nursing, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05608421 on ClinicalTrials.gov

13. Stress and Pain in People Living With HIV

    This is a basic human experimental study utilizing 4 groups of individuals with and without HIV and complex morbidities of cannabis use disorder and major depression who will participate in 2 sessions of the Yale Pain Stress Task (YPST) and follow-up phase to assess drug use and mood symptoms.

    Stage

    Not phased

    Ages

    18 to 68

    Site

    The Yale Stress Center, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06784908 on ClinicalTrials.gov

14. Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use

    This randomized clinical trial (RCT) evaluates whether metformin can reduce systemic inflammation and improve immune function in individuals with a history of injection drug use, with or without HIV. Participants will receive metformin or placebo and undergo immune system assessments, including vac…

    Stage

    Phase 4

    Ages

    18 to 64

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06829238 on ClinicalTrials.gov

15. The Synergistic Effects of Menopause and HIV on Cardiovascular Disease Risk in Women

    Menopause is associated with the acceleration of many comorbidities, including cardiovascular disease. Whether HIV and menopause together increase cardiovascular disease risk is a key knowledge gap. The goal of this observational study is to address this knowledge gap by looking at the role of meno…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT07284082 on ClinicalTrials.gov

16. Trial of a Harm Reduction Strategy for People With HIV Who Smoke Cigarettes

    Cigarette smoking is now the leading killer of people with HIV (PWH) in the US, and most cessation strategies tried to date have failed to increase long-term quit rates. An "all or none" approach to smoking cessation in PWH offers little benefit to the large majority of PWH who are unable or unwill…

    Stage

    Not phased

    Ages

    40 to 79

    Site

    Montefiore Medical Center, The Bronx, New York

    Run by

    Montefiore Medical Center

    See if you can join NCT05642715 on ClinicalTrials.gov

17. J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations

    The goal of this clinical trial is to compare two interventions - Health Navigation and Health Navigation Plus among individuals who have been impacted by the criminal legal system. The main question it aims to answer is: • Compared with the Health Navigation group, are participants in the Health N…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Chicago, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06477588 on ClinicalTrials.gov

18. Ending the HIV Epidemic: An All-facility Intervention for Patient and Healthcare Staff Well-being

    The scope of this study is to engage Ryan White HIV/AIDS Program (RWHAP) funded organizations in the South/East US to co-develop context-responsive programs utilizing evidence-informed interventions to reduce stigma against living with HIV (PLH) who have difficulties accessing and remaining engaged…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Columbia University School of Nursing, New York, New York

    Run by

    Columbia University

    See if you can join NCT05785169 on ClinicalTrials.gov

19. Finishing HIV Project

    This study aims to learn how to help enable healthy behaviors and lower the risk of HIV among Latinx Men.

    Stage

    Not phased

    Ages

    18 to 54

    Site

    University of Miami, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT06406049 on ClinicalTrials.gov

20. Collection of Blood for Multiple Collaborative Studies

    This study seeks to confidentially collect blood from HIV-positive individuals and HIV-negative controls to provide basic scientists with specimens for collaborative studies.

    Stage

    Not phased

    Ages

    18 and older

    Site

    San Francisco General Hospital, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT01336855 on ClinicalTrials.gov

21. Work2Prevent Plus: Structural Intervention to Promote HIV Care in Black Sexual Minority Men

    The goal of this observational study is to learn about the pilot test of the employment program among young Black sexual minority men. The main question it aims to answer is: What is the feasibility and acceptability of the employment program? Young Black sexual minority male participants will atte…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Chicago, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06894199 on ClinicalTrials.gov

22. Enhancing Wellness Through Affirming Services and Education

    The goal of this treatment study is to learn about the mental health, substance use and physical health outcomes associated with participating in the EASE holistic behavioral health and wellness program for individuals seeking HIV prevention and/or living with HIV. The main questions it aims to ans…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Susan Reif, Charlotte, North Carolina

    Run by

    Duke University

    See if you can join NCT05700474 on ClinicalTrials.gov

23. Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury

    This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and ot…

    Stage

    Not phased

    Ages

    25 to 59

    Site

    Biotech Place, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT04810858 on ClinicalTrials.gov

24. Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 3 Semaglutide

    This study seeks to determine the feasibility, acceptability, and preliminary efficacy of an intervention consisting of off-label use of a medication with strong efficacy data for alcohol use disorder (AUD) with medical management and a clinical pharmacist-delivered behavioral intervention in reduc…

    Stage

    Phase 2

    Ages

    18 to 99

    Site

    Atlanta VA Medical Center, Decatur, Georgia

    Run by

    Yale University

    See if you can join NCT07040592 on ClinicalTrials.gov

25. Transitional Housing and HIV Health

    The goal of this pilot study is to evaluate the implementation and outcomes of the Arms Around You (AAY) program, a supportive housing initiative launched by the Philadelphia Department of Public Health (PDPH) in 2024. The program aims to address housing instability among people with HIV (PWH) usin…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Locations

    2 in total

    Run by

    University of Pennsylvania

    See if you can join NCT06829394 on ClinicalTrials.gov