HIV Clinical Trials

101 studies are recruiting for hiv in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Small Trial of Alendronate Impact on the Reservoir of HIV

   This clinical trial is designed to test the effects of alendronate (ALN) on people living with HIV who are already receiving antiretroviral therapy (ART). Participants are randomly assigned in a 2:1 ratio to either receive alendronate or a placebo, and neither the participants nor the researchers k…

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   University of California, San Francisco HIV/AIDS (Site ID: 801), San Francisco, California

   Locations

   5 in total

   Run by

   National Institute of Allergy and Infectious Diseases (NIAID)

   See if you can join NCT07216794 on ClinicalTrials.gov

2. Bridge to Belonging: Peer Led Intervention to Reduce Loneliness and Depression Among Older Gay and Bisexual Men

   Older gay and bisexual men living with HIV (OGBMLH) are more likely to experience depression and loneliness, which can lead to negative health outcomes. This mixed-methods research study will assess the feasibility and acceptability of the Bridge to Belonging (B2B) intervention. B2B is a peer-deliv…

   Stage

   Not phased

   Ages

   50 and older

   Site

   Fenway Health, Boston, Massachusetts

   Run by

   Fenway Community Health

   See if you can join NCT07762066 on ClinicalTrials.gov

3. High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults With HIV

   This is a single site, randomized exercise trial with individuals at least 50 years of age living with HIV who experience suboptimal cognition. The overall goals of this proposal are to determine whether 16 weeks of structured high-intensity interval training (HIIT) can overcome vascular and cognit…

   Stage

   Not phased

   Ages

   50 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT05965518 on ClinicalTrials.gov

4. Optimization of a Behavioral Intervention to Increase Physical Activity in Older Adults Living With HIV

   The goal of this clinical trial is to examine 3 interventions designed to increase physical activity in older adults with HIV. We will examine 3 potential components of an intervention package: physical activity coaching, cognitive behavioral therapy targeted toward common barriers to physical acti…

   Stage

   Not phased

   Ages

   50 and older

   Site

   Hennepin Healthcare Research Institute, Minneapolis, Minnesota

   Locations

   2 in total

   Run by

   Butler Hospital

   See if you can join NCT05752500 on ClinicalTrials.gov

5. Bringing Medicines for HIV Prevention to a Family Planning Clinic

   The goal of this clinical trial is to understand what patients and physicians think about providing medications to prevent HIV transmission to patients in a family planning clinic. These medications are known as pre-exposure prophylaxis, or PrEP. The main questions to answer are: 1. Do patients fin…

   Stage

   Not phased

   Ages

   16 and older

   Site

   Women and Infants Hospital of Rhode Island, Providence, Rhode Island

   Run by

   Women and Infants Hospital of Rhode Island

   See if you can join NCT06930508 on ClinicalTrials.gov

6. Clinical Trial to Evaluate the Safety and Immunogenicity of the V2 Apex-Directed Immunogens DV201P-RNA and DV202B1-RNA in Adult Participants Without HIV

   This is a phase 1, multicenter, open-label, dose escalation, first-in-human (FIH) trial to evaluate the safety and immunogenicity of DV201P-RNA and DV202B1-RNA, immunogens designed to induce HIV-1 envelope (Env) V2 apex-specific broadly neutralizing antibodies (V2 apex bnAbs). Both vaccines consist…

   Stage

   Phase 1

   Ages

   18 to 55

   Site

   The Ponce de Leon Center CRS (Site ID 5802), Atlanta, Georgia

   Locations

   7 in total

   Run by

   National Institute of Allergy and Infectious Diseases (NIAID)

   See if you can join NCT07390474 on ClinicalTrials.gov

7. BIG Chicago: A Trial of Basic Income Guarantee for Young People Living With HIV

   The goal of this clinical trial is to compare two interventions - Basic Income Guarantee (BIG) + Treatment as Usual and Treatment as Usual among individuals living with HIV who have experienced financial hardships. The main question it aims to answer is: Compared with the Treatment as Usual group, …

   Stage

   Not phased

   Ages

   18 to 35

   Site

   University of Chicago, Chicago, Illinois

   Run by

   University of Chicago

   See if you can join NCT07502365 on ClinicalTrials.gov

8. Evaluating Gardasil HPV Vaccine Humoral and Cellular Immune Responses in People With and Without HIV

   This is a phase 2, open-label study to assess the immunogenicity of the 9-valent human papillomavirus (HPV) recombinant vaccine (Gardasil9) in people born male with current or past exposure to androgen blockers or estrogen (BM-EABE). Investigators will enroll BM-EABE with HIV and HIV negative contr…

   Stage

   Phase 2

   Ages

   18 to 70

   Site

   RIIS Clinic at Baltimore Safe Haven, Baltimore, Maryland

   Locations

   2 in total

   Run by

   University of Maryland, Baltimore

   See if you can join NCT06624839 on ClinicalTrials.gov

9. Human Immunodeficiency Virus (HIV) Food Insecurities

   The objectives of this study are to better understand how FI (food insecurities) contributes to the development of cardiometabolic comorbidities among PWH (People with HIV) and to test a novel bilingual FI intervention designed to reduce these comorbidities among food insecure PWH. The PI and staff…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Wake Forest Health Sciences, Winston-Salem, North Carolina

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT04943861 on ClinicalTrials.gov

10. Case Management Dyad

    The overall goal of this study is to test whether dyadic and focused case management will (1) improve financial wellbeing, (2) improve access to food, (3) increase linkage and retention rates for individuals living with HIV or those taking PrEP (PrEP persistence), and (4) increase the proportion of…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Chicago, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06162897 on ClinicalTrials.gov

11. Alcohol and "Heat of the Moment" Sexual Decision Making

    HIV transmission remains a significant public health concern, especially among men who have sex with men (MSM). Condomless anal intercourse (CAI) continues to be the major route of transmission for MSM. Thus, to reduce the incidence of HIV, it is critical to identify how contextual risk factors inf…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Boston University Department of Psychological and Brain Sciences, Boston, Massachusetts

    Run by

    Boston University Charles River Campus

    See if you can join NCT05729256 on ClinicalTrials.gov

12. Cabotegravir-Hormone PK/PD Interactions for HIV Prevention

    This is a research study to better understand how long-acting cabotegravir (CAB-LA) works to prevent HIV in people. This study will also evaluate the impact of endogenous and therapeutic hormones on CAB-LA pharmacology. The investigators will also evaluate if participants experience any medical pro…

    Stage

    Phase 1

    Ages

    19 and older

    Site

    Johns Hopkins School of Medicine, Drug Development Unit, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT07672717 on ClinicalTrials.gov

13. Healthy Behaviors for Insomnia Prevention in People With HIV and Ongoing Pain

    The purpose of this research study is to test whether Brief Behavioral Treatment for Insomnia (BBTI) delivered over the phone or Brief Mindfulness Training (BMT) delivered over the phone is better able to improve the symptoms of insomnia, reduce chronic pain, and slow the pace of biological aging i…

    Stage

    Not phased

    Ages

    25 to 65

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT07270406 on ClinicalTrials.gov

14. The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV

    To elucidate mechanisms of substance use disorders (SUD) and comorbid mental illnesses in people living with HIV (PLWH), the study team seeks to investigate reward and pain circuitry in cannabis use and depression comorbidity, two highly prevalent conditions in PLWH. The study team proposes a tight…

    Stage

    Not phased

    Ages

    18 to 59

    Site

    University of Miami, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT05453513 on ClinicalTrials.gov

15. Practice Facilitation as a Strategy to Improve Alcohol Treatment Adoption and Implementation in HIV Care

    Despite availability of evidence-based alcohol reduction interventions (EBI), unhealthy alcohol use remains a barrier to HIV medication adherence, viral suppression and retention in HIV care and consequently HIV treatment as prevention (TASP). Guided by complementary implementation and evaluation f…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California, San Diego, San Diego, California

    Locations

    3 in total

    Run by

    Johns Hopkins University

    See if you can join NCT05241990 on ClinicalTrials.gov

16. A Study to Improve Skeletal Muscle in Veterans With HIV

    The Department of Veterans Affairs is the largest single provider of medical care to people with HIV in the United States. The condition of excess lipid within and around muscle, termed myosteatosis, predisposes Veterans to physical function decline, frailty, disability, and cardiometabolic disease…

    Stage

    Not phased

    Ages

    20 to 80

    Site

    Tennessee Valley Healthcare System Nashville Campus, Nashville, TN, Nashville, Tennessee

    Run by

    VA Office of Research and Development

    See if you can join NCT06845046 on ClinicalTrials.gov

17. Implementing Depression and Adherence Treatment

    The goal of this clinical trial is to compare a core set and enhanced set of implementation strategies in increasing the reach of evidence-based treatments to patients with HIV and depression. The main questions it aims to answer are: What proportion of patients start an evidence-based treatment fo…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Miami, Miami, Florida

    Locations

    3 in total

    Run by

    University of Miami

    See if you can join NCT07032363 on ClinicalTrials.gov

18. Mitigating the Impact of Stigma and Shame Among People Living With HIV and Substance Use Disorders

    People living with HIV and substance use disorders (SUDs) are less likely to be virally suppressed, which can lead to HIV transmission and negative health outcomes. This hybrid type 1 study will assess the efficacy, mechanisms, as well as facilitators and barriers to implementing the MATTER interve…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Florida International University, Miami, Florida

    Locations

    2 in total

    Run by

    Boston University

    See if you can join NCT05934305 on ClinicalTrials.gov

19. Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

    This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with vs without HIV.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    18 in total

    Run by

    Johns Hopkins University

    See if you can join NCT06263426 on ClinicalTrials.gov

20. Behavioral Activation and Risk Reduction for Stimulant Use Among Sexually Active Adolescents and Young Adults

    The use of behavioral intervention to reduce stimulant use and concurrent HIV sexual transmission risk.

    Stage

    Not phased

    Ages

    16 to 24

    Site

    University of California, Los Angeles, Los Angeles, California

    Locations

    2 in total

    Run by

    Westat

    See if you can join NCT06444360 on ClinicalTrials.gov

21. Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP

    The investigators will conduct an optimization trial among N=256 PWID newly started on medication for opioid use disorder and Pre-Exposure Prophylaxis (PrEP) to assess the performance of four intervention components (Attention, Executive Functioning, Memory, and Information Processing) aimed at enh…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    APT Foundation, New Haven, Connecticut

    Run by

    University of Connecticut

    See if you can join NCT05669534 on ClinicalTrials.gov

22. RESTORE Study R61 Phase: Recovery and Engagement for Stimulant Users on Re-entry

    Justice-involved individuals face disproportionately high rates of stimulant use disorder and HIV, along with disrupted access to HIV treatment and prevention services like ART and PrEP. Contingency management (CM) is the most effective intervention for stimulant use, but its use in justice-involve…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Yale University, New Haven, Connecticut

    Locations

    2 in total

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT07136363 on ClinicalTrials.gov

23. Open Trial of Trauma-focused Psychodynamic Psychotherapy for People Living With HIV and PTSD

    People living with HIV (PLWH) have a higher rate of post-traumatic stress disorder (PTSD) diagnosis than the general population. Comorbid PTSD is also associated with negative HIV-related health outcomes. Unfortunately, little outcome research has examined the usefulness of PTSD treatments for PTSD…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Albert Einstein College of Medicine, The Bronx, New York

    Run by

    Montefiore Medical Center

    See if you can join NCT05929911 on ClinicalTrials.gov

24. Skeletal Muscle Energetics and Fatiguability in Older Individuals

    The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.

    Stage

    Not phased

    Ages

    60 to 90

    Site

    Johns Hopkins Hospital, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT04142047 on ClinicalTrials.gov

25. Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice Involved Women

    The purpose of this 2-site (CT, AL) study is to test innovative interventions to reduce stigma and improve the pre-exposure prophylaxis (PrEP) and opioid use disorder (OUD) care continua in women involved in the criminal justice system (WICJ). This study evaluates a newly validated PrEP decision ai…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    University of Alabama in Birmingham, Birmingham, Alabama

    Locations

    2 in total

    Run by

    Yale University

    See if you can join NCT05547048 on ClinicalTrials.gov