HIV Clinical Trials in Boston, Massachusetts

14 studies are recruiting for hiv in Boston, Massachusetts right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Trial to Evaluate the Safety and Tolerability of DV700P-RNA and DV701B1.1-RNA Immunization in Combination With Antiretroviral Analytical Treatment Interruption (ATI) in People Living With HIV for Elicitation of V3-glycan Antibodies

   This phase 1 study will evaluate the safety, tolerability, and immune responses of two experimental mRNA HIV vaccines in adults living with HIV who are in overall good health. The study will enroll about 42 participants at multiple study sites. Researchers will assess whether these vaccines can sta…

   Stage

   Phase 1

   Ages

   18 to 60

   Site

   Beth Israel Deaconess Medical Center / BIDMC VCRS (Site ID: 32077), Boston, Massachusetts

   Locations

   16 in total

   Run by

   National Institute of Allergy and Infectious Diseases (NIAID)

   See if you can join NCT07569029 on ClinicalTrials.gov

2. Liver Transplantation From Donors With HIV: Impact on Opportunistic Infections, Cancer, and Long-Term Outcomes (Expanding HOPE Liver)

   This research is being done to better understand opportunistic infections and cancer in transplant recipients with HIV who receive livers from a donor with HIV compared to livers from donors without HIV.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Locations

   19 in total

   Run by

   Johns Hopkins University

   See if you can join NCT07665372 on ClinicalTrials.gov

3. A Study of Safety and Drug Levels of ePGT121v1-LS, PGDM1400LS, and VRC07-523LS in Adult Participants Without HIV-1

   This study is testing a lab-made antibody called ePGT121v1-LS that targets a specific part of HIV. Researchers will give it by vein (IV) and under the skin (SC), both on its own and together with two other antibodies, VRC07-523LS and PGDM1400LS, which target different parts of the virus. They will …

   Stage

   Phase 1

   Ages

   18 to 55

   Site

   Brigham and Women's Hospital Vaccine CRS (BWH VCRS) (Site ID: 30007), Boston, Massachusetts

   Locations

   11 in total

   Run by

   National Institute of Allergy and Infectious Diseases (NIAID)

   See if you can join NCT07390955 on ClinicalTrials.gov

4. Bridge to Belonging: Peer Led Intervention to Reduce Loneliness and Depression Among Older Gay and Bisexual Men

   Older gay and bisexual men living with HIV (OGBMLH) are more likely to experience depression and loneliness, which can lead to negative health outcomes. This mixed-methods research study will assess the feasibility and acceptability of the Bridge to Belonging (B2B) intervention. B2B is a peer-deliv…

   Stage

   Not phased

   Ages

   50 and older

   Site

   Fenway Health, Boston, Massachusetts

   Run by

   Fenway Community Health

   See if you can join NCT07762066 on ClinicalTrials.gov

5. Clinical Trial to Evaluate the Safety and Immunogenicity of the V2 Apex-Directed Immunogens DV201P-RNA and DV202B1-RNA in Adult Participants Without HIV

   This is a phase 1, multicenter, open-label, dose escalation, first-in-human (FIH) trial to evaluate the safety and immunogenicity of DV201P-RNA and DV202B1-RNA, immunogens designed to induce HIV-1 envelope (Env) V2 apex-specific broadly neutralizing antibodies (V2 apex bnAbs). Both vaccines consist…

   Stage

   Phase 1

   Ages

   18 to 55

   Site

   Beth Israel Deaconess Medical Center VCRS (BIDMC VCRS Site # 32077), Boston, Massachusetts

   Locations

   7 in total

   Run by

   National Institute of Allergy and Infectious Diseases (NIAID)

   See if you can join NCT07390474 on ClinicalTrials.gov

6. Alcohol and "Heat of the Moment" Sexual Decision Making

   HIV transmission remains a significant public health concern, especially among men who have sex with men (MSM). Condomless anal intercourse (CAI) continues to be the major route of transmission for MSM. Thus, to reduce the incidence of HIV, it is critical to identify how contextual risk factors inf…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Boston University Department of Psychological and Brain Sciences, Boston, Massachusetts

   Run by

   Boston University Charles River Campus

   See if you can join NCT05729256 on ClinicalTrials.gov

7. Practice Facilitation as a Strategy to Improve Alcohol Treatment Adoption and Implementation in HIV Care

   Despite availability of evidence-based alcohol reduction interventions (EBI), unhealthy alcohol use remains a barrier to HIV medication adherence, viral suppression and retention in HIV care and consequently HIV treatment as prevention (TASP). Guided by complementary implementation and evaluation f…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Fenway Community Health, Boston, Massachusetts

   Locations

   3 in total

   Run by

   Johns Hopkins University

   See if you can join NCT05241990 on ClinicalTrials.gov

8. Implementing Depression and Adherence Treatment

   The goal of this clinical trial is to compare a core set and enhanced set of implementation strategies in increasing the reach of evidence-based treatments to patients with HIV and depression. The main questions it aims to answer are: What proportion of patients start an evidence-based treatment fo…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Locations

   3 in total

   Run by

   University of Miami

   See if you can join NCT07032363 on ClinicalTrials.gov

9. Mitigating the Impact of Stigma and Shame Among People Living With HIV and Substance Use Disorders

   People living with HIV and substance use disorders (SUDs) are less likely to be virally suppressed, which can lead to HIV transmission and negative health outcomes. This hybrid type 1 study will assess the efficacy, mechanisms, as well as facilitators and barriers to implementing the MATTER interve…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Fenway Health, Boston, Massachusetts

   Locations

   2 in total

   Run by

   Boston University

   See if you can join NCT05934305 on ClinicalTrials.gov

10. Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

    This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with vs without HIV.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Locations

    18 in total

    Run by

    Johns Hopkins University

    See if you can join NCT06263426 on ClinicalTrials.gov

11. Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs

    The goal of this study is to determine the feasibility and impact of delivering long-acting injectable cabotegravir HIV pre-exposure prophylaxis and suite of support services to adults who inject non-prescription drugs who are risk for HIV through known sexual risk.

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT07199335 on ClinicalTrials.gov

12. Clinical Trial to Evaluate the Safety and Immunogenicity of a Priming Regimen of 426c.Mod.Core-C4b Followed by HxB2.WT.Core-C4b Boosts, Both Adjuvanted With 3M-052 AF + Alum, in Adult Participants Without HIV and in Overall Good Health

    This is a partially randomized, open-label phase 1 study to evaluate the safety and immunogenicity of a priming regimen of 426c.Mod.Core-C4b adjuvanted with 3M-052 AF + Alum followed by boosts with HxB2.WT.Core-C4b adjuvanted with 3M-052 AF + Alum. The primary hypothesis is that the boosting with H…

    Stage

    Phase 1

    Ages

    18 to 55

    Site

    Brigham and Women's Hospital Vaccine CRS (BWH VCRS), Boston, Massachusetts

    Locations

    6 in total

    Run by

    National Institute of Allergy and Infectious Diseases (NIAID)

    See if you can join NCT06796686 on ClinicalTrials.gov

13. Mindfulness and Behavior Change to Improve Cardiovascular Health of Older People With HIV

    Older people with HIV (OPWH) are disproportionately impacted by cardiovascular disease (CVD) attributable to behavioral risk factors, and chronic HIV immune dysregulation resulting inflammation. Systemic inflammation is exacerbated by psychological distress via activating the immune response and dr…

    Stage

    Not phased

    Ages

    50 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06001814 on ClinicalTrials.gov

14. Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV

    This study will determine the effects of pregnenolone on brain function, inflammation and depressive symptoms in people with HIV who have depression. Participants in this study will receive a pill of either pregnenolone or placebo, and can stay on their current antidepression medications. Brain ima…

    Stage

    Phase 2

    Ages

    18 to 85

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT05570812 on ClinicalTrials.gov