Epilepsy Clinical Trials

74 studies are recruiting for epilepsy in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Readiness Brain Operation Optimization Training (ReBOOT) for Epilepsy Surgery

   The goal of this clinical trial is to learn if new educational program prior to epilepsy surgery can either decrease the risk of cognitive decline after surgery or be a help to those patients who experience a decline after undergoing epilepsy surgery. Participants will participate in 2 individual v…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   Cleveland Clinic, Cleveland, Ohio

   Run by

   Kayela Arrotta

   See if you can join NCT05992402 on ClinicalTrials.gov

2. Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of SIF001 in Healthy Subjects and in Epilepsy Patients

   This is a dose escalation study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of SIF001, a monoclonal antibody with the potential to treat epilespy

   Stage

   Phase 1

   Ages

   18 to 70

   Site

   Center for Neurosciences, Tucson, Arizona

   Locations

   10 in total

   Run by

   Suninflam Inc

   See if you can join NCT07051629 on ClinicalTrials.gov

3. Healthy Aging in People With Epilepsy Program

   The goal of this clinical trial is to develop and test an educational program about dementia in older adults living with epilepsy. The main questions it aims to answer are: 1. Can providing education on healthy aging, chronic disease management, dementia, and modifiable lifestyle dementia risk fact…

   Stage

   Not phased

   Ages

   55 to 90

   Site

   Cleveland Clinic, Cleveland, Ohio

   Run by

   Anny Reyes

   See if you can join NCT06052605 on ClinicalTrials.gov

4. Effect of Rose Odor Exposure on Ictal Apnea

   This study will investigate the potential benefits of rose scent in reducing the risk of Sudden Unexpected Death in Epilepsy (SUDEP) in patients with epilepsy. Participants will engage in their routine inpatient observational EEG monitoring for 24 hours followed by an additional 24 hours of observa…

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT07116421 on ClinicalTrials.gov

5. Investigating Epilepsy: Screening and Evaluation

   Background: Epilepsy affects about 1 percent of the U.S. population. Most people with epilepsy respond well to medicine, but some do not. Researchers want people who have diagnosed or suspected epilepsy to participate in ongoing studies. They want to learn more about clinical care for epilepsy. The…

   Stage

   Not phased

   Ages

   8 to 110

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Neurological Disorders and Stroke (NINDS)

   See if you can join NCT03478852 on ClinicalTrials.gov

6. Brain Metabolism Observed at 3 Tesla or 7 Tesla in Health and Metabolic Disease

   The goal is to develop methodology to monitor flux in the citric acid cycle in brain via 13C nuclear magnetic resonance (NMR) spectroscopy at 7 Tesla or 3 Tesla.

   Stage

   Not phased

   Ages

   16 to 80

   Site

   Weill Cornell Medicine, New York, New York

   Locations

   2 in total

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT05085704 on ClinicalTrials.gov

7. NYU Epilepsy Self-Management Study

   The investigators will conduct two-arm randomized controlled trials (RCTs) comparing effects of UPLIFT vs. enhanced usual care and PACES vs. enhanced usual care, respectively, on quality of life, depressive symptoms and seizures over 12 months in NYU patients with epilepsy.

   Stage

   Not phased

   Ages

   18 and older

   Site

   NYU Langone Health - NYU Langone Hospital-Brooklyn, Brooklyn, New York

   Locations

   2 in total

   Run by

   NYU Langone Health

   See if you can join NCT07087821 on ClinicalTrials.gov

8. AI-Based Mobile Intervention on Medication Non-Adherence and Transition

   This study aims to examine whether the AI-personalized version of the Medilepsy® app is more effective than the non-AI (standard version without AI personalization) can improve key outcomes, such as medical adherence and transition readiness, among underserved adolescents and young adults with epil…

   Stage

   Not phased

   Ages

   14 to 24

   Site

   Orlando Health Arnold Palmer Hospital, Orlando, Florida

   Locations

   2 in total

   Run by

   University of Central Florida

   See if you can join NCT07445074 on ClinicalTrials.gov

9. Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through a Web-based Music Application

   This is a prospective, placebo-controlled, double-blinded randomized study of self-administered auditory intervention in a naturalistic home environment.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

   Locations

   2 in total

   Run by

   Dartmouth-Hitchcock Medical Center

   See if you can join NCT06425029 on ClinicalTrials.gov

10. Computational Neuroscience of Language Processing in the Human Brain

    Language is a signature human cognitive skill, but the precise computations that support language understanding remain unknown. This study aims to combine high-quality human neural data obtained through intracranial recordings with advances in computational modeling of human cognition to shed light…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT05222594 on ClinicalTrials.gov

11. Physiological-based Pharmacokinetics Approach to Medication Exposure During Pregnancy and Breastfeeding

    This project focuses on anti-seizure medication (ASM) clearance and physiological factors determining blood concentrations in pregnant adult women with epilepsy and amounts of exposure to their unborn children and nursing infants.

    Stage

    Not phased

    Ages

    18 to 45

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT05450978 on ClinicalTrials.gov

12. Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders

    The study involves up to 5 visits for a fasting blood draw, behavioral assessments, and/or questionnaires. Other samples may be collected when appropriate. This study is currently recruiting. There is no cost for visits or study-related exams.

    Stage

    Not phased

    Ages

    Up to 18

    Site

    Southwestern Research and Resource Center, Phoenix, Arizona

    Locations

    2 in total

    Run by

    Southwest Autism Research & Resource Center

    See if you can join NCT04322734 on ClinicalTrials.gov

13. PET/MRI/EEG Imaging Study in Epilepsy

    This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography [FDG-PET], and blood flow, measured by functio…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Athinoula A. Martinos Center, Charlestown, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06974305 on ClinicalTrials.gov

14. An Examination of Whether Infrared Light Therapy Can Reduce Stress in People With Epilepsy

    Do you have Epilepsy? Would you like to participate in a study using PhotoBioModulation (PBM)? PBM is being researched for potential benefits in resolving many stress-related brain disorders. It is a non-invasive technique that delivers light energy to cells and tissues that can promote brain stabi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brain Health Center Miami, North Miami, Florida

    Locations

    4 in total

    Run by

    Cynthia Kerson

    See if you can join NCT07509177 on ClinicalTrials.gov

15. Understanding Ketamine's Dissociative Effects (KD Study)

    The purpose of this study is to understand how ketamine brings about dissociative symptoms.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Stanford University School of Medicine, Palo Alto, California

    Run by

    Stanford University

    See if you can join NCT04861051 on ClinicalTrials.gov

16. Safety and Tolerability Study of SPN-817 in Adult Patients With Treatment Resistant Epilepsy

    This study will evaluate the safety and tolerability of SPN-817 in adults with treatment resistant seizures

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    Green Leaf Clinical Trials, LLC, Jacksonville, Florida

    Locations

    10 in total

    Run by

    Supernus Pharmaceuticals, Inc.

    See if you can join NCT05518578 on ClinicalTrials.gov

17. Methylphenidate for the Treatment of Epilepsy-related Cognitive Deficits

    Methylphenidate (MPH) is a stimulant, FDA-approved for the treatment of attention deficit hyperactivity disorder (ADHD). It is unknown, however, if stimulants would be of benefit for memory and thinking problems due to epilepsy. In this study, participants will be assigned randomly (i.e., by flip o…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Miami VA Healthcare System, Miami, FL, Miami, Florida

    Locations

    4 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT04419272 on ClinicalTrials.gov

18. Microelectrode Recordings From the Vagus Nerve in Awake Humans

    This Anchillary project uses a refined technique of ultrasound-guided microneurography of the human cervical vagus nerve, an approach developed by Professor Vaughan Macefield and used safely to-date in 44 prior study participants. The overall goal of this project is to build upon prior data obtaine…

    Stage

    Phase 1

    Ages

    18 to 40

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT06016686 on ClinicalTrials.gov

19. Patterns of Neurodevelopmental Disorders

    The purpose of this study is to systematically evaluate the results of medical investigations to identify symptom and biological patterns and common etiologies of neurodevelopmental disorders.

    Stage

    Not phased

    Ages

    Any age

    Site

    Rossignol Medical Center, Phoenix, Arizona

    Run by

    Richard Frye

    See if you can join NCT06213090 on ClinicalTrials.gov

20. Intracranial Stimulation Mapping In Epilepsy

    This is a single group prospective study to determine the feasibility for generating brain maps that localize cerebral functions and inter-regional information flow in partial epilepsy in adult patients.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT05290610 on ClinicalTrials.gov

21. Bridging the Gap: Educating Patients on Social Determinants of Health to Improve Epilepsy Surgery Access and Outcomes

    The goal of this study is to identify the needs and barriers to accessing and undergoing epilepsy surgery for patients with epilepsy and then to pilot an educational program regarding the social determinants of health and how they can influence surgical rates and epilepsy outcomes. For the first pa…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    Anny Reyes

    See if you can join NCT07509190 on ClinicalTrials.gov

22. A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes

    The Epilepsy-Dyskinesia Study aims to advance the understanding of the clinical and molecular spectrum of epilepsy-dyskinesia syndromes, monogenic diseases that cause both movement disorders and epilepsy. Addressing challenges in rare disease research -such as small, geographically dispersed patien…

    Stage

    Not phased

    Ages

    0 to 18

    Site

    Boston Children's Hospital, Boston, Massachusetts

    Run by

    Boston Children's Hospital

    See if you can join NCT06585605 on ClinicalTrials.gov

23. Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans

    Transcranial magnetic stimulation (TMS) is an effective treatment for depression, but clinical outcome is suboptimal, partially because investigators are missing biologically-grounded brain markers which show that TMS is modifying activity at the intended target in the brain. The goal of this propo…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Stanford University, Stanford, California

    Run by

    Stanford University

    See if you can join NCT05996900 on ClinicalTrials.gov

24. Effects of Recorded Music on Clinical and EEG Seizure Activity

    This research is being done to determine if Mozart music and/or age-appropriate music can reduce the frequency of seizures and epileptiform discharges.

    Stage

    Not phased

    Ages

    4 to 17

    Site

    Johns Hopkins School of Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05289934 on ClinicalTrials.gov

25. Intracranial Investigation of Neural Circuity Underlying Human Mood

    Depression is one of the most common disorders of mental health, affecting 7-8% of the population and causing tremendous disability to afflicted individuals and economic burden to society. In order to optimize existing treatments and develop improved ones, the investigators need a deeper understand…

    Stage

    Not phased

    Ages

    21 to 70

    Site

    Baylor College of Medicine, Houston, Texas

    Run by

    Baylor College of Medicine

    See if you can join NCT05871372 on ClinicalTrials.gov