Epilepsy Clinical Trials

75 studies are recruiting for epilepsy in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Mapping of Human Cognition

   The purpose of this study is to compare organization of normal brain function as detected using Functional magnetic resonance imaging (fMRI) in normal subjects as opposed to patients with epilepsy or brain tumors, to ascribe precise anatomic labels (including Brodmann Areas) and functional signific…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   The University of Texas Health Science Center at Houston, Houston, Texas

   Run by

   The University of Texas Health Science Center, Houston

   See if you can join NCT05989893 on ClinicalTrials.gov

2. HOBSCOTCH-YOUTH and Young Adults

   The goal of this clinical trial is to learn more about the home-based epilepsy self-management program, HOBSCOTCH, for improving cognitive function (thinking and memory) and quality of life specifically in young adults, ages 18 - 29 years, who have epilepsy. It will also learn if a modification of …

   Stage

   Not phased

   Ages

   13 to 29

   Site

   Dartmouth-Hitchcock, Lebanon, New Hampshire

   Run by

   Dartmouth-Hitchcock Medical Center

   See if you can join NCT07735715 on ClinicalTrials.gov

3. Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

   Background: - The blood-brain barrier separates the brain from the rest of the body. Epilepsy is a neurological disease that causes seizures. It can affect this barrier. Researchers think a contrast agent called mangafodipir might be better able to show areas of the brain that epilepsy affects. Obj…

   Stage

   Phase 1

   Ages

   18 to 60

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Neurological Disorders and Stroke (NINDS)

   See if you can join NCT02531880 on ClinicalTrials.gov

4. PET/MRI/EEG Imaging Study in Epilepsy

   This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography [FDG-PET], and blood flow, measured by functio…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Athinoula A. Martinos Center, Charlestown, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06974305 on ClinicalTrials.gov

5. Epilepsy Seizure Detection With Innovative Tripolar EEG (tEEG)

   Concurrent electroencephalography (EEG) and new tripolar EEG (tEEG) will be recorded from adult and pediatric patients. In some patients stereo EEG (sEEG) will also be recorded concurrently.

   Stage

   Not phased

   Ages

   6 and older

   Site

   Barrow Neurological Institute Dignity Health dba St. Joseph's Hospital and Medical Center, Phoenix, Arizona

   Locations

   2 in total

   Run by

   CREmedical

   See if you can join NCT05944692 on ClinicalTrials.gov

6. Surgery as a Treatment for Medically Intractable Epilepsy

   Background: - Drug resistant epilepsy is the term used to describe epilepsy that cannot be controlled by medication. Many people whose seizures do not respond to medication will respond to surgical treatment, relieving seizures completely or almost completely in one-half to two-thirds of patients w…

   Stage

   Not phased

   Ages

   8 to 99

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Neurological Disorders and Stroke (NINDS)

   See if you can join NCT01273129 on ClinicalTrials.gov

7. Tumor Related Epilepsy

   Background: Some people with brain tumors have seizures related to the tumor. This is called tumor-related epilepsy. Usually brain tumors are treated by removing as much of the brain tumor as possible without causing problems. Researchers think this may improve the outcome for people with brain tum…

   Stage

   Not phased

   Ages

   8 to 99

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Neurological Disorders and Stroke (NINDS)

   See if you can join NCT02639325 on ClinicalTrials.gov

8. Investigating Epilepsy: Screening and Evaluation

   Background: Epilepsy affects about 1 percent of the U.S. population. Most people with epilepsy respond well to medicine, but some do not. Researchers want people who have diagnosed or suspected epilepsy to participate in ongoing studies. They want to learn more about clinical care for epilepsy. The…

   Stage

   Not phased

   Ages

   8 to 110

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Neurological Disorders and Stroke (NINDS)

   See if you can join NCT03478852 on ClinicalTrials.gov

9. Diagnosing Epilepsy To EffeCT Change

   The purpose of this research is to address the challenges of diagnosing and long-term management of epilepsy in participants whose seizures are not well captured by standard electroencephalography (EEG) tests and who cannot use or are not able to use more standard monitoring techniques. This resear…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   UAB Epilepsy Center, Birmingham, Alabama

   Locations

   23 in total

   Run by

   Epiminder America, Inc.

   See if you can join NCT07110337 on ClinicalTrials.gov

10. Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1

    This is a clinical research study for an investigational drug called RAP-219 in adult participants with focal seizures. This study is being conducted to determine if RAP-219 is safe and effective in reducing focal seizure frequency.

    Stage

    Phase 3

    Ages

    18 to 75

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    18 in total

    Run by

    Rapport Therapeutics Inc.

    See if you can join NCT07563881 on ClinicalTrials.gov

11. Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up

    The purpose of this research is to address the challenges of correctly monitoring, managing, and diagnosing epilepsy in participants whose seizures are not well captured by standard electroencephalography (EEG) tests and who cannot use or are not able to use more standard monitoring techniques. Thi…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    UAB Epilepsy Center, Birmingham, Alabama

    Locations

    21 in total

    Run by

    Epiminder America, Inc.

    See if you can join NCT07110454 on ClinicalTrials.gov

12. EXercise-induced PhysioLogical Adaptations In Neurological Disorders

    The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers. The main questions the study aims to answer are: * How do fitness level, exercise performance, and physical…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT07883720 on ClinicalTrials.gov

13. Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database

    Objectives: The overall study objective is to compare the sensitivities and specificities of morphometric analysis techniques using structural MRI images based on pre- and postsurgical localization of epileptic foci in patients undergoing presurgical evaluation for medically refractory epilepsy. To…

    Stage

    Not phased

    Ages

    8 to 120

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Neurological Disorders and Stroke (NINDS)

    See if you can join NCT02107989 on ClinicalTrials.gov

14. Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures

    This is a clinical research study for an investigational drug called RAP-219 in adult participants with focal seizures. This study is being conducted to determine if RAP-219 is safe and effective in reducing focal seizure frequency.

    Stage

    Phase 3

    Ages

    18 to 75

    Site

    Clinic for Neurology, Huntsville, Alabama

    Locations

    13 in total

    Run by

    Rapport Therapeutics Inc.

    See if you can join NCT07594119 on ClinicalTrials.gov

15. Ear-Seizure Detection (EarSD) Study

    The proposed study is an investigator-initiated study that aims to measure the accuracy of a wearable seizure detection and prediction device (Ear-Seizure Detection Device (EarSD)) by simultaneous recording with conventional video-EEG (Electroencephalogram) on patients with epileptic seizures in th…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Ummmc-Memorial Campus, Worcester, Massachusetts

    Locations

    2 in total

    Run by

    Felicia Chu

    See if you can join NCT06598189 on ClinicalTrials.gov

16. Clinical and Electrographic Changes in Responsive Neurostimulation System (RNS) Patients With Acupuncture Treatment

    The purpose of this study is to determine effects of Acupuncture on a Patient's mood and cognition,evaluate changes in clinically-reported seizure frequency and severity and analyze effects of Acupuncture on electrographic epileptiform activity stored by the RNS System

    Stage

    Not phased

    Ages

    15 to 60

    Site

    The University of Texas Health Science Center at Houston, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT04677751 on ClinicalTrials.gov

17. Pharmacological Modulation of Brain Oscillations in Memory Processing

    The goal of this study is to learn about the effects of scopolamine (an anticholinergic drug) on areas of the brain involved in memory, and changes it may have on brain activity. The investigators will do this by testing epileptic patients who are already undergoing intracranial surgery for seizure…

    Stage

    EARLY_Phase 1

    Ages

    18 to 55

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT05594017 on ClinicalTrials.gov

18. Effect of Vagal Nerve Stimulation on Gastric Motor Functions

    The specific aim of this study is to compare simultaneous assessment of gastric emptying and gastric accommodation in response to a caloric meal In patients who have previously undergone activation of left cervical VNS for the treatment of medication-resistant depression. Our hypothesis is that cer…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Locations

    2 in total

    Run by

    Mayo Clinic

    See if you can join NCT06038929 on ClinicalTrials.gov

19. A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy

    This will be a prospective, open-label, single-arm, multi-center, pilot study to evaluate the safety, tolerability, and preliminary efficacy of low-intensity focused ultrasound (LIFU) neuromodulation using NaviFUS System in patients with drug-resistant unilateral or bilateral temporal lobe epilepsy…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Stanford University School of Medicine, Palo Alto, California

    Locations

    3 in total

    Run by

    NaviFUS Corporation

    See if you can join NCT06388707 on ClinicalTrials.gov

20. SeizEAR Safety Study

    Determine the safety and feasibility of an in-ear device to measure seizures or suspected seizures compared to the standard scalp-based electroencephalogram (EEG). The study team anticipates enrolling five healthy participants through meeting announcements and a research email list serv in the Neur…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Icahn School of Medicine at Mount Sinai, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT07088835 on ClinicalTrials.gov

21. Physiological Brain Atlas Development

    The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume. This initially was used to improve DBS implants for Parkinson's Disease, Dystonia, Essentia…

    Stage

    Not phased

    Ages

    6 to 90

    Site

    Vanderbilt Univeristy, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT00575081 on ClinicalTrials.gov

22. Subcortical Arousal in Perceptual Awareness

    The study consists of prospective enrollment of healthy participants and patients with epilepsy, as well as analysis of an existing data set. Healthy participants will be studied with fMRI, eye metrics and behavioral testing at Yale. Patients will be studied with intracranial thalamic and cortical …

    Stage

    Not phased

    Ages

    13 and older

    Site

    Yale School of Medicine, New Haven, Connecticut

    Locations

    8 in total

    Run by

    Yale University

    See if you can join NCT06934356 on ClinicalTrials.gov

23. Implementation and Cost Evaluation of Project UPLIFT

    This study tests Project Using Practice and Learning to Increase Favorable Thoughts (UPLIFT) which is a Mindfulness-based Cognitive Behavioral Therapy program teaching participants with epilepsy methods that include challenging thoughts, behavioral activation, coping, problem-solving, and mindfulne…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Rollins School of Public Health, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT06865820 on ClinicalTrials.gov

24. Outcomes After Planned Discontinuation of AntiSeizure Medication

    The main purpose of this study is to understand the effects of continuing versus discontinuing antiseizure medications after a period of seizure-freedom. Physician guidelines endorse that after a period of seizure-freedom, the risk of another seizure may be low enough to allow patients to consider …

    Stage

    Phase 4

    Ages

    18 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT07750496 on ClinicalTrials.gov

25. A Study to Test the Safety and Tolerability of Brivaracetam in Children and Adolescents With Seizures

    The purpose of the study is to evaluate the long-term safety and tolerability of brivaracetam.

    Stage

    Phase 3

    Ages

    0 and older

    Site

    Ep0156 815, Kodaira-shi,

    Locations

    36 in total

    Run by

    UCB Biopharma SRL

    See if you can join NCT04715646 on ClinicalTrials.gov