Epilepsy Clinical Trials

74 studies are recruiting for epilepsy in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database

   Objectives: The overall study objective is to compare the sensitivities and specificities of morphometric analysis techniques using structural MRI images based on pre- and postsurgical localization of epileptic foci in patients undergoing presurgical evaluation for medically refractory epilepsy. To…

   Stage

   Not phased

   Ages

   8 to 120

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Neurological Disorders and Stroke (NINDS)

   See if you can join NCT02107989 on ClinicalTrials.gov

2. Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

   Background: - The blood-brain barrier separates the brain from the rest of the body. Epilepsy is a neurological disease that causes seizures. It can affect this barrier. Researchers think a contrast agent called mangafodipir might be better able to show areas of the brain that epilepsy affects. Obj…

   Stage

   Phase 1

   Ages

   18 to 60

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Neurological Disorders and Stroke (NINDS)

   See if you can join NCT02531880 on ClinicalTrials.gov

3. A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy

   This will be a prospective, open-label, single-arm, multi-center, pilot study to evaluate the safety, tolerability, and preliminary efficacy of low-intensity focused ultrasound (LIFU) neuromodulation using NaviFUS System in patients with drug-resistant unilateral or bilateral temporal lobe epilepsy…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Stanford University School of Medicine, Palo Alto, California

   Locations

   3 in total

   Run by

   NaviFUS Corporation

   See if you can join NCT06388707 on ClinicalTrials.gov

4. Diagnosing Epilepsy To EffeCT Change

   The purpose of this research is to address the challenges of diagnosing and long-term management of epilepsy in participants whose seizures are not well captured by standard electroencephalography (EEG) tests and who cannot use or are not able to use more standard monitoring techniques. This resear…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   UAB Epilepsy Center, Birmingham, Alabama

   Locations

   21 in total

   Run by

   Epiminder America, Inc.

   See if you can join NCT07110337 on ClinicalTrials.gov

5. Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up

   The purpose of this research is to address the challenges of correctly monitoring, managing, and diagnosing epilepsy in participants whose seizures are not well captured by standard electroencephalography (EEG) tests and who cannot use or are not able to use more standard monitoring techniques. Thi…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   UAB Epilepsy Center, Birmingham, Alabama

   Locations

   18 in total

   Run by

   Epiminder America, Inc.

   See if you can join NCT07110454 on ClinicalTrials.gov

6. SeizEAR Safety Study

   Determine the safety and feasibility of an in-ear device to measure seizures or suspected seizures compared to the standard scalp-based electroencephalogram (EEG). The study team anticipates enrolling five healthy participants through meeting announcements and a research email list serv in the Neur…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Icahn School of Medicine at Mount Sinai, New York, New York

   Run by

   Icahn School of Medicine at Mount Sinai

   See if you can join NCT07088835 on ClinicalTrials.gov

7. Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures

   This is a clinical research study for an investigational drug called RAP-219 in adult participants with focal seizures. This study is being conducted to determine if RAP-219 is safe and effective in reducing focal seizure frequency.

   Stage

   Phase 3

   Ages

   18 to 75

   Site

   Clinic for Neurology, Huntsville, Alabama

   Locations

   11 in total

   Run by

   Rapport Therapeutics Inc.

   See if you can join NCT07594119 on ClinicalTrials.gov

8. Surgery as a Treatment for Medically Intractable Epilepsy

   Background: - Drug resistant epilepsy is the term used to describe epilepsy that cannot be controlled by medication. Many people whose seizures do not respond to medication will respond to surgical treatment, relieving seizures completely or almost completely in one-half to two-thirds of patients w…

   Stage

   Not phased

   Ages

   8 to 99

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Neurological Disorders and Stroke (NINDS)

   See if you can join NCT01273129 on ClinicalTrials.gov

9. Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1

   This is a clinical research study for an investigational drug called RAP-219 in adult participants with focal seizures. This study is being conducted to determine if RAP-219 is safe and effective in reducing focal seizure frequency.

   Stage

   Phase 3

   Ages

   18 to 75

   Site

   Amicis Research Center, Palmdale, California

   Locations

   11 in total

   Run by

   Rapport Therapeutics Inc.

   See if you can join NCT07563881 on ClinicalTrials.gov

10. Tumor Related Epilepsy

    Background: Some people with brain tumors have seizures related to the tumor. This is called tumor-related epilepsy. Usually brain tumors are treated by removing as much of the brain tumor as possible without causing problems. Researchers think this may improve the outcome for people with brain tum…

    Stage

    Not phased

    Ages

    8 to 99

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Neurological Disorders and Stroke (NINDS)

    See if you can join NCT02639325 on ClinicalTrials.gov

11. Physiological Brain Atlas Development

    The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume. This initially was used to improve DBS implants for Parkinson's Disease, Dystonia, Essentia…

    Stage

    Not phased

    Ages

    6 to 90

    Site

    Vanderbilt Univeristy, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT00575081 on ClinicalTrials.gov

12. Subcortical Arousal in Perceptual Awareness

    The study consists of prospective enrollment of healthy participants and patients with epilepsy, as well as analysis of an existing data set. Healthy participants will be studied with fMRI, eye metrics and behavioral testing at Yale. Patients will be studied with intracranial thalamic and cortical …

    Stage

    Not phased

    Ages

    13 and older

    Site

    Yale School of Medicine, New Haven, Connecticut

    Locations

    8 in total

    Run by

    Yale University

    See if you can join NCT06934356 on ClinicalTrials.gov

13. Implementation and Cost Evaluation of Project UPLIFT

    This study tests Project Using Practice and Learning to Increase Favorable Thoughts (UPLIFT) which is a Mindfulness-based Cognitive Behavioral Therapy program teaching participants with epilepsy methods that include challenging thoughts, behavioral activation, coping, problem-solving, and mindfulne…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Rollins School of Public Health, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT06865820 on ClinicalTrials.gov

14. Outcomes After Planned Discontinuation of AntiSeizure Medication

    The main purpose of this study is to understand the effects of continuing versus discontinuing antiseizure medications after a period of seizure-freedom. Physician guidelines endorse that after a period of seizure-freedom, the risk of another seizure may be low enough to allow patients to consider …

    Stage

    Phase 4

    Ages

    18 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT07750496 on ClinicalTrials.gov

15. A Study to Test the Safety and Tolerability of Brivaracetam in Children and Adolescents With Seizures

    The purpose of the study is to evaluate the long-term safety and tolerability of brivaracetam.

    Stage

    Phase 3

    Ages

    0 and older

    Site

    Ep0156 815, Kodaira-shi,

    Locations

    36 in total

    Run by

    UCB Biopharma SRL

    See if you can join NCT04715646 on ClinicalTrials.gov

16. Mapping of Human Cognition

    The purpose of this study is to compare organization of normal brain function as detected using Functional magnetic resonance imaging (fMRI) in normal subjects as opposed to patients with epilepsy or brain tumors, to ascribe precise anatomic labels (including Brodmann Areas) and functional signific…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    The University of Texas Health Science Center at Houston, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT05989893 on ClinicalTrials.gov

17. Hippocampal Oscillations During Exploration

    The objective of this study is to determine how visuomotor exploration relates to hippocampal activity along its long axis. The study will investigate the neurophysiological mechanisms in the hippocampus during (1) visual exploration in surgical patients using high-resolution iEEG, and (2) ambulato…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT07224191 on ClinicalTrials.gov

18. Understanding Prefrontal and Medial Temporal Neuronal Responses to Algorithmic Cognitive Variables in Epilepsy Patients

    Humans have a remarkable ability to flexibly interact with the environment. A compelling demonstration of this cognitive flexibility is human's ability to respond correctly to novel contextual situations on the first attempt, without prior rehearsal. The investigators refer to this ability as 'ad h…

    Stage

    Not phased

    Ages

    10 to 64

    Site

    University of California, Los Angeles, Los Angeles, California

    Locations

    3 in total

    Run by

    Baylor College of Medicine

    See if you can join NCT05283811 on ClinicalTrials.gov

19. Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant Epilepsy

    The goal of this study is to investigate the effects of a non-invasive, low intensity focused ultrasound (LIFU) stimulation on seizure frequency and the epileptogenic network in drug-resistant epilepsy. LIFU uses focused sound waves to modulate deep brain regions and to enable changes in brain netw…

    Stage

    Not phased

    Ages

    21 to 65

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT07680842 on ClinicalTrials.gov

20. Effects of Social Feedback on Intracranial EEG

    This study aims to assess the impact of social influence on direct neural recordings in human patients undergoing surgical treatment of epilepsy. 24 patients recruited from the Epilepsy Center at Dartmouth Health Medical Center (DHMC) will undergo electrode implantation throughout the brain to loca…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire

    Run by

    Trustees of Dartmouth College

    See if you can join NCT06975800 on ClinicalTrials.gov

21. MEHMO Natural History and Biomarkers

    This observational natural history study will follow individuals with MEHMO (Mental disability, Epileptic seizure, Hypopituitarism/Hypogenitalism, Microcephaly, Obesity) syndrome or an eIF2-pathway related disorder, who have symptoms such as intellectual delay, seizures, abnormal hormone and blood …

    Stage

    Not phased

    Ages

    0 to 100

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

    See if you can join NCT06019182 on ClinicalTrials.gov

22. Carbon Dioxide (CO2) Chemosensitivity and SUDEP

    The purpose of this research study is to better understand what causes Sudden Unexpected Death in Epilepsy (SUDEP). This study will enroll subjects from the University of Iowa Hospitals and Clinics (UIHC) Epilepsy Monitoring Unit (EMU) and Epilepsy Clinics. The investigators will analyze the effect…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    University of Iowa Hospitals and Clinics, Iowa City, Iowa

    Run by

    University of Iowa

    See if you can join NCT04134754 on ClinicalTrials.gov

23. Stimulation-Induced Changes in Fronto-Limbic Network

    The purpose of this research is to better understand how emotion processing unfolds in the brain using stereoelectroencephalography (sEEG) and direct brain stimulation. This study will use standard behavioral emotion processing tasks combined with neural recording and direct brain stimulation to as…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Epilepsy Monitoring Unit UAB Hospital, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT05854160 on ClinicalTrials.gov

24. Cognitive and Electrophysiological Assessment of Non-Invasive Temporally-Interfering Electric Fields Stimulation (TIEFS)

    The goal of this clinical trial is to learn how a non-invasive brain stimulation method called Temporally Interfering Electric Fields Stimulation (TIEFS) affects brain activity and thinking in adults. TIEFS uses electrical currents applied to the scalp to influence brain activity without surgery. T…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    University of California Davis Medical Center, Sacramento, California

    Run by

    University of California, Davis

    See if you can join NCT07663578 on ClinicalTrials.gov

25. De-identified UNMH EEG Corpus Database Creation With Fully De-identified Clinical Information

    This proposal outlines the steps required for the creation of a pilot database of EEG recordings and de-identified medical records from patients internally referred within the UNMH Comprehensive Epilepsy Center. The UNMH EEG Corpus would be the first database of its kind. Other public databases con…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of New Mexico Health Science, Albuquerque, New Mexico

    Run by

    University of New Mexico

    See if you can join NCT05140265 on ClinicalTrials.gov