Epilepsy Clinical Trials

74 studies are recruiting for epilepsy in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Boston, Massachusetts 13 Houston, Texas 12 New York, New York 9 Bethesda, Maryland 7 Cleveland, Ohio 6 Philadelphia, Pennsylvania 6 Phoenix, Arizona 6 Rochester, Minnesota 6 Miami, Florida 5 Nashville, Tennessee 5 Palo Alto, California 5 Birmingham, Alabama 4 Cincinnati, Ohio 4 Durham, North Carolina 4 Lebanon, New Hampshire 4 Minneapolis, Minnesota 4 St Louis, Missouri 4 Charlotte, North Carolina 3 Dallas, Texas 3 Jacksonville, Florida 3 Los Angeles, California 3 New Haven, Connecticut 3 Salt Lake City, Utah 3

Studies, page 3

  1. Telephone-Based Support Programs for People With Epilepsy

    This is a two-arm randomized controlled trial to compare telephone-based depression self-management (UPLIFT) to telephone-based support groups (BOOST). A sample of 120 English- and Spanish-speaking people with epilepsy (PWE) with elevated depressive symptoms will be enrolled. Both interventions are…

    Stage
    Not phased
    Ages
    18 to 99
    Site
    NYU Langone Health, New York, New York
    Run by
    NYU Langone Health

    See if you can join NCT05082181 on ClinicalTrials.gov

  2. Localizing Epileptic Networks Using MRI and iEEG

    Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Findings from the present study may inform current and new therapies to map and alt…

    Stage
    EARLY_Phase 1
    Ages
    18 and older
    Site
    University of Pennsylvania, Philadelphia, Pennsylvania
    Run by
    University of Pennsylvania

    See if you can join NCT04649008 on ClinicalTrials.gov

  3. Prediction of Anxiety and Memory State

    The purpose of this study is to look at how signals in the brain, body, and behavior relate to anxiety and memory function. This project seeks to develop the CAMERA (Context-Aware Multimodal Ecological Research and Assessment) platform, a state-of-the-art open multimodal hardware/software system fo…

    Stage
    Not phased
    Ages
    18 to 55
    Site
    Columbia University Irving Medical Center, New York, New York
    Run by
    Columbia University

    See if you can join NCT06551090 on ClinicalTrials.gov

  4. A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures

    This is a clinical research study for an investigational drug called RAP-219 in patients with Refractory Focal Epilepsy. This study is being conducted to determine RAP-219 Long- term safety and open-label antiseizure activity in patients with Refractory Focal Epilepsy.

    Stage
    Phase 2
    Ages
    18 to 70
    Site
    Consultants in Epilepsy and Neurology, PLLC, Boise, Idaho
    Locations
    7 in total
    Run by
    Rapport Therapeutics Inc.

    See if you can join NCT07219407 on ClinicalTrials.gov

  5. Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study

    This trial is a Phase II randomized, double-blind, placebo controlled multi-site study to evaluate the safety and efficacy of early sirolimus to prevent or delay seizure onset in TSC infants. This study is supported by research funding from the Office of Orphan Products Division (OOPD) of the US Fo…

    Stage
    Phase 2
    Ages
    0 to 0
    Site
    University of Alabama at Birmingham, Birmingham, Alabama
    Locations
    11 in total
    Run by
    Darcy Krueger

    See if you can join NCT05104983 on ClinicalTrials.gov

  6. Human Intracranial Electrophysiology

    This study will enroll patients with epilepsy who are being evaluated for epilepsy surgery and have electrodes implanted in the brain and/or have electrodes on the scalp. Additionally, this study will recruit normal and online controls (participants who do not have epilepsy). Participants will be a…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
    Run by
    Dartmouth-Hitchcock Medical Center

    See if you can join NCT05529264 on ClinicalTrials.gov

  7. Genetics of Epilepsy and Related Disorders

    Investigators at Boston Children's Hospital are conducting research in order to better understand the genetic factors which may contribute to epilepsy and related disorders. These findings may help explain the broad spectrum of clinical characteristics and outcomes seen in people with epilepsy.

    Stage
    Not phased
    Ages
    Any age
    Site
    Boston Children's Hospital, Boston, Massachusetts
    Run by
    Boston Children's Hospital

    See if you can join NCT01858285 on ClinicalTrials.gov

  8. Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)

    Rare genetic neurodevelopmental disorders, such as Syt-1 or Baker Gordon Syndrome (BAGOS) arise from mutations in genes essential for brain development and function, often disrupting neurotransmission and neuronal connectivity. These conditions present with a wide range of symptoms including develo…

    Stage
    Not phased
    Ages
    Up to 99
    Site
    University of Missouri - Columbia, Columbia, Missouri
    Run by
    University of Missouri-Columbia

    See if you can join NCT07329257 on ClinicalTrials.gov

  9. ESIS in Pediatric DRE

    The main reason for this research study is to gain information about how the brain makes seizures by causing seizures using very small amounts of current, or electrical stimulation. Using small amounts of current to cause seizures (or stimulate) is not new at CCHMC - it is part of routine clinical …

    Stage
    Not phased
    Ages
    1 to 30
    Site
    Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
    Run by
    Sarah Katie Ihnen

    See if you can join NCT05469373 on ClinicalTrials.gov

  10. Epilepsy Seizure Detection With Innovative Tripolar EEG (tEEG)

    Concurrent electroencephalography (EEG) and new tripolar EEG (tEEG) will be recorded from adult and pediatric patients. In some patients stereo EEG (sEEG) will also be recorded concurrently.

    Stage
    Not phased
    Ages
    6 and older
    Site
    Barrow Neurological Institute Dignity Health dba St. Joseph's Hospital and Medical Center, Phoenix, Arizona
    Locations
    2 in total
    Run by
    CREmedical

    See if you can join NCT05944692 on ClinicalTrials.gov

  11. Ear-Seizure Detection (EarSD) Study

    The proposed study is an investigator-initiated study that aims to measure the accuracy of a wearable seizure detection and prediction device (Ear-Seizure Detection Device (EarSD)) by simultaneous recording with conventional video-EEG (Electroencephalogram) on patients with epileptic seizures in th…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Ummmc-Memorial Campus, Worcester, Massachusetts
    Locations
    2 in total
    Run by
    Felicia Chu

    See if you can join NCT06598189 on ClinicalTrials.gov

  12. Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing

    The overall goal of this study is to map the spatiotemporal dynamics of social affective processing and to examine selective modulation of these dynamics in humans undergoing invasive intracranial monitoring for treatment-resistant epilepsy and depression. Pursuing this signal from a novel platform…

    Stage
    Not phased
    Ages
    22 to 70
    Site
    Baylor College of Medicine, Houston, Texas
    Run by
    Baylor College of Medicine

    See if you can join NCT05418894 on ClinicalTrials.gov

  13. Effect of Vagal Nerve Stimulation on Gastric Motor Functions

    The specific aim of this study is to compare simultaneous assessment of gastric emptying and gastric accommodation in response to a caloric meal In patients who have previously undergone activation of left cervical VNS for the treatment of medication-resistant depression. Our hypothesis is that cer…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Minnesota, Minneapolis, Minnesota
    Locations
    2 in total
    Run by
    Mayo Clinic

    See if you can join NCT06038929 on ClinicalTrials.gov

  14. Pharmacological Modulation of Brain Oscillations in Memory Processing

    The goal of this study is to learn about the effects of scopolamine (an anticholinergic drug) on areas of the brain involved in memory, and changes it may have on brain activity. The investigators will do this by testing epileptic patients who are already undergoing intracranial surgery for seizure…

    Stage
    EARLY_Phase 1
    Ages
    18 to 55
    Site
    University of Texas Southwestern Medical Center, Dallas, Texas
    Run by
    University of Texas Southwestern Medical Center

    See if you can join NCT05594017 on ClinicalTrials.gov

  15. Genetic Markers of Cardiovascular Disease in Epilepsy

    Epilepsy is a common condition which affects over 3 million people in the US. Patients with uncontrolled epilepsy have a lifetime risk of sudden unexpected death (SUDEP) of 35%, which is greatest in those under 40 years of age. The exact mechanisms and causes are not understood but can be due to un…

    Stage
    Not phased
    Ages
    18 to 50
    Site
    Mayo Clinic, Rochester, Minnesota
    Run by
    Mayo Clinic

    See if you can join NCT02824822 on ClinicalTrials.gov

  16. Registry and Natural History of Epilepsy-Dyskinesia Syndromes

    The Registry and Natural History of Epilepsy-Dyskinesia Syndromes is focused on gathering longitudinal clinical data as well as biological samples (blood, urine, and/or skin/tissue) from male and female patients, of all ages, who have a genetic diagnosis of epilepsy-dyskinesia syndromes. Through pr…

    Stage
    Not phased
    Ages
    0 to 30
    Site
    Boston Children's Hospital, Boston, Massachusetts
    Run by
    Boston Children's Hospital

    See if you can join NCT06967727 on ClinicalTrials.gov

  17. Amygdala Memory Enhancement

    The objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories. The project is relevant to disorders of memory and to disorders involving affect and memory, including traumatic brain injury and post-traumatic stress disorder.

    Stage
    Not phased
    Ages
    18 to 75
    Site
    Washington University School of Medicine, St Louis, Missouri
    Run by
    Washington University School of Medicine

    See if you can join NCT05065450 on ClinicalTrials.gov

  18. Capturing Autobiographical Memory Formation in Real World Spaces Using Multimodal Recordings

    The goal of this observational study is to develop novel methods for integrating multimodal data streams with invasive neural recordings to study autobiographical memory (AM) formation in individuals with implanted neurostimulation devices (e.g., NeuroPace RNS) for epilepsy treatment. The main ques…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah
    Run by
    University of Utah

    See if you can join NCT06883981 on ClinicalTrials.gov

  19. Functional Brain Mapping for Patients with Epilepsy

    We aim to determine the clinical utility of 'dynamic tractography': a novel method for visualizing electrical neural transfers that incorporates the underlying white matter tracts and supporting linguistic processing. We will also determine how well objective electrophysiology biomarkers will impro…

    Stage
    Not phased
    Ages
    0 to 21
    Site
    Children's Hospital of Michigan, Detroit, Michigan
    Locations
    2 in total
    Run by
    Wayne State University

    See if you can join NCT05755919 on ClinicalTrials.gov

  20. Lemborexant Treatment of Insomnia Linked to Epilepsy

    The goal of this clinical trial is to assess whether Lemborexant can improve sleep in patients with epilepsy.

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Health Sciences Centre, Winnipeg, Manitoba
    Locations
    2 in total
    Run by
    University of Manitoba

    See if you can join NCT06262594 on ClinicalTrials.gov

  21. Neurobehavioral Therapy For Epilepsy And Major Depressive Disorder

    The purpose of this study is to examine the feasibility and acceptability of an online group Neuro-behavioral Therapy (NBT) with text messaging intervention for Veterans with epilepsy and major depressive disorder (MDD).

    Stage
    Not phased
    Ages
    18 and older
    Site
    Michael E. DeBakey VA Medical Center, Houston, Texas
    Locations
    2 in total
    Run by
    The University of Texas Health Science Center, Houston

    See if you can join NCT06695767 on ClinicalTrials.gov

  22. VNS Prospective Neuromodulation of Immune and Gastrointestinal Systems

    Vagal nerve stimulation is a neurosurgical procedure consisting of implantation of an impulse generator battery with leads placed into the vagus nerve in the neck. This procedure was FDA approved for epilepsy in the 1990s and is commonly performed as an outpatient surgery. The mechanism of action i…

    Stage
    Not phased
    Ages
    0 to 60
    Site
    University of Louisville, Louisville, Kentucky
    Locations
    4 in total
    Run by
    University of Louisville

    See if you can join NCT03953768 on ClinicalTrials.gov

  23. Epilepsy Learning Healthcare System (ELHS)

    The Epilepsy Learning Health System (ELHS) is a quality improvement and research network to improve outcomes for people with epilepsy. The ELHS is designed as a model of value-based chronic care for epilepsy as envisioned by the National Academies of Medicine Committee in their landmark reports "Th…

    Stage
    Not phased
    Ages
    Any age
    Site
    Barrow Neurological Institute Comprehensive Epilepsy Center, Phoenix, Arizona
    Locations
    13 in total
    Run by
    Epilepsy Foundation of America

    See if you can join NCT06265103 on ClinicalTrials.gov

  24. Human Epilepsy Genetics--Neuronal Migration Disorders Study

    The purpose of this study is to identify genes responsible for epilepsy, brain malformations and disorders of human cognition.

    Stage
    Not phased
    Ages
    Any age
    Site
    Boston Children's Hospital, Walsh Laboratory, Boston, Massachusetts
    Run by
    Harvard University Faculty of Medicine

    See if you can join NCT00041600 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.