Dementia Clinical Trials

84 studies are recruiting for dementia in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).

   The main purpose of this study is to determine if participants who previously took donanemab get clinical benefit when they receive annual doses. For each participant, the study will last up to 2.5 years and will include 6 visits.

   Stage

   Phase 3

   Ages

   55 and older

   Site

   Care Access - Huntington Beach, Huntington Beach, California

   Locations

   59 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07602582 on ClinicalTrials.gov

2. Financial Counseling for Dementia Family Caregivers in Early and Middle Adulthood

   The goal of this National Institutes of Health (NIH) Stage 1a study is to develop and pilot test a research- and community-informed financial counseling and advocacy (FCA) intervention for dementia family caregivers in early and middle adulthood. The main question it aims to answer is: Is a researc…

   Stage

   Not phased

   Ages

   25 to 55

   Site

   University of Utah College of Nursing, Salt Lake City, Utah

   Run by

   University of Utah

   See if you can join NCT07681401 on ClinicalTrials.gov

3. Neurologic Stem Cell Treatment Study

   This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will provide improvement in neurologic function for patients with certain n…

   Stage

   Not phased

   Ages

   18 and older

   Site

   MD Stem Cells, Westport, Connecticut

   Locations

   3 in total

   Run by

   MD Stem Cells

   See if you can join NCT02795052 on ClinicalTrials.gov

4. e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most

   The overarching goal of this study is to pilot an intervention in which older adults with mild cognitive impairment and dementia and the older adult's care partners are identified in primary care and provided with educational materials through the patient portal to engage the participant in depresc…

   Stage

   Not phased

   Ages

   65 and older

   Site

   Johns Hopkins Community Physicians, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT07454824 on ClinicalTrials.gov

5. Web-based Cognitive Behavioral Treatment for Insomnia in Dementia Caregivers

   Over the next 30 years, more than 10 million persons living with dementia in the United States will receive care at home from an unpaid and untrained family caregiver. At home care is preferred by caregivers and persons with dementia alike, but increases the caregiver's risk of insomnia and related…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Missouri, Columbia, Missouri

   Run by

   University of South Florida

   See if you can join NCT04632628 on ClinicalTrials.gov

6. Music for Pain and Dementia

   This study aims to provide mechanistic insights into how group drumming as a music-based intervention (MBI) affects pain responses and nociceptive function in individuals with Alzheimer's Disease (AD), mild dementia or mild cognitive impairment (MCI). Heart rate (HR), heart rate variability (HRV), …

   Stage

   Not phased

   Ages

   50 to 80

   Site

   Connecticut Mental Health Clinic, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT07602283 on ClinicalTrials.gov

7. Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia

   Difficulties with speech and language are the first and most notable symptoms of primary progressive aphasia (PPA). While there is evidence that demonstrates positive effects of speech-language treatment for individuals with PPA who only speak one language (monolinguals), there is a significant nee…

   Stage

   Not phased

   Ages

   40 and older

   Site

   University of Texas at Austin, Austin, Texas

   Locations

   3 in total

   Run by

   Stephanie Grasso

   See if you can join NCT05741853 on ClinicalTrials.gov

8. Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia

   The current study aims to examine the benefits of an education/support group program for individuals with progressive aphasia (caused by various etiologies, diagnoses) and their carepartners. The current study utilizes pre-, post-treatment, and follow-up assessments to measure effects of a psychoed…

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   University of Texas at Austin, Austin, Texas

   Run by

   University of Texas at Austin

   See if you can join NCT06511752 on ClinicalTrials.gov

9. Resilient Together for Dementia (RT-D)

   This study will evaluate the feasibility and preliminary efficacy of the novel Resilient Together for Dementia (RT-D) intervention for couples following dementia diagnoses. The primary target is emotional distress, and the program aims to prevent chronic distress in at-risk couples.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Brain Injury Research Center at Mount Sinai, New York, New York

   Run by

   Icahn School of Medicine at Mount Sinai

   See if you can join NCT06619327 on ClinicalTrials.gov

10. The INSPIRE -Faith Study: Intervention Strategies for Preserving Intellectual Resilience and Engagement

    The INSPIRE-Faith Study, initiated by the Healthy Minds Initiative, is a community-based research project aimed at demonstrating the impact of lifestyle factors on cognitive health and the prevention of dementia. Conducted in collaboration with the American College of Lifestyle Medicine, Charles Dr…

    Stage

    Not phased

    Ages

    55 to 85

    Site

    Crenshaw Christian Center, Los Angeles, California

    Run by

    Healthy Minds Initiative

    See if you can join NCT06741865 on ClinicalTrials.gov

11. Preventing Medication Mismanagement in People Living With Dementia

    The purpose of this research is to learn whether the HiDO-ALZ device can improve medication compliance and health outcomes in participants with dementia that need to take daily medication.

    Stage

    Not phased

    Ages

    65 and older

    Site

    HiDO Technologies, Folsom, California

    Run by

    HiDO Technologies

    See if you can join NCT07600684 on ClinicalTrials.gov

12. Trial-Ready Cohort-Down Syndrome (TRC-DS)

    The purpose of the Trial-Ready Cohort - Down Syndrome (TRC-DS) is to enroll 120 healthy adults with Down syndrome (DS), between the ages of 25-55, into a trial ready cohort (TRC), and up to 550 participants in total including co-enrolled in the Alzheimer Biomarkers Consortium - Down Syndrome (ABC-D…

    Stage

    Not phased

    Ages

    25 to 55

    Site

    Barrow Neurological Institute, Phoenix, Arizona

    Locations

    22 in total

    Run by

    University of Southern California

    See if you can join NCT04165109 on ClinicalTrials.gov

13. Tele-Savvy for Latino Caregivers

    Latino caregivers of individuals with Alzheimer's disease and related dementias experience high levels of stress burden and depressive symptoms and are underrepresented in caregiver intervention research. Tele Savvy is an evidence based caregiver education program that focuses on developing caregiv…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Rochester School of Nursing, Rochester, New York

    Run by

    University of Rochester

    See if you can join NCT07290387 on ClinicalTrials.gov

14. Multi-modal Large Language Model-Empowered Talk Therapy for Older Adults With ADRD

    The purpose of this study is to test the usefulness and the effect of Smart Virtual Reminiscence (SVR) therapy intervention on the Behavioral and Psychological Symptoms of Dementia (BPSD) of patients with Alzheimer's Disease and Related Dementias (ADRD). SVR is designed to help older adults improve…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Sidney & Lois Eskenazi Hospital, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT07499570 on ClinicalTrials.gov

15. δ in Dementia Clinical Trials

    The goal of this clinical trial is to demonstrate potential improvements in clinical trial methods relating to dementia and cognitive decline. The main questions it aims to answer are: * Can an intervention's outcome be better assessed by a latent variable ("δ") integrating cognitive performance wi…

    Stage

    Not phased

    Ages

    65 to 100

    Site

    Univeristy of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT05592678 on ClinicalTrials.gov

16. NiteCAPP: Web-based Interventions for Insomnia in Rural Dementia Caregivers

    The goal of this project evaluate the efficacy of NiteCAPP in improving insomnia in a rural dementia caregiver sample (n of 100 caregiver and PWD dyads). We will measure both the short term (post-treatment) and long term (6 and 12 months) effects of the intervention on CG sleep, arousal, inflammati…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of South Florida, Tampa, Florida

    Run by

    University of South Florida

    See if you can join NCT04896775 on ClinicalTrials.gov

17. Investigating Dynamic Interactions in Distributed Cognitive Control Networks

    The purpose of this study is to investigate the brain activity associated with cognitive tasks (thinking, reasoning, remembering) in order to understand how the brain works during certain tasks and to improve treatment for diseases like dementia and attention deficit disorders. Cognitive (thinking)…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT05927974 on ClinicalTrials.gov

18. The Black Immigrant Project

    This stage I trial will examine if the culturally adapted ACES intervention affects cognitive appraisal (self-efficacy and dysfunctional thoughts) and behavioral activation with Black immigrant living with dementia and their care partners over a 1-month and 3-month period.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT07546708 on ClinicalTrials.gov

19. Combating Alzheimer's Through Sleep and Exercise

    The purpose of this research is to see how sleep and exercise affects dementia risk over time.

    Stage

    Not phased

    Ages

    45 to 80

    Site

    University of Miami Hospitals, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT04855630 on ClinicalTrials.gov

20. 5-Cog 2.0: A Pragmatic Clinical Trial

    Cognitive impairment related to dementia is frequently under-diagnosed in primary care settings. This problem is more prevalent in health disparities populations. The investigators developed the 5-Cog brief cognitive assessment that is simple to use, standardized, takes <5 minutes, does not require…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Indiana University, Bloomington, Indiana

    Locations

    2 in total

    Run by

    Albert Einstein College of Medicine

    See if you can join NCT05515224 on ClinicalTrials.gov

21. Improving PCP Advance Care Planning for People With ADRD

    This study will test the Dementia Advance Care Planning (AD ACP) Toolkit intervention to usual care in facilitating goals of care (GOC) discussions between People Living with Dementia (PLwD) and primary care team members over an 18-month period. The primary outcome is to assess the frequency and qu…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    University of North Carolina, Chapel Hill, Chapel Hill, North Carolina

    Run by

    University of Pittsburgh

    See if you can join NCT06565169 on ClinicalTrials.gov

22. Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce

    This project will compare two training models of an evidence-based online dementia care training program for direct care staff in assisted living to a waitlist control: 1) essentiALZ training and 2) essentiALZ training + Project ECHO. It will examine the extent to which each model is implemented an…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06239688 on ClinicalTrials.gov

23. Ultralow Dose PET Imaging of 18F-Florbetapir, 18F-Flutemetamol

    The goal of this clinical trial is to evaluate an investigational ultralow dose Positron Emission Tomography (PET) imaging technique for Alzheimer's disease, mild cognitive impairment, other forms of dementia detection and monitoring. The main question it aims to answer is: Can the investigators op…

    Stage

    Phase 2

    Ages

    18 to 120

    Site

    Nuclear Imaging Institute, Englewood, New Jersey

    Run by

    Akiva Mintz

    See if you can join NCT07012993 on ClinicalTrials.gov

24. Connect-Home: Alzheimer's Disease and Related Dementias

    This study is a parallel arm, cluster randomized trial (CRT) to test the efficacy of Connect-Home ADRD, a transitional care intervention focusing on Skilled Nursing Facility (SNF) patients with Alzheimer's disease and dementias and their caregivers during transitions from SNFs to home, assisted, li…

    Stage

    Not phased

    Ages

    19 and older

    Site

    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06840587 on ClinicalTrials.gov

25. Early-Stage Partner in Care Living Alone Plus

    EPICLA+ (Early-Stage Partners in Care Living Alone Plus) is a research project designed to assist people with early-stage memory loss who live alone in the community by providing early-stage related education and skill-training sessions, held via Zoom, designed to reduce stress, enhance well-being,…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Arizona State University, Phoenix, Arizona

    Run by

    Arizona State University

    See if you can join NCT06962111 on ClinicalTrials.gov