Dementia Clinical Trials

84 studies are recruiting for dementia in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease

   Background: About 5 million adults in the U.S. have Alzheimer s disease or another adult-onset neurodegenerative disorder. Many studies have found that inflammation in the brain contributes to these diseases. Researchers want to find a better way to measure this inflammation. Objective: To learn wh…

   Stage

   Phase 1

   Ages

   18 to 99

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT04396873 on ClinicalTrials.gov

2. Genetic Characterization of Movement Disorders and Dementias

   Background: There are two basic types of movement disorders. Some cause excessive movement, some cause slowness or lack of movement. Some of these are caused by mutations in genes. On the other hand, dementia is a condition of declining mental abilities, especially memory. Dementia can occur at any…

   Stage

   Not phased

   Ages

   18 to 120

   Site

   National Institute of Aging, Clinical Research Unit, Baltimore, Maryland

   Run by

   National Institute on Aging (NIA)

   See if you can join NCT02014246 on ClinicalTrials.gov

3. Clinical Applications of Advanced Ophthalmic Imaging

   The purpose of this study is to determine the clinical application of advanced ophthalmic imaging devices such as optical coherence tomography (OCT), retinal function imager (RFI), slit-lamp biomicroscopy (SLB), PERG in diseased eyes and normal controls. There are two phases in this study. The firs…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   Bascom Palmer Eye Institute, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT03135327 on ClinicalTrials.gov

4. Cooking Health-Oriented Meals to Prevent Dementia and Diabetes

   Previous research demonstrates that 1) adherence to a DASH dietary pattern and diets low in certain UPFs are linked to lower likelihood of experiencing cognitive impairments in later life, that 2) engagement in cooking is linked to healthier eating, reduced UPF consumption, and higher food self-eff…

   Stage

   Not phased

   Ages

   50 to 75

   Site

   Virginia Tech, Blacksburg, Virginia

   Run by

   Virginia Polytechnic Institute and State University

   See if you can join NCT07661368 on ClinicalTrials.gov

5. Making Connections Thru Music

   Healthcare systems around the world, including within the United States, have long-established shortages of trained caregivers. The American Health Care Association states that "the health care system has experienced a shortage of trained caregivers for critical roles for some time." This scarcity …

   Stage

   Not phased

   Ages

   18 to 103

   Site

   Hopeful Aging, Winchester, Massachusetts

   Locations

   2 in total

   Run by

   Hopeful Aging

   See if you can join NCT06079216 on ClinicalTrials.gov

6. The BRAIN App (Phase 2 SBIR)

   There are currently 6.7 million Americans living with dementia and, without significant breakthroughs, this figure will double to 12.7 million by 2050. There are about 46,000 long-term care (LTC) facilities in the U.S. More than half of LTC residents have some form of dementia (Alzheimer's Associat…

   Stage

   Not phased

   Ages

   65 and older

   Site

   Hopeful Aging, Winchester, Massachusetts

   Run by

   Hopeful Aging

   See if you can join NCT06298474 on ClinicalTrials.gov

7. Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium

   The goal of this prospective cohort study is to assess potential differences in sleep biomarkers in older adult patients undergoing major orthopedic surgery. The main questions it aims to answer are: 1. To define sleep/circadian biomarkers of delirium (sleep duration, regularity, stability and timi…

   Stage

   Not phased

   Ages

   70 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06052397 on ClinicalTrials.gov

8. Study to Understand Novel Biomarkers in Researching Dementia

   The purpose of this study is to determine the relationships between amyloid, tau, and neurodegeneration biomarkers in the blood and the presence of Alzheimer's disease (AD) pathology, clinical cognitive decline, and diagnosis. We aim to understand how well blood-based biomarkers can diagnose and pr…

   Stage

   Not phased

   Ages

   60 and older

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT06547099 on ClinicalTrials.gov

9. Alzheimer's Disease Genetics Study

   The purpose of the Alzheimer's Disease Genetics Study is to identify the genes that are responsible for causing Alzheimer's Disease (AD). One of the ways in which the risk factor genes for late onset AD can be investigated is by identifying and collecting genetic material from families with multipl…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Participants are being recruited from all over the United States, Nationwide, Indiana

   Run by

   Indiana University

   See if you can join NCT00064870 on ClinicalTrials.gov

10. 100-Year Human Aging Study

    The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed clinical sites, mobile clinical sites, and an online participation pathway (current and future) to undergo comprehensive multi-system health screening and longitudinal follow-up until…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Longevity Metrics, Boulder, Colorado

    Run by

    Longevity Metrics, Inc.

    See if you can join NCT07563777 on ClinicalTrials.gov

11. Human Observatory Study

    The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level. Individual multi-system clinical data from enrolled participants are linked to a con…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Longevity Metrics, Boulder, Colorado

    Run by

    Longevity Metrics, Inc.

    See if you can join NCT07646782 on ClinicalTrials.gov

12. ADRC Clinical Cohort (Alzheimer's Disease)

    The purpose of the study is to establish a clinical cohort for the Duke/UNC Alzheimer's Disease Research Center (ADRC). The cohort will be composed of subjects ages 25 to 44 at enrollment with normal cognition and subjects ages 45 to 80 at enrollment with normal cognition, mild cognitive impairment…

    Stage

    Not phased

    Ages

    25 to 80

    Site

    Duke University, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06703541 on ClinicalTrials.gov

13. Microbiome in Aging of Gut and Brain

    The Microbiome in Aging Gut and Brain (MiaGB) Study is an observational study designed to examine whether differences in the microorganisms living in the gut and mouth are associated with cognitive health and cognitive decline. The study includes young healthy adults, cognitively healthy older adul…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Department of Neurosurgery and Brain and Spine and Faculty of USF Center for Microbiome Re-search, Microbiomes Institute, Tampa, Florida

    Run by

    University of South Florida

    See if you can join NCT07799402 on ClinicalTrials.gov

14. Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

    PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the …

    Stage

    Phase 4

    Ages

    75 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    106 in total

    Run by

    Duke University

    See if you can join NCT04262206 on ClinicalTrials.gov

15. The Impact of Music Intervention on Sleep

    The primary purpose of this Stage 1b NIH-funded clinical trial (K23AG073618, PI Petrovsky) is to determine the efficacy of a 1-month music intervention (Calming Music Personalized for Sleep Enhancement in PeRsons living with Dementia, CoMPoSER) on health outcomes in 72 dyads (144 participants) of p…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    Duke University School of Nursing, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06088810 on ClinicalTrials.gov

16. Enhancing Shared Decision-making to Guide Care for People With Dementia and Diabetes

    The goal of this study is to test CGM ASSIST. This is a digital tool that uses an interactive information display-an easy-to-read screen designed to help people with dementia (or memory loss) and diabetes, as well as their caregivers and doctors. Managing diabetes is often difficult for people with…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Eskenazi Health, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT05643144 on ClinicalTrials.gov

17. Effect of Cognitive Empathy Training on Dementia Caregivers

    The goal of this project is to investigate the effect of cognitive empathy training on mental health, inflammation, and immune function in caregivers of people living with dementia (PLWD), and to examine the underlying psychological and neurobiological mechanisms. The primary aim is to establish th…

    Stage

    Not phased

    Ages

    50 and older

    Site

    Alter, Atlanta, Georgia

    Locations

    3 in total

    Run by

    Emory University

    See if you can join NCT06650527 on ClinicalTrials.gov

18. Establishing Normal Cognitive Test Scores for Adults Using a Voice-Enabled Digital Testing Platform Across the Lifespan

    Trial weblink: https://www.memoryexam.com/job/norms/ Participants enrolled in this study will complete a single-session, non-invasive, computerized cognitive assessment administered through a secure, web-based digital platform. The purpose of the study is to establish normative cognitive performanc…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    The Neurology Center of Southern California, Carlsbad, California

    Run by

    The Neurology Center of Southern California

    See if you can join NCT07763392 on ClinicalTrials.gov

19. Dementia Care Partner Hospital Assessment Tool

    The purpose of this study is to see whether an adapted questionnaire called the Care Partner Hospital Assessment Tool (CHAT) for care partners of hospitalized patients living with Alzheimer's disease and related dementias (ADRD) (CHAT-AD) can help people with dementia receive better care after they…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Wisconsin, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT05592366 on ClinicalTrials.gov

20. Medication Collaboration Feasibility Study

    This study examines the feasibility and acceptability of a brief medication collaboration intervention among older adults (age 60+) with early-stage dementia or mild cognitive impairment who take multiple medications and their family caregivers. The main aims are to: 1) determine the feasibility an…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Northwestern University, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT07742189 on ClinicalTrials.gov

21. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

    The purpose is to evaluate the biomarker effect, safety, and tolerability of investigational study drugs in participants who are known to have an Alzheimer's disease (AD)-causing mutation. Stage 1 will determine if treatment with the study drug prevents or slows the rate of amyloid beta (Aβ) pathol…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Alabama in Birmingham, Birmingham, Alabama

    Locations

    37 in total

    Run by

    Washington University School of Medicine

    See if you can join NCT05552157 on ClinicalTrials.gov

22. A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

    The purpose of this research study is to test the study drug, referred to as remternetug, to determine its effectiveness for the study treatment of asymptomatic (at risk) Alzheimer disease in individuals with AD-causing mutations. This study will also investigate the effects of remternetug on bioma…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Alabama in Birmingham, Birmingham, Alabama

    Locations

    37 in total

    Run by

    Washington University School of Medicine

    See if you can join NCT06647498 on ClinicalTrials.gov

23. Testing the Pain Clinical Practice Guideline

    There are evidence based processes for assessment and management of pain using pharmacologic and nonpharmacological approaches. These were reviewed and included within the Pain Management Clinical Practice Guideline (Pain Management CPG) recently developed by AMDA: The Society for Post-Acute and Lo…

    Stage

    Phase 2

    Ages

    60 and older

    Site

    Lorien Mays Chapel, Timonium, Maryland

    Locations

    11 in total

    Run by

    University of Maryland, Baltimore

    See if you can join NCT05858996 on ClinicalTrials.gov

24. Paradoxical Lucidity in Severe End-Stage Dementia

    Cognitive decline in dementia is considered irreversible, however episodes of paradoxical lucidity (PL) in severe dementia suggest other mechanisms may be in play. Beyond anecdotal reports of transient PL events occurring in patients predominantly in late-stage dementia and typically lasting anywhe…

    Stage

    Not phased

    Ages

    18 and older

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT05234866 on ClinicalTrials.gov

25. Low-Dose Radiotherapy for Alzheimer's Disease

    To evaluate the safety and tolerability of low-dose whole brain radiotherapy (WBRT) delivered as an induction course of 0.3 Gy × 10 fractions (3.0 Gy total) followed by 12 months of monthly maintenance LDRT (0.3 Gy × 10 fractions; 3.0 Gy total) in patients with Alzheimer's disease or dementia with …

    Stage

    Phase 1

    Ages

    50 and older

    Site

    Renaissance Institute of Precision Oncology & Radiosurgery, Winter Park, Florida

    Run by

    Evan Thomas

    See if you can join NCT07693140 on ClinicalTrials.gov