Dementia Clinical Trials

86 studies are recruiting for dementia in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease

   Background: About 5 million adults in the U.S. have Alzheimer s disease or another adult-onset neurodegenerative disorder. Many studies have found that inflammation in the brain contributes to these diseases. Researchers want to find a better way to measure this inflammation. Objective: To learn wh…

   Stage

   Phase 1

   Ages

   18 to 99

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT04396873 on ClinicalTrials.gov

2. Genetic Characterization of Movement Disorders and Dementias

   Background: There are two basic types of movement disorders. Some cause excessive movement, some cause slowness or lack of movement. Some of these are caused by mutations in genes. On the other hand, dementia is a condition of declining mental abilities, especially memory. Dementia can occur at any…

   Stage

   Not phased

   Ages

   18 to 120

   Site

   National Institute of Aging, Clinical Research Unit, Baltimore, Maryland

   Run by

   National Institute on Aging (NIA)

   See if you can join NCT02014246 on ClinicalTrials.gov

3. A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).

   The main purpose of this study is to determine if participants who previously took donanemab get clinical benefit when they receive annual doses. For each participant, the study will last up to 2.5 years and will include 6 visits.

   Stage

   Phase 3

   Ages

   55 and older

   Site

   Banner Alzheimer's Institute, Phoenix, Arizona

   Locations

   62 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07602582 on ClinicalTrials.gov

4. Combating Alzheimer's Through Sleep and Exercise

   The Combating Alzheimer's through Sleep and Exercise (CASE) study is an exploratory, hypothesis-generating trial designed to: (1) assess whether improvements in sleep are associated with improvements in cognitive performance and cardiovascular and metabolic health; (2) evaluate the effects of struc…

   Stage

   Not phased

   Ages

   55 to 80

   Site

   University of Miami Hospitals, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT04855630 on ClinicalTrials.gov

5. The WeACT Program for Family Caregivers of People Living With Dementia

   The goal of this clinical trial is to learn whether WeACT, a self-paced, web-based program, is feasible and helpful for adult family caregivers of a relative living with dementia. WeACT is based on acceptance and commitment therapy (ACT), which teaches skills to handle difficult thoughts and feelin…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of South Florida, Tampa, Florida

   Run by

   University of South Florida

   See if you can join NCT07342569 on ClinicalTrials.gov

6. EXercise-induced PhysioLogical Adaptations In Neurological Disorders

   The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers. The main questions the study aims to answer are: * How do fitness level, exercise performance, and physical…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Run by

   Brigham and Women's Hospital

   See if you can join NCT07883720 on ClinicalTrials.gov

7. Dementia and Diabetes Prevention Program

   This is a multicenter, randomized 2-arm clinical trial of two lifestyle interventions varying in intensity and format, in 400 older African American and non-Hispanic whites at increased risk of cognitive decline and dementia in the East San Francisco Bay Area. The trial will include two lifestyle i…

   Stage

   Not phased

   Ages

   60 and older

   Site

   University of California, Davis Alzheimer's Disease Center, Walnut Creek, California

   Run by

   University of California, Davis

   See if you can join NCT04141878 on ClinicalTrials.gov

8. CommunityRx-Dementia + Peer Navigation (CRxDpeer)

   The CRxDpeer intervention, delivered by a trained peer navigator, in practice called a "peer mentor", includes three evidence-based components: (a) focused education about common social (e.g., food and housing insecurity) and caregiving (e.g., respite and end of life care) needs, (b) activation of …

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Chicago, Chicago, Illinois

   Run by

   University of Chicago

   See if you can join NCT07346183 on ClinicalTrials.gov

9. Fostering Positive Care Interactions in Assisted Living

   The purpose of this study is to improve the quality of staff-resident care interactions particularly among residents living with Alzheimer's disease or related dementias (ADRD ) by testing the Fostering Positive Care Interactions in Assisted Living (FPCI-AL) intervention. This study will be a criti…

   Stage

   Not phased

   Ages

   55 and older

   Site

   Caraway Assisted Living, Elkton, Maryland

   Locations

   3 in total

   Run by

   University of Maryland, Baltimore

   See if you can join NCT07378800 on ClinicalTrials.gov

10. Enhancing Shared Decision-making to Guide Care for People With Dementia and Diabetes

    The goal of this study is to test CGM ASSIST. This is a digital tool that uses an interactive information display-an easy-to-read screen designed to help people with dementia (or memory loss) and diabetes, as well as their caregivers and doctors. Managing diabetes is often difficult for people with…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Eskenazi Health, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT05643144 on ClinicalTrials.gov

11. Comparison of Two Group Wellness Interventions for Individuals With Neurologic Conditions and Their Support Persons

    Approximately 5.3 million people live with a long-term disability resulting from a traumatic brain injury (TBI) and between 5-8% of those older than 60 suffer from Alzheimer's disease or other forms of dementia (ADRD). Consequences of these conditions can result in dramatic and persistent changes i…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Kessler Foundation, East Hanover, New Jersey

    Run by

    Kessler Foundation

    See if you can join NCT05048966 on ClinicalTrials.gov

12. Music for Pain and Dementia

    This study aims to provide mechanistic insights into how group drumming as a music-based intervention (MBI) affects pain responses and nociceptive function in individuals with Alzheimer's Disease (AD), mild dementia or mild cognitive impairment (MCI). Heart rate (HR), heart rate variability (HRV), …

    Stage

    Not phased

    Ages

    50 to 80

    Site

    Connecticut Mental Health Clinic, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT07602283 on ClinicalTrials.gov

13. Microbiome in Aging of Gut and Brain

    The Microbiome in Aging Gut and Brain (MiaGB) Study is an observational study designed to examine whether differences in the microorganisms living in the gut and mouth are associated with cognitive health and cognitive decline. The study includes young healthy adults, cognitively healthy older adul…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Department of Neurosurgery and Brain and Spine and Faculty of USF Center for Microbiome Re-search, Microbiomes Institute, Tampa, Florida

    Run by

    University of South Florida

    See if you can join NCT07799402 on ClinicalTrials.gov

14. Clinical Applications of Advanced Ophthalmic Imaging

    The purpose of this study is to determine the clinical application of advanced ophthalmic imaging devices such as optical coherence tomography (OCT), retinal function imager (RFI), slit-lamp biomicroscopy (SLB), PERG in diseased eyes and normal controls. There are two phases in this study. The firs…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Bascom Palmer Eye Institute, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT03135327 on ClinicalTrials.gov

15. Cooking Health-Oriented Meals to Prevent Dementia and Diabetes

    Previous research demonstrates that 1) adherence to a DASH dietary pattern and diets low in certain UPFs are linked to lower likelihood of experiencing cognitive impairments in later life, that 2) engagement in cooking is linked to healthier eating, reduced UPF consumption, and higher food self-eff…

    Stage

    Not phased

    Ages

    50 to 75

    Site

    Virginia Tech, Blacksburg, Virginia

    Run by

    Virginia Polytechnic Institute and State University

    See if you can join NCT07661368 on ClinicalTrials.gov

16. Making Connections Thru Music

    Healthcare systems around the world, including within the United States, have long-established shortages of trained caregivers. The American Health Care Association states that "the health care system has experienced a shortage of trained caregivers for critical roles for some time." This scarcity …

    Stage

    Not phased

    Ages

    18 to 103

    Site

    Hopeful Aging, Winchester, Massachusetts

    Locations

    2 in total

    Run by

    Hopeful Aging

    See if you can join NCT06079216 on ClinicalTrials.gov

17. The BRAIN App (Phase 2 SBIR)

    There are currently 6.7 million Americans living with dementia and, without significant breakthroughs, this figure will double to 12.7 million by 2050. There are about 46,000 long-term care (LTC) facilities in the U.S. More than half of LTC residents have some form of dementia (Alzheimer's Associat…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Hopeful Aging, Winchester, Massachusetts

    Run by

    Hopeful Aging

    See if you can join NCT06298474 on ClinicalTrials.gov

18. Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium

    The goal of this prospective cohort study is to assess potential differences in sleep biomarkers in older adult patients undergoing major orthopedic surgery. The main questions it aims to answer are: 1. To define sleep/circadian biomarkers of delirium (sleep duration, regularity, stability and timi…

    Stage

    Not phased

    Ages

    70 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06052397 on ClinicalTrials.gov

19. Study to Understand Novel Biomarkers in Researching Dementia

    The purpose of this study is to determine the relationships between amyloid, tau, and neurodegeneration biomarkers in the blood and the presence of Alzheimer's disease (AD) pathology, clinical cognitive decline, and diagnosis. We aim to understand how well blood-based biomarkers can diagnose and pr…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT06547099 on ClinicalTrials.gov

20. Alzheimer's Disease Genetics Study

    The purpose of the Alzheimer's Disease Genetics Study is to identify the genes that are responsible for causing Alzheimer's Disease (AD). One of the ways in which the risk factor genes for late onset AD can be investigated is by identifying and collecting genetic material from families with multipl…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Participants are being recruited from all over the United States, Nationwide, Indiana

    Run by

    Indiana University

    See if you can join NCT00064870 on ClinicalTrials.gov

21. 100-Year Human Aging Study

    The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed clinical sites, mobile clinical sites, and an online participation pathway (current and future) to undergo comprehensive multi-system health screening and longitudinal follow-up until…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Longevity Metrics, Boulder, Colorado

    Run by

    Longevity Metrics, Inc.

    See if you can join NCT07563777 on ClinicalTrials.gov

22. Human Observatory Study

    The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level. Individual multi-system clinical data from enrolled participants are linked to a con…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Longevity Metrics, Boulder, Colorado

    Run by

    Longevity Metrics, Inc.

    See if you can join NCT07646782 on ClinicalTrials.gov

23. ADRC Clinical Cohort (Alzheimer's Disease)

    The purpose of the study is to establish a clinical cohort for the Duke/UNC Alzheimer's Disease Research Center (ADRC). The cohort will be composed of subjects ages 25 to 44 at enrollment with normal cognition and subjects ages 45 to 80 at enrollment with normal cognition, mild cognitive impairment…

    Stage

    Not phased

    Ages

    25 to 80

    Site

    Duke University, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06703541 on ClinicalTrials.gov

24. Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

    PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the …

    Stage

    Phase 4

    Ages

    75 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    106 in total

    Run by

    Duke University

    See if you can join NCT04262206 on ClinicalTrials.gov

25. Effect of Cognitive Empathy Training on Dementia Caregivers

    The goal of this project is to investigate the effect of cognitive empathy training on mental health, inflammation, and immune function in caregivers of people living with dementia (PLWD), and to examine the underlying psychological and neurobiological mechanisms. The primary aim is to establish th…

    Stage

    Not phased

    Ages

    50 and older

    Site

    Alter, Atlanta, Georgia

    Locations

    3 in total

    Run by

    Emory University

    See if you can join NCT06650527 on ClinicalTrials.gov