Dementia Clinical Trials

84 studies are recruiting for dementia in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Enhancing Triadic Communication About Cognition for Older Adults With Alzheimer's Disease or Related Dementias Facing a Cancer Management Decision

   Building upon prior work, the investigator team developed a communication intervention for older adults with ADRD who are considering a decision about cancer management (adapted intervention: COACH-Cog). The investigators hypothesize that for patients with dual diagnoses of ADRD and cancer, COACH-C…

   Stage

   Not phased

   Ages

   65 and older

   Site

   University of Rochester Wilmot Cancer Institute, Rochester, New York

   Run by

   University of Rochester

   See if you can join NCT06313853 on ClinicalTrials.gov

2. Dementia Caregivers' Link to Assistance and Resources

   The goal of this clinical trial is to learn if the Dementia Caregivers' Link to Assistance and Resources (DECLARE) program can improve support of, and engagement with, caregivers of home health patients with dementia. DECLARE includes a caregiver self-assessment that is reported in the home health …

   Stage

   Not phased

   Ages

   Any age

   Site

   VNS Health Home Care, New York, New York

   Run by

   Visiting Nurse Service of New York

   See if you can join NCT06860035 on ClinicalTrials.gov

3. Anxiety Sensitivity Treatment to Reduce Anxiety in Alzheimer's

   The goal of this clinical trial is to test the effectiveness of a computerized anxiety sensitivity treatment (CAST) compared to a health education control (HEC) in older adults with mild cognitive impairment (MCI) or mild Alzheimer's Disease and related dementias (ADRD) and their care partners. The…

   Stage

   Not phased

   Ages

   60 and older

   Site

   Anxiety and Behavioral Health Clinic, Tallahassee, Florida

   Locations

   3 in total

   Run by

   Florida State University

   See if you can join NCT05748613 on ClinicalTrials.gov

4. Testing & Refinement of CarePair: An Assessment and Referral Platform to Support Family Caregivers of Alzheimer's Disease and Related Dementias.

   The purpose of this study is to develop and test CarePair, a mobile application-based needs assessment and service referral platform for family caregivers of persons with dementia designed to alleviate stress and promote psychosocial well being. The main aims of this study are: * To evaluate the fe…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Southern California, Los Angeles, California

   Run by

   University of Southern California

   See if you can join NCT06418971 on ClinicalTrials.gov

5. Sleep Enhancement for Older Adults Living With Memory Loss And Their Care Partners

   The purpose of this study is to determine if a 6-week videoconference intervention to teach skills to improve sleep is practical, acceptable, and helpful to persons living with memory loss, cognitive impairment, and/or dementia and care partners, individually or together.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Emory Healthcare System, Atlanta, Georgia

   Run by

   Emory University

   See if you can join NCT06250725 on ClinicalTrials.gov

6. Comparing Structured Retrieval Practice and Reading-Based Education for Dementia Caregivers

   Caring for a person living with dementia can be stressful, and many family caregivers report limited access to effective educational resources for managing dementia-related behaviors and caregiver stress. This study will evaluate a learning-based educational intervention called structured retrieval…

   Stage

   Not phased

   Ages

   50 and older

   Site

   Virginia Wesleyan University, Virginia Beach, Virginia

   Run by

   Virginia Wesleyan University

   See if you can join NCT07413406 on ClinicalTrials.gov

7. Evaluating the Efficacy of the Pain Identification and Communication Toolkit

   This study will evaluate the Pain Identification and Communication Toolkit (PICT), a multicomponent intervention for caregivers of people with Alzheimer's disease and related dementias (ADRD). PICT provides training in observational pain assessment and coaching in effective pain communication techn…

   Stage

   Not phased

   Ages

   21 and older

   Site

   Weill Cornell Medicine, New York, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT06168604 on ClinicalTrials.gov

8. Assessment of Foralumab Safety and Modulation of Microglial Activation in Alzheimer's Disease

   This phase 2a study will research the safety and tolerability of Foralumab, a human anti-CD3 antibody. An antibody is a molecule secreted by the immune system. These molecules are created to identify a specific pathogen. Previous data on experimental mice has suggested that Foralumab increases the …

   Stage

   Phase 2

   Ages

   60 to 85

   Site

   Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Boston, Massachusetts

   Run by

   Brigham and Women's Hospital

   See if you can join NCT06489548 on ClinicalTrials.gov

9. Tennessee Alzheimer's Project

   The primary objective of the Vanderbilt Alzheimer's Disease Research Center (VADRC) is to provide local and national researchers with access to a well-characterized and diverse clinical cohort, including participant referrals, biosamples, clinical data, and neuroimaging data. The VADRC Clinical Cor…

   Stage

   Not phased

   Ages

   60 and older

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT05372172 on ClinicalTrials.gov

10. Development of a Personalized, Psychosocial Intervention for Menopausal Individuals With Elevated Dementia Risk

    By age 45, women's lifetime risk of dementia is estimated to be 1 in 5. Two-thirds of people currently living with a dementia diagnosis are women, and-women make up the majority of carers for people with dementia. Because women bear a larger burden of the dementia epidemic, they tend to be more fea…

    Stage

    Not phased

    Ages

    40 to 58

    Site

    University of Chicago Medicine, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06965686 on ClinicalTrials.gov

11. Exploration of an Online Education Program to Support Caregivers' Knowledge Transfer

    The overarching goal of this work is to determine methods that improve caregiver education about the behavioral and psychological symptoms (BPSD) of dementia. The specific goal of this project is to extend our prior work to evaluate the impact of our educational intervention on caregivers' ability …

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Texas Christian University, Fort Worth, Texas

    Locations

    2 in total

    Run by

    Texas Christian University

    See if you can join NCT07377331 on ClinicalTrials.gov

12. Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia

    This project aims to examine the efficacy of remote, caregiver-led tES/brain stimulation intervention targeted to improve memory, mobility, and executive functioning among older adults with mild cognitive impairment or mild dementia.

    Stage

    Not phased

    Ages

    55 and older

    Site

    Hinda and Arthur Marcus Institute for Aging Research, Boston, Massachusetts

    Run by

    Hebrew SeniorLife

    See if you can join NCT05661084 on ClinicalTrials.gov

13. Caregiver as Navigator: Develop Skills Online (CAN-DO)

    This study is designed to learn more about ways to promote caregiver mastery online. 270 dementia family caregivers will be enrolled and randomized to take the CAN-DO online course immediately or after a waiting period. They will participate in interviews before and after the course; total time of …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Emory Roybal Center for Dementia Caregiving Mastery, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT06177990 on ClinicalTrials.gov

14. Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0

    The goal of this pragmatic cluster randomized clinical trial is to compare management of suspected infection in nursing home residents with dementia The main questions it aims to answer whether residents with dementia in nursing homes randomized to use a multicomponent intervention to optimize susp…

    Stage

    Not phased

    Ages

    60 to 106

    Site

    Hebrew SeniorLife, Boston, Massachusetts

    Run by

    Hebrew SeniorLife

    See if you can join NCT05950607 on ClinicalTrials.gov

15. Alzheimer's Prevention Registry: A Program to Accelerate Enrollment Into Studies

    The Alzheimer's Prevention Registry (www.endALZnow.org) will collect contact and demographic information on individuals. The objective is to provide information the latest news and advances in Alzheimer's prevention research, and to inform enrollees about research studies in their community. Enroll…

    Stage

    Not phased

    Ages

    18 to 110

    Site

    Banner Alzheimer's Institute, Phoenix, Arizona

    Run by

    Banner Health

    See if you can join NCT02022943 on ClinicalTrials.gov

16. The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia

    Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown. The aim is to discover the most efficacious combination of CT exercises as compared to cognitive stimulat…

    Stage

    Not phased

    Ages

    55 to 89

    Site

    University of California San Francisco, San Francisco, California

    Locations

    6 in total

    Run by

    University of Alabama at Birmingham

    See if you can join NCT04171323 on ClinicalTrials.gov

17. Dementia and Diabetes Prevention Program

    This is a multicenter, randomized 2-arm clinical trial of two lifestyle interventions varying in intensity and format, in 400 older African American and non-Hispanic whites at increased risk of cognitive decline and dementia in the East San Francisco Bay Area. The trial will include two lifestyle i…

    Stage

    Not phased

    Ages

    60 and older

    Site

    University of California, Davis Alzheimer's Disease Center, Walnut Creek, California

    Run by

    University of California, Davis

    See if you can join NCT04141878 on ClinicalTrials.gov

18. HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms

    This randomized controlled trial study aims to evaluate a revised hearing care intervention for older adults with Alzheimer's Disease and Related Dementias (ADRD). The community-delivered hearing care intervention utilizes tailored strategies to assess impact on communication, neuropsychiatric symp…

    Stage

    Not phased

    Ages

    60 to 100

    Site

    Johns Hopkins Memory and Alzheimer's Treatment Center, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06930560 on ClinicalTrials.gov

19. Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside

    This project's main goal is to use state-of-the-art passive sensing techniques to identify digital biomarkers that relate to bioenergetic changes in the brain due to nicotinamide riboside supplementation in those with mild cognitive impairment and mild Alzheimer's dementia.

    Stage

    Not phased

    Ages

    18 to 89

    Site

    McLean Hospital, Belmont, Massachusetts

    Run by

    Mclean Hospital

    See if you can join NCT05245903 on ClinicalTrials.gov

20. TabCAT Brain Health Assessment in Primary Care

    Efficient and user-friendly paradigms to detect cognitive impairment, including dementia are needed in primary care. The TabCAT Brain Health Assessment accurately detects cognitive impairment via an appealing tablet interface with automated scoring and EMR integration. This study will evaluate the …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Kaiser Permanente Southern California Department of Research & Evaluation, Pasadena, California

    Run by

    University of California, San Francisco

    See if you can join NCT06090578 on ClinicalTrials.gov

21. OCT Angiography and NRAI in Dementia

    The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: 1. Detect retinal blood vessel and blood flow changes in participants with dementia. 2. Detect amyloid protein deposits in the retinas of participants with dementia.

    Stage

    Not phased

    Ages

    55 and older

    Site

    Oregon Health & Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT03761381 on ClinicalTrials.gov

22. A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

    Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge. Older ICU survivors (ages 60 and older) are at highest risk for delirium and subsequent cognitive impairment, which con…

    Stage

    Not phased

    Ages

    60 and older

    Site

    University of Washington, Seattle, Washington

    Run by

    University of Washington

    See if you can join NCT06411561 on ClinicalTrials.gov

23. Alzheimer Prevention Trials (APT) Webstudy

    The goal of the Alzheimer Prevention Trials (APT) Webstudy is to accelerate enrollment for Alzheimer's disease (AD) clinical trials by identifying and tracking individuals who may be at higher risk for developing AD dementia.

    Stage

    Not phased

    Ages

    50 to 85

    Site

    Https://Www.Aptwebstudy.Org, San Diego, California

    Run by

    University of Southern California

    See if you can join NCT03638583 on ClinicalTrials.gov

24. E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app

    The goal of this clinical trial is to test whether a web-based application called the Pain Control Enhancement App (PACE-app) can support family caregivers in managing pain for their care recipients with dementia. The main questions it aims to answer are: Is it feasible and acceptable for family ca…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    College of Nursing, Iowa City, Iowa

    Run by

    University of Iowa

    See if you can join NCT07032350 on ClinicalTrials.gov

25. Dynamic Light Scattering Ocular Measurement in the Detection of Dementia

    This is a human clinical study making a noninvasive measurement from a patient's eye to determine whether there is a quantitative difference in measurements between patients with and without the diagnosis of dementia.

    Stage

    Not phased

    Ages

    18 and older

    Site

    3T Radiology, Coconut Creek, Florida

    Run by

    MD Stem Cells

    See if you can join NCT06613971 on ClinicalTrials.gov