Prostate Cancer Clinical Trials

289 studies are recruiting for prostate cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 8

1. Castrate Resistant Prostate Cancer Enhertu Therapy

   Use of Enhertu as a Subsequent Line of Therapy in HER2-Positive Metastatic Castration-Resistant Prostate Adenocarcinoma.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Washington DC VAMC, Washington D.C., District of Columbia

   Run by

   Washington D.C. Veterans Affairs Medical Center

   See if you can join NCT06610825 on ClinicalTrials.gov

2. Multimodal Telerehabilitation of Rural Patients With Advanced Prostate Cancer

   Prostate cancer has a significant impact on patient quality of life (QoL) directly, as well as through the management of localized disease (such as surgery and radiation-related incontinence, erectile dysfunction, and bowel dysfunction), and via direct side effects of androgen deprivation therapy (…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Huntsman Cancer Institute at University of Utah, Salt Lake City, Utah

   Run by

   University of Utah

   See if you can join NCT07093177 on ClinicalTrials.gov

3. Helping Men Adhere to Sexual Rehabilitation Following Prostate Cancer Surgery

   The purpose of this study is to test two different ways to help men with sexual rehabilitation.

   Stage

   Not phased

   Ages

   21 and older

   Site

   Memorial Sloan Kettering Cancer Center, New York, New York

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT02706561 on ClinicalTrials.gov

4. Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer

   This is a prospective, open-label, multi-center seamless phase II to phase III randomized clinical trial designed to compare SST with or without PET-directed local therapy in improving the castration-resistant prostate cancer-free survival (CRPC-free survival) for Veterans with oligometastatic pros…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   VA Long Beach Healthcare System, Long Beach, CA, Long Beach, California

   Locations

   20 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT04787744 on ClinicalTrials.gov

5. Cleveland African American Prostate Cancer Project

   The purpose of this research is to test intervention strategies that encourage and support Black or African American men who are 40 and older to complete prostate cancer screening, and specifically to complete a prostate-specific antigen (PSA) test.

   Stage

   Not phased

   Ages

   40 and older

   Site

   Barbershops Local to Cleveland, Cleveland, Ohio

   Run by

   Case Comprehensive Cancer Center

   See if you can join NCT05469269 on ClinicalTrials.gov

6. Microendoscopic EI Sensing for Real-time Intraoperative Surgical Margin Assessment

   This research will study a custom device developed to detect if any prostate cancer tissue is left behind when the prostate is removed. This device is called an Electrical Impedance Imaging (EII) probe.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

   Run by

   Ryan J. Halter

   See if you can join NCT06039085 on ClinicalTrials.gov

7. This is a Phase 1 Trial of ZM008, an Anti-LLT1 Antibody, Used as Single Agent Followed by Combination Treatment With Toripalimab in Patients With Advanced Solid Tumors

   This is a phase 1 dose escalation trial of ZM008, an anti-LLT1 antibody as a single agent followed by combination with Toripalimab in patients with advanced solid tumors who have exhausted all standard therapy available or are intolerant of the same.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Dana Farber Cancer Institute, Boston, Massachusetts

   Locations

   3 in total

   Run by

   Zumutor Biologics Inc.

   See if you can join NCT06451497 on ClinicalTrials.gov

8. Using a mHealth App to Improve Quality-of-Life Outcomes in Black Prostate Cancer Survivors

   The goal of this clinical trial is to ensure that the mobile health application for Black patients with prostate cancer (either actively undergoing treatment or survivors) is usable and acceptable to patients, get feedback about how to improve the app and assess its usefulness in examining their qu…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Florida State University, Tallahassee, Florida

   Locations

   3 in total

   Run by

   University of Oklahoma

   See if you can join NCT06651359 on ClinicalTrials.gov

9. SBRT Boost for Unfavorable Prostate Cancer'

   The purpose of this study is to find out whether giving a short course of focused radiation called an SBRT "boost" is a safe and effective way to treat prostate cancer. This boost delivers a high dose of radiation to the prostate in a non-invasive way, similar to what is done with high dose rate (H…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Orange Coast Memorial Medical Center, Fountain Valley, California

   Locations

   3 in total

   Run by

   MemorialCare Health System

   See if you can join NCT02016248 on ClinicalTrials.gov

10. Adjuvant Curcumin to Assess Recurrence Free Survival in Patients Who Have Had a Radical Prostatectomy

    This is a prospective study to determine if the adjuvant use of Curcumin improves recurrence-free survival.

    Stage

    Phase 3

    Ages

    30 to 80

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    yair lotan

    See if you can join NCT02064673 on ClinicalTrials.gov

11. SPECT Imaging for Pharmacokinetics and dosimEtry Towards TREATment Optimization

    The investigators will study SPECT imaging of radiopharmaceutical therapies given as standard of care or as part of other compatible research protocols. The goal is to validate the quantitative SPECT image reconstruction methods developed in this proposal, and to investigate the relation between do…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    Johns Hopkins University, Baltimore, Maryland

    Run by

    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    See if you can join NCT06389097 on ClinicalTrials.gov

12. A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

    This is a two-part, open-label, multicenter, dose escalation and dose expansion study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PDx), and anti- tumor activity of ETX-19477, a novel reversible small molecule inhibitor of PARG.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Mayo Clinic, Phoenix, Arizona

    Locations

    14 in total

    Run by

    858 Therapeutics, Inc.

    See if you can join NCT06395519 on ClinicalTrials.gov

13. Utility of 18F-rhPSMA-7.3 in the Diagnosis of Prostate Cancer After Focal Gland Treatment

    To evaluate the effectiveness of a PSMA-PET scan in identifying recurrent prostate cancer after focal therapy

    Stage

    Not phased

    Ages

    18 and older

    Site

    John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey

    Run by

    Hackensack Meridian Health

    See if you can join NCT07011342 on ClinicalTrials.gov

14. Mechanisms of Resistance to PSMA Radioligand Therapy

    This is a multicenter, correlative study to existing Lutetium based prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) trials and uses.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California, Los Angeles, Los Angeles, California

    Locations

    3 in total

    Run by

    University of California, San Francisco

    See if you can join NCT05435495 on ClinicalTrials.gov

15. 64Cu-GRIP B in Patients With Advanced Malignancies

    This phase I/II clinical trial evaluates if using a radiotracer targeting granzyme B, 64-copper granzyme targeting restricted interaction peptide specific to family member B (64 Cu-GRIP B) with positron emission tomography (PET) imaging can be safe and useful for detecting granzyme B (GrB) in patie…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    Rahul Aggarwal

    See if you can join NCT05888532 on ClinicalTrials.gov

16. Safety and Efficacy of 21 Gy, 23 Gy and 25 Gy for High Dose Rate (HDR) Prostate Brachytherapy

    The purpose of this research study is to learn more about the outcomes and early and late side effects of treating early stage prostate cancer with high dose rate brachytherapy.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT03424850 on ClinicalTrials.gov

17. Intensive Cholesterol-Lowering and CD8+ T Cells in Prostate Cancer

    To test the hypothesis that intensive cholesterol lowering (iCL) therapy has anti-tumor immune modulating activity, the investigators will conduct an open-label, single-arm phase II trial in prostate cancer patients who are in active surveillance and undergoing a planned surveillance biopsy in 3-6 …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Cedars-Sinai Medical Center, Los Angeles, California

    Run by

    Cedars-Sinai Medical Center

    See if you can join NCT06437574 on ClinicalTrials.gov

18. Evaluation of Tumor Control Based on Serial Multiparametric MRI and Post-Treatment Biopsies For Patients Treated With Dose Intensification to the Dominant Intra-Prostatic Lesion (DIL) Using Ultra-Hypofractionated, MR-Guided Radiotherapy

    The purpose of this study is to assess the impact of this MR-guided radiotherapy on tumor control of the dominant intraprostatic lesion among patients with intermediate risk prostate cancer. This study of Radiotherapy to the Prostate and Dominant Lesion Using Ultra-Hypofractionated, MR-adaptive Rad…

    Stage

    Not phased

    Ages

    18 and older

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT06542757 on ClinicalTrials.gov

19. Patient Decision-making About Precision Oncology in Veterans With Advanced Prostate Cancer

    This clinical trial explores and implements methods to improve informed decision making (IDM) regarding precision oncology tests amongst veterans with prostate cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Precision o…

    Stage

    Not phased

    Ages

    18 and older

    Site

    San Francisco Veterans Affairs Medical Center, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT05396872 on ClinicalTrials.gov

20. Stratagen Quantitative Prostate MRI Platform Pilot Study

    The goal of this clinical trial is to assess the safety and feasibility of the Stratagen Quantitative Prostate MRI Platform when used in addition to the standard scans conducted during the existing prostate MRI sessions. * What severe problems, if any, occur because of the use of the Stratagen Quan…

    Stage

    Not phased

    Ages

    40 to 90

    Site

    Urology Clinic at Sawgrass, Rochester, New York

    Locations

    2 in total

    Run by

    Stratagen Bio, Inc.

    See if you can join NCT06985238 on ClinicalTrials.gov

21. The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

    The Multi-OutcoMe EvaluatioN of radiation Therapy Using the Unity MR-Linac Study (MOMENTUM) is a multi-institutional, international registry facilitating evidenced based implementation of the Unity MR-Linac technology and further technical development of the MR-Linac system with the ultimate purpos…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Allegheny Health Network, Pittsburgh, Pennsylvania

    Locations

    18 in total

    Run by

    UMC Utrecht

    See if you can join NCT04075305 on ClinicalTrials.gov

22. Collection and Measurement of Biomarkers in Prostate Cancer Radiotherapy Patients

    The purpose of this research study is to learn about: 1) How standard radiation treatment to prostate (primary radiotherapy) or the pelvis after prostatectomy (postoperative radiotherapy) may cause changes in MRI and PET imaging traits that might be used in the future to predict response. 2) Compar…

    Stage

    Not phased

    Ages

    30 and older

    Site

    University of Miami, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT02997709 on ClinicalTrials.gov

23. T-reg Function Changes: a Novel Immune Regulatory Effect Underlying Benefit of Statin Use on Lethal Prostate Cancer

    This study will evaluate whether simvastatin reduces intraprostatic immunosuppressive microenvironment through YAP-mediated T-reg dysfunction, and increases intraprostatic anti-tumor immune response in men recently diagnosed with localized prostate cancer electing to receive prostatectomy for their…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Hollings Cancer Center at Medical University of South Carolina, Charleston, South Carolina

    Locations

    2 in total

    Run by

    Medical University of South Carolina

    See if you can join NCT05586360 on ClinicalTrials.gov

24. Using MRI to Identify Areas to Receive Lower Doses of Radiation Treatment in Men With Prostate Cancerdose Mapping to Preserve Quality of Life

    The purpose of this research is to gather information on the safety and effectiveness of using an imaging technique called magnetic resonance imaging (MRI) to decrease radiation dose to the uninvolved prostate (areas of the prostate that do not clearly have cancer cells) while increasing radiation …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06171269 on ClinicalTrials.gov

25. PSMA-PET Imaging for Detecting Early Metastatic Prostate Cancer in Men w/ High Decipher Test Scores

    This study will enroll 60 patients previously enrolled to MCC#18523, "A Validation Study on the Impact of Decipher® Testing on Treatment Recommendations in African-American and Non-African American Men with Prostate Cancer: (VANDAAM)" that had high risk Decipher test results (Decipher score >0.45).…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida

    Run by

    H. Lee Moffitt Cancer Center and Research Institute

    See if you can join NCT03495427 on ClinicalTrials.gov