Prostate Cancer Clinical Trials

287 studies are recruiting for prostate cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 8

1. Photodynamic Therapy of Primary Localized Prostate Cancer With the SpectraCure P18 System

   The goal of this study is to obtain safety data, establish dose parameters, and effectiveness of treatment for the SpectraCure P18 System with IDOSE®, together with verteporfin for injection (VFI) as photosensitizer, for the treatment of primary localized prostate cancer. The study will be divided …

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Memorial Sloan Kettering Cancer Center, New York, New York

   Locations

   3 in total

   Run by

   SpectraCure AB

   See if you can join NCT06807359 on ClinicalTrials.gov

2. Pilot Study of (MR) Imaging With Pyruvate (13C) to Detect High Grade Prostate Cancer

   This pilot clinical trial studies how well magnetic resonance spectroscopic imaging (MRSI) with hyperpolarized carbon 13 (13C) pyruvate alone or in combination with 13C 15N2 Urea works in finding prostate cancer that exhibits poorly differentiated or undifferentiated cells (high-grade) and that is …

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   University of California, San Francisco, San Francisco, California

   Run by

   Ivan de Kouchkovsky, MD

   See if you can join NCT02526368 on ClinicalTrials.gov

3. Metabolic Impact and Compliance of Controlled, Varying, Mediterranean Diets in Pre-Surgical Prostate Cancer Populations (PROVISIONS)

   The study aims to investigate whether following a controlled Mediterranean-style diet prior to robotic-assisted radical prostatectomy surgery in patients diagnosed with prostate cancer affects fasting insulin levels and other values that can be measured in blood and tissue samples from surgery.

   Stage

   Not phased

   Ages

   18 to 80

   Site

   University of Miami, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT06487507 on ClinicalTrials.gov

4. Clinical Trial of Approaches to Prostate Cancer Surgery

   This is a prospective, randomized controlled trial to compare cancer control and health-related quality of life following pelvic fascia-sparing radical prostatectomy versus standard radical prostatectomy. The investigators hypothesize that pelvic fascia-sparing radical prostatectomy will have simil…

   Stage

   Not phased

   Ages

   40 to 80

   Site

   Beckman Research Institute of City of Hope, Duarte, California

   Locations

   9 in total

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT05155501 on ClinicalTrials.gov

5. Intermittent Fasting in Prostate Cancer Patients Receiving Androgen Deprivation Therapy

   This is a a pilot study to assess the feasibility of intermittent caloric restriction (plus a plant-enriched diet optionally) in prostate cancer patients receiving androgen deprivation therapy. Study feasibility measures will include enrollment rate, drop-out rate and compliance with diet measured …

   Stage

   Not phased

   Ages

   18 and older

   Site

   University at Buffalo/Great Lakes Cancer Center, Buffalo, New York

   Run by

   State University of New York at Buffalo

   See if you can join NCT06172283 on ClinicalTrials.gov

6. Phase I/II Trial of Pembrolizumab and Androgen-receptor Inhibitor With or Without 225Ac-J591 for Progressive Metastatic Castration Resistant Prostate Cancer

   This is a phase I/II study investigating the combination of 225Ac-J591 (a drug that can deliver radiation to prostate cancer cells) with pembrolizumab (immunotherapy, a drug that increases the immune system's ability to destroy cancer cells). This study will assess whether 225Ac-J591 + pembrolizuma…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   New York Presbyterian/Brooklyn Methodist Hospital, Brooklyn, New York

   Locations

   4 in total

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT04946370 on ClinicalTrials.gov

7. Outcomes of Focal Ablation for Prostate Cancer

   This study will be designed to define the efficacy and safety of ablative therapies in the management of localized prostate cancer and comprehensively evaluate quality of life outcomes and oncologic control following treatment.

   Stage

   Not phased

   Ages

   18 to 90

   Site

   UTSW, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT05478694 on ClinicalTrials.gov

8. HIFU for Focal Ablation of Prostate Tissue: An Observational Study

   The Sonablate HIFU device was approved by the U.S.FDA for prostate tissue ablation in October, 2015. The purpose of this observational research study is to investigate the localized treatment of prostate cancer using HIFU through clinical data and health-related quality of life (HRQOL) questionnair…

   Stage

   Not phased

   Ages

   40 to 85

   Site

   University of California, Los Angeles, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT03620786 on ClinicalTrials.gov

9. Tumor Genomic Pre-test Counseling Tool for Black or African-American Men With Prostate Cancer

   The overall goal of the study is to improve equitable delivery of pre-Tumor genetic testing (TGT) counseling tool for Black or African American men with metastatic prostate cancer and evaluating the tool for implementation.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of California, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT06171139 on ClinicalTrials.gov

10. A Study of 2141-V11 in Combination With Standard Treatments in People With Prostate Cancer

    The purpose of this study is to see whether combining 2141-V11 with various standard treatments is an effective treatment approach for prostate cancer. 2141-V11 works by activating the immune system to find and kill cancer cells. Researchers will look at whether this treatment approach is able to c…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey

    Locations

    7 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT06347705 on ClinicalTrials.gov

11. Androgen Suppression Combined With Nodal Irradiation and Dose Escalated Prostate Treatment

    This study is being done to answer the following question: Is the strategy to give higher doses of radiotherapy treatment over a shorter period of time using special equipment and fewer treatments (also known as Stereotactic Body Radiation Therapy or SBRT) as effective as usual external radiation t…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Kaiser Permanente-Deer Valley Medical Center, Antioch, California

    Locations

    57 in total

    Run by

    Canadian Cancer Trials Group

    See if you can join NCT06235697 on ClinicalTrials.gov

12. Fatty Acid Synthase Inhibition in Castration Refractory Prostate Cancer

    The purpose of this research study is to find out what effects (good and bad) omeprazole and cabazitaxel, or omeprazole and docetaxel, has on participants and their condition. Investigators believe omeprazole may help the other medications work.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    W.G. Bill Hefner VA Medical Center, Salisbury, North Carolina

    Locations

    2 in total

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT04337580 on ClinicalTrials.gov

13. Prospective Evaluation of Pencil Beam Scanning Proton Therapy for Previously Irradiated Tumors

    The goal of this clinical research trial is to study the use of differing investigational doses and scheduling for Proton Therapy for tumors previously treated with radiation therapy. Generally, when patients are first treated for cancer with radiation therapy, they are treated with traditional pho…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The New York Proton Center, New York, New York

    Run by

    The New York Proton Center

    See if you can join NCT05313191 on ClinicalTrials.gov

14. Gedatolisib in Combination With Darolutamide in Metastatic Castration-Resistant Prostate Cancer

    This is a Phase 1/2, open-label, randomized, dose finding and dose expansion study to evaluate the safety, preliminary efficacy, and PK of gedatolisib in combination with darolutamide in subjects with mCRPC.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Barbara Ann Karmanos Cancer Institute, Detroit, Michigan

    Locations

    13 in total

    Run by

    Celcuity Inc

    See if you can join NCT06190899 on ClinicalTrials.gov

15. Castrate Resistant Prostate Cancer Enhertu Therapy

    Use of Enhertu as a Subsequent Line of Therapy in HER2-Positive Metastatic Castration-Resistant Prostate Adenocarcinoma.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Washington DC VAMC, Washington D.C., District of Columbia

    Run by

    Washington D.C. Veterans Affairs Medical Center

    See if you can join NCT06610825 on ClinicalTrials.gov

16. Multimodal Telerehabilitation of Rural Patients With Advanced Prostate Cancer

    Prostate cancer has a significant impact on patient quality of life (QoL) directly, as well as through the management of localized disease (such as surgery and radiation-related incontinence, erectile dysfunction, and bowel dysfunction), and via direct side effects of androgen deprivation therapy (…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Huntsman Cancer Institute at University of Utah, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT07093177 on ClinicalTrials.gov

17. Helping Men Adhere to Sexual Rehabilitation Following Prostate Cancer Surgery

    The purpose of this study is to test two different ways to help men with sexual rehabilitation.

    Stage

    Not phased

    Ages

    21 and older

    Site

    Memorial Sloan Kettering Cancer Center, New York, New York

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT02706561 on ClinicalTrials.gov

18. Cleveland African American Prostate Cancer Project

    The purpose of this research is to test intervention strategies that encourage and support Black or African American men who are 40 and older to complete prostate cancer screening, and specifically to complete a prostate-specific antigen (PSA) test.

    Stage

    Not phased

    Ages

    40 and older

    Site

    Barbershops Local to Cleveland, Cleveland, Ohio

    Run by

    Case Comprehensive Cancer Center

    See if you can join NCT05469269 on ClinicalTrials.gov

19. Microendoscopic EI Sensing for Real-time Intraoperative Surgical Margin Assessment

    This research will study a custom device developed to detect if any prostate cancer tissue is left behind when the prostate is removed. This device is called an Electrical Impedance Imaging (EII) probe.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

    Run by

    Ryan J. Halter

    See if you can join NCT06039085 on ClinicalTrials.gov

20. This is a Phase 1 Trial of ZM008, an Anti-LLT1 Antibody, Used as Single Agent Followed by Combination Treatment With Toripalimab in Patients With Advanced Solid Tumors

    This is a phase 1 dose escalation trial of ZM008, an anti-LLT1 antibody as a single agent followed by combination with Toripalimab in patients with advanced solid tumors who have exhausted all standard therapy available or are intolerant of the same.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Dana Farber Cancer Institute, Boston, Massachusetts

    Locations

    3 in total

    Run by

    Zumutor Biologics Inc.

    See if you can join NCT06451497 on ClinicalTrials.gov

21. Using a mHealth App to Improve Quality-of-Life Outcomes in Black Prostate Cancer Survivors

    The goal of this clinical trial is to ensure that the mobile health application for Black patients with prostate cancer (either actively undergoing treatment or survivors) is usable and acceptable to patients, get feedback about how to improve the app and assess its usefulness in examining their qu…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Florida State University, Tallahassee, Florida

    Locations

    3 in total

    Run by

    University of Oklahoma

    See if you can join NCT06651359 on ClinicalTrials.gov

22. SBRT Boost for Unfavorable Prostate Cancer'

    The purpose of this study is to find out whether giving a short course of focused radiation called an SBRT "boost" is a safe and effective way to treat prostate cancer. This boost delivers a high dose of radiation to the prostate in a non-invasive way, similar to what is done with high dose rate (H…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Orange Coast Memorial Medical Center, Fountain Valley, California

    Locations

    3 in total

    Run by

    MemorialCare Health System

    See if you can join NCT02016248 on ClinicalTrials.gov

23. Adjuvant Curcumin to Assess Recurrence Free Survival in Patients Who Have Had a Radical Prostatectomy

    This is a prospective study to determine if the adjuvant use of Curcumin improves recurrence-free survival.

    Stage

    Phase 3

    Ages

    30 to 80

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    yair lotan

    See if you can join NCT02064673 on ClinicalTrials.gov

24. SPECT Imaging for Pharmacokinetics and dosimEtry Towards TREATment Optimization

    The investigators will study SPECT imaging of radiopharmaceutical therapies given as standard of care or as part of other compatible research protocols. The goal is to validate the quantitative SPECT image reconstruction methods developed in this proposal, and to investigate the relation between do…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    Johns Hopkins University, Baltimore, Maryland

    Run by

    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    See if you can join NCT06389097 on ClinicalTrials.gov

25. A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

    This is a two-part, open-label, multicenter, dose escalation and dose expansion study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PDx), and anti- tumor activity of ETX-19477, a novel reversible small molecule inhibitor of PARG.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Mayo Clinic, Phoenix, Arizona

    Locations

    14 in total

    Run by

    858 Therapeutics, Inc.

    See if you can join NCT06395519 on ClinicalTrials.gov