Prostate Cancer Clinical Trials

287 studies are recruiting for prostate cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 7

1. Postoperative or Salvage Radiotherapy (RT) for Node Negative Prostate Cancer Following Radical Prostatectomy

   The purpose of this study is to see what effects, good and/or bad, proton radiation, and/or conventional radiation and hormonal therapy (if applicable), has on prostate cancer that has already returned or the risk of prostate cancer returning.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Proton Center of Arkansas, Little Rock, Arkansas

   Locations

   6 in total

   Run by

   Proton Collaborative Group

   See if you can join NCT00969111 on ClinicalTrials.gov

2. Prostate Cancer Treatment Using Androgen Deprivation Therapy and Focal Prostate Ablation

   The purpose of this research is to gather information on the safety and effectiveness of combining focal prostate ablation therapy ((aka Focal Therapy, a surgical procedure) and androgen deprivation therapy (hormone therapy).

   Stage

   Phase 2

   Ages

   18 and older

   Site

   UChicago Medicine Comprehensive Cancer Center, Chicago, Illinois

   Run by

   University of Chicago

   See if you can join NCT05790213 on ClinicalTrials.gov

3. PSMA-Directed Para-Aortic Radiation Therapy for Oligorecurrent Prostate Cancer

   The purpose of this prostate cancer research study is to learn about: 1. Improving control of prostate cancer using radiation therapy, delivered to the para-aortic and pelvic lymph nodes, in addition to systemic androgen suppression therapy; 2. Preserving quality of life after radiation therapy; 3.…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Miami, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT06392295 on ClinicalTrials.gov

4. Trial of Curcumin to Prevent Progression of Low-risk Prostate Cancer Under Active Surveillance

   This is a prospective study to determine if the use of curcumin randomized against placebo will reduce cancer progression in patients with prostate cancer undergoing active surveillance.

   Stage

   Phase 3

   Ages

   40 to 89

   Site

   UT Southwestern Medical Center, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT03769766 on ClinicalTrials.gov

5. HER2 FPBMC in Patients With Metastatic Breast and Prostate Cancer (AM006)

   The purpose of this study is to understand the safety and estimate the efficacy of anti-CD3 x anti-HER2 bispecific antibody (HER2Bi) armed fresh peripheral blood mononuclear cells (HER2 FPBMC) for patients with metastatic breast or prostate cancer. Participants receive 5 weekly doses of CD33 FPBMC …

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of Virginia, Charlottesville, Virginia

   Run by

   University of Virginia

   See if you can join NCT07441889 on ClinicalTrials.gov

6. Phase I Study of 225Ac-J591 Plus 177Lu-PSMA Small Molecule for Progressive Metastatic Castration Resistant Prostate Cancer

   This is a phase I dose-escalation study of 225Ac-J591 administered together with 177Lu-PSMA small molecule. Both drugs are designed to deliver radiation to prostate cancer cells; they are known as radionuclide conjugates (radiation linked to antibodies/molecules that recognize prostate cancer cells…

   Stage

   Phase 1

   Ages

   18 to 99

   Site

   Brooklyn Methodist Hospital - New York Presbyterian, Brooklyn, New York

   Locations

   2 in total

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT04886986 on ClinicalTrials.gov

7. The Use of Nanoparticles to Guide the Surgical Treatment of Prostate Cancer

   The purpose of this study is to see whether using the copper-64 (64Cu) or zirconium-89 (89Zr) radiolabeled PSMA-targeting C' dot tracer, termed 64Cu-NOTA-PSMAi-PEG-Cy5.5-C' dots or 89Zr-DFO-PSMAi-PEG-Cy5.5-C' dots, is a safe way to identify tumor cells before and during surgery for prostate cancer.…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Memorial Sloan Kettering Cancer Center, New York, New York

   Locations

   2 in total

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT04167969 on ClinicalTrials.gov

8. Dose Determining Study of EXS74539 (REC-4539) in Participants With Select Solid Tumors

   The primary purpose of this study is to determine the safety, tolerability, and maximum tolerated dose (MTD) of EXS74539 (REC-4539) in participants with select solid tumors.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Start Lacn, Los Angeles, California

   Locations

   3 in total

   Run by

   Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc.

   See if you can join NCT07517198 on ClinicalTrials.gov

9. A Feasibility Study of Biometric Measurements Via Wearable Smart Watch Technology for Evaluation of Vasomotor Symptoms in Patients Treated With Androgen Deprivation Therapy for Prostate Cancer (Prostate 007)

   The purpose of this study is to find out if patients with prostate cancer who have vasomotor symptoms, commonly called hot flashes, from their Androgen Deprivation Therapy (ADT) will consistently wear a smartwatch device to track their health data, log hot flashes on their smartwatch, and how these…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Virginia Health System, Charlottesville, Virginia

   Run by

   University of Virginia

   See if you can join NCT07535541 on ClinicalTrials.gov

10. High Intensity Focused Ultrasound in Prostate Cancer

    This study will investigate the efficacy of focal high intensity focused ultrasound (HIFU) in patients with localized radiorecurrent prostate cancer. This study will also investigate the change in participant quality of life after HIFU therapy as compared to before HIFU therapy.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT06402357 on ClinicalTrials.gov

11. Neoadjuvant Atezolizumab-Based Combination Therapy in Men With Localized Prostate Cancer Prior to Radical Prostatectomy

    This phase II trial studies how well atezolizumab works alone or in combination with etrumadenant or tocilizumab in treating men with localized prostate cancer before radical prostatectomy. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of California, San Francisco, San Francisco, California

    Locations

    2 in total

    Run by

    David Oh

    See if you can join NCT03821246 on ClinicalTrials.gov

12. Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer

    The purpose of this post-marketing study is to further characterize the long-term outcome of known or potential risks of lutetium (177Lu) vipivotide tetraxetan also known as [177Lu]Lu-PSMA-617 or 177Lu-PSMA-617 and hereinafter referred to as AAA617. The study also seeks to further characterize (as …

    Stage

    Phase 4

    Ages

    18 to 100

    Site

    Mayo Clinic Arizona, Scottsdale, Arizona

    Locations

    54 in total

    Run by

    Novartis Pharmaceuticals

    See if you can join NCT05803941 on ClinicalTrials.gov

13. TERPS Trial for de Novo Oligometastic Prostate Cancer

    This research is being done to see if we can improve the outcome of prostate cancer patients who present with metastatic lesions at initial diagnosis.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    UC San Diego Moores Cancer Center, La Jolla, California

    Locations

    10 in total

    Run by

    University of Maryland, Baltimore

    See if you can join NCT05223803 on ClinicalTrials.gov

14. CUIMC Focal Therapy Registry

    Patients undergoing high intensity focused ultrasound (HIFU) or irreversible electroporation (IRE) for prostate cancer will be invited to consent to have their data collected in a detailed comprehensive system to record and store patient, disease, and treatment-related characteristics. No treatment…

    Stage

    Not phased

    Ages

    40 to 85

    Site

    Columbia University Irving Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT07623941 on ClinicalTrials.gov

15. An Evidence-Based Focal Cryotherapy Protocol for Focal Ablation of Intermediate Risk Prostate Cancer

    To learn if using cryotherapy to treat only the part of the prostate known to contain cancer is effective in controlling prostate cancer

    Stage

    Phase 2

    Ages

    18 and older

    Site

    MD Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT05454488 on ClinicalTrials.gov

16. 177Lu-PSMA-617 With Liver Directed Therapy in Metastatic Castration Resistant Prostate Cancer

    This is an open label, single arm, phase 1b study to determine the safety of combining sequential Prostate-Specific Membrane Antigen (PSMA)-targeted 177Lu-PSMA-617 radionuclide therapy with liver-directed therapy in metastatic castrate-resistant prostate cancer (mCRPC) patients with liver metastase…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT07145177 on ClinicalTrials.gov

17. Androgen-responsive POSLUMA-guided Intra-prostatic Boost

    This research study is for men with intermediate- or high-risk prostate cancer who are planning to receive hormone therapy and radiation treatment. The purpose of the study is to see whether a special type of diagnostic imaging done during hormone therapy can help doctors more accurately target rem…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Medical Center, Milford, Massachusetts

    Locations

    4 in total

    Run by

    Martin T. King, MD, PhD

    See if you can join NCT07393867 on ClinicalTrials.gov

18. Active Surveillance for Cancer of the Prostate (ASCaP)

    Active Surveillance (A.S.) of prostate cancer (CaP) is the systematic monitoring of men with low-risk, localized lesions, with curative treatment of those whose tumors show substantial progression. A.S. is different from Watchful Waiting (W.W.), which is the palliative treatment of men with progres…

    Stage

    Not phased

    Ages

    30 to 85

    Site

    University of California Los Angeles, Los Angeles, California

    Run by

    Jonsson Comprehensive Cancer Center

    See if you can join NCT00949819 on ClinicalTrials.gov

19. International Registry for Men With Advanced Prostate Cancer (IRONMAN)

    Our intent is to establish the International Registry to Improve Outcomes in Men with Advanced Prostate Cancer (IRONMAN) as a prospective, international cohort of minimum 5,000 men with advanced cancer, including men with mHSPC and M0/M1 CRPC. The goal is to establish a population-based registry an…

    Stage

    Not phased

    Ages

    21 and older

    Site

    University of Alabama- Tuscaloosa, Tuscaloosa, Alabama

    Locations

    121 in total

    Run by

    Prostate Cancer Clinical Trials Consortium

    See if you can join NCT03151629 on ClinicalTrials.gov

20. Robotic Opioid-free Prostatectomy Enhanced Strategy (ROPES)

    This prospective, interventional, open-label, phase 3 randomized study evaluates a multimodal analgesia discharge pathway to reduce automatic opioid prescribing following routine robotic-assisted laparoscopic prostatectomy (RALP). Patients are counseled on post-operative pain management and then ma…

    Stage

    Phase 3

    Ages

    45 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Brigham and Women's Hospital

    See if you can join NCT07427043 on ClinicalTrials.gov

21. Hyperpolarized Pyruvate (13C) MR Imaging in Monitoring Patients With Prostate Cancer on Active Surveillance

    This phase II trial studies the side how well hyperpolarized carbon C 13 pyruvate (HP C-13 pyruvate) magnetic resonance imaging (MRI) works in monitoring patients with prostate cancer on active surveillance who have not received treatment. Diagnostic procedures, such as MRI, may help visualize HP C…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT03933670 on ClinicalTrials.gov

22. Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection

    To determine the dose, safety, radiation dosimetry and efficacy of 177Lu-rhPSMA-10.1 in participants with PSMA-expressing metastatic castrate resistant prostate cancer.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Biogenix Molecular LLC, Miami, Florida

    Locations

    21 in total

    Run by

    Blue Earth Therapeutics Ltd

    See if you can join NCT05413850 on ClinicalTrials.gov

23. Brodalumab in the Treatment of Immune-Related Adverse Events

    The purpose of this study is to test the safety and effectiveness of using brodalumab in patients who develop side effects from cancer immune therapy. Immune-related side effects are due to activation of the immune system in patients who previously received immunotherapy and the goal of this study …

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Columbia University Irving Medical Center, New York, New York

    Run by

    Brian Henick, MD

    See if you can join NCT06673329 on ClinicalTrials.gov

24. Axelopran for Advanced Cancer in Patients Receiving Opioids

    The primary objective of this single arm, open label, phase II trial is to determine if axelopran use impacts cancer control in patients with advanced cancers of the lung, breast, pancreas, and prostate. The primary study period for assessing the primary aim is through day 43 (6 weeks). The main qu…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    HealthPartners Frauenshuh Cancer Research Center, Saint Louis Park, Minnesota

    Locations

    2 in total

    Run by

    HealthPartners Institute

    See if you can join NCT07354919 on ClinicalTrials.gov

25. Evaluation of Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography in Active Surveillance for Prostate CancEr

    This study will be assessing the ability of PSMA-PET CT to determine the absence of clinically significant prostate cancer in patients on active surveillance (AS) with low risk and favorable intermediate-risk prostate cancer.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Weill Cornell Medicine - New York Presbyterian Hospital, New York, New York

    Locations

    4 in total

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT05948657 on ClinicalTrials.gov