Prostate Cancer Clinical Trials

289 studies are recruiting for prostate cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 7

1. International Registry for Men With Advanced Prostate Cancer (IRONMAN)

   Our intent is to establish the International Registry to Improve Outcomes in Men with Advanced Prostate Cancer (IRONMAN) as a prospective, international cohort of minimum 5,000 men with advanced cancer, including men with mHSPC and M0/M1 CRPC. The goal is to establish a population-based registry an…

   Stage

   Not phased

   Ages

   21 and older

   Site

   University of Alabama- Tuscaloosa, Tuscaloosa, Alabama

   Locations

   121 in total

   Run by

   Prostate Cancer Clinical Trials Consortium

   See if you can join NCT03151629 on ClinicalTrials.gov

2. Video Education With Result Dependent dIsclosure

   The overall study objective of this trial study is to identify and evaluate strategies to improve the accessibility of the video education with result dependent disclosure (VERDI) model, increasingly utilized as a pre-genetic testing (pretest) education alternative in clinical practice, to better s…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Dana Farber Cancer Institute, Boston, Massachusetts

   Run by

   Dana-Farber Cancer Institute

   See if you can join NCT05225428 on ClinicalTrials.gov

3. Robotic Opioid-free Prostatectomy Enhanced Strategy (ROPES)

   This prospective, interventional, open-label, phase 3 randomized study evaluates a multimodal analgesia discharge pathway to reduce automatic opioid prescribing following routine robotic-assisted laparoscopic prostatectomy (RALP). Patients are counseled on post-operative pain management and then ma…

   Stage

   Phase 3

   Ages

   45 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Locations

   2 in total

   Run by

   Brigham and Women's Hospital

   See if you can join NCT07427043 on ClinicalTrials.gov

4. Hyperpolarized Pyruvate (13C) MR Imaging in Monitoring Patients With Prostate Cancer on Active Surveillance

   This phase II trial studies the side how well hyperpolarized carbon C 13 pyruvate (HP C-13 pyruvate) magnetic resonance imaging (MRI) works in monitoring patients with prostate cancer on active surveillance who have not received treatment. Diagnostic procedures, such as MRI, may help visualize HP C…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of California, San Francisco, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT03933670 on ClinicalTrials.gov

5. Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection

   To determine the dose, safety, radiation dosimetry and efficacy of 177Lu-rhPSMA-10.1 in participants with PSMA-expressing metastatic castrate resistant prostate cancer.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Biogenix Molecular LLC, Miami, Florida

   Locations

   21 in total

   Run by

   Blue Earth Therapeutics Ltd

   See if you can join NCT05413850 on ClinicalTrials.gov

6. Brodalumab in the Treatment of Immune-Related Adverse Events

   The purpose of this study is to test the safety and effectiveness of using brodalumab in patients who develop side effects from cancer immune therapy. Immune-related side effects are due to activation of the immune system in patients who previously received immunotherapy and the goal of this study …

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Columbia University Irving Medical Center, New York, New York

   Run by

   Brian Henick, MD

   See if you can join NCT06673329 on ClinicalTrials.gov

7. Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

   This study is designed to characterize the safety, tolerability, and anti-tumor activity of MDX2001 in patients with advanced solid tumors.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Sarah Cannon Research Institute, Denver, Colorado

   Locations

   6 in total

   Run by

   ModeX Therapeutics, An OPKO Health Company

   See if you can join NCT06239194 on ClinicalTrials.gov

8. Axelopran for Advanced Cancer in Patients Receiving Opioids

   The primary objective of this single arm, open label, phase II trial is to determine if axelopran use impacts cancer control in patients with advanced cancers of the lung, breast, pancreas, and prostate. The primary study period for assessing the primary aim is through day 43 (6 weeks). The main qu…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   HealthPartners Frauenshuh Cancer Research Center, Saint Louis Park, Minnesota

   Locations

   2 in total

   Run by

   HealthPartners Institute

   See if you can join NCT07354919 on ClinicalTrials.gov

9. Evaluation of Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography in Active Surveillance for Prostate CancEr

   This study will be assessing the ability of PSMA-PET CT to determine the absence of clinically significant prostate cancer in patients on active surveillance (AS) with low risk and favorable intermediate-risk prostate cancer.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Weill Cornell Medicine - New York Presbyterian Hospital, New York, New York

   Locations

   4 in total

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT05948657 on ClinicalTrials.gov

10. Photodynamic Therapy of Primary Localized Prostate Cancer With the SpectraCure P18 System

    The goal of this study is to obtain safety data, establish dose parameters, and effectiveness of treatment for the SpectraCure P18 System with IDOSE®, together with verteporfin for injection (VFI) as photosensitizer, for the treatment of primary localized prostate cancer. The study will be divided …

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Cancer Center, New York, New York

    Locations

    3 in total

    Run by

    SpectraCure AB

    See if you can join NCT06807359 on ClinicalTrials.gov

11. Pilot Study of (MR) Imaging With Pyruvate (13C) to Detect High Grade Prostate Cancer

    This pilot clinical trial studies how well magnetic resonance spectroscopic imaging (MRSI) with hyperpolarized carbon 13 (13C) pyruvate alone or in combination with 13C 15N2 Urea works in finding prostate cancer that exhibits poorly differentiated or undifferentiated cells (high-grade) and that is …

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    Ivan de Kouchkovsky, MD

    See if you can join NCT02526368 on ClinicalTrials.gov

12. Metabolic Impact and Compliance of Controlled, Varying, Mediterranean Diets in Pre-Surgical Prostate Cancer Populations (PROVISIONS)

    The study aims to investigate whether following a controlled Mediterranean-style diet prior to robotic-assisted radical prostatectomy surgery in patients diagnosed with prostate cancer affects fasting insulin levels and other values that can be measured in blood and tissue samples from surgery.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of Miami, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT06487507 on ClinicalTrials.gov

13. Clinical Trial of Approaches to Prostate Cancer Surgery

    This is a prospective, randomized controlled trial to compare cancer control and health-related quality of life following pelvic fascia-sparing radical prostatectomy versus standard radical prostatectomy. The investigators hypothesize that pelvic fascia-sparing radical prostatectomy will have simil…

    Stage

    Not phased

    Ages

    40 to 80

    Site

    Beckman Research Institute of City of Hope, Duarte, California

    Locations

    9 in total

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT05155501 on ClinicalTrials.gov

14. Intermittent Fasting in Prostate Cancer Patients Receiving Androgen Deprivation Therapy

    This is a a pilot study to assess the feasibility of intermittent caloric restriction (plus a plant-enriched diet optionally) in prostate cancer patients receiving androgen deprivation therapy. Study feasibility measures will include enrollment rate, drop-out rate and compliance with diet measured …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University at Buffalo/Great Lakes Cancer Center, Buffalo, New York

    Run by

    State University of New York at Buffalo

    See if you can join NCT06172283 on ClinicalTrials.gov

15. Phase I/II Trial of Pembrolizumab and Androgen-receptor Inhibitor With or Without 225Ac-J591 for Progressive Metastatic Castration Resistant Prostate Cancer

    This is a phase I/II study investigating the combination of 225Ac-J591 (a drug that can deliver radiation to prostate cancer cells) with pembrolizumab (immunotherapy, a drug that increases the immune system's ability to destroy cancer cells). This study will assess whether 225Ac-J591 + pembrolizuma…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    New York Presbyterian/Brooklyn Methodist Hospital, Brooklyn, New York

    Locations

    4 in total

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT04946370 on ClinicalTrials.gov

16. Outcomes of Focal Ablation for Prostate Cancer

    This study will be designed to define the efficacy and safety of ablative therapies in the management of localized prostate cancer and comprehensively evaluate quality of life outcomes and oncologic control following treatment.

    Stage

    Not phased

    Ages

    18 to 90

    Site

    UTSW, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT05478694 on ClinicalTrials.gov

17. PSMA-PET Guided De-escalation of Salvage Radiation Treatment in Recurrent Prostate Cancer

    Purpose: Prospective, single-site Phase II study testing whether PSMA-PET/MRI-guided, de-escalated salvage radiation reduces acute Grade ≥2 toxicity versus a 44% historical rate, while maintaining cancer control after prostatectomy.Population/Eligibility: Adult men ≥30 years with prior radical pros…

    Stage

    Phase 2

    Ages

    30 and older

    Site

    University of Nebraska Medical Center, Omaha, Nebraska

    Run by

    University of Nebraska

    See if you can join NCT07234981 on ClinicalTrials.gov

18. HIFU for Focal Ablation of Prostate Tissue: An Observational Study

    The Sonablate HIFU device was approved by the U.S.FDA for prostate tissue ablation in October, 2015. The purpose of this observational research study is to investigate the localized treatment of prostate cancer using HIFU through clinical data and health-related quality of life (HRQOL) questionnair…

    Stage

    Not phased

    Ages

    40 to 85

    Site

    University of California, Los Angeles, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT03620786 on ClinicalTrials.gov

19. Older Men's Decision Making About Active Surveillance for Prostate Cancer - Aim 3: Decision Aid Cognitive and Usability Testing

    This protocol describes development and user testing of an educational shared decision making intervention to help men with prostate cancer who are on active surveillance make decisions with their health care providers about if and when to de-escalate surveillance testing. The project is important …

    Stage

    Not phased

    Ages

    65 and older

    Site

    M D Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT05497024 on ClinicalTrials.gov

20. Tumor Genomic Pre-test Counseling Tool for Black or African-American Men With Prostate Cancer

    The overall goal of the study is to improve equitable delivery of pre-Tumor genetic testing (TGT) counseling tool for Black or African American men with metastatic prostate cancer and evaluating the tool for implementation.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT06171139 on ClinicalTrials.gov

21. A Study of 2141-V11 in Combination With Standard Treatments in People With Prostate Cancer

    The purpose of this study is to see whether combining 2141-V11 with various standard treatments is an effective treatment approach for prostate cancer. 2141-V11 works by activating the immune system to find and kill cancer cells. Researchers will look at whether this treatment approach is able to c…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey

    Locations

    7 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT06347705 on ClinicalTrials.gov

22. Androgen Suppression Combined With Nodal Irradiation and Dose Escalated Prostate Treatment

    This study is being done to answer the following question: Is the strategy to give higher doses of radiotherapy treatment over a shorter period of time using special equipment and fewer treatments (also known as Stereotactic Body Radiation Therapy or SBRT) as effective as usual external radiation t…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Kaiser Permanente-Deer Valley Medical Center, Antioch, California

    Locations

    57 in total

    Run by

    Canadian Cancer Trials Group

    See if you can join NCT06235697 on ClinicalTrials.gov

23. Fatty Acid Synthase Inhibition in Castration Refractory Prostate Cancer

    The purpose of this research study is to find out what effects (good and bad) omeprazole and cabazitaxel, or omeprazole and docetaxel, has on participants and their condition. Investigators believe omeprazole may help the other medications work.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    W.G. Bill Hefner VA Medical Center, Salisbury, North Carolina

    Locations

    2 in total

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT04337580 on ClinicalTrials.gov

24. Prospective Evaluation of Pencil Beam Scanning Proton Therapy for Previously Irradiated Tumors

    The goal of this clinical research trial is to study the use of differing investigational doses and scheduling for Proton Therapy for tumors previously treated with radiation therapy. Generally, when patients are first treated for cancer with radiation therapy, they are treated with traditional pho…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The New York Proton Center, New York, New York

    Run by

    The New York Proton Center

    See if you can join NCT05313191 on ClinicalTrials.gov

25. Gedatolisib in Combination With Darolutamide in Metastatic Castration-Resistant Prostate Cancer

    This is a Phase 1/2, open-label, randomized, dose finding and dose expansion study to evaluate the safety, preliminary efficacy, and PK of gedatolisib in combination with darolutamide in subjects with mCRPC.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Barbara Ann Karmanos Cancer Institute, Detroit, Michigan

    Locations

    13 in total

    Run by

    Celcuity Inc

    See if you can join NCT06190899 on ClinicalTrials.gov