Prostate Cancer Clinical Trials in Indianapolis, Indiana

11 studies are recruiting for prostate cancer in Indianapolis, Indiana right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

Studies now recruiting

1. Positron Emission Tomography Using 64Cu-SAR-bisPSMA in Participants With High-risk Prostate Cancer Prior to Radical Prostatectomy

   The aim for this study is to assess the diagnostic performance of 64Cu-SAR-bisPSMA PET to detect regional nodal metastases.

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Indiana University School of Medicine, Indianapolis, Indiana

   Locations

   34 in total

   Run by

   Clarity Pharmaceuticals Ltd

   See if you can join NCT06056830 on ClinicalTrials.gov

2. A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

   The purpose of this study is to find out whether the study drug, LY4052031, is safe, tolerable and effective in participants with advanced, or metastatic solid tumors including urothelial cancer. The study is conducted in two parts - phase Ia (dose-escalation, dose-optimization) and phase Ib (dose-…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   IU Simon Cancer Center, Indianapolis, Indiana

   Locations

   39 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT06465069 on ClinicalTrials.gov

3. Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer

   The overall aim of the trial is to evaluate the safety, tolerability, and pharmacokinetics (PK) of AMG 509 (monotherapy and in combination with abiraterone acetate and enzalutamide) and to evaluate preliminary efficacy. As of Protocol Amendment 10 (09 July 2025), only Parts 4A expansion, 6, and 7 a…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Indiana University, Indianapolis, Indiana

   Locations

   57 in total

   Run by

   Amgen

   See if you can join NCT04221542 on ClinicalTrials.gov

4. A Phase 1b/2a Study of Pocenbrodib as Monotherapy and in Combination With Darolutamide in Participants With mCRPC

   This is a dose-finding study to assess the safety and preliminary antitumor activity of Pocenbrodib alone or with darolutamide in patients with metastatic castration-resistant prostate cancer (mCRPC)

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Community Health Network, Indianapolis, Indiana

   Locations

   19 in total

   Run by

   Pathos AI, Inc.

   See if you can join NCT06785636 on ClinicalTrials.gov

5. PSMA PET Combined With MRI for the Detection of PCa

   This is an open label, longitudinal Phase 3 study of prostate specific membrane antigen (PSMA) positron emission tomography (PET) combined with magnetic resonance imaging (MRI) compared to standard of care (SOC) for the detection of prostate cancer (PCa).

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Indiana University, Indianapolis, Indiana

   Locations

   18 in total

   Run by

   Telix Pharmaceuticals (Innovations) Pty Limited

   See if you can join NCT07052214 on ClinicalTrials.gov

6. Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy

   This is a Phase II/III study. Patient population is adult participants with PSMA-positive mCRPC who had treatments with androgen receptor pathway inhibitor (ARPI) and taxane-based chemotherapy and progressed on or after [177Lu]Lu-PSMA targeted therapy. Treatment of interest: the investigational tre…

   Stage

   Phase 2

   Ages

   18 to 100

   Site

   Indiana University, Indianapolis, Indiana

   Locations

   81 in total

   Run by

   Novartis Pharmaceuticals

   See if you can join NCT06780670 on ClinicalTrials.gov

7. Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer

   This is a prospective, open-label, multi-center seamless phase II to phase III randomized clinical trial designed to compare SST with or without PET-directed local therapy in improving the castration-resistant prostate cancer-free survival (CRPC-free survival) for Veterans with oligometastatic pros…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Richard L. Roudebush VA Medical Center, Indianapolis, IN, Indianapolis, Indiana

   Locations

   20 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT04787744 on ClinicalTrials.gov

8. ASCVD Management Using CCTA in Prostate Cancer Patients on ADT

   This is a randomized pilot study of Coronary CT Angiography (CCTA) for coronary atherosclerosis vs. Usual Care in patients with prostate cancer who are either planning to begin, or are currently taking androgen deprivation therapy (ADT) .

   Stage

   Not phased

   Ages

   40 and older

   Site

   Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana

   Locations

   3 in total

   Run by

   Indiana University

   See if you can join NCT05879913 on ClinicalTrials.gov

9. Randomized Phase II Trial of Targeted Radiation With no Castration for Mcrpc

   This trial tests if the combination of comprehensive metastasis directed therapy delivered by a precision form of external beam radiotherapy (stereotactic ablative radiotherapy), combined with PSMA targeted radiopharmaceutical therapy and cessation of castration, and then followed by testosterone r…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Richard L. Roudebush VA Medical Center, Indianapolis, IN, Indianapolis, Indiana

   Locations

   4 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT06084338 on ClinicalTrials.gov

10. Evaluating Tolerability of ePUHRT With Brachytherapy Boost

    The purpose of this study is to evaluate the tolerability and toxicity of combining two radiation therapy methods for prostate cancer: Elective Pelvic Ultra Hypofractionated Irradiation Treatment (ePUHRT), which is an external beam radiotherapy with High Dose Rate Brachytherapy Boost (form of inter…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT06817668 on ClinicalTrials.gov

11. PSMA-PET to Guide Prostatectomy

    In this study, 196 patients will be randomized 1:1 to either having only the standard of care MRI prior to surgery versus having the standard of care MRI and the PSMA PET scan. PET (and MRI) findings will be validated against whole mount pathology. Pre-surgical imaging findings will also be evaluat…

    Stage

    Phase 2

    Ages

    40 to 80

    Site

    Goodman Hall, Indiana Institute for Biomedical Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana

    Run by

    Five Eleven Pharma, Inc.

    See if you can join NCT05381103 on ClinicalTrials.gov