Prostate Cancer Clinical Trials

287 studies are recruiting for prostate cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 9

1. Utility of 18F-rhPSMA-7.3 in the Diagnosis of Prostate Cancer After Focal Gland Treatment

   To evaluate the effectiveness of a PSMA-PET scan in identifying recurrent prostate cancer after focal therapy

   Stage

   Not phased

   Ages

   18 and older

   Site

   John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey

   Run by

   Hackensack Meridian Health

   See if you can join NCT07011342 on ClinicalTrials.gov

2. Mechanisms of Resistance to PSMA Radioligand Therapy

   This is a multicenter, correlative study to existing Lutetium based prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) trials and uses.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of California, Los Angeles, Los Angeles, California

   Locations

   3 in total

   Run by

   University of California, San Francisco

   See if you can join NCT05435495 on ClinicalTrials.gov

3. 64Cu-GRIP B in Patients With Advanced Malignancies

   This phase I/II clinical trial evaluates if using a radiotracer targeting granzyme B, 64-copper granzyme targeting restricted interaction peptide specific to family member B (64 Cu-GRIP B) with positron emission tomography (PET) imaging can be safe and useful for detecting granzyme B (GrB) in patie…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of California, San Francisco, San Francisco, California

   Run by

   Rahul Aggarwal

   See if you can join NCT05888532 on ClinicalTrials.gov

4. Safety and Efficacy of 21 Gy, 23 Gy and 25 Gy for High Dose Rate (HDR) Prostate Brachytherapy

   The purpose of this research study is to learn more about the outcomes and early and late side effects of treating early stage prostate cancer with high dose rate brachytherapy.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT03424850 on ClinicalTrials.gov

5. Intensive Cholesterol-Lowering and CD8+ T Cells in Prostate Cancer

   To test the hypothesis that intensive cholesterol lowering (iCL) therapy has anti-tumor immune modulating activity, the investigators will conduct an open-label, single-arm phase II trial in prostate cancer patients who are in active surveillance and undergoing a planned surveillance biopsy in 3-6 …

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Cedars-Sinai Medical Center, Los Angeles, California

   Run by

   Cedars-Sinai Medical Center

   See if you can join NCT06437574 on ClinicalTrials.gov

6. Evaluation of Tumor Control Based on Serial Multiparametric MRI and Post-Treatment Biopsies For Patients Treated With Dose Intensification to the Dominant Intra-Prostatic Lesion (DIL) Using Ultra-Hypofractionated, MR-Guided Radiotherapy

   The purpose of this study is to assess the impact of this MR-guided radiotherapy on tumor control of the dominant intraprostatic lesion among patients with intermediate risk prostate cancer. This study of Radiotherapy to the Prostate and Dominant Lesion Using Ultra-Hypofractionated, MR-adaptive Rad…

   Stage

   Not phased

   Ages

   18 and older

   Site

   NYU Langone Health, New York, New York

   Run by

   NYU Langone Health

   See if you can join NCT06542757 on ClinicalTrials.gov

7. Patient Decision-making About Precision Oncology in Veterans With Advanced Prostate Cancer

   This clinical trial explores and implements methods to improve informed decision making (IDM) regarding precision oncology tests amongst veterans with prostate cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Precision o…

   Stage

   Not phased

   Ages

   18 and older

   Site

   San Francisco Veterans Affairs Medical Center, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT05396872 on ClinicalTrials.gov

8. The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

   The Multi-OutcoMe EvaluatioN of radiation Therapy Using the Unity MR-Linac Study (MOMENTUM) is a multi-institutional, international registry facilitating evidenced based implementation of the Unity MR-Linac technology and further technical development of the MR-Linac system with the ultimate purpos…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Allegheny Health Network, Pittsburgh, Pennsylvania

   Locations

   18 in total

   Run by

   UMC Utrecht

   See if you can join NCT04075305 on ClinicalTrials.gov

9. Collection and Measurement of Biomarkers in Prostate Cancer Radiotherapy Patients

   The purpose of this research study is to learn about: 1) How standard radiation treatment to prostate (primary radiotherapy) or the pelvis after prostatectomy (postoperative radiotherapy) may cause changes in MRI and PET imaging traits that might be used in the future to predict response. 2) Compar…

   Stage

   Not phased

   Ages

   30 and older

   Site

   University of Miami, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT02997709 on ClinicalTrials.gov

10. T-reg Function Changes: a Novel Immune Regulatory Effect Underlying Benefit of Statin Use on Lethal Prostate Cancer

    This study will evaluate whether simvastatin reduces intraprostatic immunosuppressive microenvironment through YAP-mediated T-reg dysfunction, and increases intraprostatic anti-tumor immune response in men recently diagnosed with localized prostate cancer electing to receive prostatectomy for their…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Hollings Cancer Center at Medical University of South Carolina, Charleston, South Carolina

    Locations

    2 in total

    Run by

    Medical University of South Carolina

    See if you can join NCT05586360 on ClinicalTrials.gov

11. Using MRI to Identify Areas to Receive Lower Doses of Radiation Treatment in Men With Prostate Cancerdose Mapping to Preserve Quality of Life

    The purpose of this research is to gather information on the safety and effectiveness of using an imaging technique called magnetic resonance imaging (MRI) to decrease radiation dose to the uninvolved prostate (areas of the prostate that do not clearly have cancer cells) while increasing radiation …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06171269 on ClinicalTrials.gov

12. PSMA-PET Imaging for Detecting Early Metastatic Prostate Cancer in Men w/ High Decipher Test Scores

    This study will enroll 60 patients previously enrolled to MCC#18523, "A Validation Study on the Impact of Decipher® Testing on Treatment Recommendations in African-American and Non-African American Men with Prostate Cancer: (VANDAAM)" that had high risk Decipher test results (Decipher score >0.45).…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida

    Run by

    H. Lee Moffitt Cancer Center and Research Institute

    See if you can join NCT03495427 on ClinicalTrials.gov

13. Behavioral Exercise Training to Reduce Cardiovascular Disease Risk

    To test the preliminary effectiveness of a home-based exercise training (ET) intervention to improve exercise capacity (VO2 peak \& 6-minute walk distance [6MWD]) among prostate cancer (PC) patients compared to controls receiving healthy living education (HLE) at 12 weeks.

    Stage

    Phase 1

    Ages

    40 to 85

    Site

    Virginia Commonwealth University Massey Cancer Center, Richmond, Virginia

    Locations

    2 in total

    Run by

    Virginia Commonwealth University

    See if you can join NCT06237179 on ClinicalTrials.gov

14. Performance of Inherited Risk Assessment for Predicting Prostate Cancer From Prostate Biopsy

    Condition: Prostate cancer Intervention: Biopsy and inherited risk assessment

    Stage

    Not phased

    Ages

    40 to 69

    Site

    NorthShore University HealthSystem, Evanston, Illinois

    Run by

    Endeavor Health

    See if you can join NCT05295407 on ClinicalTrials.gov

15. GU-01: Glycyrrhizin in Prostate Cancer

    This is a pilot, randomized, window-of-opportunity treatment trial in which participants with previously untreated prostate cancer (PCa) who are candidates for surgery (radical prostatectomy)

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Illinois, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT06378346 on ClinicalTrials.gov

16. Diagnostic Utility of rhPSMA-7.3 (18F) PET/CT in Men With Prostate Cancer on Active Surveillance

    This investigator-initiated, prospective study evaluates the diagnostic utility of rhPSMA-7.3 (¹⁸F) PET/CT (flotufolastat F18, marketed as POSLUMA®) in men with biopsy-proven, low-risk or favorable intermediate-risk prostate cancer managed with active surveillance. The study aims to determine wheth…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Mount Sinai Hospital / Icahn School of Medicine at Mount Sinai, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT07285057 on ClinicalTrials.gov

17. Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

    Earlier detection of disease recurrence will enable greater treatment options and has strong potential to improve patient outcomes. This project is translational and has the potential to lead to future translational research opportunities, including interventional trials in which therapeutic escala…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT04354064 on ClinicalTrials.gov

18. Metabolic Impact of Prospective Controlled Mediterranean Type Diets on Prostate Cancer

    The purpose of this study is to examine the impact of Mediterranean-type diets on the metabolism of men with localized prostate cancer. The optimal diet for men with a suspected diagnosis of Prostate Cancer (PCa) is currently unknown. More specifically, the suggested benefits of low carbohydrate an…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Case Comprehensive Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio

    Run by

    Case Comprehensive Cancer Center

    See if you can join NCT05590624 on ClinicalTrials.gov

19. Study of STM-416p Administered to Patients Undergoing Radical Prostatectomy

    A Study of STM-416p Administered Intraoperatively to Patients Undergoing Radical Prostatectomy

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Arizona Urology Specialists, Tucson, Arizona

    Locations

    4 in total

    Run by

    SURGE Therapeutics

    See if you can join NCT06450106 on ClinicalTrials.gov

20. The University of Miami Adapt (UAdapt) Trial

    The purpose of this prostate cancer research study is to investigate: 1. For early-stage patients, the use of a single session of high dose stereotactic body radiotherapy (SBRT) delivered to the tumor within the prostate, not to the entire prostate, as curative treatment of prostate cancer; 2. The …

    Stage

    Phase 2

    Ages

    35 to 85

    Site

    University of Miami, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT06111313 on ClinicalTrials.gov

21. Image-guided, Tumor-focused Radiotherapy Treatment in Intermediate and High-risk Prostate Cancer

    This is a phase II non-blinded randomized controlled trial of image-guided, tumor-focused radiotherapy in patients with intermediate- or high-risk prostate cancer planning to undergo definitive radiotherapy with or without systemic therapy. The image-guided, tumor-focused radiotherapy will be compa…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of California, San Diego, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT06990542 on ClinicalTrials.gov

22. Image-guided Focal Brachytherapy Utilizing Combined 18F-DCFPyl PET/CT

    The Principal Investigator's (PI) working hypothesis is that the PI can utilize the high predictive value of 18F-DCFPyl PSMA to identify clinically significant tumors in patients who will undergo brachytherapy, as well as areas which are uninvolved or contain only clinically insignificant disease. …

    Stage

    EARLY_Phase 1

    Ages

    18 to 100

    Site

    SKCCC at Johns Hopkins, Baltimore, Maryland

    Run by

    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    See if you can join NCT03861676 on ClinicalTrials.gov

23. A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

    Phase 1 dose escalation and expansion study of CLSP-1025, a first-in-class HLA-A*02:01 specific T cell engager (TCE) targeting solid tumors that harbor the p53 R175H mutation.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    HonorHealth Research Institute, Scottsdale, Arizona

    Locations

    21 in total

    Run by

    Clasp Therapeutics, Inc.

    See if you can join NCT06778863 on ClinicalTrials.gov

24. AVI Didactic Experience for Latinx Patient Treatment Adherence and Non-English Speaker Trial Enrollment Study in Rad Onc

    The study aims to develop educational media interventions to prepare Latinx Spanish-speaking radiation oncology patients for a course of breast or prostate cancer radiation therapy and to foster receptivity and informed decision-making around cancer clinical trial participation.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mount Sinai Medical Center, Miami Beach, Florida

    Locations

    2 in total

    Run by

    Columbia University

    See if you can join NCT05351424 on ClinicalTrials.gov

25. Hypofractionated WPPT With HDR Boost

    This is a phase II study of ultrahypofractionated whole pelvis proton therapy with brachytherapy boost for patients with high risk or unfavorable intermediate risk prostate with elevated risk of lymph node involvement.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Abramson Cancer Center at Penn Medicine

    See if you can join NCT06591819 on ClinicalTrials.gov