Prostate Cancer Clinical Trials

289 studies are recruiting for prostate cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 9

1. Behavioral Exercise Training to Reduce Cardiovascular Disease Risk

   To test the preliminary effectiveness of a home-based exercise training (ET) intervention to improve exercise capacity (VO2 peak \& 6-minute walk distance [6MWD]) among prostate cancer (PC) patients compared to controls receiving healthy living education (HLE) at 12 weeks.

   Stage

   Phase 1

   Ages

   40 to 85

   Site

   Virginia Commonwealth University Massey Cancer Center, Richmond, Virginia

   Locations

   2 in total

   Run by

   Virginia Commonwealth University

   See if you can join NCT06237179 on ClinicalTrials.gov

2. Performance of Inherited Risk Assessment for Predicting Prostate Cancer From Prostate Biopsy

   Condition: Prostate cancer Intervention: Biopsy and inherited risk assessment

   Stage

   Not phased

   Ages

   40 to 69

   Site

   NorthShore University HealthSystem, Evanston, Illinois

   Run by

   Endeavor Health

   See if you can join NCT05295407 on ClinicalTrials.gov

3. Pre-Surgical Tirzepatide-Assisted Weight Loss in Overweight and Obese Men With Intermediate Risk Prostate Cancer: A Pilot Feasibility Study

   The goal of this clinical research study is to determine how well a tirzepatide-assisted weight loss program works before a prostatectomy in patients with intermediate risk prostate cancer

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   The University of Texas M. D. Anderson Cancer Center, Houston, Texas

   Run by

   M.D. Anderson Cancer Center

   See if you can join NCT06759701 on ClinicalTrials.gov

4. ASCVD Management Using CCTA in Prostate Cancer Patients on ADT

   This is a randomized pilot study of Coronary CT Angiography (CCTA) for coronary atherosclerosis vs. Usual Care in patients with prostate cancer who are either planning to begin, or are currently taking androgen deprivation therapy (ADT) .

   Stage

   Not phased

   Ages

   40 and older

   Site

   IU Health Joe and Shelly Schwarz Cancer Center, Carmel, Indiana

   Locations

   3 in total

   Run by

   Indiana University

   See if you can join NCT05879913 on ClinicalTrials.gov

5. GU-01: Glycyrrhizin in Prostate Cancer

   This is a pilot, randomized, window-of-opportunity treatment trial in which participants with previously untreated prostate cancer (PCa) who are candidates for surgery (radical prostatectomy)

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Illinois, Chicago, Illinois

   Run by

   University of Illinois at Chicago

   See if you can join NCT06378346 on ClinicalTrials.gov

6. Diagnostic Utility of rhPSMA-7.3 (18F) PET/CT in Men With Prostate Cancer on Active Surveillance

   This investigator-initiated, prospective study evaluates the diagnostic utility of rhPSMA-7.3 (¹⁸F) PET/CT (flotufolastat F18, marketed as POSLUMA®) in men with biopsy-proven, low-risk or favorable intermediate-risk prostate cancer managed with active surveillance. The study aims to determine wheth…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Mount Sinai Hospital / Icahn School of Medicine at Mount Sinai, New York, New York

   Run by

   Icahn School of Medicine at Mount Sinai

   See if you can join NCT07285057 on ClinicalTrials.gov

7. Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

   Earlier detection of disease recurrence will enable greater treatment options and has strong potential to improve patient outcomes. This project is translational and has the potential to lead to future translational research opportunities, including interventional trials in which therapeutic escala…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT04354064 on ClinicalTrials.gov

8. Metabolic Impact of Prospective Controlled Mediterranean Type Diets on Prostate Cancer

   The purpose of this study is to examine the impact of Mediterranean-type diets on the metabolism of men with localized prostate cancer. The optimal diet for men with a suspected diagnosis of Prostate Cancer (PCa) is currently unknown. More specifically, the suggested benefits of low carbohydrate an…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Case Comprehensive Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio

   Run by

   Case Comprehensive Cancer Center

   See if you can join NCT05590624 on ClinicalTrials.gov

9. Study of STM-416p Administered to Patients Undergoing Radical Prostatectomy

   A Study of STM-416p Administered Intraoperatively to Patients Undergoing Radical Prostatectomy

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Arizona Urology Specialists, Tucson, Arizona

   Locations

   4 in total

   Run by

   SURGE Therapeutics

   See if you can join NCT06450106 on ClinicalTrials.gov

10. The University of Miami Adapt (UAdapt) Trial

    The purpose of this prostate cancer research study is to investigate: 1. For early-stage patients, the use of a single session of high dose stereotactic body radiotherapy (SBRT) delivered to the tumor within the prostate, not to the entire prostate, as curative treatment of prostate cancer; 2. The …

    Stage

    Phase 2

    Ages

    35 to 85

    Site

    University of Miami, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT06111313 on ClinicalTrials.gov

11. Image-guided, Tumor-focused Radiotherapy Treatment in Intermediate and High-risk Prostate Cancer

    This is a phase II non-blinded randomized controlled trial of image-guided, tumor-focused radiotherapy in patients with intermediate- or high-risk prostate cancer planning to undergo definitive radiotherapy with or without systemic therapy. The image-guided, tumor-focused radiotherapy will be compa…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of California, San Diego, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT06990542 on ClinicalTrials.gov

12. Image-guided Focal Brachytherapy Utilizing Combined 18F-DCFPyl PET/CT

    The Principal Investigator's (PI) working hypothesis is that the PI can utilize the high predictive value of 18F-DCFPyl PSMA to identify clinically significant tumors in patients who will undergo brachytherapy, as well as areas which are uninvolved or contain only clinically insignificant disease. …

    Stage

    EARLY_Phase 1

    Ages

    18 to 100

    Site

    SKCCC at Johns Hopkins, Baltimore, Maryland

    Run by

    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    See if you can join NCT03861676 on ClinicalTrials.gov

13. A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

    Phase 1 dose escalation and expansion study of CLSP-1025, a first-in-class HLA-A*02:01 specific T cell engager (TCE) targeting solid tumors that harbor the p53 R175H mutation.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    HonorHealth Research Institute, Scottsdale, Arizona

    Locations

    21 in total

    Run by

    Clasp Therapeutics, Inc.

    See if you can join NCT06778863 on ClinicalTrials.gov

14. AVI Didactic Experience for Latinx Patient Treatment Adherence and Non-English Speaker Trial Enrollment Study in Rad Onc

    The study aims to develop educational media interventions to prepare Latinx Spanish-speaking radiation oncology patients for a course of breast or prostate cancer radiation therapy and to foster receptivity and informed decision-making around cancer clinical trial participation.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mount Sinai Medical Center, Miami Beach, Florida

    Locations

    2 in total

    Run by

    Columbia University

    See if you can join NCT05351424 on ClinicalTrials.gov

15. Hypofractionated WPPT With HDR Boost

    This is a phase II study of ultrahypofractionated whole pelvis proton therapy with brachytherapy boost for patients with high risk or unfavorable intermediate risk prostate with elevated risk of lymph node involvement.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Abramson Cancer Center at Penn Medicine

    See if you can join NCT06591819 on ClinicalTrials.gov

16. Telehealth Exercise Program Evaluating Fatigue and Physical Function in Rural Cancer Survivors

    This study investigates the efficacy of a telehealth exercise program designed specifically for rural cancer survivors with cancer-related fatigue (CRF). Small dried blood samples and measures of physical function will be collected throughout the program. The main questions it aims to answer are: *…

    Stage

    Phase 2

    Ages

    18 to 89

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Locations

    2 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT07001241 on ClinicalTrials.gov

17. Hypofractionated Radiotherapy With a Focal Microboost for High-Risk and Locally Advanced Prostate Cancer

    This study is for adult men with previously untreated high risk, very high risk, or pelvic lymph node positive prostate cancer. The purpose of this study is to evaluate the safety and effectiveness of the combination of two emerging radiation treatment techniques (hypofractionated radiotherapy and …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Medical University of South Carolina Hollings Cancer Center, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07325721 on ClinicalTrials.gov

18. A Safety and Dose-finding Study of PRL-02 Depot in Men With Advanced Prostate Cancer

    Medicines that reduce the amount of testosterone in the body are commonly used to treat prostate cancer. PRL-02 depot is a potential treatment for men with advanced prostate cancer. It is given by an injection into the muscle. Men with advanced prostate cancer can take part in this study. Their can…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Los Angeles Cancer Network, Anaheim, California

    Locations

    25 in total

    Run by

    Astellas Pharma Global Development, Inc.

    See if you can join NCT04729114 on ClinicalTrials.gov

19. Stereotactic Ablative Radiotherapy (SABR) for the Treatment of Patients With Metastatic Cancer, ID-COMET Trial

    This protocol is comprised of three unblinded, randomized, single-center studies to evaluate the impact of immediate versus three-month delayed comprehensive ablative treatment on survival in newly diagnosed metastatic patients with lung (Trial 1), colorectal (Trial 2), and prostate (Trial 3) cance…

    Stage

    Phase 3

    Ages

    1 and older

    Site

    Roswell Park Comprehensive Cancer Center, Buffalo, New York

    Run by

    Roswell Park Cancer Institute

    See if you can join NCT06563388 on ClinicalTrials.gov

20. Prostate Ablation Registry and Database for Information, Surveillance, and Evaluation (PARADISE)

    Prostate cancer (PCa) is the most commonly diagnosed non-cutaneous cancer of men in the world. In 2023 alone, it is estimated that 288,300 US men will be diagnosed with prostate cancer and 34,700 will die from the disease despite the approval of multiple systemic agents. Due to advances in screenin…

    Stage

    Not phased

    Ages

    22 and older

    Site

    The University of Chicago, Hyde Park, Illinois

    Locations

    2 in total

    Run by

    University of Chicago

    See if you can join NCT06705803 on ClinicalTrials.gov

21. Improving Health Literacy in African-American Prostate Cancer Patients

    Investigators propose an observational interview study to explore how patients understand treatment conversations with their physicians within the framework of health literacy. The study team will test whether patients' understanding of treatment options and side effects can be improved when patien…

    Stage

    Not phased

    Ages

    25 to 100

    Site

    Atlanta VA Medical Center, Atlanta, Georgia

    Locations

    4 in total

    Run by

    Emory University

    See if you can join NCT03322891 on ClinicalTrials.gov

22. Two Fraction Prostate SBRT With DIL SIB

    Phase I/Ib, single arm trial of Two-Fraction Stereotactic Body Radiation Therapy (SBRT) with an MRI directed, dominant intraprostatic lesion (DIL), simultaneous integrated boost (SIB) based on genomic classification in the treatment of localized prostate cancer. The primary purpose of this study is…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    NYU Langone Hospital - Long Island, Mineola, New York

    Locations

    2 in total

    Run by

    NYU Langone Health

    See if you can join NCT05864196 on ClinicalTrials.gov

23. Pilot of 18F-DCFPyL-PSMA PET in mCRPC Patients Receiving 117Lu-Vipivotide Tetraxetan

    The purpose of this research study is to see how well an imaging test, called 18FDCFPyL prostate specific membrane antigen (PSMA) positron emission tomography (PET), can show the extent of prostate cancer when comparing to 68Ga-PSMA-11 PET/CT (another type of diagnostic scan for prostate cancer).

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Dana Farber Cancer Institute, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Brigham and Women's Hospital

    See if you can join NCT06099093 on ClinicalTrials.gov

24. ADT and SBRT vs SBRT Alone for Unfavorable Intermediate Risk Prostate Cancer

    For this study, unfavorable intermediate risk prostate cancer patients will select whether they are to be treated with the standard of care (SOC) 6 months of Androgen Deprivation Therapy (ADT) in conjunction with stereotactic body radiation therapy/radiosurgery (SBRT) directed to the prostate versu…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT06397703 on ClinicalTrials.gov

25. Phase II Non-Randomized Study Evaluating POSLUMA-PSMA PET Response After Oligo- Metastatic/Progressive-directed Treatment With Radiotherapy (PROMPT-R)

    This study aims to evaluate the role of PSMA-PET and circulating tumor DNA (ctDNA) in monitoring prostate cancer progression and response to radiotherapy (RT). Specifically, it investigates how often early progression is detected on PSMA-PET before PSA rise, examines PET responses of lesions treate…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    City of Hope Medical Center, Duarte, California

    Run by

    City of Hope Medical Center

    See if you can join NCT07210086 on ClinicalTrials.gov