Osteosarcoma Clinical Trials

33 studies are recruiting for osteosarcoma in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Trastuzumab Deruxtecan (DS-8201a) for the Treatment of Recurrent or Refractory Osteosarcoma, Wilms Tumor, and Desmoplastic Small Round Cell Tumor

   This phase I/II trial studies the effects of trastuzumab deruxtecan (DS-8201a) in treating patients with osteosarcoma, Wilms tumor (WT) or desmoplastic small round cell tumor (DSRCT) that is newly diagnosed or has come back after a period of improvement (recurrent) or that has not responded to prev…

   Stage

   Phase 2

   Ages

   12 to 39

   Site

   Children's Hospital Los Angeles, Los Angeles, California

   Locations

   29 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT04616560 on ClinicalTrials.gov

2. Clinical Orthopaedic Data Bank (Acute and Chronic)

   Data involving orthopaedic conditions and rehabilitation aspects of musculoskeletal and neuromuscular disorders will be collected and stored as part of the normal clinical care of patients seen in the University of Florida (UF) and Shands Orthopaedics and Sports Medicine Institute.

   Stage

   Not phased

   Ages

   Any age

   Site

   UF&Shands Orthopaedics and Sports Medicine Institute, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT00411060 on ClinicalTrials.gov

3. Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas

   The purpose of this study is to better understand how safe and effective the drug cabozantinib in combination with high-dose ifosfamide is in the treatment of children and adults with relapsed/refractory sarcomas.

   Stage

   Phase 1

   Ages

   5 to 40

   Site

   University of California San Francisco, San Francisco, California

   Locations

   4 in total

   Run by

   Children's Hospital of Philadelphia

   See if you can join NCT06156410 on ClinicalTrials.gov

4. Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

   The purpose of this study is to evaluate the investigational oral drug AMXT 1501 in combination with oral eflornithine (DFMO). An investigational drug is one that has not been approved by the U.S. Food \& Drug Administration (FDA), or any other regulatory authorities around the world for use alone …

   Stage

   Phase 1

   Ages

   Up to 26

   Site

   University of Alabama/Children's of Alabama, Birmingham, Alabama

   Locations

   14 in total

   Run by

   Milton S. Hershey Medical Center

   See if you can join NCT06465199 on ClinicalTrials.gov

5. Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

   The purpose of this study is to evaluate the investigational drug, silmitasertib (a pill taken by mouth), in combination with FDA approved drugs for solid tumors. An investigational drug is one that has not been approved by the U.S. Food \& Drug Administration (FDA), or any other regulatory authori…

   Stage

   Phase 1

   Ages

   Up to 30

   Site

   University of Alabama/Children's of Alabama, Birmingham, Alabama

   Locations

   23 in total

   Run by

   Milton S. Hershey Medical Center

   See if you can join NCT06541262 on ClinicalTrials.gov

6. Domatinostat With Sirolimus for Relapsed, Refractory Sarcoma and Osteosarcoma

   This is a multicenter, open-label, Phase 1/2 study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity of domatinostat in combination with sirolimus in adolescents and adults with relapsed or refractory sarcoma and osteosarcoma.

   Stage

   Phase 1

   Ages

   12 to 40

   Site

   Moffitt Cancer Center, Tampa, Florida

   Locations

   4 in total

   Run by

   H. Lee Moffitt Cancer Center and Research Institute

   See if you can join NCT07725380 on ClinicalTrials.gov

7. Losartan + Sunitinib in Treatment of Osteosarcoma

   This study is a Phase 1/1b clinical trial that aims to determine the Maximally Tolerated Dose of Losartan and Sunitinib Combination Therapy. Patients will first be accrued to the Dose Escalation phase of the study, using a 3+3 design. Medication dosages will increase until a maximally tolerated dos…

   Stage

   Phase 1

   Ages

   10 and older

   Site

   Children's Hospital Los Angeles, Los Angeles, California

   Locations

   4 in total

   Run by

   University of Colorado, Denver

   See if you can join NCT03900793 on ClinicalTrials.gov

8. Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

   This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastases). Open thoracic surgery is a type of surgery done through …

   Stage

   Phase 3

   Ages

   Up to 50

   Site

   Children's Hospital of Alabama, Birmingham, Alabama

   Locations

   233 in total

   Run by

   Children's Oncology Group

   See if you can join NCT05235165 on ClinicalTrials.gov

9. Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma

   Pediatric patients receiving proton therapy for solid tumors or Hodgkin's lymphoma may experience anatomical changes during treatment that can affect proton therapy accuracy. This prospective single-arm study uses regular low-dose imaging to monitor these changes and adjust treatment plans as neede…

   Stage

   Not phased

   Ages

   Any age

   Site

   St. Jude Children's Research Hospital, Memphis, Tennessee

   Run by

   St. Jude Children's Research Hospital

   See if you can join NCT07514819 on ClinicalTrials.gov

10. SPEARHEAD-3 Pediatric Study

    This is a pediatric basket study to investigate the safety and efficacy of afamitresgene autoleucel in HLA-A*02 eligible and MAGE-A4 positive subjects aged 2-17 years of age with advanced cancers.

    Stage

    Phase 1

    Ages

    2 to 21

    Site

    Stanford University, Palo Alto, California

    Locations

    10 in total

    Run by

    USWM CT, LLC

    See if you can join NCT05642455 on ClinicalTrials.gov

11. Musculoskeletal Cancers Remote Monitoring and Care

    This study aims to evaluate how walking stability and the ability to perform daily activities change during cancer treatment, and whether a smartwatch can detect these changes. The goal is to develop proactive, personalized tools that automatically monitor treatment response and predict potential c…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Case Comprehensive Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio

    Run by

    Case Comprehensive Cancer Center

    See if you can join NCT07129226 on ClinicalTrials.gov

12. Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors

    This is a pilot clinical trial determining the effect of a Methionine-reduced diet on serum levels in subjects with solid tumors. These are subjects who will receive systemic standard of care cancer therapy.

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, California

    Run by

    University of California, Irvine

    See if you can join NCT07628634 on ClinicalTrials.gov

13. Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration

    This is a single-arm, phase II study that will enroll a total of 45 subjects. All subjects will have a confirmed diagnosis of metastatic or unresectable soft tissue sarcoma or bone sarcoma. All subjects must have intact Rb, identified at the time of screening, by immunohistochemistry testing of sub…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Mayo Clinic, Jacksonville, Florida

    Locations

    4 in total

    Run by

    Medical College of Wisconsin

    See if you can join NCT04040205 on ClinicalTrials.gov

14. AOH1996 for the Treatment of Refractory Solid Tumors

    This phase I trial studies the side effects and best dose of AOH1996 in treating patients with solid tumors that do not respond to treatment (refractory). AOH1996 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    City of Hope Medical Center, Duarte, California

    Locations

    3 in total

    Run by

    City of Hope Medical Center

    See if you can join NCT05227326 on ClinicalTrials.gov

15. Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma

    Ewing sarcoma (EWS) and osteosarcoma primarily affect adolescents and young adults. Common treatments include chemotherapy, surgery and radiation, however, there have been few recent advancements in the standard of care. By incorporating eflornithine (DFMO) as an additional therapy and/or maintenan…

    Stage

    Phase 2

    Ages

    0 to 50

    Site

    St. Joseph's Children's Hospital, Tampa, Florida

    Locations

    2 in total

    Run by

    Milton S. Hershey Medical Center

    See if you can join NCT07321912 on ClinicalTrials.gov

16. Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors

    Hematopoietic stem cell transplantation can cure patients with blood cancer and other underlying diseases. αβ-T cell and B cell depletion has been introduced to decrease GVHD and PTLD and has demonstrated effectiveness for hematologic malignancies and non-malignant diseases additionally increasing …

    Stage

    Phase 1

    Ages

    0 to 25

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT06625190 on ClinicalTrials.gov

17. Safety and Feasibility of Intraoperative Visualization With Cytalux in Children

    Pediatric subjects aged 6-17 with biopsy confirmed cancer and imaging findings suspicious for pulmonary metastatic disease scheduled to undergo pulmonary metastasectomy via and open or minimally invasive approach.

    Stage

    Phase 1

    Ages

    6 to 17

    Site

    Ann & Robert H. Lurie Children's Hospital, Chicago, Illinois

    Run by

    Ann & Robert H Lurie Children's Hospital of Chicago

    See if you can join NCT06235125 on ClinicalTrials.gov

18. Atezolizumab in Combination With Stereotactic Body Radiation Therapy (SBRT) and Surgery for Relapsed Osteosarcoma

    This study aims to determine the safety and tolerability of combined Atezolizumab, stereotactic body radiation therapy (SBRT), and surgical resection of pulmonary metastases in patients with pulmonary recurrence of osteosarcoma

    Stage

    Phase 1

    Ages

    Up to 50

    Site

    Chilldren's Healthcare of Atlanta, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT06492954 on ClinicalTrials.gov

19. B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

    3CAR is being done to investigate an immunotherapy for patients with solid tumors. It is a Phase I clinical trial evaluating the use of autologous T cells genetically engineered to express B7-H3-CARs for patients ≤ 21 years old, with relapsed/refractory B7-H3+ solid tumors. This study will evaluate…

    Stage

    Phase 1

    Ages

    Up to 21

    Site

    St. Jude Children's Research Hospital, Memphis, Tennessee

    Run by

    St. Jude Children's Research Hospital

    See if you can join NCT04897321 on ClinicalTrials.gov

20. Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment

    This clinical trial studies the effects of dexrazoxane hydrochloride on biomarkers associated with cardiomyopathy and heart failure after cancer treatment. Studying samples of blood in the laboratory from patients receiving dexrazoxane hydrochloride may help doctors learn more about the effects of …

    Stage

    Not phased

    Ages

    Any age

    Site

    Children's Hospital of Alabama, Birmingham, Alabama

    Locations

    79 in total

    Run by

    Children's Oncology Group

    See if you can join NCT01790152 on ClinicalTrials.gov

21. An Organoid-based Functional Precision Medicine Trial in Osteosarcoma

    The purpose of this study is to examine if we can predict sensitivity of osteosarcoma to different chemotherapy agents using tissue cultures in the laboratory. We know that different chemotherapy agents can be used in the treatment, but not every sarcoma responds to them equally. It is important to…

    Stage

    Not phased

    Ages

    Any age

    Site

    UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California

    Run by

    Jonsson Comprehensive Cancer Center

    See if you can join NCT06064682 on ClinicalTrials.gov

22. Autologous B7-H3 Chimeric Antigen Receptor T Cells in Relapsed/Refractory Solid Tumors

    The purpose of this study is to test the manufacturing feasibility and safety of intravenous (IV) administration of B7-H3CART in children and young adult subjects with relapsed and/or refractory solid tumors expressing B7-H3 target using a standard 3+3 dose escalation design.

    Stage

    Phase 1

    Ages

    2 to 30

    Site

    Stanford University, Palo Alto, California

    Run by

    Stanford University

    See if you can join NCT06500819 on ClinicalTrials.gov

23. Assessment of Healing and Function After Reconstruction Surgery for Bone Sarcomas

    The purpose of this study is to look at the amount of function that returns in participants that have reconstruction with bone graft or artificial device and in participants who have tumor surgery plus regenerative osseous surgery. The study will look at the level of function for a period of 3 year…

    Stage

    Not phased

    Ages

    4 and older

    Site

    Memorial Sloan Kettering at Basking Ridge (Consent and Follow Up), Basking Ridge, New Jersey

    Locations

    5 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT03442465 on ClinicalTrials.gov

24. Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma or Relapsed/Refractory Osteosarcoma

    The body has different ways of fighting infections and disease. No single way seems perfect for fighting cancer. This research study combines two different ways of fighting disease: antibodies and T cells. Antibodies are molecules that fight infections and protect your body from diseases caused by …

    Stage

    Phase 1

    Ages

    1 and older

    Site

    Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill, North Carolina

    Locations

    2 in total

    Run by

    UNC Lineberger Comprehensive Cancer Center

    See if you can join NCT03721068 on ClinicalTrials.gov

25. A Study of Gefitinib, Trametinib, Disulfiram, and Sunitinib in Addition to Standard Chemotherapy in People With Osteosarcoma

    The researchers are doing this study to find out whether adding gefitinib, trametinib, disulfiram, and sunitinib to standard chemotherapy is a more effective treatment approach for people with osteosarcoma than standard chemotherapy on its own. The researchers will also look at the safety of adding…

    Stage

    Phase 2

    Ages

    6 to 49

    Site

    Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey

    Locations

    7 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT07477457 on ClinicalTrials.gov