Osteosarcoma Clinical Trials in St Louis, Missouri

8 studies are recruiting for osteosarcoma in St Louis, Missouri right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Trastuzumab Deruxtecan (DS-8201a) for the Treatment of Recurrent or Refractory Osteosarcoma, Wilms Tumor, and Desmoplastic Small Round Cell Tumor

   This phase I/II trial studies the effects of trastuzumab deruxtecan (DS-8201a) in treating patients with osteosarcoma, Wilms tumor (WT) or desmoplastic small round cell tumor (DSRCT) that is newly diagnosed or has come back after a period of improvement (recurrent) or that has not responded to prev…

   Stage

   Phase 2

   Ages

   12 to 39

   Site

   Washington University School of Medicine, St Louis, Missouri

   Locations

   29 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT04616560 on ClinicalTrials.gov

2. Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

   The purpose of this study is to evaluate the investigational oral drug AMXT 1501 in combination with oral eflornithine (DFMO). An investigational drug is one that has not been approved by the U.S. Food \& Drug Administration (FDA), or any other regulatory authorities around the world for use alone …

   Stage

   Phase 1

   Ages

   Up to 26

   Site

   Cardinal Glennon Children's Medical Center, St Louis, Missouri

   Locations

   14 in total

   Run by

   Milton S. Hershey Medical Center

   See if you can join NCT06465199 on ClinicalTrials.gov

3. Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

   The purpose of this study is to evaluate the investigational drug, silmitasertib (a pill taken by mouth), in combination with FDA approved drugs for solid tumors. An investigational drug is one that has not been approved by the U.S. Food \& Drug Administration (FDA), or any other regulatory authori…

   Stage

   Phase 1

   Ages

   Up to 30

   Site

   Cardinal Glennon Children's Medical Center, St Louis, Missouri

   Locations

   23 in total

   Run by

   Milton S. Hershey Medical Center

   See if you can join NCT06541262 on ClinicalTrials.gov

4. Domatinostat With Sirolimus for Relapsed, Refractory Sarcoma and Osteosarcoma

   This is a multicenter, open-label, Phase 1/2 study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity of domatinostat in combination with sirolimus in adolescents and adults with relapsed or refractory sarcoma and osteosarcoma.

   Stage

   Phase 1

   Ages

   12 to 40

   Site

   Washington University in St. Louis, St Louis, Missouri

   Locations

   4 in total

   Run by

   H. Lee Moffitt Cancer Center and Research Institute

   See if you can join NCT07725380 on ClinicalTrials.gov

5. Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

   This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastases). Open thoracic surgery is a type of surgery done through …

   Stage

   Phase 3

   Ages

   Up to 50

   Site

   Cardinal Glennon Children's Medical Center, St Louis, Missouri

   Locations

   233 in total

   Run by

   Children's Oncology Group

   See if you can join NCT05235165 on ClinicalTrials.gov

6. SPEARHEAD-3 Pediatric Study

   This is a pediatric basket study to investigate the safety and efficacy of afamitresgene autoleucel in HLA-A*02 eligible and MAGE-A4 positive subjects aged 2-17 years of age with advanced cancers.

   Stage

   Phase 1

   Ages

   2 to 21

   Site

   Washington University, St Louis, Missouri

   Locations

   10 in total

   Run by

   USWM CT, LLC

   See if you can join NCT05642455 on ClinicalTrials.gov

7. Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration

   This is a single-arm, phase II study that will enroll a total of 45 subjects. All subjects will have a confirmed diagnosis of metastatic or unresectable soft tissue sarcoma or bone sarcoma. All subjects must have intact Rb, identified at the time of screening, by immunohistochemistry testing of sub…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Washington University in St. Louis, St Louis, Missouri

   Locations

   4 in total

   Run by

   Medical College of Wisconsin

   See if you can join NCT04040205 on ClinicalTrials.gov

8. Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment

   This clinical trial studies the effects of dexrazoxane hydrochloride on biomarkers associated with cardiomyopathy and heart failure after cancer treatment. Studying samples of blood in the laboratory from patients receiving dexrazoxane hydrochloride may help doctors learn more about the effects of …

   Stage

   Not phased

   Ages

   Any age

   Site

   Washington University School of Medicine, St Louis, Missouri

   Locations

   79 in total

   Run by

   Children's Oncology Group

   See if you can join NCT01790152 on ClinicalTrials.gov