Obstructive Sleep Apnea Clinical Trials

56 studies are recruiting for obstructive sleep apnea in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies, page 2

1. The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)

   Major progress has been made in the area of cardiovascular disease, but we believe that further progress will involve mechanistically addressing underlying respiratory causes including chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA). The most common cause of death in …

   Stage

   Phase 2

   Ages

   40 to 79

   Site

   UCSD Sleep Research, La Jolla, California

   Run by

   University of California, San Diego

   See if you can join NCT05237505 on ClinicalTrials.gov

2. Continuous Positive Airway Pressure, Arousability and Links to Mechanisms in Obstructive Sleep Apnea

   The study design is a randomized, controlled clinical trial to test the hypothesis that arousal threshold (ArTH) will affect how individuals with obstructive sleep apnea (OSA, Apnea-Hypopnea Index (AHI) of 10/hour of higher) respond to CPAP therapy regarding adherence and cognitive function (execut…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Yale Centers for Sleep Medicine, North Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT07332442 on ClinicalTrials.gov

3. OSA-18 in Children With Mild Obstructive Sleep Apnea: Can it be a Helpful Decision Making Tool?

   The concept is a novel research idea that incorporates the potential impact of patient quality of life (QOL) on decision-making for treatment of mild obstructive sleep apnea (OSA). Our hypothesis is that in children with mild OSA there is significant conflict with parental decision-making; in the a…

   Stage

   Not phased

   Ages

   3 to 12

   Site

   Connecticut Children's Medical Center, Hartford, Connecticut

   Run by

   Connecticut Children's Medical Center

   See if you can join NCT05911646 on ClinicalTrials.gov

4. Neurocognitive and Health Impact of Sleep Apnea in Elderly Veterans With Comorbid COPD

   Cognitive dysfunction in the aging Veteran population is a growing health concern in the Veterans Health System. It is not known whether OSA coexisting with COPD will enhance the risk for cognitive dysfunction. The investigators sought to investigate whether these two highly prevalent diseases, tha…

   Stage

   Not phased

   Ages

   60 to 89

   Site

   John D. Dingell VA Medical Center, Detroit, MI, Detroit, Michigan

   Run by

   VA Office of Research and Development

   See if you can join NCT02703207 on ClinicalTrials.gov

5. Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea

   This research study is designed to learn, first, whether two anesthetics have different effects on collapse seen within the upper airway during sleep endoscopy. A second purpose is to learn whether collapse at several levels of the upper airway is associated with obstructive sleep apnea that persis…

   Stage

   Phase 2

   Ages

   3 to 11

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   Erin Kirkham

   See if you can join NCT05303987 on ClinicalTrials.gov

6. Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis

   This study will evaluate the influence of sleep apnea on clinical and radiological features of MS. Sleep apnea is associated with hypoxemia during sleep, which is likely detrimental to MS. Clinical data (MRI, lab results, medical history, labs, and sleep studies) of MS patients will be collected an…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Beth Israel Deaconess Medical Center, Boston, Massachusetts

   Run by

   Beth Israel Deaconess Medical Center

   See if you can join NCT04603196 on ClinicalTrials.gov

7. Patient-centered and Neurocognitive Outcomes With Acetazolamide for Sleep Apnea

   Obstructive sleep apnea (OSA) is a severe type of snoring causing people to choke in their sleep. It affects millions of Americans, causing many health problems. For example, patients with OSA often feel very sleepy and are at risk of falling asleep while driving. OSA also causes elevated blood pre…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   UC San Diego; Altman Clinical and Translational Research Institute Building, La Jolla, California

   Run by

   University of California, San Diego

   See if you can join NCT05804084 on ClinicalTrials.gov

8. Obstructive Sleep Apnea Non-PAP Outcomes and Viable Alternatives

   OSANOVA is a non-randomized clinical trial which aims to compare outcomes of mandibular advancement device (MAD) and hypoglossal nerve stimulation (HGNS) therapies in moderate-to-severe OSA patients who fail, decline, or are intolerant to positive airway pressure (PAP) therapy (referred to as PAP-f…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Washington University, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT07074288 on ClinicalTrials.gov

9. Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders

   Background: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is the most common periodic fever syndrome of childhood. Symptoms can include swelling of the glands in the throat, mouth ulcers, and tonsillitis. Removal of the tonsils can stop the periodic flareups. But r…

   Stage

   Not phased

   Ages

   0 to 99

   Site

   Indiana University School of Medicine, Indianapolis, Indiana

   Locations

   3 in total

   Run by

   National Institute of Allergy and Infectious Diseases (NIAID)

   See if you can join NCT05656365 on ClinicalTrials.gov

10. Metabolism and Sleep Apnea Treatment

    The purpose of this research study is to see if obstructive sleep apnea (OSA) is associated with abnormalities in fat metabolism. Through this research study, the Investigator will evaluate how fat is metabolized in people with and without sleep apnea, what substances the fat tissue releases, and h…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of Miami, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT05539716 on ClinicalTrials.gov

11. Reducing Obstructive Sleep Apnea After Hypoglossal Nerve Stimulation Through Mandibular Advancement

    The purpose of this study is to evaluate the effectiveness, feasibility, and safety of mandibular advancement devices (MAD) for treating severe obstructive sleep apnea (OSA) in patients who are CPAP intolerant and have failed hypoglossal nerve stimulation (HGNS).

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT07132307 on ClinicalTrials.gov

12. Severe Label Expansion for EVO Products Trial

    Title: Severe Label Expansion for EVO Positioner (SLEEP) Study Description: Single-arm study to determine the safety and effectiveness of treating severe obstructive sleep apnea using the EVO Sleep and Snore Device (ProSomnus Sleep Technologies, Pleasanton, CA). Objectives: To determine the safety …

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Mount Sinai Integrative Sleep Center, New York, New York

    Locations

    2 in total

    Run by

    ProSomnus Sleep Technologies

    See if you can join NCT07090395 on ClinicalTrials.gov

13. OurSleepKit To Support CPAP Adherence

    The goal of this clinical trial is to learn if a couple-focused mobile health intervention will improve the use of continuous positive airway pressure (CPAP), the primary treatment option for obstructive sleep apnea (OSA). Participants include newly diagnosed patients with OSA who are candidates fo…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Locations

    2 in total

    Run by

    National Heart, Lung, and Blood Institute (NHLBI)

    See if you can join NCT06621511 on ClinicalTrials.gov

14. Metabolic Endpoints for Obstructive Sleep Apnea Following Twelfth Cranial Nerve Stimulation

    The purpose of this study is to determine if the treatment of Obstructive sleep apnea (OSA) by hypoglossal nerve stimulation (HGNS) will alter glucose metabolism. The study team will also determine if the treatment of Obstructive sleep apnea (OSA) by (hypoglossal nerve stimulation) HGNS will alter …

    Stage

    Not phased

    Ages

    18 and older

    Site

    The University of Chicago, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06317701 on ClinicalTrials.gov

15. Predictors of Post-COVID-19 Clinical and Cognitive Consequences

    The CDC describes Post-acute sequelae of SARS-COV-2 infection (PASC) for the wide range of physical and mental health consequences experienced by some patients. These sequelae may be present four or more weeks after SARS-COV-2 infection, including patients who had initial mild or asymptomatic acute…

    Stage

    Not phased

    Ages

    18 and older

    Site

    John D. Dingell VA Medical Center, Detroit, MI, Detroit, Michigan

    Run by

    VA Office of Research and Development

    See if you can join NCT06291870 on ClinicalTrials.gov

16. Magnetic Apnea Prevention(MAGNAP) Device to Treat Obstructive Sleep Apnea:First-In-Human Study of Feasibility and Safety

    The purpose of this study is to determine the safety and feasibility of the Magnap magnetic device in the treatment of obstructive sleep apnea (OSA).

    Stage

    Not phased

    Ages

    21 to 70

    Site

    University of California San Francisco/Mount Zion Hospital, San Francisco, California

    Run by

    Michael Harrison

    See if you can join NCT02431507 on ClinicalTrials.gov

17. Obstructive Sleep Apnea Therapeutic Intervention for REsiDual Sleepiness

    Obstructive sleep apnea (OSA) is a sleep disorder that is commonly treated using positive airway pressure, yet 50% of patients still experience residual sleepiness after successful therapy. A potential neuromodulation strategy that can decrease residual sleepiness is transcranial photobiomodulation…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT06698809 on ClinicalTrials.gov

18. Bright Light Therapy for OSA

    Persistent daytime symptoms of sleepiness in individuals with obstructive sleep apnea (OSA) who are using Continuous Positive Airway Pressure (CPAP) are associated with adverse long term medical and functional outcomes. Supplementary exposure to bright light has beneficial effects on sleep quality …

    Stage

    Not phased

    Ages

    40 to 65

    Site

    VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania

    Run by

    VA Office of Research and Development

    See if you can join NCT05917119 on ClinicalTrials.gov

19. Cognition After OSA Treatment Among Native American People (CATNAP)

    This research project will develop and implement a motivational interviewing and electronic messaging intervention to address obstructive sleep apnea (OSA), positive airway pressure (PAP) adherence, and risk of Alzheimer's disease and related dementias in American Indians. The project will work wit…

    Stage

    Not phased

    Ages

    40 and older

    Site

    Missouri Breaks Industries Research Inc, Eagle Butte, South Dakota

    Run by

    Washington State University

    See if you can join NCT06227572 on ClinicalTrials.gov

20. Improving Outcomes in Pediatric Obstructive Sleep Apnea With Computational Fluid Dynamics

    To create a validated computational tool to predict surgical outcomes for pediatric patients with obstructive sleep apnea (OSA). The first line of treatment for children with OSA is to remove their tonsils and adenoids; however, these surgeries do not always cure the patient. Another treatment, con…

    Stage

    Phase 4

    Ages

    3 to 18

    Site

    Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

    Run by

    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT04991389 on ClinicalTrials.gov

21. A Study of Sex Differences in Neurocirculatory Control

    The purpose of this study is to investigate potential sex differences in neurocirculatory control of blood pressure in patients with untreated obstructive sleep apnea (OSA).

    Stage

    Not phased

    Ages

    20 to 70

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06261034 on ClinicalTrials.gov

22. Community Health Advocates for Motivating PAP Use in Our Neighborhoods.

    The purpose of this research is to compare the impact of motivational enhancement therapy (MET), delivered by culturally congruent community health care workers (CHWs) versus usual care patients with previously untreated moderate-to-severe obstructive sleep apnea (OSA) on adherence to positive airw…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    University of Miami, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT06047353 on ClinicalTrials.gov

23. Intermittent Hypoxia-initiated Plasticity in Humans: A Multi-pronged Therapeutic Approach to Treat Sleep Apnea and Overlapping Co-morbidities

    The prevalence of obstructive sleep apnea (OSA) is high in the United States and is a major health concern. This disorder is linked to numerous heart, blood vessel and nervous system abnormalities, along with increased tiredness while performing exercise likely because of a reduced blood supply to …

    Stage

    Phase 1

    Ages

    30 to 60

    Site

    John D. Dingell VA Medical Center, Detroit, MI, Detroit, Michigan

    Run by

    VA Office of Research and Development

    See if you can join NCT05558501 on ClinicalTrials.gov

24. The Recovery in Stroke Using PAP Study

    The proposed study is a randomized controlled trial among an anicipated 180 participants with acute ischemic stroke and mod/severe OSA diagnosed by ambulatory polysomnography (PSG) comparing PAP treatment with usual care concerning the primary outcome of functional recovery.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT04130503 on ClinicalTrials.gov

25. Cardiometabolic Risk Effects of Short-term Cessation of Neurostimulation Therapy

    Hypoglossal nerve stimulation (HGNS) is an implantable therapy that treats obstructive sleep apnea. The study will evaluate the effect of this treatment on cardiovascular and metabolism-related measures to see if it affects patients' risk of medical problems associated with obstructive sleep apnea …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Columbia University Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT06720545 on ClinicalTrials.gov