Obstructive Sleep Apnea Clinical Trials

56 studies are recruiting for obstructive sleep apnea in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Boston, Massachusetts 8 Ann Arbor, Michigan 6 Cincinnati, Ohio 4 Detroit, Michigan 4 New York, New York 4 Philadelphia, Pennsylvania 4 Chicago, Illinois 3 Dallas, Texas 3 La Jolla, California 3 Miami, Florida 3 Norfolk, Virginia 3 Pittsburgh, Pennsylvania 3 Rochester, Minnesota 3

Studies now recruiting

  1. The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study

    The Effects of Successful OSA TreatmENT on Memory and AD BIomarkers in Older AduLts (ESSENTIAL) study is a 5-year, multicenter randomized open-label trial that will screen 400 cognitively normal older adults recruited from well-established sleep clinics at 4 academic medical centers, with newly dia…

    Stage
    Not phased
    Ages
    55 to 85
    Site
    University of Arizona, Tucson, Arizona
    Locations
    4 in total
    Run by
    California Pacific Medical Center Research Institute

    See if you can join NCT05988385 on ClinicalTrials.gov

  2. OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit

    Substance use disorder (SUD) and posttraumatic stress disorder (PTSD) frequently co-occur and having both disorders is associated with greater psychological and functional impairment than having either disorder alone. This is especially true in residential settings where both disorders are more sev…

    Stage
    Not phased
    Ages
    18 and older
    Site
    VA San Diego Healthcare System, San Diego, CA, San Diego, California
    Run by
    VA Office of Research and Development

    See if you can join NCT05156112 on ClinicalTrials.gov

  3. SUNOSI® (Solriamfetol) Pregnancy Registry

    The SUNOSI (solriamfetol) Pregnancy Registry is a US- and Canada-based prospective, observational study to evaluate the safety of solriamfetol exposure during pregnancy in women with a diagnosis of narcolepsy or obstructive sleep apnea (OSA).

    Stage
    Not phased
    Ages
    Any age
    Site
    Evidera, a PPD business unit, Morrisville, North Carolina
    Locations
    2 in total
    Run by
    Axsome Therapeutics, Inc.

    See if you can join NCT06413420 on ClinicalTrials.gov

  4. Disrupted Sleep and Concurrent Ectopy or Atrial Fibrillation

    Whereas the available evidence mostly supports chronic sleep disruption as a risk factor for incident AF, less is known about the near-term risk of a discrete atrial fibrillation (AF) episode following a night of disrupted or poor-quality sleep. This prospective, randomized, case-crossover study ai…

    Stage
    Not phased
    Ages
    21 and older
    Site
    UCSF Medical Center at Parnassus, San Francisco, California
    Run by
    University of California, San Francisco

    See if you can join NCT07220525 on ClinicalTrials.gov

  5. Down Syndrome Obstructive Sleep Apnea

    The purpose of this study is to assess whether oxygen supplementation during sleep improves working memory and other clinical and patient-reported outcomes among children who have Down Syndrome (DS) with moderate to severe Obstructive Sleep Apnea (OSA).

    Stage
    Phase 2
    Ages
    5 to 18
    Site
    Children's Hospital of Los Angeles, Los Angeles, California
    Locations
    7 in total
    Run by
    Brigham and Women's Hospital

    See if you can join NCT06043440 on ClinicalTrials.gov

  6. Head to Head Comparison of Upper Airway Stimulation and Continuous Positive Airway Pressure; a Pilot Study.

    To date, there has been no head to head comparison of Upper Airway Stimulation (UAS) and Continuous Positive Airway Pressure (CPAP) utilizing a full night polysomnographic evaluation. With this study we aim to evaluate a pilot cohort of patients with OSA treated with CPAP or UAS using the WatchPAT …

    Stage
    Not phased
    Ages
    22 and older
    Site
    Thomas Jefferson University Department of Otolaryngology, Philadelphia, Pennsylvania
    Run by
    Thomas Jefferson University

    See if you can join NCT04191512 on ClinicalTrials.gov

  7. Obstructive Sleep Apnea Among Somali-Americans

    The investigators seek to advance the understanding of obstructive sleep apnea as it relates to different ethnic origins as well as sex differences. The investigators will compare Somali patients with known obstructive sleep apnea (OSA) to individuals without OSA, and to individuals of other ethnic…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Mayo Clinic, Rochester, Minnesota
    Run by
    Mayo Clinic

    See if you can join NCT04124848 on ClinicalTrials.gov

  8. Combination Upper-Airway Electrical and Pharmacological Stimulation for Obstructive Sleep Apnea

    Obstructive sleep apnea (OSA) is a common condition in which the airway repeatedly collapses during sleep, leading to poor sleep quality and reduced oxygen levels. Hypoglossal nerve stimulation (HGNS) is an approved treatment that uses a small implanted device to stimulate the genioglossus muscle a…

    Stage
    Phase 1
    Ages
    18 to 79
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Run by
    Brigham and Women's Hospital

    See if you can join NCT07577661 on ClinicalTrials.gov

  9. Combination Tonsillectomy and Hypoglossal Nerve Stimulation for OSA Patients With Lateral Pharyngeal Collapse

    The goal of this clinical trial is to learn whether removing the tonsils at the time of hypoglossal nerve stimulation improves treatment of obstructive sleep apnea in adults whose airway collapses from the side of the upper airway during sleep. The main questions it aims to answer are: 1. Does hypo…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Run by
    Brigham and Women's Hospital

    See if you can join NCT07724938 on ClinicalTrials.gov

  10. Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)

    The overall objective of this randomized clinical trial is to test the effectiveness of a personalized approach to the surgical treatment of OSA in children with Down syndrome (DS).The estimated prevalence of obstructive sleep apnea (OSA) in children with DS ranges from 45-83%, compared to 1-6% in …

    Stage
    Not phased
    Ages
    2 to 17
    Site
    Colorado Children's Hospital, Aurora, Colorado
    Locations
    7 in total
    Run by
    Oregon Health and Science University

    See if you can join NCT05508971 on ClinicalTrials.gov

  11. Effects of Lung Volume on Upper Airway Patency During Drug Induced Sleep Endoscopy

    Obstructive sleep apnea (OSA) is a disorder where a person has recurrent choking episodes during sleep. Surgery can treat OSA and drug induced sleep endoscopy (DISE) is a procedure that surgeons use to evaluate the throat while a person is sedated, mimicking sleep, to help determine if surgery migh…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Emory University Hospital Midtown, Atlanta, Georgia
    Run by
    Emory University

    See if you can join NCT05350332 on ClinicalTrials.gov

  12. Smart Pillows for Enhancing Sleep Quality

    The purpose of this study is to examine the impact of smart pillows on the sleep quality of individuals who experience a snoring issue and/or obstructive sleep apnea (OSA), as well as their sleep partners. Furthermore, this study will explore whether enhancements in sleep quality positively influen…

    Stage
    Not phased
    Ages
    50 and older
    Site
    Indiana University, Indianapolis, Indiana
    Run by
    Indiana University

    See if you can join NCT06594627 on ClinicalTrials.gov

  13. Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia

    The researchers are investigating if the Self-Supporting Nasopharyngeal Airway (ssNPA) device can be used in the treatment of obstructive sleep apnea in children with Hypotonic Upper Airway Obstruction (HUAO).

    Stage
    Not phased
    Ages
    3 to 21
    Site
    The University of Michigan, Ann Arbor, Michigan
    Run by
    University of Michigan

    See if you can join NCT05527652 on ClinicalTrials.gov

  14. App-Based Optimization of Long-Term CPAP Adherence and Quality of Life

    The purpose of this study is to optimize the time of CPAP usage to at least 6 hours a night for 6 nights per week for people who have OSA with the help of a smartphone application called SmartWell24. This application aims to target CPAP adherence.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Mayo Clinic in Arizona, Scottsdale, Arizona
    Locations
    2 in total
    Run by
    Mayo Clinic

    See if you can join NCT06381115 on ClinicalTrials.gov

  15. DRonabinol Treatment of OSA

    This is an open-label trial that tests the effectiveness of Dronabinol in treating obstructive sleep apnea (OSA). All participants will take oral Dronabinol for two weeks. Sleep studies will be conducted before and after treatment to measure OSA severity.

    Stage
    Phase 1
    Ages
    Up to 65
    Site
    Jesse Brown VA Medical Center, Chicago, IL, Chicago, Illinois
    Run by
    VA Office of Research and Development

    See if you can join NCT06477952 on ClinicalTrials.gov

  16. MicroRNAs as Biomarkers for Obstructive Sleep Apnea

    Although obstructive sleep apnea (OSA) is a common disorder, there are no blood biomarkers for identification and management of these patients. This project will study microRNAs in order to develop and validate blood biomarkers that are specific to OSA, useful for identification of cases with OSA, …

    Stage
    Not phased
    Ages
    18 to 75
    Site
    The Ohio State University - Martha Morehouse Medical Pavilion, Suite 2600, Columbus, Ohio
    Locations
    3 in total
    Run by
    University of Pennsylvania

    See if you can join NCT06189755 on ClinicalTrials.gov

  17. Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention

    The investigators will conduct a Type I hybrid effectiveness-implementation study to test an integrated telehealth intervention among 400 overweight and obese patients with Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA). The investigators will include eligible partic…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Boise VA Medical Center, Boise, Idaho
    Locations
    5 in total
    Run by
    Seattle Institute for Biomedical and Clinical Research

    See if you can join NCT06390345 on ClinicalTrials.gov

  18. Rescue Pharmacotherapy for OSA

    Persistent obstructive sleep apnea (OSA) is common in people treated with mandibular advancement device (MAD) or hypoglossal nerve stimulation (HGNS). For most patients, these treatments are the last line of defense. If MAD or HGNS do not work, then patients are left to suffer the consequences of u…

    Stage
    Phase 1
    Ages
    21 to 70
    Site
    Sleep Disorders Research Program Brigham and Women's Hospital, Boston, Massachusetts
    Run by
    Brigham and Women's Hospital

    See if you can join NCT05293600 on ClinicalTrials.gov

  19. Atomoxetine and DAW2022 on OSA Severity

    Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. In previous research atomoxetine and oxybutynin showed promising effect at reducing OSA severity, however they reduced arousal threshold, one of the key traits responsible for OSA. Since oxy…

    Stage
    Phase 1
    Ages
    21 to 70
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Run by
    Brigham and Women's Hospital

    See if you can join NCT05350215 on ClinicalTrials.gov

  20. Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Small Tonsils

    The purpose of this study is to compare the effectiveness of a novel personalized surgical approach to the standard AT in children with small tonsils (ST). This will be accomplished by randomizing children with ST and OSA to one of these two treatments and comparing outcomes after 6 months. It is t…

    Stage
    Not phased
    Ages
    2 to 17
    Site
    University of Michigan, Ann Arbor, Michigan
    Locations
    2 in total
    Run by
    Oregon Health and Science University

    See if you can join NCT06258837 on ClinicalTrials.gov

  21. Endotypic Traits and Obstructive Sleep Apnea Surgery

    This study will examine factors associated with outcomes after soft palate surgery and medications (acetazolamide, eszopiclone) that may treat other potential causes of obstructive sleep apnea (loop gain, arousal threshold).

    Stage
    Phase 2
    Ages
    21 and older
    Site
    UCLA Santa Monica Medical Center, Santa Monica, California
    Locations
    2 in total
    Run by
    University of California, Los Angeles

    See if you can join NCT05953610 on ClinicalTrials.gov

  22. Ansa Cervicalis and Hypoglossal Nerve Stimulation in OSA

    Polysomnography (PSG) and drug-induced sleep endoscopy (DISE) are widely used diagnostic studies for assessing obstructive sleep apnea (OSA) severity and collapse patterns of the upper airway anatomy during sleep. Hypoglossal nerve stimulation (HNS) therapy for obstructive sleep apnea suffers from …

    Stage
    Not phased
    Ages
    18 and older
    Site
    Vanderbilt University Medical Center, Nashville, Tennessee
    Run by
    Vanderbilt University Medical Center

    See if you can join NCT05501236 on ClinicalTrials.gov

  23. Bi-lateral HGN Therapy in Real-World Patients -Post Approval Research Investigation

    The objective of the BREATHE study is to demonstrate the continued safety and effectiveness of the Genio® System in treating subjects diagnosed with moderate to severe obstructive sleep apnea (OSA) who are intolerant to or failed/refused PAP treatments.

    Stage
    Not phased
    Ages
    22 and older
    Site
    PharmaDev Clinical Research Institute, LLC, Miami, Florida
    Locations
    2 in total
    Run by
    Nyxoah Inc.

    See if you can join NCT07331285 on ClinicalTrials.gov

  24. Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study

    The investigators hypothesize that Obstructive Sleep Apnea (OSA) is an independent risk factor for atrial fibrosis development. The investigators aim to prove the presence of atrial fibrosis on Delayed Enhancement Magnetic Resonance Imaging (DE-MRI) in OSA patients without atrial fibrillation (AF).

    Stage
    Not phased
    Ages
    18 to 75
    Site
    East Jefferson General Hospital, New Orleans, Louisiana
    Locations
    3 in total
    Run by
    Tulane University

    See if you can join NCT04814420 on ClinicalTrials.gov

  25. Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)

    Obstructive sleep apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD) are highly prevalent chronic respiratory diseases in the Veteran population. OSA co-occurring with COPD, known as Overlap Syndrome (OVS), is a complex chronic medical condition associated with grave consequences. OVS is …

    Stage
    Not phased
    Ages
    60 and older
    Site
    John D. Dingell VA Medical Center, Detroit, MI, Detroit, Michigan
    Run by
    VA Office of Research and Development

    See if you can join NCT04179981 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.