Obstructive Sleep Apnea Clinical Trials

57 studies are recruiting for obstructive sleep apnea in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Combination Tonsillectomy and Hypoglossal Nerve Stimulation for OSA Patients With Lateral Pharyngeal Collapse

   The goal of this clinical trial is to learn whether removing the tonsils at the time of hypoglossal nerve stimulation improves treatment of obstructive sleep apnea in adults whose airway collapses from the side of the upper airway during sleep. The main questions it aims to answer are: 1. Does hypo…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Run by

   Brigham and Women's Hospital

   See if you can join NCT07724938 on ClinicalTrials.gov

2. Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)

   The overall objective of this randomized clinical trial is to test the effectiveness of a personalized approach to the surgical treatment of OSA in children with Down syndrome (DS).The estimated prevalence of obstructive sleep apnea (OSA) in children with DS ranges from 45-83%, compared to 1-6% in …

   Stage

   Not phased

   Ages

   2 to 17

   Site

   Colorado Children's Hospital, Aurora, Colorado

   Locations

   7 in total

   Run by

   Oregon Health and Science University

   See if you can join NCT05508971 on ClinicalTrials.gov

3. Effects of Lung Volume on Upper Airway Patency During Drug Induced Sleep Endoscopy

   Obstructive sleep apnea (OSA) is a disorder where a person has recurrent choking episodes during sleep. Surgery can treat OSA and drug induced sleep endoscopy (DISE) is a procedure that surgeons use to evaluate the throat while a person is sedated, mimicking sleep, to help determine if surgery migh…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Emory University Hospital Midtown, Atlanta, Georgia

   Run by

   Emory University

   See if you can join NCT05350332 on ClinicalTrials.gov

4. Smart Pillows for Enhancing Sleep Quality

   The purpose of this study is to examine the impact of smart pillows on the sleep quality of individuals who experience a snoring issue and/or obstructive sleep apnea (OSA), as well as their sleep partners. Furthermore, this study will explore whether enhancements in sleep quality positively influen…

   Stage

   Not phased

   Ages

   50 and older

   Site

   Indiana University, Indianapolis, Indiana

   Run by

   Indiana University

   See if you can join NCT06594627 on ClinicalTrials.gov

5. Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia

   The researchers are investigating if the Self-Supporting Nasopharyngeal Airway (ssNPA) device can be used in the treatment of obstructive sleep apnea in children with Hypotonic Upper Airway Obstruction (HUAO).

   Stage

   Not phased

   Ages

   3 to 21

   Site

   The University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT05527652 on ClinicalTrials.gov

6. App-Based Optimization of Long-Term CPAP Adherence and Quality of Life

   The purpose of this study is to optimize the time of CPAP usage to at least 6 hours a night for 6 nights per week for people who have OSA with the help of a smartphone application called SmartWell24. This application aims to target CPAP adherence.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic in Arizona, Scottsdale, Arizona

   Locations

   2 in total

   Run by

   Mayo Clinic

   See if you can join NCT06381115 on ClinicalTrials.gov

7. Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy

   This Phase 3 clinical trial is designed to evaluate the efficacy and safety of maridebart cafraglutide compared to placebo over a 52-week period in adults with obstructive sleep apnea (OSA) who are not on PAP therapy and are living with overweight or obesity.

   Stage

   Phase 3

   Ages

   18 to 99

   Site

   Valley Clinical Trials, Northridge, California

   Locations

   57 in total

   Run by

   Amgen

   See if you can join NCT07226765 on ClinicalTrials.gov

8. DRonabinol Treatment of OSA

   This is an open-label trial that tests the effectiveness of Dronabinol in treating obstructive sleep apnea (OSA). All participants will take oral Dronabinol for two weeks. Sleep studies will be conducted before and after treatment to measure OSA severity.

   Stage

   Phase 1

   Ages

   Up to 65

   Site

   Jesse Brown VA Medical Center, Chicago, IL, Chicago, Illinois

   Run by

   VA Office of Research and Development

   See if you can join NCT06477952 on ClinicalTrials.gov

9. The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study

   The Effects of Successful OSA TreatmENT on Memory and AD BIomarkers in Older AduLts (ESSENTIAL) study is a 5-year, multicenter randomized open-label trial that will screen 400 cognitively normal older adults recruited from well-established sleep clinics at 4 academic medical centers, with newly dia…

   Stage

   Not phased

   Ages

   55 to 85

   Site

   University of Arizona, Tucson, Arizona

   Locations

   4 in total

   Run by

   California Pacific Medical Center Research Institute

   See if you can join NCT05988385 on ClinicalTrials.gov

10. Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy

    This Phase 3 clinical trial is designed to evaluate the efficacy and safety of maridebart cafraglutide compared to placebo over a 52-week period in adults with obstructive sleep apnea (OSA) who are receiving positive airway pressure (PAP) therapy and are living with overweight or obesity.

    Stage

    Phase 3

    Ages

    18 to 99

    Site

    Valley Clinical Trials, Northridge, California

    Locations

    61 in total

    Run by

    Amgen

    See if you can join NCT07225686 on ClinicalTrials.gov

11. MicroRNAs as Biomarkers for Obstructive Sleep Apnea

    Although obstructive sleep apnea (OSA) is a common disorder, there are no blood biomarkers for identification and management of these patients. This project will study microRNAs in order to develop and validate blood biomarkers that are specific to OSA, useful for identification of cases with OSA, …

    Stage

    Not phased

    Ages

    18 to 75

    Site

    The Ohio State University - Martha Morehouse Medical Pavilion, Suite 2600, Columbus, Ohio

    Locations

    3 in total

    Run by

    University of Pennsylvania

    See if you can join NCT06189755 on ClinicalTrials.gov

12. Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention

    The investigators will conduct a Type I hybrid effectiveness-implementation study to test an integrated telehealth intervention among 400 overweight and obese patients with Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA). The investigators will include eligible partic…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Boise VA Medical Center, Boise, Idaho

    Locations

    5 in total

    Run by

    Seattle Institute for Biomedical and Clinical Research

    See if you can join NCT06390345 on ClinicalTrials.gov

13. Rescue Pharmacotherapy for OSA

    Persistent obstructive sleep apnea (OSA) is common in people treated with mandibular advancement device (MAD) or hypoglossal nerve stimulation (HGNS). For most patients, these treatments are the last line of defense. If MAD or HGNS do not work, then patients are left to suffer the consequences of u…

    Stage

    Phase 1

    Ages

    21 to 70

    Site

    Sleep Disorders Research Program Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT05293600 on ClinicalTrials.gov

14. Atomoxetine and DAW2022 on OSA Severity

    Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. In previous research atomoxetine and oxybutynin showed promising effect at reducing OSA severity, however they reduced arousal threshold, one of the key traits responsible for OSA. Since oxy…

    Stage

    Phase 1

    Ages

    21 to 70

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT05350215 on ClinicalTrials.gov

15. Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Small Tonsils

    The purpose of this study is to compare the effectiveness of a novel personalized surgical approach to the standard AT in children with small tonsils (ST). This will be accomplished by randomizing children with ST and OSA to one of these two treatments and comparing outcomes after 6 months. It is t…

    Stage

    Not phased

    Ages

    2 to 17

    Site

    University of Michigan, Ann Arbor, Michigan

    Locations

    2 in total

    Run by

    Oregon Health and Science University

    See if you can join NCT06258837 on ClinicalTrials.gov

16. Endotypic Traits and Obstructive Sleep Apnea Surgery

    This study will examine factors associated with outcomes after soft palate surgery and medications (acetazolamide, eszopiclone) that may treat other potential causes of obstructive sleep apnea (loop gain, arousal threshold).

    Stage

    Phase 2

    Ages

    21 and older

    Site

    UCLA Santa Monica Medical Center, Santa Monica, California

    Locations

    2 in total

    Run by

    University of California, Los Angeles

    See if you can join NCT05953610 on ClinicalTrials.gov

17. Ansa Cervicalis and Hypoglossal Nerve Stimulation in OSA

    Polysomnography (PSG) and drug-induced sleep endoscopy (DISE) are widely used diagnostic studies for assessing obstructive sleep apnea (OSA) severity and collapse patterns of the upper airway anatomy during sleep. Hypoglossal nerve stimulation (HNS) therapy for obstructive sleep apnea suffers from …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT05501236 on ClinicalTrials.gov

18. Bi-lateral HGN Therapy in Real-World Patients -Post Approval Research Investigation

    The objective of the BREATHE study is to demonstrate the continued safety and effectiveness of the Genio® System in treating subjects diagnosed with moderate to severe obstructive sleep apnea (OSA) who are intolerant to or failed/refused PAP treatments.

    Stage

    Not phased

    Ages

    22 and older

    Site

    PharmaDev Clinical Research Institute, LLC, Miami, Florida

    Locations

    2 in total

    Run by

    Nyxoah Inc.

    See if you can join NCT07331285 on ClinicalTrials.gov

19. Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study

    The investigators hypothesize that Obstructive Sleep Apnea (OSA) is an independent risk factor for atrial fibrosis development. The investigators aim to prove the presence of atrial fibrosis on Delayed Enhancement Magnetic Resonance Imaging (DE-MRI) in OSA patients without atrial fibrillation (AF).

    Stage

    Not phased

    Ages

    18 to 75

    Site

    East Jefferson General Hospital, New Orleans, Louisiana

    Locations

    3 in total

    Run by

    Tulane University

    See if you can join NCT04814420 on ClinicalTrials.gov

20. Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)

    Obstructive sleep apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD) are highly prevalent chronic respiratory diseases in the Veteran population. OSA co-occurring with COPD, known as Overlap Syndrome (OVS), is a complex chronic medical condition associated with grave consequences. OVS is …

    Stage

    Not phased

    Ages

    60 and older

    Site

    John D. Dingell VA Medical Center, Detroit, MI, Detroit, Michigan

    Run by

    VA Office of Research and Development

    See if you can join NCT04179981 on ClinicalTrials.gov

21. The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)

    Major progress has been made in the area of cardiovascular disease, but we believe that further progress will involve mechanistically addressing underlying respiratory causes including chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA). The most common cause of death in …

    Stage

    Phase 2

    Ages

    40 to 79

    Site

    UCSD Sleep Research, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT05237505 on ClinicalTrials.gov

22. Continuous Positive Airway Pressure, Arousability and Links to Mechanisms in Obstructive Sleep Apnea

    The study design is a randomized, controlled clinical trial to test the hypothesis that arousal threshold (ArTH) will affect how individuals with obstructive sleep apnea (OSA, Apnea-Hypopnea Index (AHI) of 10/hour of higher) respond to CPAP therapy regarding adherence and cognitive function (execut…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Yale Centers for Sleep Medicine, North Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT07332442 on ClinicalTrials.gov

23. OSA-18 in Children With Mild Obstructive Sleep Apnea: Can it be a Helpful Decision Making Tool?

    The concept is a novel research idea that incorporates the potential impact of patient quality of life (QOL) on decision-making for treatment of mild obstructive sleep apnea (OSA). Our hypothesis is that in children with mild OSA there is significant conflict with parental decision-making; in the a…

    Stage

    Not phased

    Ages

    3 to 12

    Site

    Connecticut Children's Medical Center, Hartford, Connecticut

    Run by

    Connecticut Children's Medical Center

    See if you can join NCT05911646 on ClinicalTrials.gov

24. Neurocognitive and Health Impact of Sleep Apnea in Elderly Veterans With Comorbid COPD

    Cognitive dysfunction in the aging Veteran population is a growing health concern in the Veterans Health System. It is not known whether OSA coexisting with COPD will enhance the risk for cognitive dysfunction. The investigators sought to investigate whether these two highly prevalent diseases, tha…

    Stage

    Not phased

    Ages

    60 to 89

    Site

    John D. Dingell VA Medical Center, Detroit, MI, Detroit, Michigan

    Run by

    VA Office of Research and Development

    See if you can join NCT02703207 on ClinicalTrials.gov

25. Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea

    This research study is designed to learn, first, whether two anesthetics have different effects on collapse seen within the upper airway during sleep endoscopy. A second purpose is to learn whether collapse at several levels of the upper airway is associated with obstructive sleep apnea that persis…

    Stage

    Phase 2

    Ages

    3 to 11

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    Erin Kirkham

    See if you can join NCT05303987 on ClinicalTrials.gov