Obesity Clinical Trials

274 studies are recruiting for obesity in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes

   The primary objective of this study is to demonstrate that ribupatide (KAI-9531) subcutaneous (SC) injection once weekly is superior to semaglutide SC once weekly and to placebo SC once weekly on percent change in body weight.

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Kailera Clinical Site, Glendale, Arizona

   Locations

   59 in total

   Run by

   Kailera

   See if you can join NCT07284979 on ClinicalTrials.gov

2. A Study of LY4174794 in Participants With Obesity or Overweight Who Are Otherwise Healthy

   The main purpose of this study is to understand how safe and well-tolerated LY4174794 is in participants with obesity or overweight who are otherwise healthy. Blood tests will be performed to check how much LY4174794 gets into the bloodstream and how long it takes the body to eliminate it. Particip…

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   ICON Early Phase Services, LLC, San Antonio, Texas

   Locations

   3 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07654972 on ClinicalTrials.gov

3. Concurrent Laparoscopic Hysterectomy and Weight Loss Surgery in Obese Patients With Endometrial Carcinoma or Endometrial Intraepithelial Neoplasia

   To assess the feasibility of an expedited referral process for the obese endometrial cancer or EIN patient from her gynecologic oncologist to the Brigham Center for Metabolic and Bariatric Surgery (CMBS) in order to undergo concurrent weight loss surgery and hysterectomy within 8 weeks of first app…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Locations

   2 in total

   Run by

   Dana-Farber Cancer Institute

   See if you can join NCT04839614 on ClinicalTrials.gov

4. The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics

   The investigator hypothesizes that treatment with the ß3 agonist mirabegron results in improved glucose metabolism, including a reversal of prediabetes in obese, insulin-resistant human research participants, and this is further improved by combination therapy with tadalafil. The investigator will …

   Stage

   Phase 4

   Ages

   35 to 65

   Site

   University of Kentucky, Lexington, Kentucky

   Run by

   Philip Kern

   See if you can join NCT05051436 on ClinicalTrials.gov

5. A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight

   This study will look at how well CagriSema and cagrilintide help children and adolescents with excess body weight lose weight. The study has 2 parts: main and extension study. In the main study, participants will either get CagriSema (a new study drug), cagrilintide (a new study drug), semaglutide …

   Stage

   Phase 3

   Ages

   8 to 18

   Site

   Neighborhood Healthcare, Escondido, California

   Locations

   121 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT07253285 on ClinicalTrials.gov

6. A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight

   This clinical study is testing how the study medicine CagriSema helps people living with obesity, with or without type 2 diabetes (T2D), lose weight. The purpose of the study is to find out how safe and effective CagriSema is for body weight loss in these participants. Participants will receive eit…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   CEMEDIC, CABA, Buenos Aires

   Locations

   303 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT07564414 on ClinicalTrials.gov

7. The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure

   Background: Diet-induced thermogenesis (DIT) is the amount of energy one's body uses to eat food, absorb the nutrients from the food, and process those nutrients. Researchers would like to understand more about how changing the balances of protein, fat, carbohydrates, and total calories in the diet…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   NIDDK, Phoenix, Phoenix, Arizona

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT05545306 on ClinicalTrials.gov

8. GLP-1R Actions on Muscle and the Skeleton

   The GRAMS study objectives are to assess the musculoskeletal changes that occur after weight loss using GLP-1 based therapy. A lifestyle intervention with diet and exercise is included to assess any mitigating effects are provided, versus a control group with regular exercise and diet.

   Stage

   Phase 4

   Ages

   18 to 50

   Site

   MaineHealth Center for Clinical and Translational Science, Scarborough, Maine

   Locations

   2 in total

   Run by

   Pennington Biomedical Research Center

   See if you can join NCT07154719 on ClinicalTrials.gov

9. PPDTM CorEvitasTM Obesity (OBR) Drug Effectiveness and Safety Registry

   The design is an open-ended prospective observational (non-interventional) registry for subjects living with excess weight or obesity under the care of a qualified provider with documented experience treating patients with obesity

   Stage

   Not phased

   Ages

   18 and older

   Site

   CorEvitas, LLC, Waltham, Massachusetts

   Run by

   CorEvitas

   See if you can join NCT07598981 on ClinicalTrials.gov

10. A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

    The purpose of this pediatric, chronic weight management, Phase 3 Master Protocol (PWMP) is to create a framework to evaluate the safety and efficacy of pharmacologic agents for the treatment of obesity or overweight in pediatric participants.

    Stage

    Phase 3

    Ages

    6 to 17

    Site

    Lucas Research, Inc, Morehead City, North Carolina

    Locations

    117 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT06672549 on ClinicalTrials.gov

11. A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities

    The main purpose of this study, performed under Master Protocol J4M-MC-PWMP (NCT06672549), is to evaluate the efficacy, safety, and pharmacokinetics of orforglipron once daily oral versus Placebo in adolescent participants with obesity, or overweight with related comorbidities. Participation in the…

    Stage

    Phase 3

    Ages

    12 to 17

    Site

    Saitama Medical University Hospital, Iruma-Gun,

    Locations

    34 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT06672939 on ClinicalTrials.gov

12. Using Tailored mHealth Strategies to Promote Weight Management Among Adolescent and Young Adult Cancer Survivors

    The AYA WELL study is a 2-arm randomized clinical trial to test the efficacy of a theory-based, mHealth weight management intervention adapted specifically for adolescent and young adult cancer survivors compared to a self-guided arm. Participants, diagnosed with cancer between ages 15-39, currentl…

    Stage

    Not phased

    Ages

    18 to 39

    Site

    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

    Run by

    UNC Lineberger Comprehensive Cancer Center

    See if you can join NCT06848491 on ClinicalTrials.gov

13. Incretin Therapies in Obesity-related HFpEF

    The central hypothesis to be tested is that patients with obesity and heart failure with preserved ejection fraction (HFpEF) prescribed tirzepatide will demonstrate reductions in measured plasma volume. In conjunction with state-of-the-art body composition analysis and measures of adipokines, this …

    Stage

    Phase 4

    Ages

    40 and older

    Site

    Columbia University Irving Medical Center (CUIMC) / NewYork Presbyterian Hospital (NYP), New York, New York

    Run by

    Columbia University

    See if you can join NCT07554638 on ClinicalTrials.gov

14. The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action

    Ovwerweight and obesity prevalence in persons with T1D has increased, which further complicates management and risk for complications. The proposed study is relevant to public health because it helps us understand the role of the gut microbiome in disease pathophysiology in T1D youth with overweigh…

    Stage

    Phase 2

    Ages

    11 to 18

    Site

    Indiana University School of Medicine, Indianapolis, Indiana

    Run by

    Heba M. Ismail

    See if you can join NCT05414409 on ClinicalTrials.gov

15. A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes

    The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes. The study has two phases: a main phase and an extension phase. Participation in the main phase of the study will last about 75 weeks. Participants w…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    MFA Clinical Research, Tuscaloosa, Alabama

    Locations

    162 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07321886 on ClinicalTrials.gov

16. A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight

    The main purpose of this study is to find out how significantly Eloralintide slows stomach emptying in participants who are overweight or obese. For each participant, the study will last approximately 21 weeks and will include 2 overnight stays in the clinical research unit (CRU) lasting between 4 …

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    ICON Early Phase Services, San Antonio, Texas

    Locations

    2 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07738614 on ClinicalTrials.gov

17. Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL

    This study is for older children, adolescents, and young adults with B-cell Acute Lymphoblastic Leukemia (B-ALL). Higher amounts of body fat is associated with resistance to chemotherapy in patients with B-ALL. Chemotherapy during the first month causes large gains in body fat in most people, even …

    Stage

    Phase 2

    Ages

    7 to 25

    Site

    Children's Hospital Los Angeles, Los Angeles, California

    Locations

    16 in total

    Run by

    Etan Orgel

    See if you can join NCT05082519 on ClinicalTrials.gov

18. Digital InteGrated Behavioral treatmeNt for Comorbid obesITy and deprEssion Among Racial and Ethnic Adults Age 50 and Older

    The goal of this randomized clinical trial is to test the efficacy of a fully digital intervention, combining the Lumen problem-solving therapy virtual coach for depression management with the Diabetes Prevention Program video-based program for weight loss, among racial and ethnic minorities with c…

    Stage

    Not phased

    Ages

    50 to 74

    Site

    Department of Medicine, Vitoux Program on Aging and Prevention, Chicago, Illinois

    Locations

    2 in total

    Run by

    University of Illinois at Chicago

    See if you can join NCT06636058 on ClinicalTrials.gov

19. The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity

    The purpose of this study is to determine the effect of tirzepatide on vasomotor symptoms and on measures of biological aging.

    Stage

    Phase 4

    Ages

    46 to 60

    Site

    Mayo Clinic in Florida, Jacksonville, Florida

    Run by

    Mayo Clinic

    See if you can join NCT07218445 on ClinicalTrials.gov

20. A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

    This study is being done to look at the safety and effect of NNC0487-0111 in people with Heart Failure with preserved Ejection Fraction (HFpEF) or Heart Failure with mildly reduced Ejection Fraction (HFmrEF) and excess body weight when compared to placebo. The purpose of this clinical study is to f…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Advanced Cardiovascular, LLC, Alexander City, Alabama

    Locations

    838 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07567001 on ClinicalTrials.gov

21. A Research Study on How UBT251 Affects Levels of Midazolam, Caffeine and Warfarin in the Blood of Participants With Excess Body Weight

    The purpose of this clinical study is to find out if UBT251 is safe and effective to be taken together with medicines, like midazolam, caffeine and warfarin in participants living with overweight or obesity.

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Altasciences Clinical LA, Inc., Cypress, California

    Run by

    Novo Nordisk A/S

    See if you can join NCT07710768 on ClinicalTrials.gov

22. Role of Adiposomes in Endothelial Dysfunction

    The development of type II diabetes (T2D) is strongly associated with obesity and both are well-established risk factors for cardiovascular disease. Knowing that vascular dysfunction is an early event in the development of cardiovascular disease in obese diabetic (OB-T2D) patients, The investigator…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    University of Illinois at Chicago, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT05199454 on ClinicalTrials.gov

23. AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

    This study is being done to look at the safety and effect of NNC0487-0111 in people with excess body weight and knee osteoarthritis when compared to placebo. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the tr…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Neighborhood Healthcare, Escondido, California

    Locations

    81 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07509307 on ClinicalTrials.gov

24. A Novel Digital Tool Physicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors

    The investigators will conduct a feasibility and pilot efficacy randomized controlled trial to test the usability and user satisfaction of an evidence-based digital health tool the investigators developed for physicians to use to Prioritize Personalize Prescribe EXercise (P3-EX) to patients with ca…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    Hartford HealthCare, Hartford, Connecticut

    Locations

    3 in total

    Run by

    University of Connecticut

    See if you can join NCT07238556 on ClinicalTrials.gov

25. Collaborative Multi-level Obesity Intervention Engaging Communities Trial

    The goal of this clinical trial is to test the effectiveness of an evidence-based multi-level intervention for weight loss and the feasibility, fidelity, and sustainability of implementing the intervention in people living with obesity in Louisiana. The main questions it aims to answer are: * Will …

    Stage

    Not phased

    Ages

    18 to 75

    Site

    InclusivCare - Avondale Clinic, Avondale, Louisiana

    Locations

    18 in total

    Run by

    Tulane University

    See if you can join NCT06835686 on ClinicalTrials.gov