Major Depressive Disorder Clinical Trials

96 studies are recruiting for major depressive disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Mindfulness Engaged Neurostimulation for Depression (MEND II)

   Repetitive Transcranial Magnetic stimulation (rTMS) is an FDA-approved therapy for treatment resistant depression (TRD) that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. But studies of rTMS alone show remission rates of ~30%. Additionally, r…

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   UC San Diego Health Psychiatry, San Diego, California

   Run by

   University of California, San Diego

   See if you can join NCT07512284 on ClinicalTrials.gov

2. RESISTance Exercise for Depression Trial

   Depression is a leading cause of disability worldwide and current treatments are ineffective for many people. This trial will investigate the efficacy of a 16-week high vs low dose resistance exercise training program for the treatment of Major Depressive Disorder (MDD) in 200 adults.

   Stage

   Not phased

   Ages

   18 to 65

   Site

   University of Wisconsin - Madison, Madison, Wisconsin

   Locations

   2 in total

   Run by

   University of Wisconsin, Madison

   See if you can join NCT06110897 on ClinicalTrials.gov

3. Mindful Self-compassion for Anxiety and Depression: Impact of Delivery Method

   The study will compare the delivery of an 8-week Mindful Self-Compassion training, in-person against video-conference, on anxiety and depression symptom severity in patients with diagnosed anxiety disorders (generalized anxiety disorder, social anxiety disorder, and panic disorder) or major depress…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Georgetown University Medical Center, Washington D.C., District of Columbia

   Run by

   Georgetown University

   See if you can join NCT07028216 on ClinicalTrials.gov

4. Regulation of Affect and Physiology in Depression

   Although treatments for depression are effective for many people, not everyone responds to treatment. This lack of treatment response could be due, in part, to the presence of multiple underlying causes of people's depression. This study aims to identify subtypes of depression, based on two factors…

   Stage

   Phase 2

   Ages

   18 to 27

   Site

   University of Southern California, Los Angeles, California

   Run by

   University of Southern California

   See if you can join NCT06345859 on ClinicalTrials.gov

5. Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression

   The purpose of the study is to identify brain biomarkers and characteristics that predict individual responses to treatment of major depression with the antidepressant drug sertraline (tradename Zoloft), a common selective serotonin reuptake inhibitor (SSRI) antidepressant. Our central hypothesis i…

   Stage

   Phase 4

   Ages

   18 to 65

   Site

   Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600, Austin, Texas

   Run by

   University of Texas at Austin

   See if you can join NCT05892744 on ClinicalTrials.gov

6. Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study

   The purpose of this research is to measure brain activity in individuals with mood disorders and memory problems using a simple, safe, and noninvasive method called functional near-infrared spectroscopy (fNIRS). By comparing brain activity across different groups and relating it to symptom severity…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06897670 on ClinicalTrials.gov

7. Maintenance rTMS for Depression (Maitr-De)

   Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising intervention for treatment-resistant depression (TRD), yet substantial uncertainties persist regarding its efficacy as a maintenance treatment. This prospective study seeks to investigate the efficacy of maintenance rTMS…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   University of California, San Diego, San Diego, California

   Locations

   3 in total

   Run by

   University of California, San Diego

   See if you can join NCT06938841 on ClinicalTrials.gov

8. Neutralizing Interleukin (IL)-6

   The proposed study aims to establish the feasibility and safety of subcutaneous tocilizumab, a monoclonal antibody (mAb) against interleukin (IL)-6 receptor, in adults with Major Depressive Disorder (MDD) and evidence of peripheral immune activation. IL-6 is a pro-inflammatory cytokine implicated i…

   Stage

   Phase 2

   Ages

   18 to 70

   Site

   Icahn School of Medicine at Mount Sinai, New York, New York

   Run by

   Icahn School of Medicine at Mount Sinai

   See if you can join NCT07493317 on ClinicalTrials.gov

9. Neural Response to Inflammatory Challenge in Major Depressive Disorder

   This is a parallel group, double-blinded, placebo-controlled study. Participants with MDD (n=90) and HC (n=90) will be randomly assigned (2:1) to receive either lipopolysaccharide (LPS) (0.8ng/kg of body weight) or placebo (same volume of 0.9% saline) administered as an intravenous bolus. This will…

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   Laureate Institute for Brain Research, Tulsa, Oklahoma

   Run by

   Laureate Institute for Brain Research, Inc.

   See if you can join NCT04751331 on ClinicalTrials.gov

10. Peer-Delivered Behavioral Activation in a CCBHC

    Low-income individuals have limited access to evidence-based interventions for mental health. Peer recovery specialists, individuals in recovery from mental health and/or substance use problems, have the potential to increase access to evidence-based interventions for individuals from low-resource …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Detroit Recovery Project, Detroit, Michigan

    Run by

    Wayne State University

    See if you can join NCT07219394 on ClinicalTrials.gov

11. MicroRNA Correlates of Childhood Maltreatment and Suicidality

    This is a research study to find out if childhood trauma and stress are associated with depression or suicidal risk. The study will assess the effects of both short-term and long-term stress on biomarker (e.g. miRNA [MiRNA]) levels. miRNAs are a type of RNA (genetic material that is translated into…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    2 in total

    Run by

    University of Alabama at Birmingham

    See if you can join NCT04923685 on ClinicalTrials.gov

12. Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality

    The investigators hypothesized that during the 9-week course of Engage \& Connect treatment there will be an increase in brain functions of the Positive Valence System which in turn will lead to reduction in suicidality.

    Stage

    Not phased

    Ages

    50 to 80

    Site

    Weill Cornell Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT05925322 on ClinicalTrials.gov

13. Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans

    Transcranial magnetic stimulation (TMS) is an effective treatment for depression, but clinical outcome is suboptimal, partially because investigators are missing biologically-grounded brain markers which show that TMS is modifying activity at the intended target in the brain. The goal of this propo…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Stanford University, Stanford, California

    Run by

    Stanford University

    See if you can join NCT05996900 on ClinicalTrials.gov

14. Imaging Depression in Parkinson's Disease

    The goal of this observational study is to identify targetable neural substrates of depression in Parkinson's Disease for the first time in people with Parkinson's between the ages of 40 and 80, who are experiencing symptoms of depression.

    Stage

    Phase 2

    Ages

    40 to 80

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06402955 on ClinicalTrials.gov

15. Amygdala Neurofeedback for Depression - Large Scale Clinical Trial

    The goal of this study is to evaluate whether rtfMRI-nf training to increase the amygdala response to positive memories may serve as a stand-alone intervention for major depressive disorder

    Stage

    Not phased

    Ages

    18 to 55

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    Kymberly Young

    See if you can join NCT05703256 on ClinicalTrials.gov

16. Exercise-priming of CBT for Depression: the CBT+ Trial

    This study investigates the effects of intentionally sequencing aerobic exercise immediately prior to cognitive behavioral therapy (CBT) to determine its effects on mechanisms of CBT (i.e., working alliance, behavioral activation). To assess the utility of this treatment augmentation, investigators…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    University of Wisconsin, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT07221929 on ClinicalTrials.gov

17. University of Iowa Interventional Psychiatry Service Patient Registry

    The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD). These treatments include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), racemic ketamine infusion a…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    University of Iowa Health Care, Iowa City, Iowa

    Run by

    Mark Niciu

    See if you can join NCT04480918 on ClinicalTrials.gov

18. Using TMS to Understand Neural Processes of Social Motivation

    The purpose of this study is to use transcranial magnetic stimulation (TMS) to better understand the neural circuits associated with social motivation. Participant includes four study visits each that range from 1.5 - 3.0 hours in duration over approximately a one month period. The first study visi…

    Stage

    Not phased

    Ages

    25 to 50

    Site

    Auburn University, Auburn, Alabama

    Run by

    Auburn University

    See if you can join NCT06274112 on ClinicalTrials.gov

19. Biomarker-guided rTMS for Treatment Resistant Depression

    Repetitive transcranial magnetic stimulation (rTMS) is a treatment for depression. The investigators are continuing to learn how to optimize outcomes from rTMS treatment. The purpose of this research project is to use brain network connectivity patterns as measured by resting state functional magne…

    Stage

    Phase 3

    Ages

    22 to 65

    Site

    Stanford University, Stanford, California

    Locations

    2 in total

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT04041479 on ClinicalTrials.gov

20. Optimizing Brain Excitability in Depression

    The goal of this study is to improve depression treatment by establishing reliable prefrontal excitability markers through Targeting with Automated Real-time Guidance for Enhancing TEPs (TARGET).

    Stage

    Not phased

    Ages

    18 to 65

    Site

    University of Iowa, Iowa City, California

    Locations

    2 in total

    Run by

    Stanford University

    See if you can join NCT07242105 on ClinicalTrials.gov

21. Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33

    The purpose of this research study is to determine if application of near infrared energy to the forehead can change blood flow in the brains of people with depression. Near infrared energy is like light but is not visible to the human eye.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Harvard Medical School, Boston, Massachusetts

    Locations

    3 in total

    Run by

    NYU Langone Health

    See if you can join NCT05573074 on ClinicalTrials.gov

22. Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

    The goal of this clinical trial is to learn if ABX-002 added to an existing antidepressant treatment will benefit depression symptoms in adults with moderate to severe major depressive disorder who have had an inadequate response to their antidepressant. This is a double-blind, placebo-controlled, …

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Autobahn Site #131, Birmingham, Alabama

    Locations

    50 in total

    Run by

    Autobahn Therapeutics, Inc.

    See if you can join NCT06633016 on ClinicalTrials.gov

23. Taking Action for College Students

    The goal of this research is to investigate whether a peer-delivered illness self-management program called Taking Action can help college students with serious mental illnesses. Participants will be randomly assigned to either the experimental condition (Taking Action) or the control condition (in…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Temple University, Philadelphia, Pennsylvania

    Run by

    Temple University

    See if you can join NCT06700902 on ClinicalTrials.gov

24. Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression

    The study will consist of a 24-week-long trial examining outcomes in patients with Major Depressive Disorder and suicidal ideation who will receive intravenous (IV) ketamine and intranasal (IN) esketamine, compared to a large sample of matched historical controls. Patients will be recruited from an…

    Stage

    Phase 4

    Ages

    18 to 70

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT05450432 on ClinicalTrials.gov

25. Psilocybin rTMS for Treatment Resistant Depression

    The purpose of this study is to determine the safety and feasibility of sequencing psilocybin therapy with a short-duration, aiTBS protocol (Stanford Accelerated Intelligent Neuromodulation Therapy, or SAINT) in individuals with treatment-resistant major depressive disorder.

    Stage

    Phase 2

    Ages

    22 to 65

    Site

    Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600, Austin, Texas

    Run by

    University of Texas at Austin

    See if you can join NCT06132178 on ClinicalTrials.gov