Major Depressive Disorder Clinical Trials

95 studies are recruiting for major depressive disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression

   Anhedonia, the inability to seek-out and experience pleasure, is a common symptom in depression that predicts treatment-resistance and is sometimes exacerbated by first-line antidepressants. In our previous research, we found that anhedonia decreases goal-directed behavior and its related neural ac…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Florida State University, Tallahassee, Florida

   Run by

   Florida State University

   See if you can join NCT06132581 on ClinicalTrials.gov

2. 5-HTP and Creatine for Depression R33 Phase

   This is a three-armed clinical trial examining the effect of 5-hydroxytryptophan and creatine monohydrate as augmenting agents for the treatment of depression. Subjects will be randomized between 5-HTP 100mg BID + creatine 5g daily, 5-HTP 200mg BID + creatine 10g daily, vs double placebo, for 8 wee…

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   University of Utah Department of Psychiatry, Salt Lake City, Utah

   Run by

   University of Utah

   See if you can join NCT05895747 on ClinicalTrials.gov

3. Positive Processes and Transition to Health (PATH)

   The R33 will be a randomized controlled trial to replicate changes in the targets (unproductive processing, avoidance, reward deficits) from the R61 phase in a larger sample of 135 participants who have experienced a destabilizing life event involving profound loss or threat, report persistent stre…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   University of Delaware, Newark, Delaware

   Locations

   3 in total

   Run by

   Case Western Reserve University

   See if you can join NCT06093906 on ClinicalTrials.gov

4. Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents

   This is a single-site open-label clinical trial of fMRI-guided accelerated intermittent theta burst stimulation. The goal of this clinical trial is to learn if a new form of transcranial magnetic stimulation (TMS)-known generally as accelerated intermittent theta burst stimulation (aiTBS)-is effect…

   Stage

   Not phased

   Ages

   13 to 20

   Site

   Dell Medical School at University of Texas at Austin, Austin, Texas

   Run by

   University of Texas at Austin

   See if you can join NCT06523439 on ClinicalTrials.gov

5. Enhancing Veteran-Clinical Collaboration in VA PRRCs

   Over 60% of Veterans with serious mental illness have a service-connected disability that impairs their ability to work, go to school, and/or have successful personal lives. Although traditional treatments tend to focus on symptom remission, Veterans prioritize a range of treatment goals, including…

   Stage

   Not phased

   Ages

   18 and older

   Site

   New Mexico VA Health Care System, Albuquerque, NM, Albuquerque, New Mexico

   Locations

   3 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT06898879 on ClinicalTrials.gov

6. The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder

   This open-label functional Magnetic Resonance Imaging (fMRI) study will assess the effects of a single dose of psilocybin on rumination and the neural correlates of rumination in individuals with major depressive disorder.

   Stage

   Phase 3

   Ages

   18 to 55

   Site

   Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts

   Run by

   Sharmin Ghaznavi

   See if you can join NCT06247839 on ClinicalTrials.gov

7. Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy

   This protocol proposes an initial randomized clinical trial that includes all patients with suicidal ideation (SI) at baseline, and with SI as the primary outcome measure to examine whether Right Unilateral Low-Amplitude Pulse - Seizure Therapy (RUL LAP-ST) treatment has more magnitude and rate of …

   Stage

   Phase 2

   Ages

   18 to 90

   Site

   Pine Rest Christian Mental Health Services, Grand Rapids, Michigan

   Run by

   Michigan State University

   See if you can join NCT06529029 on ClinicalTrials.gov

8. Pain and Major Depressive Disorder

   This study will examine the effects of brain stimulation on pain symptoms associated with Major depressive disorder. This study will enroll 54 Subjects. Study subjects will be asked to complete surveys about their mood and well-being, 2 blood draws, 2 MRIs, 3 electroencephalograms, and receive 30 t…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   UCLA Semel Institute, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT04556890 on ClinicalTrials.gov

9. NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

   The study will evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in participants with MDD on improving symptoms of depression.

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Neurocrine Clinical Site, Huntsville, Alabama

   Locations

   39 in total

   Run by

   Neurocrine Biosciences

   See if you can join NCT06911112 on ClinicalTrials.gov

10. Remote Evaluation and Alerting for Collaborative Health (REACH) in Depression

    Researchers hope to see if the data smartphones collect continuously can be used to predict if patient's depression symptoms will return. They will do this by collecting data from patient's smartphones and comparing it to their depression symptoms. If this method is successful, researchers could de…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dartmouth College, Hanover, New Hampshire

    Locations

    2 in total

    Run by

    Dartmouth-Hitchcock Medical Center

    See if you can join NCT07174557 on ClinicalTrials.gov

11. NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

    The study will evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in participants with MDD on improving symptoms of depression.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Neurocrine Clinical Site, Chino, California

    Locations

    35 in total

    Run by

    Neurocrine Biosciences

    See if you can join NCT06963021 on ClinicalTrials.gov

12. Closed-Loop Deep Brain Stimulation for Major Depression

    Neurons are specialized types of cells that are responsible for carrying out the functions of the brain. Neurons communicate with electrical signals. In diseases such as major depression this electrical communication can go awry. One way to change brain function is using electrical stimulation to h…

    Stage

    Not phased

    Ages

    22 to 70

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    Andrew Krystal

    See if you can join NCT04004169 on ClinicalTrials.gov

13. Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

    The goal of this clinical trial is to learn if zelquistinel works to treat depression in adults. It will also learn about the safety of zelquistinel. The main questions it aims to answer are: Does zelquistinel reduce depression scores in participants compared to participants who take a placebo (a l…

    Stage

    Phase 2

    Ages

    18 to 64

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    34 in total

    Run by

    Syndeio Biosciences, Inc

    See if you can join NCT06547489 on ClinicalTrials.gov

14. Mindful Self-Compassion for Anxiety Disorders and Depression

    The study will compare 8-week Mindful Self-Compassion training, compared to a control group that does not receive the intervention, on anxiety and depression symptom severity in patients with diagnosed anxiety disorders (generalized anxiety disorder, social anxiety disorder, and panic disorder) or …

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Georgetown University Medical Center, Washington D.C., District of Columbia

    Run by

    Georgetown University

    See if you can join NCT05671419 on ClinicalTrials.gov

15. A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

    The goal of this clinical trial is to learn if zelquistinel works to treat depression in adults. It will also learn about the safety of zelquistinel. The main questions it aims to answer are: Does zelquistinel reduce depression scores in participants compared to participants who take a placebo (a l…

    Stage

    Phase 2

    Ages

    18 to 64

    Site

    NoesisPharma, LLC, Phoenix, Arizona

    Locations

    32 in total

    Run by

    Syndeio Biosciences, Inc

    See if you can join NCT07115329 on ClinicalTrials.gov

16. RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS

    In this research study, investigators examine how brain activity changes during tests of emotional processing, attention, and memory using multimodal neuroimaging methods including electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and functional near-infrared spectroscopy …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Medical Univeristy of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT05977439 on ClinicalTrials.gov

17. Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness

    Participants will receive Transcranial Magnetic Stimulation (TMS) at a random location in the left prefrontal cortex, excluding sites that are potentially unsafe. Extensive behavioral testing will be conducted to determine which behaviors are modulated by stimulating which circuits.

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Acacia Clinics, Sunnyvale, California

    Locations

    2 in total

    Run by

    Brigham and Women's Hospital

    See if you can join NCT06376734 on ClinicalTrials.gov

18. Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents

    This study is dedicated to help identify biomarkers for depression and suicide. The purpose of the study is to better understand these links to improve medical and psychiatric care in the future. This research is also to test the effects of standard treatment of depression on improvement in depress…

    Stage

    Not phased

    Ages

    10 to 24

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    2 in total

    Run by

    University of Alabama at Birmingham

    See if you can join NCT05437588 on ClinicalTrials.gov

19. Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)

    This pilot study evaluates the feasibility, safety, and preliminary efficacy of home-based 60Hz intermittent light therapy in adults with a major depressive episode (MDE). Participants will be randomized in a 2:1 ratio to receive either active or sham 60Hz intermittent light stimulation for 30 minu…

    Stage

    Not phased

    Ages

    24 to 65

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT07111390 on ClinicalTrials.gov

20. CARED : A Novel Rapid Treatment Paradigm for Depression

    The purpose of this study is to primarily assess the feasibility and secondarily assess the efficacy of a single session intervention (SSI) that combines non-invasive brain stimulation and psychotherapy for Major Depressive Disorder (MDD). investigators will recruit 30 people with MDD, with at leas…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Carolina Center for Neurostimulation, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT07507370 on ClinicalTrials.gov

21. A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder

    Major depressive disorder (MDD; depression) is a mood disorder that causes a continued feeling of sadness and loss of interest. It is a common and serious illness that can cause both emotional and physical symptoms such as feelings of sadness, irritability, not being able to focus on activities, ti…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Harmonex /ID# 277517, Dothan, Alabama

    Locations

    33 in total

    Run by

    AbbVie

    See if you can join NCT07276997 on ClinicalTrials.gov

22. Evaluating tDCS Brain-stimulation in Depression Using MRI

    Patients, physicians, and those who fund depression research are keenly interested in depression treatments that do not involve taking medications. One promising candidate treatment is transcranial direct current stimulation (tDCS), a low-cost technique that involves placing electrodes on specific …

    Stage

    Not phased

    Ages

    20 to 55

    Site

    University of California Los Angeles (UCLA), Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT05598034 on ClinicalTrials.gov

23. tDCS: Sleep to Mood in Depression (S2M-D)

    The purpose of this study is to determine whether changes in sleep consolidation occur during home-based transcranial direct current stimulation (tDCS) in adults with moderate depression and whether these changes are temporally associated with improvements in depressive symptoms.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT07572526 on ClinicalTrials.gov

24. Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis

    The purpose of this research is to examine the effects of two different exercise training regimens for managing depression and improving other health indicators among persons with multiple sclerosis (MS). The project will enroll persons with MS and major depressive disorder (MDD) between 18 and 64 …

    Stage

    Not phased

    Ages

    18 to 64

    Site

    University of Illinois at Chicago, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT05051618 on ClinicalTrials.gov

25. Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With Ketamine

    The main purpose of this study is to investigate the effects of ketamine on decision-making and emotion processing in a sample of individuals diagnosed with Major Depressive Disorder (MDD).

    Stage

    EARLY_Phase 1

    Ages

    18 to 65

    Site

    Emory University, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT05327699 on ClinicalTrials.gov