Heart Failure With Preserved Ejection Fraction Clinical Trials

32 studies are recruiting for heart failure with preserved ejection fraction in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Boston, Massachusetts 6 Dallas, Texas 6 New York, New York 6 Philadelphia, Pennsylvania 6 Rochester, Minnesota 6 Indianapolis, Indiana 5 Ann Arbor, Michigan 4 Birmingham, Alabama 4 Pittsburgh, Pennsylvania 4 San Antonio, Texas 4 Winston-Salem, North Carolina 4 Atlanta, Georgia 3 Baltimore, Maryland 3 Chicago, Illinois 3 Cincinnati, Ohio 3 Detroit, Michigan 3 Durham, North Carolina 3 Houston, Texas 3 Kansas City, Missouri 3 Tucson, Arizona 3

Studies, page 2

  1. Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction

    This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.

    Stage
    Not phased
    Ages
    50 to 80
    Site
    UConn Health / John Dempsey Hospital, Farmington, Connecticut
    Run by
    UConn Health

    See if you can join NCT05174351 on ClinicalTrials.gov

  2. Home-Based Cardiac Rehabilitation for Patients With Heart Failure

    The vast majority of individuals with heart failure do not participate in center based cardiac rehabilitation (CBCR). While steps to increase utilization of CBCR are important, many individuals will still not participate for a variety of reasons. This pilot randomized controlled trial is evaluating…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Vanderbilt University Medical Center, Nashville, Tennessee
    Run by
    Vanderbilt University Medical Center

    See if you can join NCT06479876 on ClinicalTrials.gov

  3. Pioglitazone on Heart Failure in Type-2 Diabetes Mellitus Participants

    Our goal of the study is to learn the effects of the diabetes medication named Pioglitazone, in type-2 diabetic obese participants with Heart failure. The main question it aims to answer are: 1. To demonstrate that impaired mitochondrial function leading to reduced ATP generation plays a key pathop…

    Stage
    Phase 4
    Ages
    30 to 70
    Site
    Texas Diabetes Institute/UH, San Antonio, Texas
    Run by
    The University of Texas Health Science Center at San Antonio

    See if you can join NCT05838287 on ClinicalTrials.gov

  4. Fiber Supplementation in Heart Failure With Preserved Ejection Fraction (HFpEF)

    The study team is studying how increasing dietary fiber, specifically through adding potato starch to participant's diet, may impact the species of bacteria in participant's gut microbiome. The study team also wants to understand if adding potato starch to participant's diet helps these bacteria ma…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Michigan, Ann Arbor, Michigan
    Run by
    University of Michigan

    See if you can join NCT06337812 on ClinicalTrials.gov

  5. The PeriCut Catheter System Early Feasibility Study (REIMAGINE-HFpEF)

    The PeriCut early feasibility study will evaluate the safety and feasibility of successfully performing a minimally invasive pericardiotomy in patients with heart failure with preserved ejection fraction using the PeriCut Catheter System.

    Stage
    Not phased
    Ages
    30 and older
    Site
    Mayo Clinic, Rochester, Minnesota
    Run by
    Heart Failure Solutions, Inc.

    See if you can join NCT06702501 on ClinicalTrials.gov

  6. Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction

    Heart failure with preserved ejection fraction (HFPEF) is common and deadly but without therapy. Inconclusive studies such as TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) suggest spironolactone may be effective in HFPEF, but it is generic and will no…

    Stage
    Phase 3
    Ages
    50 to 99
    Site
    Falu lasarett, Falun,
    Locations
    78 in total
    Run by
    Uppsala University

    See if you can join NCT02901184 on ClinicalTrials.gov

  7. Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Preserved Ejection Fraction

    The goal of this clinical trial is to test an experimental gene therapy in participants with heart failure with preserved ejection fraction, also known as diastolic heart failure. The main questions it aims to answer are: * safety and tolerability of the gene therapy; and * whether the gene therapy…

    Stage
    Phase 1
    Ages
    50 and older
    Site
    Duke University, Durham, North Carolina
    Locations
    2 in total
    Run by
    Sardocor Corp.

    See if you can join NCT06061549 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.