Heart Failure With Preserved Ejection Fraction Clinical Trials in Philadelphia, Pennsylvania

6 studies are recruiting for heart failure with preserved ejection fraction in Philadelphia, Pennsylvania right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

  1. Assessment of CCM in HF With Higher Ejection Fraction

    The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and ≤70%.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Penn Presbyterian Medical Center, Philadelphia, Pennsylvania
    Locations
    105 in total
    Run by
    Impulse Dynamics

    See if you can join NCT05064709 on ClinicalTrials.gov

  2. Matching Perfusion and Metabolic Activity in HFpEF

    This study will test whether pharmacologic agents that increase perfusion [Potassium Nitrate (KNO3)], with and without additional supplements that may improve mitochondrial function [Propionyl-L-Carnitine (PLC) and Nicotinamide Riboside (NR)], improve submaximal exercise endurance and skeletal musc…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    University of Pennsylvania, Philadelphia, Pennsylvania
    Run by
    University of Pennsylvania

    See if you can join NCT04913805 on ClinicalTrials.gov

  3. SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial

    This study will test whether pharmacologic agents that may improve mitochondrial function and energy fuel metabolism [Empagliflozin (Empa)], with and without additional supplements that increase perfusion and fatty acid oxidation [Potassium Nitrate (KNO3)], improve submaximal exercise endurance and…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    University of Pennsylvania Health System, Philadelphia, Pennsylvania
    Run by
    University of Pennsylvania

    See if you can join NCT05138575 on ClinicalTrials.gov

  4. HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

    HeartShare is a comprehensive study of heart failure, a common and serious medical condition which occurs when the heart is unable to keep up with the demands of the body, resulting in shortness of breath, fluid retention, and fatigue. HeartShare aims to better classify heart failure into subtypes …

    Stage
    Not phased
    Ages
    30 and older
    Site
    University of Pennsylvania, Philadelphia, Pennsylvania
    Locations
    6 in total
    Run by
    Northwestern University

    See if you can join NCT05873634 on ClinicalTrials.gov

  5. Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

    The purpose of this study is to identify changes in heart tissue structure and biological function in patients with heart failure by performing an endomyocardial biopsy (EMB or heart biopsy) during a right heart catheterization (RHC). The ultimate goal is to use this information to develop new trea…

    Stage
    Not phased
    Ages
    30 and older
    Site
    University of Pennsylvania, Philadelphia, Pennsylvania
    Locations
    6 in total
    Run by
    Northwestern University

    See if you can join NCT06517186 on ClinicalTrials.gov

  6. Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction

    Heart failure with preserved ejection fraction (HFPEF) is common and deadly but without therapy. Inconclusive studies such as TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) suggest spironolactone may be effective in HFPEF, but it is generic and will no…

    Stage
    Phase 3
    Ages
    50 to 99
    Site
    Jefferson University Hospital, Philadelphia, Pennsylvania
    Locations
    78 in total
    Run by
    Uppsala University

    See if you can join NCT02901184 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.