Heart Failure With Preserved Ejection Fraction Clinical Trials in Boston, Massachusetts

6 studies are recruiting for heart failure with preserved ejection fraction in Boston, Massachusetts right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Assessment of CCM in HF With Higher Ejection Fraction

   The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and ≤70%.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Locations

   105 in total

   Run by

   Impulse Dynamics

   See if you can join NCT05064709 on ClinicalTrials.gov

2. EXercise and Activin Inhibition to Modulate InflammatioN Effects on Heart Failure and Cognition (EXAMINE-HFC)

   The goal of this clinical trial is to learn if therapy with activin ligand-trap biological therapy (an investigational drug) combined with exercise training can improve exercise capacity and cognitive function in heart failure with preserved ejection fraction (HFpEF). The main questions it aims to …

   Stage

   Phase 2

   Ages

   40 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT07202000 on ClinicalTrials.gov

3. HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

   HeartShare is a comprehensive study of heart failure, a common and serious medical condition which occurs when the heart is unable to keep up with the demands of the body, resulting in shortness of breath, fluid retention, and fatigue. HeartShare aims to better classify heart failure into subtypes …

   Stage

   Not phased

   Ages

   30 and older

   Site

   Mass General Brigham, Boston, Massachusetts

   Locations

   6 in total

   Run by

   Northwestern University

   See if you can join NCT05873634 on ClinicalTrials.gov

4. Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

   The purpose of this study is to identify changes in heart tissue structure and biological function in patients with heart failure by performing an endomyocardial biopsy (EMB or heart biopsy) during a right heart catheterization (RHC). The ultimate goal is to use this information to develop new trea…

   Stage

   Not phased

   Ages

   30 and older

   Site

   Mass General Brigham, Boston, Massachusetts

   Locations

   6 in total

   Run by

   Northwestern University

   See if you can join NCT06517186 on ClinicalTrials.gov

5. Purinergic Signaling and the Postmenopausal Heart

   There is an increased risk of diastolic heart failure in post menopausal women. Estrogen plays a positive role in regulating molecular pathways in heart remodeling. Such pathways may work through purinergic signaling and its downstream effects on the heart's mitochondrial metabolism and angiogenic …

   Stage

   Not phased

   Ages

   30 to 88

   Site

   Beth Israel Deaconess Medical Center, Boston, Massachusetts

   Run by

   Beth Israel Deaconess Medical Center

   See if you can join NCT06015776 on ClinicalTrials.gov

6. Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction

   Heart failure with preserved ejection fraction (HFPEF) is common and deadly but without therapy. Inconclusive studies such as TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) suggest spironolactone may be effective in HFPEF, but it is generic and will no…

   Stage

   Phase 3

   Ages

   50 to 99

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Locations

   78 in total

   Run by

   Uppsala University

   See if you can join NCT02901184 on ClinicalTrials.gov