Cystic Fibrosis Clinical Trials

45 studies are recruiting for cystic fibrosis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-272 in Healthy Participants

   The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of single and multiple ascending doses of VX-272.

   Stage

   Phase 1

   Ages

   18 to 55

   Site

   Celerion - Tempe, Tempe, Arizona

   Run by

   Vertex Pharmaceuticals Incorporated

   See if you can join NCT07437105 on ClinicalTrials.gov

2. Exercise in Child Health

   This study is a cooperative investigation funded by the NIH. The project is a collaboration among three major NIH Clinical Translational Science Awardees: 1) UCI (lead site with its affiliate CHOC), 2) Northwestern University (with its affiliate Lurie Children's Hospital), and 3) USC (with its affi…

   Stage

   Not phased

   Ages

   10 to 17

   Site

   University of California, Irvine, Irvine, California

   Run by

   University of California, Irvine

   See if you can join NCT05359991 on ClinicalTrials.gov

3. Personalized Theratyping Trial

   The purpose of this study is to explore the use of off-label CFTR modulators that may affect CFTR function in patients with CFTR mutations that are not currently approved for these drugs.

   Stage

   EARLY_Phase 1

   Ages

   6 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Run by

   George Solomon

   See if you can join NCT03587961 on ClinicalTrials.gov

4. Beta-cell Response to Incretin Hormones in Cystic Fibrosis

   In recent years, diabetes has emerged as one of the most significant co-diseases that many Cystic Fibrosis (CF) patients develop. Type 1 (T1D) and Type 2 (T2D) diabetes results when either the body does not make enough insulin or the body does not respond correctly to this insulin, respectively. In…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT01851694 on ClinicalTrials.gov

5. Regional Monitoring of CF Lung Disease

   The main reason for this research study is to learn more about some new tests that are being developing for patients with Cystic Fibrosis (CF) to measure changes in the lungs. In this study, the focus will be to learn how stopping Airway Clearance (ACT) and re-starting ACT can affect these tests. T…

   Stage

   EARLY_Phase 1

   Ages

   12 to 21

   Site

   Cincinnati Children's Hospital, Cincinnati, Ohio

   Run by

   Children's Hospital Medical Center, Cincinnati

   See if you can join NCT06339593 on ClinicalTrials.gov

6. Skin-interfaced Colorimetric Bifluidic Sweat Sensor Device for the Diagnosis of Cystic Fibrosis (CF)

   Cystic fibrosis (CF) is a multisystem autosomal recessive inherited disease affecting approximately 75,000 individuals in USA. The sweat chloride (Cl) test remains the gold standard for diagnosis of CF but still has a number of limitations. The objectives of this study are: 1)To evaluate a skin-int…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania

   Run by

   Milton S. Hershey Medical Center

   See if you can join NCT05998629 on ClinicalTrials.gov

7. Testing Drug Efficacy in Cystic Fibrosis Through N-of-1 Trials

   The purpose of this study is to validate and utilize a personalized medicine approach to identify potential treatments with current FDA approved CFTR modifiers for non-approved CF gene mutations. The study will perform ex vivo testing of CFTR function and current marketed CFTR modulating drugs on e…

   Stage

   Not phased

   Ages

   6 and older

   Site

   CCHMC, Cincinnati, Ohio

   Run by

   Children's Hospital Medical Center, Cincinnati

   See if you can join NCT04580368 on ClinicalTrials.gov

8. Impact of Highly Effective Modulator Therapy on the Cystic Fibrosis Microbiome

   The goal of this observational study is to learn about the effects of a specific cystic fibrosis therapy (Cystic Fibrosis Transmembrane Conductance Regulator Modulator Therapy) on chronic sinonasal disease. The main questions it aims to answer are: 1. How does this therapy impact bacterial communit…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

   Run by

   Dartmouth-Hitchcock Medical Center

   See if you can join NCT05982795 on ClinicalTrials.gov

9. Estrogen Supplementation and Bone Health in Women With CF

   The goal of this study is to learn about the role of estrogen and other hormones in bone development in adolescent and young adult women with cystic fibrosis (CF). The study has two main components, an observational study and a feasibility sub-study. The main questions it aims to answer are: * How …

   Stage

   Phase 4

   Ages

   0 to 100

   Site

   Johns Hopkins, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT05704036 on ClinicalTrials.gov

10. Health Outcomes of Parents With Cystic Fibrosis-Aim 2

    The goal of this observational prospective study is to determine the health impact of parenthood on United States (US) people with CF in the era of CF transmembrane regulator protein (CFTR) modulators. The investigators will collect physical and mental health data to comprehensively evaluate the im…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama-Birmingham, Birmingham, Alabama

    Locations

    18 in total

    Run by

    University of Pittsburgh

    See if you can join NCT06296394 on ClinicalTrials.gov

11. Restarting Triple Therapy With Robust Monitoring for Adverse Events (RETRIAL)

    RETRIAL is a multi-site observational study of people with Cystic Fibrosis (PWCF) ages 6 and up starting the new triple-therapy modulator (vanzacaftor/tezacaftor/deutivacaftor (VTD)), after having experienced neuropsychiatric events and/or liver injury while taking elexacaftor/tezacaftor/ivacaftor …

    Stage

    Not phased

    Ages

    6 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    18 in total

    Run by

    Boston Children's Hospital

    See if you can join NCT06683092 on ClinicalTrials.gov

12. Skeletal Health and Bone Marrow Composition in Adolescents With Cystic Fibrosis

    The investigators will be evaluating bone marrow composition via magnetic resonance imaging in adolescents diagnosed with cystic fibrosis (CF) compared to healthy, matched controls. The investigators will also be assessing their bone mineral density via other imaging modalities, including dual-ener…

    Stage

    Not phased

    Ages

    13 to 20

    Site

    Boston Children's Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06216704 on ClinicalTrials.gov

13. Acoustic Waveform Respiratory Evaluation

    The study will evaluate the feasibility of using smartphone speakers and microphones to evaluate the caliber of the airways, detect airway obstruction, aid in airway disease diagnosis, and identify disease exacerbations.

    Stage

    Not phased

    Ages

    8 to 70

    Site

    Indiana University, Indianapolis, Indiana

    Locations

    2 in total

    Run by

    Indiana University

    See if you can join NCT06512064 on ClinicalTrials.gov

14. A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

    The REACH study is for people with CF who do not take cystic fibrosis transmembrane conductance regulator (CFTR) modulators. The goal of the REACH study is to collect research data, including health data and specimens, from people with CF who do not take CFTR modulators. This data may be used to in…

    Stage

    Not phased

    Ages

    12 and older

    Site

    The Children's Hospital Alabama, University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    68 in total

    Run by

    Nicole Hamblett

    See if you can join NCT06504589 on ClinicalTrials.gov

15. The Effects of a Low Glycemic Load Diet on Dysglycemia and Body Composition in Adults With Cystic Fibrosis-Related Diabetes

    This study will evalute the effect of a low glycemic load (LGL diet on dysglycemia, insulin requirements, DXA-derived body composition, gastrointestinal symptoms and quality of life measures in adults with cystic fibrosis-related diabetes (CFRD). We will use continuous glucose monitors (CGM) to ass…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Boston Children's Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Rhode Island Hospital

    See if you can join NCT05723445 on ClinicalTrials.gov

16. Targeting Inflammation With Losartan to Improve Response to Modulator Therapy in Cystic Fibrosis.

    The goal of this clinical trial is to test use of losartan in those with cystic fibrosis (CF) on modulator therapy. The main question it aims to answer is if treatment with losartan improves response of the CF transmembrane conductance regulator (CFTR) channel to modulator therapy. Participants wil…

    Stage

    Phase 2

    Ages

    12 and older

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT06364176 on ClinicalTrials.gov

17. Regional Phenotyping of CF and Non-CF Bronchiectasis

    The Investigators propose to study pediatric subjects who are diagnosed with cystic fibrosis (CF) and patients with non-CF bronchiectasis, with the goal of developing markers of CF lung disease severity, progression, and therapy response. The Investigator's central hypothesis is that image-based ma…

    Stage

    Not phased

    Ages

    5 to 100

    Site

    Penny New, Cincinnati, Ohio

    Run by

    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT04793867 on ClinicalTrials.gov

18. Lung Transplant READY CF 2: CARING CF Ancillary RCT

    Lung transplant is an option for treating end-stage lung disease in cystic fibrosis (CF). In the United States, more people with CF and low lung function die each year than undergo lung transplant. More than half of people with CF who die without a lung transplant were never referred for considerat…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Washington Medical Center - Montlake, Seattle, Washington

    Run by

    University of Washington

    See if you can join NCT06032273 on ClinicalTrials.gov

19. A Phase 1/2 Trial of SP-101 for the Treatment of Cystic Fibrosis (CF)

    This is a Phase 1/2 multicenter, open-label, single dose trial of SP-101 investigational gene therapy in adults with CF who are ineligible for or intolerant to CFTR modulator therapy.

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Locations

    4 in total

    Run by

    Spirovant Sciences, Inc.

    See if you can join NCT06526923 on ClinicalTrials.gov

20. BEGIN Novel ImagiNG Biomarkers

    To determine the treatment effect of triple-combination therapy in 6-8 year olds after presumed FDA approval, using rapid structural and functional pulmonary and abdominal MRI (UTE and 129Xe).

    Stage

    Phase 4

    Ages

    6 to 8

    Site

    University of Virginia, Charlottesville, Virginia

    Locations

    3 in total

    Run by

    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT05517655 on ClinicalTrials.gov