Cystic Fibrosis Clinical Trials

45 studies are recruiting for cystic fibrosis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Genetics of Insulin and Incretins in Cystic Fibrosis

   Cystic fibrosis related diabetes (CFRD) is associated with worse CF-relevant outcomes. The mechanisms underlying CFRD development are not fully understood, but recent evidence suggests Type 2 Diabetes Mellitus (T2DM) mechanisms may be involved and may involve incretins (gut secreted hormones that a…

   Stage

   Not phased

   Ages

   2 and older

   Site

   The Children's Hopsital of Philadelphia, Philadelphia, Pennsylvania

   Locations

   2 in total

   Run by

   Children's Hospital of Philadelphia

   See if you can join NCT01852448 on ClinicalTrials.gov

2. Natural History of Noncirrhotic Portal Hypertension

   Background: - Noncirrhotic Portal Hypertension (NCPH) is caused by liver diseases that increase pressure in the blood vessels of the liver. It seems to start slowly and not have many warning signs. Many people may not even know that they have a liver disease. There are no specific treatments for NC…

   Stage

   Not phased

   Ages

   12 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT02417740 on ClinicalTrials.gov

3. Role of Genetic Factors in the Development of Lung Disease

   This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examining the genes in lung cells of patients with lung disease. The study will focus on defining the distribution of abnormal genes responsible fo…

   Stage

   Not phased

   Ages

   2 to 90

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Locations

   2 in total

   Run by

   National Heart, Lung, and Blood Institute (NHLBI)

   See if you can join NCT00001532 on ClinicalTrials.gov

4. Impact of Sinus Surgery on Individuals With Cystic Fibrosis

   This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS). Individuals who do not undergo surgery but are treated medically for CRS will also be enrolled to serve as a control group. Outcomes analy…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   University of California, Los Angeles, Los Angeles, California

   Locations

   9 in total

   Run by

   University of California, Los Angeles

   See if you can join NCT04469439 on ClinicalTrials.gov

5. Sinus Disease in Young Children With Cystic Fibrosis

   This is a prospective, observational study examining the impact of highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators on chronic rhinosinusitis (CRS) and olfactory dysfunction (OD) in young children with cystic fibrosis (YCwCF). This study involves two groups: ch…

   Stage

   Not phased

   Ages

   2 to 8

   Site

   Children's Hospital Colorado, Aurora, Colorado

   Locations

   6 in total

   Run by

   University of California, Los Angeles

   See if you can join NCT06191640 on ClinicalTrials.gov

6. Natural History of Bronchiectasis

   Background: * Bronchiectasis is a disease characterized by airways that are inflamed, abnormally dilated, and chronically infected. Individuals with bronchiectasis have a history of chronic and recurring respiratory infections. Depending on the underlying cause, these infections may involve the ent…

   Stage

   Not phased

   Ages

   5 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Heart, Lung, and Blood Institute (NHLBI)

   See if you can join NCT00943514 on ClinicalTrials.gov

7. Hormonal Responses to a Mixed Meal in People With Cystic Fibrosis

   In this exploratory study, the hormonal responses to a mixed meal will be examined in people with cystic fibrosis. The aim of this study is to find correlates with impaired glucose tolerance that is associated with this population.

   Stage

   Not phased

   Ages

   18 to 45

   Site

   University of Cincinnati, Cincinnati, Ohio

   Run by

   University of Cincinnati

   See if you can join NCT06163482 on ClinicalTrials.gov

8. Remote Sputum Collection in Cystic Fibrosis

   Elexacaftor/Tezacaftor/Ivacaftor or Trikafta improves lung health in people with cystic fibrosis (CF), including decreased cough and mucous production. Diagnosing lung infections has become more challenging due to the decrease in sputum and rise of telehealth services. While the option of collectin…

   Stage

   Not phased

   Ages

   18 and older

   Site

   National Jewish Health, Denver, Colorado

   Locations

   4 in total

   Run by

   University of Pennsylvania

   See if you can join NCT06950892 on ClinicalTrials.gov

9. Streamlined Treatment of Pulmonary Exacerbations in Pediatrics

   The STOP PEDS RCT is a multicenter, parallel, open label randomized controlled trial evaluating the long-term (one year) and short-term safety and efficacy of two antibiotic treatment strategies for the management of outpatient pulmonary exacerbations (PEx) in the pediatric CF population.

   Stage

   Not phased

   Ages

   3 to 18

   Site

   The Children's Hospital Alabama & University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   33 in total

   Run by

   University of Washington, the Collaborative Health Studies Coordinating Center

   See if you can join NCT06654752 on ClinicalTrials.gov

10. Continuous Glucose Monitoring and OGTT Screen for Cystic Fibrosis Related Diabetes in Cystic Fibrosis

    Cystic Fibrosis (CF) related diabetes (CFRD) is a unique form of diabetes mellitus, different from type 1 diabetes and type 2 diabetes. The diagnosis of CFRD is associated with a decline in pulmonary function, decreased nutritional status, and increased mortality. CFRD is extremely common in people…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Medical College of Wisconsin, Milwaukee, Wisconsin

    Run by

    Medical College of Wisconsin

    See if you can join NCT06560463 on ClinicalTrials.gov

11. Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-581 in Healthy Participants

    The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of single dose of VX-581 and multiple ascending doses of VX-581 alone and in combination with tezacaftor (TEZ)/deutivacaftor (D-IVA) or D-IVA for up to ten days.

    Stage

    Phase 1

    Ages

    18 to 55

    Site

    Altasciences - Kansas City, Overland Park, Kansas

    Run by

    Vertex Pharmaceuticals Incorporated

    See if you can join NCT07283770 on ClinicalTrials.gov

12. Study to Evaluate Biological & Clinical Effects of Significantly Corrected CFTR Function in Infants & Young Children

    This is a two-part, multi-center, prospective longitudinal, exploratory study of highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators and their impact on children with cystic fibrosis (CF).

    Stage

    Not phased

    Ages

    Up to 10

    Site

    The Children's Hospital Alabama, University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    35 in total

    Run by

    Sonya Heltshe

    See if you can join NCT04509050 on ClinicalTrials.gov

13. Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

    The purpose of this study is to look at pulmonary exacerbations in people with cystic fibrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of respiratory symptoms in people with CF that needs me…

    Stage

    Phase 4

    Ages

    6 and older

    Site

    The Children's Hospital Alabama, University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    60 in total

    Run by

    Chris Goss

    See if you can join NCT05548283 on ClinicalTrials.gov

14. Quantitation and Spatial Registration of Airways Dysfunction With Dynamic 19F MRI in Cystic Fibrosis

    The purpose of this study is to look at lung ventilation in people with cystic fibrosis over time (1 year) using magnetic resonance imaging (MRI) with an inhaled contrast gas, and compare these measures to lung function assessed by spirometry and multiple breath nitrogen washout. This study also lo…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Univeristy of North Carolina at Chapel Hill, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06057714 on ClinicalTrials.gov

15. FEED-Cystic Fibrosis (FEED-CF)

    The goal of this study is to determine the extent to which excess dietary sugars serve as a precipitating factor in glucose intolerance in adults with cystic fibrosis (CF), a population at especially high risk for a unique form of diabetes (CF-related diabetes, CFRD) and with standard-of-care dieta…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Emory University Hospital, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT05766774 on ClinicalTrials.gov

16. Rare CFTR Mutation Cell Collection Protocol (RARE)

    Over 1,900 mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein are implicated in causing Cystic Fibrosis (CF). Potential therapies that directly target defective CFTR are being evaluated in important clinical trials, but most target the most common CFTR …

    Stage

    Not phased

    Ages

    17 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    George Solomon

    See if you can join NCT03161808 on ClinicalTrials.gov

17. Role of Body Fat Distribution in Metabolic and Pulmonary Decline in Cystic Fibrosis (ORBIT-CF)

    Nutrition and body composition, the amount of muscle and fat in the body, has a role in overall health. This study wants to learn more about how nutrition and body composition affects health outcomes like glucose tolerance and lung function in patients with cystic fibrosis (CF) who are ages 16-30 y…

    Stage

    Not phased

    Ages

    16 and older

    Site

    Emory University/Children's Hospital of Atlanta (CHOA), Atlanta, Georgia

    Locations

    2 in total

    Run by

    Emory University

    See if you can join NCT04002882 on ClinicalTrials.gov

18. GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance

    Diabetes is a major co-morbidity in pancreatic insufficient cystic fibrosis (PI-CF) and associated with worse outcomes. While reduced β-cell mass contributes to the insulin secretory defects that characterizes cystic fibrosis-related diabetes (CFRD), other modifiable determinants appear operative i…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Children's Hospital of Colorado, Aurora, Colorado

    Locations

    2 in total

    Run by

    University of Pennsylvania

    See if you can join NCT04731272 on ClinicalTrials.gov

19. Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of SPL84 in Patients With Cystic Fibrosis

    The goal of this clinical trial is to learn if drug SPL84 is safe for adult patients with cystic fibrosis (CF). It will also learn if the drug works to treat works to treat CF with a specific mutation (3849 +10kb C-->T). The purpose of this research study is to test the safety and effectiveness of …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Southern California, Los Angeles, California

    Locations

    3 in total

    Run by

    SpliSense Ltd.

    See if you can join NCT06429176 on ClinicalTrials.gov

20. Safety, Tolerability and Efficacy Study of ARCT-032 in People With Cystic Fibrosis

    ARCT-032-02 is a Phase 2, open-label, multicenter, multiple-ascending dose study of ARCT-032 in adults with CF who are not eligible for CFTR modulator therapy or are not taking CFTR modulators due to drug intolerance, poor response, or lack of access to modulators.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Arizona, Tucson, Arizona

    Locations

    13 in total

    Run by

    Arcturus Therapeutics, Inc.

    See if you can join NCT06747858 on ClinicalTrials.gov

21. A Study Assessing KB407 for the Treatment of Cystic Fibrosis

    This study will evaluate safety and tolerability of ascending doses of nebulized KB407 in adults with cystic fibrosis.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of Florida, Gainesville, Gainesville, Florida

    Locations

    6 in total

    Run by

    Krystal Biotech, Inc.

    See if you can join NCT05504837 on ClinicalTrials.gov

22. Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

    The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.

    Stage

    Phase 1

    Ages

    3 and older

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    Mario Castro, MD, MPH

    See if you can join NCT04624490 on ClinicalTrials.gov

23. Markers of Osteoporosis in Cystic Fibrosis

    Main Study Up to 100 subjects, both non-CF volunteers and Cystic Fibrosis (CF) patients, will participate in a single study visit that will include a DEXA scan, micro CT, and blood collection. Denosumab (Prolia) Sub study Approximately 10 adult subjects with CF who participated in the main study an…

    Stage

    Phase 4

    Ages

    18 to 64

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT03921060 on ClinicalTrials.gov

24. Maralixibat in Patients With Cystic Fibrosis and Constipation

    Chronic constipation is common in children with cystic fibrosis (CF), likely due to impaired chloride channel function that reduces intestinal secretions. Standard osmotic laxatives often provide inadequate relief in this population. Maralixibat is an ileal bile acid transporter inhibitor (IBATi) t…

    Stage

    Phase 2

    Ages

    1 to 18

    Site

    Children's Hospital Los Angeles, Los Angeles, California

    Run by

    Children's Hospital Los Angeles

    See if you can join NCT06413368 on ClinicalTrials.gov

25. Metformin for People With CFRD on CFTR Modulator Therapy to Improve Ion Channel Function

    The purpose of this study is to assess the efficacy of metformin to improve airway ion channel function in those with CF-related diabetes (CFRD)

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT04530383 on ClinicalTrials.gov