Coronary Artery Disease Clinical Trials

51 studies are recruiting for coronary artery disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies, page 2

1. PET/CT* vs. Cardiac CT for Detecting Coronary Atherosclerotic Disease [*PET: Positron Emission Tomography; CT: Computed Tomography]

   Early detection of coronary atherosclerotic disease facilitates adequate prevention. The purpose of this study is to compare an assessment of coronary atherosclerotic disease burden by positron emission tomography / computed tomography (NaF-PET/CT) with those of conventional and ultra-high-resoluti…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Johns Hopkins Hospital, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT05994014 on ClinicalTrials.gov

2. CTSN Embolic Protection Trial

   This is a prospective, multi-center, randomized effectiveness trial of the CardioGard Embolic Protection Cannula in high-risk valve surgery patients.

   Stage

   Not phased

   Ages

   60 and older

   Site

   CHI St. Vincent Heart Institute, North Little Rock, Arkansas

   Locations

   28 in total

   Run by

   Icahn School of Medicine at Mount Sinai

   See if you can join NCT06027788 on ClinicalTrials.gov

3. Comparison of Dual Antiplatelet Therapy De-escalation by Dose Reduction Versus Switching in Patients Undergoing PCI: The Switching Antiplatelet-8 (SWAP-8) Study

   Dual antiplatelet therapy (DAPT) with low-dose aspirin and a P2Y12 inhibitor is the current standard of care in patients with coronary artery disease experiencing an acute event or undergoing percutaneous coronary intervention. However, the ischemic benefits are counterbalanced by a significant inc…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   University of Florida, Jacksonville, Florida

   Run by

   University of Florida

   See if you can join NCT06821191 on ClinicalTrials.gov

4. The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)

   The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy (STICH3C) trial is a prospective, unblinded, international multi-center randomized trial of 754 subjects enrolled in approximately 45 centers comparing revascularization by percutaneous coronary intervention (PCI) vs. coronary artery…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cedars-Sinai, Los Angeles, California

   Locations

   43 in total

   Run by

   Sunnybrook Health Sciences Centre

   See if you can join NCT05427370 on ClinicalTrials.gov

5. Prevail Global Study

   The purpose of the study is to evaluate the clinical safety and efficacy of the Prevail DCB.

   Stage

   Not phased

   Ages

   18 and older

   Site

   The University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   51 in total

   Run by

   Medtronic Vascular

   See if you can join NCT06535854 on ClinicalTrials.gov

6. The Peri-OPerative COlchicine to Reduce Negative Events (POPCORN) Trial

   Heart disease remains the leading cause of death in Veterans. Inflammation in the arteries of the heart may increase the risk of cardiac death. Patients with heart disease undergoing major surgery are at increased risk of complications after surgery, including heart attack, stroke, and death. The p…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Birmingham VA Medical Center, Birmingham, AL, Birmingham, Alabama

   Locations

   9 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT05618353 on ClinicalTrials.gov

7. Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

   The central hypothesis of ROMA:Women is that the use of multiple arterial grafting (MAG) will improve clinical outcomes and quality of life (QOL) compared to single arterial grafting (SAG). The specific aims of ROMA:Women are: Aim 1: Determine the impact of MAG vs SAG on major adverse cardiac and c…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cedars-Sinai Medical Center, Los Angeles, California

   Locations

   146 in total

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT04124120 on ClinicalTrials.gov

8. Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascular Health

   The goal of this clinical trial is to evaluate whether disclosure of a polygenic risk score for coronary artery disease (CAD PRS) influences cardiovascular health and risk factor modification over one year among adults aged 30-75 years in the Mass General Brigham primary care network who are not cu…

   Stage

   Not phased

   Ages

   30 to 75

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT07087431 on ClinicalTrials.gov

9. Tailoring Bleeding Reduction Approaches in Patients Undergoing PCI

   Two strategies have both proven to be effective in reducing bleeding complications while preserving efficacy compared with maintaining long-term DAPT with aspirin and a potent P2Y12 inhibitor: a) DAPT de-escalation (i.e., switching from prasugrel or ticagrelor to clopidogrel while maintaining aspir…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   University of Florida, Jacksonville, Florida

   Run by

   University of Florida

   See if you can join NCT05681702 on ClinicalTrials.gov

10. Digital Monitoring for Patients Post Coronary Interventions to Reduce Risk for Recurrent Adverse Cardiovascular Events

    The study aims to support patients immediately after percutaneous coronary intervention (PCI) by implementing a telemonitoring program. Eligible patients have coronary heart disease and undergo PCI. The intervention group receives remote monitoring and text-based follow-up, with established health …

    Stage

    Not phased

    Ages

    Any age

    Site

    University of California, Davis Medical Center Division of Cardiovascular Medicine, Sacramento, California

    Run by

    University of California, Davis

    See if you can join NCT06114615 on ClinicalTrials.gov

11. Effects of Low-dose Ticagrelor vs. Clopidogrel in Stable Patients Undergoing Elective Percutaneous Coronary Intervention

    The proposed study aims to assess the antiplatelet effects of more potent oral P2Y12 inhibition with low-dose ticagrelor (60 mg bid) compared with standard of care clopidogrel in patients with a high ABCD-GENE score (≥10). We hypothesize that ticagrelor is associated with better pharmacodynamic eff…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    University of Florida Jacksonville, Jacksonville, Florida

    Run by

    University of Florida

    See if you can join NCT06228456 on ClinicalTrials.gov

12. Switching From Dual Antiplatelet Therapy to Monotherapy With Potent P2Y12 Inhibitors

    Ticagrelor currently represents the most tested and commonly used P2Y12 inhibitor monotherapy following percutaneous coronary intervention. The purpose of this study is to conduct a head-to-head comparison on the pharmacodynamic efficacy of ticagrelor-based and prasugrel-based single antiplatelet t…

    Stage

    Phase 4

    Ages

    18 to 75

    Site

    University of Florida Jacksonville, Jacksonville, Florida

    Run by

    University of Florida

    See if you can join NCT06691191 on ClinicalTrials.gov

13. Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence

    Socioeconomically disadvantaged populations with multiple chronic conditions have high rates of nonadherence to essential chronic disease medications after hospital discharge. Medication nonadherence after hospital discharge is significantly associated with increased mortality and higher rates of r…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Tennessee Health Science Center/Regional One Health, Memphis, Tennessee

    Locations

    2 in total

    Run by

    University of Tennessee

    See if you can join NCT06374277 on ClinicalTrials.gov

14. AI Detection of Incidental Coronary Artery Calcium to Enhance Cardiovascular Disease Prevention

    AI INFORM is a multicenter randomized trial that will test the hypothesis that providing clinicians information on the presence and amount of coronary artery calcifications (CAC), will result in initiation or intensification of preventive therapies. The study will use a cloud-based artificial intel…

    Stage

    Not phased

    Ages

    40 to 75

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT06235112 on ClinicalTrials.gov

15. A Precision Medicine Approach to Identify Patients Undergoing Elective PCI at Risk of Peri-PCI Myocardial Infarction

    Despite the relative safety of PCI with new generation stents, peri-PCI thrombotic complications, including myocardial infarction and myocardial injury, are common in elective PCI, occurring in up to 30% of patients. Importantly, these events are associated with poor prognosis. The risk of peri-PCI…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Florida Jacksonville, Jacksonville, Florida

    Run by

    University of Florida

    See if you can join NCT05332262 on ClinicalTrials.gov

16. Prevent Cardiac Surgery Associated AKI Trial

    Prevent CSA-AKI (Cardiac Surgery Associated Acute Kidney Injury) trial is a double blinded randomized controlled trial, 242 patients undergoing elective cardiopulmonary bypass surgery (CPB)will either receive a placebo or daily 1200 mg of Co enzyme Q10 (CoQ10) and 1000 mg of Glutathione (GSH), the …

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    George Washington University Hospital, Washington D.C., District of Columbia

    Run by

    George Washington University

    See if you can join NCT06620523 on ClinicalTrials.gov

17. MagicTouch™Sirolimus-Coated Balloon for Treatment of Coronary Artery Lesions in Small Vessels

    This is a multicenter, randomized, single-blind pivotal study to evaluate the safety and efficacy of the MagicTouchTM Drug coated balloon in treatment of small vessels in patients with coronary artery disease. The objective is to establish the safety and efficacy of the Magic TouchTM Drug coated ba…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Clearwater Cardiovascular and Interventional Consultants, Clearwater, Florida

    Locations

    24 in total

    Run by

    Concept Medical Inc.

    See if you can join NCT06271590 on ClinicalTrials.gov

18. South Asians and Coronary Plaque Registry

    Individuals who self-report as SAs will be recruited to participate in this registry as well as non-SA controls for comparison. All individuals who consent to participate will 1) complete a survey assessing demographics, medical history, family medical history; 2) have blood collection; 3) and CCTA…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT05367297 on ClinicalTrials.gov

19. Acceptance and Commitment Therapy for Patients Undergoing Coronary Artery Bypass Graft Surgery

    Heart disease is the leading cause of death globally, accounting for 16% of the world's total deaths. The number of cases is expected to increase as our population ages. Heart disease also results in large economic burden. It costs the United States about $219 billion per year. Some patients have s…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of Iowa Hospitals and Clinics, Iowa City, Iowa

    Run by

    University of Iowa

    See if you can join NCT06207318 on ClinicalTrials.gov

20. Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement

    Patients undergoing transcatheter aortic valve replacement (TAVR) often have concomitant coronary artery disease (CAD) which may adversely affect prognosis. There is uncertainty about the benefits and the optimal timing of revascularization for such patients. There is currently clinical equipoise r…

    Stage

    Not phased

    Ages

    Any age

    Site

    Huntsville Heart Center, Huntsville, Alabama

    Locations

    72 in total

    Run by

    University of British Columbia

    See if you can join NCT04634240 on ClinicalTrials.gov

21. Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease

    COMPLETE-2 is a prospective, multi-centre, randomized controlled trial comparing a strategy of physiology-guided complete revascularization to angiography-guided complete revascularization in patients with acute ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UCLA, Los Angeles, California

    Locations

    113 in total

    Run by

    Population Health Research Institute

    See if you can join NCT05701358 on ClinicalTrials.gov

22. PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm

    This purpose of this trial is to demonstrate 30 day safety and effectiveness outcomes of the KARDION CORY P4 System in subjects who require hemodynamic support during a high-risk PCI procedure.

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Dignity Health - Chandler Regional Medical Center, Chandler, Arizona

    Locations

    18 in total

    Run by

    Kardion Inc

    See if you can join NCT06445608 on ClinicalTrials.gov

23. Prospective Registry of Patients Undergoing Cardiac CT With NAEOTOM Alpha PCD-CT Before TAVI Procedure

    The clinical and demographic characteristics of patients undergoing transcatheter aortic valve implantation (TAVI) pose unique challenges for coronary computed tomography (CT) imaging, as this patient population is mainly composed of elderly, frail individuals with severe aortic stenosis, multiple …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Locations

    7 in total

    Run by

    Semmelweis University

    See if you can join NCT07016477 on ClinicalTrials.gov

24. MagicTouch for Treatment of In-Stent Restenosis in Coronary Artery Lesions

    A Prospective, Multicenter, Randomized, Two-Arm, Single-blind Superiority Trial to Evaluate the Safety and Efficacy of the MagicTouch™ Sirolimus- Coated Balloon in the Treatment of Coronary Drug-Eluting Stent In-Stent Restenosis. Subjects with prior DES implantation presenting with ISR lesions unde…

    Stage

    Not phased

    Ages

    18 to 110

    Site

    Cardiology, PC - Princeton Baptist Medical Center, Birmingham, Alabama

    Locations

    28 in total

    Run by

    Concept Medical Inc.

    See if you can join NCT05908331 on ClinicalTrials.gov

25. PRimary IndividualiZed Evaluation of Cardiovascular Events in Patients With Diabetes Mellitus Using hemoTAG

    To evaluate the proportion of diabetic mellitus patients with CV events as measured by HEMOTAG.

    Stage

    Not phased

    Ages

    40 and older

    Site

    Metabolic Research Institute, Inc, West Palm Beach, Florida

    Run by

    Aventusoft, LLC.

    See if you can join NCT06567795 on ClinicalTrials.gov