Coronary Artery Disease Clinical Trials

51 studies are recruiting for coronary artery disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Product Surveillance Registry

   The purpose of the Registry is to provide continuing evaluation and periodic reporting of safety and effectiveness of Medtronic market-released products. The Registry data is intended to benefit and support interests of patients, hospitals, clinicians, regulatory bodies, payers, and industry by str…

   Stage

   Not phased

   Ages

   Any age

   Site

   Research site, Birmingham, Alabama

   Locations

   401 in total

   Run by

   Medtronic

   See if you can join NCT01524276 on ClinicalTrials.gov

2. Factors Affect Outcomes in Cardiovascular Surgery

   Identify factors that contribute to perioperative morbidity and mortality in patients undergoing cardiac surgery that involves cardiopulmonary bypass. Identify factors that affect perioperative morbidity and mortality in patients undergoing cardiac surgery.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of California Davis Health System, Sacramento, California

   Run by

   University of California, Davis

   See if you can join NCT01932411 on ClinicalTrials.gov

3. Hyperpolarized 13C Pyruvate-MRI and FDG-PET in a Single Exam for the Prognosis of Ischemic Cardiomyopathy

   This prospective, non-blinded, single-center, translational research study aims to validate a multimodal advanced imaging exam for cardiac viability. The protocol utilizes three distinct imaging modalities: Single Photon Emission Computed Tomography Myocardial Perfusion Imaging (SPECT MPI), 18F-flu…

   Stage

   Not phased

   Ages

   20 to 80

   Site

   University of Texas Southwestern Medical Center, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT06814587 on ClinicalTrials.gov

4. Prognostic Value of Hyperpolarized 13C MRI for Clinical Myocardial Viability

   Heart failure due to coronary artery disease represents a significant cause of mortality. The detection of patients eligible for bypass surgery is a pivotal concern. Nevertheless, the optimal approach for patient selection based on conventional imaging scans remains unclear. The proposed method (Hy…

   Stage

   Not phased

   Ages

   20 to 80

   Site

   University of Texas Southwestern Medical Center, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT06047028 on ClinicalTrials.gov

5. Investigational Trial to Evaluate XC001 Delivered Via an Cardiac Catheter in Subjects With Chronic Angina.

   This is a two-part study, comprised of an initial open-label run-in phase (Part 1) in a subset of 3 subjects to provide first data regarding safety, and feasibility of the percutaneous endovascular catheter-facilitated intramyocardial delivery of XC001 in patients with RA due to obstructive CAD. Pa…

   Stage

   Phase 2

   Ages

   18 to 85

   Site

   Alabama Cardiology PC, Birmingham, Alabama

   Locations

   14 in total

   Run by

   XyloCor Therapeutics, Inc.

   See if you can join NCT07048808 on ClinicalTrials.gov

6. Pivotal Study of the SUpira System in Patients Undergoing High-Risk Percutaneous COronaRy InTervention (HRPCI)

   The objective of this study is to assess the safety and efficacy of the Supira System in providing temporary cardiovascular hemodynamic support in patients undergoing HRPCI. Eligible patients will be randomized to undergo HRPCI with either the Supira System (investigational device) or the commercia…

   Stage

   Not phased

   Ages

   18 to 90

   Site

   Loma Linda University Medical Center, Loma Linda, California

   Locations

   19 in total

   Run by

   Supira Medical

   See if you can join NCT07296744 on ClinicalTrials.gov

7. Influence of Pulse Electromagnetic Field Therapy on Myocardial Ischemia

   This study is being done to observe the effects of treatment from a device called the Bioboosti which utilizes pulsed electromagnetic waves on its ability to improve blood flow to the heart tissue in individuals with coronary artery disease (CAD).

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic in Arizona, Scottsdale, Arizona

   Locations

   2 in total

   Run by

   Mayo Clinic

   See if you can join NCT05111288 on ClinicalTrials.gov

8. A Phase 2b Clinical Trial of YN001 in Adults With Coronary Atherosclerosis

   This study is designed to evaluate the efficacy and safety of intravenously administered YN001 in patients diagnosed with coronary atherosclerosis, who are receiving background therapy for cardiovascular (CV) risk factors management.

   Stage

   Phase 2

   Ages

   18 to 80

   Site

   Washington University School of Medicine, St Louis, Missouri

   Locations

   40 in total

   Run by

   Beijing Inno Medicine Co., Ltd.

   See if you can join NCT07521007 on ClinicalTrials.gov

9. REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Women

   This is a research study in women to compare the outcomes of two procedures that restore blood flow to the arteries of the heart. In one procedure the blockages are ballooned and then stented with a small wire mesh tube through a small incision in the wrist or the groin. The other procedure is an o…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Adventist Health Glendale, Glendale, California

   Locations

   18 in total

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT06399692 on ClinicalTrials.gov

10. REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities

    This is a research study in minorities to compare the outcomes of two procedures that restore blood flow to the arteries of the heart. In one procedure the blockages are ballooned and then stented with a small wire mesh tube through a small incision in the wrist or the groin. The other procedure is…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Adventist Health Glendale, Glendale, California

    Locations

    18 in total

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT06399705 on ClinicalTrials.gov

11. A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)

    The OPTIMAL randomized clinical trial has been designed to compare two imaging strategies and to test the hypothesis that a calcium modification strategy informed by coronary CT angiography (CCTA) will improve procedural efficiency and effectiveness compared with the current standard of care (IVUS-…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Minneapolis Heart Institute, Minneapolis, Minnesota

    Locations

    14 in total

    Run by

    Fundación EPIC

    See if you can join NCT07286578 on ClinicalTrials.gov

12. Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold (RMS) System in Subjects With Coronary Artery Lesions

    The objective of this study is to assess the safety and efficacy of the Freesolve resorbable magnesium scaffold (RMS) in the treatment of subjects with up to two de novo lesions in native coronary arteries compared to the Xience coronary drug-eluting stent (DES) system

    Stage

    Not phased

    Ages

    18 to 80

    Site

    MedStar Washington Hospital Center, Washington D.C., District of Columbia

    Locations

    3 in total

    Run by

    Teleflex

    See if you can join NCT07258290 on ClinicalTrials.gov

13. Coronary Computed Tomography Angiography (CCTA) for the Pre-procedural Planning of Percutaneous Coronary Intervention

    The CT-PLAN PCI trial will evaluate whether CCTA-guided PCI improves procedural efficiency compared with routine PCI (without pre-procedural CCTA-guidance for PCI planning) using procedural time as the primary endpoint. Key secondary outcomes will include contrast volume, radiation dose, fluoroscop…

    Stage

    Not phased

    Ages

    22 and older

    Site

    Minneapolis Heart Institute Foundation, Minneapolis, Minnesota

    Run by

    Minneapolis Heart Institute Foundation

    See if you can join NCT07691502 on ClinicalTrials.gov

14. Randomization of Single vs Multiple Arterial Grafts

    The primary hypothesis of ROMA is that in patients undergoing primary isolated non-emergent coronary artery bypass surgery (CABG), the use of two or more arterial grafts compared to a single arterial graft is associated with a reduction in the composite outcome of death from any cause, any stroke, …

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of Colorado, Boulder, Colorado

    Locations

    59 in total

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT03217006 on ClinicalTrials.gov

15. Prospective Global Registry for the Study of Chronic Total Occlusion Intervention

    Percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs) is increasingly being performed in patients with advanced coronary artery disease, but there is limited information on the techniques utilized and the procedural outcomes. The goal of this multicenter, investigator initiate…

    Stage

    Not phased

    Ages

    Any age

    Site

    Little Rock VA Medical Center, Little Rock, Arkansas

    Locations

    48 in total

    Run by

    Minneapolis Heart Institute Foundation

    See if you can join NCT02061436 on ClinicalTrials.gov

16. Progress Complication

    Coronary angiography and percutaneous coronary intervention (PCI) is often performed in patients with ischemic heart disease. The safety of PCI has improved with new devices and strategies, but complications still occur, especially during complex procedures. The objectives of this multi-center obse…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Minneapolis Heart Institute Foundation, Minneapolis, Minnesota

    Run by

    Minneapolis Heart Institute Foundation

    See if you can join NCT05100940 on ClinicalTrials.gov

17. Progress Bifurcation Global Registry

    Coronary bifurcation lesions are lesions (or blockages) that occur at or near the intersection of a major coronary artery and one of the arteries' side branches. Numerous techniques and devices have been developed to treat coronary bifurcations; however, these types of lesions remain some of the mo…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Minneapolis Heart Institute Foundation, Minneapolis, Minnesota

    Run by

    Minneapolis Heart Institute Foundation

    See if you can join NCT05100992 on ClinicalTrials.gov

18. Late Subclinical Cardiovascular Disease in Testicular Cancer Survivors

    Late subclinical cardiovascular disease in testicular cancer survivors exposed to cisplatin-based chemotherapy and bone marrow transplant

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Indiana University, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT05611307 on ClinicalTrials.gov

19. Safety and Effectiveness of the Orsiro Mission 48-mm Sirolimus Eluting Coronary Stent System in Subjects With Coronary Artery Lesions

    The purpose of the study is to assess the safety and efficacy of the Orsiro® Mission 48- mm Sirolimus-Eluting Coronary Stent System in the treatment of subjects with atherosclerotic lesion(s) >36 mm and ≤ 44 mm in length (by visual estimate) in the native coronary arteries with a reference vessel d…

    Stage

    Not phased

    Ages

    18 and older

    Site

    John Muir Medical Center, Concord, California

    Locations

    23 in total

    Run by

    Teleflex

    See if you can join NCT06779630 on ClinicalTrials.gov

20. Virtue® SAB in the Treatment of Coronary ISR Trial

    A prospective, multi-center, single-blind, randomized (1:1), non-inferiority study comparing clinical outcomes of the Virtue® Sirolimus AngioInfusion™ Balloon (SAB) to the AGENT™ Paclitaxel Drug-Coated Balloon (DCB) in the treatment of coronary artery in-stent restenosis (ISR).

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Cardiac and Vascular Institute, Gainesville, Florida

    Locations

    15 in total

    Run by

    Orchestra BioMed, Inc

    See if you can join NCT07045194 on ClinicalTrials.gov

21. SELUTION 4 De Novo Small Vessel IDE Trial

    Prospective, randomized controlled, single-blind, multicenter, clinical trial to demonstrate the safety and efficacy of the SELUTION SLR 014 PTCA DEB for treatment of de novo lesions in small coronary vessels, defined as reference vessel diameter (RVD) of 2.00 mm to 2.75 mm, in support of a pre-mar…

    Stage

    Not phased

    Ages

    18 and older

    Site

    St. Bernards, Jonesboro, Arkansas

    Locations

    70 in total

    Run by

    M.A. Med Alliance S.A.

    See if you can join NCT05946629 on ClinicalTrials.gov

22. Intravascular Lithotripsy With or Without Rotational Atherectomy for Coronary Calcified Nodule Treatment

    The NODULE-SHOCK trial is a prospective, investigator-initiated, single-center, randomized controlled trial designed to compare the efficacy of intravascular lithotripsy (IVL) with or without rotational atherectomy (RA) in patients with coronary calcified nodules (Cohort A), and operator-determined…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mount Sinai Hospital, New York, New York

    Run by

    Annapoorna Kini

    See if you can join NCT07000045 on ClinicalTrials.gov

23. Hybrid Group Singing

    The overall objective of the planned future clinical trial is to test the investigator's central hypothesis that habitual singing over several weeks, similar to habitual exercise, will lead to sustained and favorable vascular adaptation, thereby lowering cardiovascular disease (CVD) risk. The overa…

    Stage

    Not phased

    Ages

    55 to 89

    Site

    Medical College of Wisconsin, Milwaukee, Wisconsin

    Run by

    Medical College of Wisconsin

    See if you can join NCT07355192 on ClinicalTrials.gov

24. ANDREAS Registry (Assessment of Novel Drug-coated Balloon Revascularization: Effectiveness, Angiographic Outcomes, and Safety)

    The primary objective of this protocol is to develop a comprehensive, multicenter international prospective registry to capture long-term clinical outcomes for adult patients undergoing percutaneous coronary intervention (PCI) with drug-coated balloons (DCB) for de novo coronary artery disease.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Emory University Hospital Midtown, Atlanta, Georgia

    Locations

    19 in total

    Run by

    Emory University

    See if you can join NCT07559903 on ClinicalTrials.gov

25. Physiological Assessment of Severe Coronary Stenosis for Informing Planned PCI

    Traditionally, the severity of a blockage (stenosis) in a coronary artery has been determined by visual angiographic assessment of the diameter of the artery at the level of a blockage compared to a normal healthy area of the same artery. With the advent of invasive physiological testing to assess …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT05491668 on ClinicalTrials.gov