Chronic Pain Clinical Trials

124 studies are recruiting for chronic pain in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 4

1. Neuromodulation + Prolonged Exposure Therapy: Evaluation of a Technology-Enhanced, Integrated Treatment for Pain and PTSD

   The purpose of this study is to examine comparative effectiveness of two home-based telemedicine delivered interventions: transcranial Direct Current Stimulation (tDCS) combined with Massed Prolonged Exposure (Massed-PE) vs. Sham tDCS combined with Massed PE, focusing on pain and PTSD outcomes, to …

   Stage

   Not phased

   Ages

   21 and older

   Site

   Charleston VA Healthcare System, Charleston, South Carolina

   Locations

   2 in total

   Run by

   The University of Texas Health Science Center, Houston

   See if you can join NCT07116109 on ClinicalTrials.gov

2. Psychological Options for Wellness and Recovery (POWeR) Trial for Veterans With Chronic Back/Neck Pain

   The goal of this clinical trial is to learn which treatment works better for veterans with chronic neck or back pain. This study is comparing three treatments: Pain Reprocessing Therapy (PRT), Cognitive Behavioral Therapy (CBT), and usual care (whatever a person is already doing to cope with their …

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA Eastern Colorado Health Care System, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT07137715 on ClinicalTrials.gov

3. Optimizing Accelerated TMS for Chronic Pain With Thompson Sampling

   The purpose of this study is to evaluate the safety and efficacy of accelerated intermittent theta burst stimulation (aiTBS) targeting personalized nodes within the somato-cognitive action network (SCAN) and action motor network (AMN) for the treatment of chronic pain. The study will employ Thompso…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT07103135 on ClinicalTrials.gov

4. Mind Body Intervention for Chronic Migraine Headaches

   The goal of this exploratory study is to test a mind-body interventional approach for the treatment of chronic migraines. The main goal is to obtain feasibility information on the protocol which has been used in other similar conditions. We will also evaluate multiple measurement tools in order to …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Beth Israel Deaconess Medical Center, Boston, Massachusetts

   Locations

   2 in total

   Run by

   Beth Israel Deaconess Medical Center

   See if you can join NCT06690060 on ClinicalTrials.gov

5. Optimization of NIBS for Treatment of Addiction

   The purpose of this study is to assess the effects of transcranial Direct Current Stimulation (tDCS) applied in conjunction with Transcranial Ultrasound (TUS) for the treatment of addiction in opiate use disorder with chronic pain. The investigators hypothesize that there will be a decrease in drug…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   University of Illinois Health/ University of Illinois at Chicago, Hinsdale, Illinois

   Locations

   3 in total

   Run by

   Case Western Reserve University

   See if you can join NCT04379115 on ClinicalTrials.gov

6. VR Mindfulness Training for Veterans With SCI

   This study involves delivering a mindfulness program that was developed for Veterans called VA Compassionate Awareness Learning Module (VA CALM) to Veterans with spinal cord injuries (SCI) to develop accommodations to make the VA CALM program more accessible for those with SCI. It will involve deli…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Michael E. DeBakey VA Medical Center, Houston, TX, Houston, Texas

   Run by

   VA Office of Research and Development

   See if you can join NCT06587607 on ClinicalTrials.gov

7. CIH Stepped Care for Co-occurring Chronic Pain and PTSD

   The goal of this clinical trial is to evaluate the feasibility, acceptability, appropriateness, and retention of patient participants of a CIH Stepped Care approach for co-occurring chronic pain and PTSD vs. treatment as usual in two primary care settings (one rural and one urban). Researchers will…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Washington, Seattle, Washington

   Run by

   University of Washington

   See if you can join NCT06219408 on ClinicalTrials.gov

8. VCOM Pain Free Research Collaborative

   Studies estimate that 30% of people worldwide experience chronic pain. The mechanisms causing this pain can vary: a neuropathic offender, such as nerve compression; a structural offender, such as long-term effects of soft tissue damage and repair; or nociplastic, dysfunctional offenders, such as fi…

   Stage

   Not phased

   Ages

   21 to 80

   Site

   Edward Via College of Osteopathic Medicine-Auburn, Auburn, Alabama

   Run by

   Edward Via Virginia College of Osteopathic Medicine

   See if you can join NCT06533345 on ClinicalTrials.gov

9. A Mobile Intervention to Reduce Pain and Improve Health-III

   The experience of chronic pain powerfully and negatively affects quality of life and functional independence in aging. Unfortunately, while as many as three in four older adults experience chronic pain, few have access to effective non-pharmacological pain management strategies. Participating in re…

   Stage

   Phase 2

   Ages

   65 and older

   Site

   Wake Forest University, Winston-Salem, North Carolina

   Run by

   Wake Forest University

   See if you can join NCT06623669 on ClinicalTrials.gov

10. PREVAIL Interdisciplinary Track: A Pragmatic Randomized Clinical Trial

    The goal of this clinical trial is to [primary purpose learn if a team that involves five types of pain specialists (interventional pain, psychology, pharmacy, nutrition, physical therapy) can treat chronic pain in Veterans. The main questions it aims to answer are: * Do patients report less pain a…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Salem VA Health Care System, Salem, Virginia

    Run by

    Salem Veterans Affairs Medical Center

    See if you can join NCT06427356 on ClinicalTrials.gov

11. Mind Body Intervention for Chronic Upper Extremity Pain (Repetitive Stress Injury)

    The goal of this nonrandomized pilot study is to test a mind-body interventional approach for the treatment of chronic upper extremity pain or repetitive stress injury of the upper extremity (wrist/shoulder/elbow). 1. To determine if a mind-body intervention improves upper extremity functional capa…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT06903962 on ClinicalTrials.gov

12. Under-Resourced Adults With Chronic Pain eHealth Study

    The purpose of this study is to examine the feasibility of the dissemination of a cognitive-behavioral eHealth application (app) for pain self-management with Black and LGBTQ+ adults with high-impact chronic pain lasting at least 3 months and disrupting daily functioning (Implementation aim).

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06688864 on ClinicalTrials.gov

13. CBT-CP for Veterans With SMI

    Chronic musculoskeletal pain has a highly negative impact on Veterans, especially those with serious mental illness (SMI). Chronic musculoskeletal pain leads to poorer mental and physical health-related functioning, representing a critical obstacle to rehabilitation and recovery for SMI Veterans. D…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore, Maryland

    Run by

    VA Office of Research and Development

    See if you can join NCT06758414 on ClinicalTrials.gov

14. Divided or Single Exposure (DOSE) Study

    This study will evaluate whether once versus twice daily dosing of methadone will be an effective method for managing comorbid pain and opioid use disorder.

    Stage

    Phase 2

    Ages

    18 to 100

    Site

    Addiction Treatment Services (ATS), Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT05459402 on ClinicalTrials.gov

15. Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits

    The primary aim of this implementation-effectiveness trial is to examine the effectiveness of Mindfulness-Oriented Recovery Enhancement (MORE) and patient-centered chronic pain management visits in primary care as interventions to reduce chronic pain, improve quality of life, and reduce opioid-rela…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    UCSD Health, La Jolla, California

    Locations

    3 in total

    Run by

    University of Utah

    See if you can join NCT06387290 on ClinicalTrials.gov

16. Online Yoga vs Acceptance and Commitment Therapy for Treating Chronic Musculoskeletal Pain

    This study will compare online yoga with Acceptance and Commitment Therapy (ACT), an established treatment for chronic pain. We will compare the efficacy of the two treatments for reducing chronic musculoskeletal pain in veterans.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Palo Alto VA Medical Center, Palo Alto, California

    Run by

    Palo Alto Veterans Institute for Research

    See if you can join NCT06704061 on ClinicalTrials.gov

17. Individual Differences in Gait and Osteoarthritis Pain

    The goal of this observational study is to look at inter-individual differences in knee osteoarthritis (OA) walking pain and performance. The main questions this study aims to answer are: Why do some people with knee osteoarthritis have more severe disabling pain than others, even though the degene…

    Stage

    Not phased

    Ages

    45 to 80

    Site

    UPMC Pain Medicine at Centre Commons, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT07308873 on ClinicalTrials.gov

18. Opioid Adherence and Support Through Innovative Texting Strategies

    The goal of this clinical trial is to examine the effects of reminder and mindfulness text messages on medication adherence and managing craving, pain, and withdrawal symptoms in people taking medications for opioid use disorder through assessment questions collected twice daily during the course o…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of New Mexico, Albuquerque, New Mexico

    Run by

    University of New Mexico

    See if you can join NCT07350148 on ClinicalTrials.gov

19. Evaluating the Acceptability, Feasibility and Usability of Various Conversational Data Collection Software

    This research study is being conducted to evaluate digital software tools that collect health information through conversations. The study will test how acceptable, feasible, and usable these conversational software programs are for patients with chronic pain. Purpose of the Study: The goal is to u…

    Stage

    Not phased

    Ages

    18 and older

    Site

    AugMend Health at MIT.nano Immersion Lab, Cambridge, Massachusetts

    Run by

    AugMend Health Inc.

    See if you can join NCT07336537 on ClinicalTrials.gov

20. Opioids, Low Nicotine Cigarettes, and Chronic Pain

    The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on craving, withdrawal, and pain among individuals with chronic pain who smoke cigarettes daily and are attending office-based buprenorphi…

    Stage

    Not phased

    Ages

    21 and older

    Site

    North Pavilion, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06747871 on ClinicalTrials.gov

21. Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator

    The REALITY study is a prospective, post-market, non-randomized, multi-center, single-arm, open-label study intended to collect short- and long-term safety and effectiveness data on various populations implanted with Abbott's neurostimulation systems.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Krankenhaus Porz am Rhein, Cologne, Koln

    Locations

    55 in total

    Run by

    Abbott Medical Devices

    See if you can join NCT03876054 on ClinicalTrials.gov

22. Virtual 1-Session Spanish "Empowered Relief" Group Intervention for Chronic Pain

    Empowered Relief (ER) is a 1-session pain relief skills intervention that is delivered in-person or online by certified clinicians to groups of patients with acute or chronic pain. Prior work in has shown ER efficacy for reducing chronic pain, pain-related distress, and other symptoms 6 months post…

    Stage

    Not phased

    Ages

    18 and older

    Site

    1070 Arastradero Rd, Palo Alto, California

    Run by

    Stanford University

    See if you can join NCT04546685 on ClinicalTrials.gov

23. Improving Spinal Cord Stimulation With ECAPS

    The purpose of this study will be to investigate the optimization of spinal cord stimulation with ECAPs in patients with spinal cord implants.

    Stage

    Not phased

    Ages

    22 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT04938245 on ClinicalTrials.gov

24. Group Medical Visits and Chiropractic Care for Older Adults With Chronic Spine Pain

    Chronic spine pain is one of the most common and conditions in adults over the age of 65. Treatments for pain that are non-pharmacologic (do not use over-the-counter or prescription drugs) are recognized as some of the most important to study. Chiropractic care has shown to be effective at reducing…

    Stage

    Not phased

    Ages

    65 and older

    Site

    MassGeneralBrigham, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT06632535 on ClinicalTrials.gov

25. Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain

    Individuals with chronic pain are more likely to smoke cigarettes and have more difficulty quitting smoking than the general population, in part because withdrawal from smoking can lead to temporary increases in pain. This research will examine how smoking withdrawal changes the way the brain proce…

    Stage

    Not phased

    Ages

    21 to 65

    Site

    Duke North Pavilion, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06983678 on ClinicalTrials.gov