Chronic Pain Clinical Trials

124 studies are recruiting for chronic pain in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 5

1. Improving Health for Older Adults With Pain Through Engagement

   The goal of this project is to conduct a randomized, hybrid type 1 effectiveness-implementation trial (N=200) to evaluate the effectiveness and implementation of a 10-week mind-body and walking program (GetActive+) vs treatment as usual (TAU). The investigators will test for improvements in self-re…

   Stage

   Not phased

   Ages

   55 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06119698 on ClinicalTrials.gov

2. ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain

   This study will sequentially evaluate three novel and scalable interventions for at-risk individuals on long term opioid therapy for chronic pain: (1) low-dose transdermal buprenorphine initiation without a period of opioid withdrawal; (2) a brief Cognitive Behavioral Intervention for pain (CBI); a…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT06442566 on ClinicalTrials.gov

3. Low-Intensity Focused Ultrasound and the Complex Patient

   Studying the effects of Low Intensity Focused Ultrasound (LIFU) on measures of pain, craving, and anxiety in a complex patient population.

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Fralin Biomedical Research Institute at VTC, Roanoke, Virginia

   Run by

   Virginia Polytechnic Institute and State University

   See if you can join NCT06297200 on ClinicalTrials.gov

4. Brief Mindfulness-Oriented Recovery Enhancement vs Brief Cognitive-Behavioral Therapy for Chronic Pain

   This randomized controlled trial aims to test both English and Spanish versions of two, benign behavioral interventions for adults with chronic pain -- 1) Brief Mindfulness-Oriented Recovery Enhancement (B-MORE), and 2) Brief Cognitive- Behavioral Therapy (B-CBT).

   Stage

   Not phased

   Ages

   18 and older

   Site

   Research Building B, Tallahassee, Florida

   Run by

   Florida State University

   See if you can join NCT07207174 on ClinicalTrials.gov

5. A Longitudinal Study Looking at the Prevalence, Risk Factors & Consequences of Persistent Post-surgical Pain in Children

   The purpose of this study is to investigate the prevalence, risk factors and consequences of chronic post-surgical pain in children aged 0-16 years through a number of questionnaires completed at various timepoints, from before surgery up to 1 year post surgery.

   Stage

   Not phased

   Ages

   Up to 16

   Site

   Telethon Kids Institute, Perth, Western Australia

   Locations

   16 in total

   Run by

   Telethon Kids Institute

   See if you can join NCT06354699 on ClinicalTrials.gov

6. SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease

   Peripheral arterial disease (PAD) affects over 230 million adults worldwide and is a highly morbid, costly, and disabling condition. Ischemic leg pain drives disability in PAD patients and results from oxygen supply-demand mismatch, autonomic dysfunction, and muscle breakdown. This leg pain, which …

   Stage

   Not phased

   Ages

   19 to 89

   Site

   University of Nebraska Medical Center, Omaha, Nebraska

   Run by

   University of Nebraska

   See if you can join NCT06480786 on ClinicalTrials.gov

7. Preventing the Development of Chronic Pain: Treating PTSD at Acute Pain Onset

   Although most people recover from acute pain (such as pain caused by injury, surgery, repetitive motion, or unknown causes), many people do not fully recover and will experience chronic pain. Untreated posttraumatic stress disorder (PTSD) appears to be a key risk factor for the transition from acut…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Rush University Medical Center, Chicago, Illinois

   Run by

   Rush University Medical Center

   See if you can join NCT05700279 on ClinicalTrials.gov

8. Physical Activity Pain Resilience

   The purpose of this research study is to test a new program called Pain REsilience Promotion for Youth (PREP-Y). This program is designed to help adolescents with chronic musculoskeletal pain (pain in muscles, bones, or joints that lasts more than 3 months) become more physically active and better …

   Stage

   Not phased

   Ages

   12 to 17

   Site

   Nationwide Children's Hospital, Columbus, Ohio

   Run by

   William Black

   See if you can join NCT07049029 on ClinicalTrials.gov

9. The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature

   Herbal Medicine is known as the medicinal use of herbal substances as a means of treating different conditions in the human body to ensure that the body remains in optimal health and wellness. These substances are known to contain very active ingredients in it and as such is also a very potent mean…

   Stage

   Not phased

   Ages

   21 to 80

   Site

   Health for Life Holistic Wellness Center LLC, Dover, Delaware

   Run by

   Faith A. Richardson

   See if you can join NCT05067998 on ClinicalTrials.gov

10. Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans

    This research study is being done to investigate if the GH Method exercise program positively affects body composition, improves physical abilities and can improve the overall sense of wellbeing (e.g. depression, PTSD, etc.) in U.S. Veterans. Subjects will be asked to complete 94 total visits (four…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Illinois at Chicago, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT05094297 on ClinicalTrials.gov

11. Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA

    This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary goal of the study is to use fluctuations in daily self-reported symptoms…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brown University, Providence, Rhode Island

    Run by

    Brown University

    See if you can join NCT05754190 on ClinicalTrials.gov

12. E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app

    The goal of this clinical trial is to test whether a web-based application called the Pain Control Enhancement App (PACE-app) can support family caregivers in managing pain for their care recipients with dementia. The main questions it aims to answer are: Is it feasible and acceptable for family ca…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    College of Nursing, Iowa City, Iowa

    Run by

    University of Iowa

    See if you can join NCT07032350 on ClinicalTrials.gov

13. Using Ecological Momentary Assessment to Develop an Adaptive Psychological Intervention for Young Adults With Chronic Pain

    The goal of this observational study is to determine real-time contextual vulnerabilities associated with pain in young adults to inform ideal treatment targets for a just-in-time adaptive intervention (JITAI). The main question it aims to answer is: -What contextual factors and vulnerabilities wil…

    Stage

    Not phased

    Ages

    18 to 25

    Site

    Seattle Children's Hospital, Seattle, Washington

    Run by

    Seattle Children's Hospital

    See if you can join NCT06932432 on ClinicalTrials.gov

14. Our Whole Lives Gemini: Virtual Integrative Medical Group Visits for Managing Chronic Pain

    The goal of this research study is to test the efficacy of a non-prescription medicine, web-based platform solution for patients with chronic pain, to improve pain self-management and related outcomes. The main question investigators aim to answer is; would the use of this web-based intervention pl…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cambridge Health Alliance Center for Mindfulness and Compassion, Malden, Massachusetts

    Run by

    Cambridge Health Alliance

    See if you can join NCT06515925 on ClinicalTrials.gov

15. Retrospective-Prospective PNS Study

    This is a retrospective-prospective study in which 40 patients have received a permanent Freedom PNS System. Subjects presented with chronic, intractable pain of peripheral nerve origin refractory to standard medical and/or surgical treatment. A retrospective chart review will be conducted to asses…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Metrohealth System, Cleveland, Ohio

    Run by

    Curonix LLC

    See if you can join NCT06845631 on ClinicalTrials.gov

16. Ketamine Treatment Plans for Chronic Conditions

    A study aimed to assess the efficacy of the various approaches to prescribing Ketamine currently in use off-label. The focus will be to include ketamine within the study plan of those with chronic conditions who are receiving ketamine.

    Stage

    Not phased

    Ages

    18 and older

    Site

    RIVER Telehealth, Helena, Montana

    Run by

    RIVER Foundation

    See if you can join NCT06038409 on ClinicalTrials.gov

17. RIVER At Home Ketamine Protocols

    Multiple site studies with the recruitment of other sub-investigators and sites. It's sobering to consider how chronic illness makes us more vulnerable to suicidal thoughts and behavior. However, the existence of multiple risk factors also means that there are numerous ways to intervene. Addressing…

    Stage

    Not phased

    Ages

    18 and older

    Site

    RIVER Foundation, Bigfork, Montana

    Locations

    2 in total

    Run by

    RIVER Foundation

    See if you can join NCT06070766 on ClinicalTrials.gov

18. Novel Stimulation Patterns to Improve the Effectiveness of Spinal Cord Stimulation

    The goal of this study is to compare pain outcomes achieved by spinal cord stimulation (SCS) using time varying stimulation patterns with pain outcomes achieved by current standard of care SCS.

    Stage

    Not phased

    Ages

    22 and older

    Site

    Baylor College of Medicine, Houston, Texas

    Run by

    Ashwin Viswanathan

    See if you can join NCT05968664 on ClinicalTrials.gov

19. Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Networks Training for Treatment of Pain (CBOT-P)

    The overarching goal of this study phase, Phase II component is to perform a randomized clinical trial of the refined Computerized Chemosensory-Based Orbitofrontal Networks Training for Treatment of Pain [CBOT-Pain (or CBOT-P)] from Phase I, compared to sham Computerized Chemosensory-Based Orbitofr…

    Stage

    Phase 2

    Ages

    18 to 85

    Site

    Howard University, Washington D.C., District of Columbia

    Locations

    2 in total

    Run by

    Evon Medics LLC

    See if you can join NCT06671132 on ClinicalTrials.gov

20. Embo Registry; National Registry for Artery Embolization

    Embo Registry is a retrospective and prospective observational study to evaluate real world effectiveness and the use of Artery Embolization as a treatment for chronic pain with patients that have osteoarthritis and localized pain to provide symptomatic relief. This study is to determine the effica…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Vascular Solutions of North Carolina, Cary, North Carolina

    Locations

    2 in total

    Run by

    Vascular Solutions of North Carolina

    See if you can join NCT06477965 on ClinicalTrials.gov

21. Utilizing Battlefield Acupuncture to Treat Chronic Pain

    This research study will evaluate the effectiveness of utilizing Battlefield Acupuncture (BFA) on veterans with with a history of substance use disorder and chronic pain for 8 weeks. Primary Aim: The primary aim of this study is to evaluate the effectiveness of using BFA to treat chronic pain in ve…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Bedford VA Healthcare System, Bedford, Massachusetts

    Run by

    Edith Nourse Rogers Memorial Veterans Hospital

    See if you can join NCT06128772 on ClinicalTrials.gov

22. Haloperidol for Pain Control in Patients With Acute Musculoskeletal Back Pain in the Emergency Department

    Single center, double-blind, randomized, controlled trial in patients who present to the emergency department (ED) with a chief complaint of back pain. A total of 150 patients age 18-65 presenting to the emergency department with chief complaint of backpain will be enrolled from April 2024 - April …

    Stage

    Phase 4

    Ages

    18 to 65

    Site

    Bronson Methodist Hospital, Kalamazoo, Michigan

    Run by

    Western Michigan University School of Medicine

    See if you can join NCT06395428 on ClinicalTrials.gov

23. Chronic Non-Specific Neck Pain Treated With Tai Chi and Chiropractic Care

    This feasibility project aims to evaluate the effectiveness of chiropractic care combined with Tai Chi (TC) training to reduce pain and disability in adults with chronic non-specific neck pain (CNNP).

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Osher Clinical Center at Brigham and Women's Hospital, Chestnut Hill, Massachusetts

    Run by

    Harvard University Faculty of Medicine

    See if you can join NCT05726331 on ClinicalTrials.gov

24. AIMS Medical Outcomes Study

    This epidemiologic research is being conducted as an observational prospective case series outcomes study of the use of advanced integrative specialty medical care and its effect on adult and pediatric patients with chronic or serious illnesses or mental health disorders.

    Stage

    Not phased

    Ages

    Any age

    Site

    AIMS Institute, Seattle, Washington

    Run by

    Advanced Integrative Medical Science Institute

    See if you can join NCT04512755 on ClinicalTrials.gov