Chronic Pain Clinical Trials

124 studies are recruiting for chronic pain in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Improving Sleep in Veterans With the Polytrauma Clinical Triad

   The "polytrauma clinical triad" (PCT), a highly disabling constellation of factors, is defined by the coexistence of traumatic brain injury, post-traumatic stress disorder, and chronic pain. Veterans with the PCT are medically complex, often refractory to conventional therapies, and suffer from add…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   VA Portland Health Care System, Portland, OR, Portland, Oregon

   Run by

   VA Office of Research and Development

   See if you can join NCT06477796 on ClinicalTrials.gov

2. Emotional Awareness and Expression Therapy for People With Persistent Pain Following Orthopedic Trauma

   The purpose of this single-arm trial is to determine the feasibility of emotional awareness and expression therapy (EAET) for individuals with persistent pain following orthopedic trauma. As part of this study, participants will be asked to attend weekly EAET treatment sessions and complete assessm…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Johns Hopkins School of Medicine, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT05989230 on ClinicalTrials.gov

3. Placebo Impacts Sleep and Pain Modulation in Chronic Pain

   The goal of this free-choice parallel design clinical trial is to examine the potential beneficial effects of using open-label placebo (OLP) in improving chronic pain related outcomes and sleep quality in people with temporomandibular disorders. This study will enroll a cohort of participants with …

   Stage

   Not phased

   Ages

   18 to 88

   Site

   University of Maryland Baltimore School of Nursing, Baltimore, Maryland

   Run by

   University of Maryland, Baltimore

   See if you can join NCT06225817 on ClinicalTrials.gov

4. Integrated PTSD and Chronic Pain Treatment

   Posttraumatic stress disorder (PTSD) occurs in approximately 7% of adults in the general population. PTSD greatly impacts quality of life and often co-occurs with other conditions such as chronic pain. Individuals with co-morbid PTSD and chronic pain demonstrate higher PTSD symptoms and pain (as we…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Weill Cornell Medicine, New York, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT07225049 on ClinicalTrials.gov

5. Group-based Integrative Pain Management in Primary Care Safety Net Clinics

   Socioeconomically disadvantaged populations have a high prevalence of chronic pain, exacerbated by social isolation, intersectional stigma, and disparities in pain assessment and treatment options. Effective interventions using a multilevel, biopsychosocial approach are needed to decrease the unequ…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Tom Waddell Urban Health Clinic, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT06327542 on ClinicalTrials.gov

6. Equipping Patients Using Interventions for Pain and Depression

   This project is part of the NIH Helping to End Addiction Long-term (HEAL) initiative (https://heal.nih.gov/). This randomized controlled trial (RCT) is phase 2 of a two-phase, 5-year project with the overarching goal of testing a decision aid (DA)/coaching intervention, tailored to Black patients w…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Eskenazi Health Primary Care, Indianapolis, Indiana

   Run by

   Indiana University

   See if you can join NCT06500780 on ClinicalTrials.gov

7. The PROACTIVE Study for Black Elders

   Chronic musculoskeletal pain (CMP), while a leading cause of physical disablement, is a neglected national health disparity issue in Black communities. The purpose of this study is to test a novel culturally congruent pain self-management intervention. A total of 120 persons aged 50-92, self-identi…

   Stage

   Not phased

   Ages

   50 to 92

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT06512727 on ClinicalTrials.gov

8. Mechanisms of Mindfulness Meditation and Self-Hypnosis for Pain in Older Adults With Chronic Pain

   The goal of this study is to better understand how two common psychological treatments for pain work in the brain of older adults living with chronic pain. This study will: 1. evaluate fMRI of adults receiving psychological treatments for chronic pain to determine how these interventions work withi…

   Stage

   Not phased

   Ages

   60 and older

   Site

   University of Washington, Seattle, Washington

   Run by

   University of Washington

   See if you can join NCT06957743 on ClinicalTrials.gov

9. Neuroimaging of Opioid Phase (OPAL)

   The purpose of this study is to compare activity in the brains of female adults with chronic pain and/or opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and alternatives to opioid therapy.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Duke University Medical Center, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT05905419 on ClinicalTrials.gov

10. MIVetsCan: Can-Coach Trial (Phase 2)

    The goal of the MIVetsCan Can-Coach Trial is to test four coaching sessions to help Veterans with chronic pain use their own cannabis products more effectively to manage pain and related symptoms.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06283862 on ClinicalTrials.gov

11. The PROmoting Pain Self-Management (PROs) Trial: Holistic Pain Care in the Military Health System

    The goal of this study is to improve pain care in the MHS by identifying effective, whole-person, non-pharmacologic interventions for persons with chronic musculoskeletal pain. The investigators will evaluate two promising, evidence-based holistic health interventions and compare them to usual care.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Desmond Doss Health Clinic, Schofield Barracks, Hawaii

    Locations

    5 in total

    Run by

    Brooke Army Medical Center

    See if you can join NCT06940986 on ClinicalTrials.gov

12. Stanford Pragmatic Effectiveness Comparison

    Chronic pain is a major healthcare problem with an annual cost of above $600 billion. The quality of data available for treatments of chronic pain is not optimal. Generalizability of explanatory randomized controlled trial data is problematic as these trials exclude up to 90% of patients: leaving o…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Stanford Pain Management Center, Redwood City, California

    Run by

    Stanford University

    See if you can join NCT04441034 on ClinicalTrials.gov

13. Dronabinol as an Adjunct for Reducing Pain

    This exploratory, proof-of-concept study is a double-blind (participants and investigators will be blinded), placebo-controlled, randomized, two-arm clinical trial of Marinol [dronabinol, synthetic Δ9-tetrahydrocannabinol (THC)] for chronic low back pain (cLBP) with a 2:1 allocation ratio. Up to 75…

    Stage

    Phase 2

    Ages

    18 to 64

    Site

    Michael E Debakey VA Medical Center, Houston, Texas

    Run by

    Christopher D. Verrico

    See if you can join NCT06454669 on ClinicalTrials.gov

14. The Role of Brain Dopamine in Chronic Pain

    Chronic pain is associated with plasticity in the brain limbic system composed mainly of the amygdala, hippocampus, ventral striatum, and cingulate cortex (ACC) /medial prefrontal cortex (mPFC). These brain areas, especially the ventral striatum, receive dopaminergic input from the ventral-tegmenta…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Rochester Medical Center, Rochester, New York

    Run by

    University of Rochester

    See if you can join NCT05285683 on ClinicalTrials.gov

15. Reaching Rural Veterans: Applying Mind-Body Skills for Pain Using a Whole Health Telehealth Intervention - UH3

    The goal of the RAMP mind-body program is to provide Veterans with information and tools that can help them manage their pain. The program explores the important connection between our bodies and minds, and how to use this special connection to manage pain more effectively.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Minneapolis VAMC, Minneapolis, Minnesota

    Run by

    Minneapolis Veterans Affairs Medical Center

    See if you can join NCT07541599 on ClinicalTrials.gov

16. Better Options for Chronic Cancer Pain

    This proposal is relevant to the 240,000 cancer survivors who continue to use opioids long after they have successfully completed treatment for cancer at the VHA, placing them at risk of opioid addiction and overdose, and other opioid-related problems. Yet, there are no programs at the VHA to help …

    Stage

    Phase 4

    Ages

    18 to 99

    Site

    VA Ann Arbor Healthcare System, Ann Arbor, MI, Ann Arbor, Michigan

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT06574009 on ClinicalTrials.gov

17. CARES (Comprehensive Analgesic, Recovery, and Education Support) for Surgery Trial

    The goal of this clinical trial is to learn whether a combined behavioral and pharmacologic intervention can help reduce opioid use, improve pain recovery, and prevent opioid misuse after surgery in adults undergoing elective surgery. The study includes adults aged 18 to 75 who have a history of lo…

    Stage

    Phase 3

    Ages

    18 to 75

    Site

    Stanford University Medical Center, Stanford, California

    Locations

    4 in total

    Run by

    Stanford University

    See if you can join NCT06027099 on ClinicalTrials.gov

18. Predictors of Pain in Sickle Cell Disease

    Sickle cell disease is a painful inherited disorder that affects approximately 100,000 people in the United States, and more than half of these individuals develop chronic or persistent pain that is often severe and disabling. The factors that predict whether an individual with sickle cell disease …

    Stage

    Not phased

    Ages

    15 to 40

    Site

    Duke University Medical Center, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06139510 on ClinicalTrials.gov

19. Just-In-Time Adaptive Interventions (JITAIs) in a Digital Mental Health Intervention for Middle-Aged and Older Adults With Chronic Pain

    The purpose of this research study is to refine customized in-app notifications in order to optimize users' experience with a mobile app called Wysa for Chronic Pain. This app is designed to support people who have chronic pain and who also experience symptoms of depression and/or anxiety. This ver…

    Stage

    Not phased

    Ages

    45 and older

    Site

    Washington University in St. Louis School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT06978166 on ClinicalTrials.gov

20. A Bionic Breast Project Using Neuroprosthesis to Reduce Chronic Pain After Mastectomy

    This trial seeks to establish whether or not touch sensation can be restored to the breast via neural stimulation. Data will also be obtained to inform future feasibility (including safety), efficacy, and acceptability trials.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06382272 on ClinicalTrials.gov

21. Interoceptive Awareness and Function in Adolescents With Chronic Pain

    The main objectives of this study are to compare the levels of interoceptive awareness and self-reported function pre and post completion of an occupational therapy treatment plan. The target population are adolescents aged 11-21 years that are diagnosed with chronic pain and are seen through the P…

    Stage

    Not phased

    Ages

    11 to 21

    Site

    Connecticut Children's Medical Center, Hartford, Connecticut

    Run by

    Connecticut Children's Medical Center

    See if you can join NCT07325110 on ClinicalTrials.gov

22. Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain

    The goal of this study is to test two behavioral interventions for chronic insomnia in individuals with chronic pain and use prescribed opioid medication to treat their chronic pain.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of South Florida, Tampa, Florida

    Run by

    University of South Florida

    See if you can join NCT06345872 on ClinicalTrials.gov

23. Enhancing Health in Rural Populations: Music as Therapy

    The goal of this clinical trial is to learn whether a music-based intervention can improve mental and physical health and strengthen coping skills among adults living in residential care settings in northern Arizona. The main questions it aims to answer are: Does participation in the music-based in…

    Stage

    Not phased

    Ages

    Any age

    Site

    Haven Health Flagstaff, Flagstaff, Arizona

    Locations

    2 in total

    Run by

    Northern Arizona University

    See if you can join NCT07538427 on ClinicalTrials.gov

24. Reboot Pain (tDCS)

    This study will examine the effectiveness of tDCS (Transcranial Direct Current Stimulation) in reducing chronic pain when used with Emory Healthcare Veterans Program (EHVP)-ABHP (Accelerated Behavioral Health Program) participants as measured by the Pain, Enjoyment of Life and General Activity Scal…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    The Emory Clinic, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT07411859 on ClinicalTrials.gov

25. Novel Cellular Therapy for the Treatment of Pain Associated With Chronic Pancreatitis

    The goal of this clinical trial is to test whether adult stem cells, called mesenchymal stem cells (MSCs) collected from the patient's bone marrow can help reduce pain caused by chronic pancreatitis and improve pancreatic function.

    Stage

    Phase 1

    Ages

    18 to 75

    Site

    Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina

    Run by

    VA Office of Research and Development

    See if you can join NCT05925036 on ClinicalTrials.gov