Chronic Pain Clinical Trials

125 studies are recruiting for chronic pain in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies, page 3

1. Stanford Pragmatic Effectiveness Comparison

   Chronic pain is a major healthcare problem with an annual cost of above $600 billion. The quality of data available for treatments of chronic pain is not optimal. Generalizability of explanatory randomized controlled trial data is problematic as these trials exclude up to 90% of patients: leaving o…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Stanford Pain Management Center, Redwood City, California

   Run by

   Stanford University

   See if you can join NCT04441034 on ClinicalTrials.gov

2. The BRIDGE Pain Study

   The purpose of the study is to discover at least two distinct Musculoskeletal pain subtypes. These types are caused by different brain-and-immune system signals that affect how the body feels pain, and they are also shaped by a person's biology, psychology, and social environment. Aim 1. We want to…

   Stage

   Not phased

   Ages

   14 to 26

   Site

   Cincinnati Children's Hospital, Cincinnati, Ohio

   Run by

   Children's Hospital Medical Center, Cincinnati

   See if you can join NCT07602595 on ClinicalTrials.gov

3. Dronabinol as an Adjunct for Reducing Pain

   This exploratory, proof-of-concept study is a double-blind (participants and investigators will be blinded), placebo-controlled, randomized, two-arm clinical trial of Marinol [dronabinol, synthetic Δ9-tetrahydrocannabinol (THC)] for chronic low back pain (cLBP) with a 2:1 allocation ratio. Up to 75…

   Stage

   Phase 2

   Ages

   18 to 64

   Site

   Michael E Debakey VA Medical Center, Houston, Texas

   Run by

   Christopher D. Verrico

   See if you can join NCT06454669 on ClinicalTrials.gov

4. Sana Device for Post-Treatment Lyme Disease Syndrome Chronic Pain

   This study will investigate the effectiveness of the Sana Pain Reliever (Sana PR) at reducing chronic pain. The Sana PR is a device comprised of one main component (Mask with Earbuds) and two ancillary components (Charger and Headband). The device is worn over the eyes (with earbuds in ears). The d…

   Stage

   Not phased

   Ages

   18 and older

   Site

   The Cohen Center for Recovery from Complex Chronic Illnesses (CoRE), New York, New York

   Run by

   Icahn School of Medicine at Mount Sinai

   See if you can join NCT06655844 on ClinicalTrials.gov

5. The Role of Brain Dopamine in Chronic Pain

   Chronic pain is associated with plasticity in the brain limbic system composed mainly of the amygdala, hippocampus, ventral striatum, and cingulate cortex (ACC) /medial prefrontal cortex (mPFC). These brain areas, especially the ventral striatum, receive dopaminergic input from the ventral-tegmenta…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Rochester Medical Center, Rochester, New York

   Run by

   University of Rochester

   See if you can join NCT05285683 on ClinicalTrials.gov

6. Reaching Rural Veterans: Applying Mind-Body Skills for Pain Using a Whole Health Telehealth Intervention - UH3

   The goal of the RAMP mind-body program is to provide Veterans with information and tools that can help them manage their pain. The program explores the important connection between our bodies and minds, and how to use this special connection to manage pain more effectively.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Minneapolis VAMC, Minneapolis, Minnesota

   Run by

   Minneapolis Veterans Affairs Medical Center

   See if you can join NCT07541599 on ClinicalTrials.gov

7. Better Options for Chronic Cancer Pain

   This proposal is relevant to the 240,000 cancer survivors who continue to use opioids long after they have successfully completed treatment for cancer at the VHA, placing them at risk of opioid addiction and overdose, and other opioid-related problems. Yet, there are no programs at the VHA to help …

   Stage

   Phase 4

   Ages

   18 to 99

   Site

   VA Ann Arbor Healthcare System, Ann Arbor, MI, Ann Arbor, Michigan

   Locations

   2 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT06574009 on ClinicalTrials.gov

8. CARES (Comprehensive Analgesic, Recovery, and Education Support) for Surgery Trial

   The goal of this clinical trial is to learn whether a combined behavioral and pharmacologic intervention can help reduce opioid use, improve pain recovery, and prevent opioid misuse after surgery in adults undergoing elective surgery. The study includes adults aged 18 to 75 who have a history of lo…

   Stage

   Phase 3

   Ages

   18 to 75

   Site

   Stanford University Medical Center, Stanford, California

   Locations

   4 in total

   Run by

   Stanford University

   See if you can join NCT06027099 on ClinicalTrials.gov

9. Predictors of Pain in Sickle Cell Disease

   Sickle cell disease is a painful inherited disorder that affects approximately 100,000 people in the United States, and more than half of these individuals develop chronic or persistent pain that is often severe and disabling. The factors that predict whether an individual with sickle cell disease …

   Stage

   Not phased

   Ages

   15 to 40

   Site

   Duke University Medical Center, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT06139510 on ClinicalTrials.gov

10. Just-In-Time Adaptive Interventions (JITAIs) in a Digital Mental Health Intervention for Middle-Aged and Older Adults With Chronic Pain

    The purpose of this research study is to refine customized in-app notifications in order to optimize users' experience with a mobile app called Wysa for Chronic Pain. This app is designed to support people who have chronic pain and who also experience symptoms of depression and/or anxiety. This ver…

    Stage

    Not phased

    Ages

    45 and older

    Site

    Washington University in St. Louis School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT06978166 on ClinicalTrials.gov

11. A Bionic Breast Project Using Neuroprosthesis to Reduce Chronic Pain After Mastectomy

    This trial seeks to establish whether or not touch sensation can be restored to the breast via neural stimulation. Data will also be obtained to inform future feasibility (including safety), efficacy, and acceptability trials.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06382272 on ClinicalTrials.gov

12. Mindfulness-Based Ecological Momentary Intervention for Opioid Use Disorder and Chronic Pain

    The goal of this clinical trial is to evaluate whether a smartphone app-based ecological momentary intervention called Mindful Journey, which teaches mindfulness skills, can support adults in recovery from both opioid use disorder and chronic pain. The primary objective of this pilot study is to as…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Arizona State University, Phoenix, Arizona

    Locations

    2 in total

    Run by

    Arizona State University

    See if you can join NCT06947122 on ClinicalTrials.gov

13. Interoceptive Awareness and Function in Adolescents With Chronic Pain

    The main objectives of this study are to compare the levels of interoceptive awareness and self-reported function pre and post completion of an occupational therapy treatment plan. The target population are adolescents aged 11-21 years that are diagnosed with chronic pain and are seen through the P…

    Stage

    Not phased

    Ages

    11 to 21

    Site

    Connecticut Children's Medical Center, Hartford, Connecticut

    Run by

    Connecticut Children's Medical Center

    See if you can join NCT07325110 on ClinicalTrials.gov

14. Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain

    The goal of this study is to test two behavioral interventions for chronic insomnia in individuals with chronic pain and use prescribed opioid medication to treat their chronic pain.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of South Florida, Tampa, Florida

    Run by

    University of South Florida

    See if you can join NCT06345872 on ClinicalTrials.gov

15. Enhancing Health in Rural Populations: Music as Therapy

    The goal of this clinical trial is to learn whether a music-based intervention can improve mental and physical health and strengthen coping skills among adults living in residential care settings in northern Arizona. The main questions it aims to answer are: Does participation in the music-based in…

    Stage

    Not phased

    Ages

    Any age

    Site

    Haven Health Flagstaff, Flagstaff, Arizona

    Locations

    2 in total

    Run by

    Northern Arizona University

    See if you can join NCT07538427 on ClinicalTrials.gov

16. Safety and Efficacy of Mesenchymal Stem Cells Associated With Chronic Pancreatitis Pain

    This protocol aims to test whether an infusion of allogeneic bone marrow-derived mesenchymal stromal cells (BM-MSCs) can reduce pain associated with chronic pancreatitis (CP) and explore potential mechanisms of MSC action.

    Stage

    EARLY_Phase 1

    Ages

    18 to 75

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06205342 on ClinicalTrials.gov

17. Cannabidiol in Opioid Use Disorder and Chronic Pain

    This is a randomized, placebo-controlled, crossover human laboratory study investigating the dose-dependent safety and acute effects of Cannabidiol (CBD) on measures of pain and opioid craving in outpatients with opioid use disorder (OUD) receiving medication-assisted treatment with methadone or bu…

    Stage

    EARLY_Phase 1

    Ages

    18 to 70

    Site

    Department of Veterans Affairs Hospital, West Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT04587791 on ClinicalTrials.gov

18. Reboot Pain (tDCS)

    This study will examine the effectiveness of tDCS (Transcranial Direct Current Stimulation) in reducing chronic pain when used with Emory Healthcare Veterans Program (EHVP)-ABHP (Accelerated Behavioral Health Program) participants as measured by the Pain, Enjoyment of Life and General Activity Scal…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    The Emory Clinic, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT07411859 on ClinicalTrials.gov

19. Novel Cellular Therapy for the Treatment of Pain Associated With Chronic Pancreatitis

    The goal of this clinical trial is to test whether adult stem cells, called mesenchymal stem cells (MSCs) collected from the patient's bone marrow can help reduce pain caused by chronic pancreatitis and improve pancreatic function.

    Stage

    Phase 1

    Ages

    18 to 75

    Site

    Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina

    Run by

    VA Office of Research and Development

    See if you can join NCT05925036 on ClinicalTrials.gov

20. Neuromodulation + Prolonged Exposure Therapy: Evaluation of a Technology-Enhanced, Integrated Treatment for Pain and PTSD

    The purpose of this study is to examine comparative effectiveness of two home-based telemedicine delivered interventions: transcranial Direct Current Stimulation (tDCS) combined with Massed Prolonged Exposure (Massed-PE) vs. Sham tDCS combined with Massed PE, focusing on pain and PTSD outcomes, to …

    Stage

    Not phased

    Ages

    21 and older

    Site

    Charleston VA Healthcare System, Charleston, South Carolina

    Locations

    2 in total

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT07116109 on ClinicalTrials.gov

21. Psychological Options for Wellness and Recovery (POWeR) Trial for Veterans With Chronic Back/Neck Pain

    The goal of this clinical trial is to learn which treatment works better for veterans with chronic neck or back pain. This study is comparing three treatments: Pain Reprocessing Therapy (PRT), Cognitive Behavioral Therapy (CBT), and usual care (whatever a person is already doing to cope with their …

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA Eastern Colorado Health Care System, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT07137715 on ClinicalTrials.gov

22. PAIN: A Project Assessing the Impact of a Novel Cannabinoid Product

    This study is a clinical trial of a high-cannabidiol (CBD) sublingual product compared to placebo for 9 weeks in patients with chronic pain conditions. The study will assess the impact of CBD on chronic pain symptoms, conventional medication use, clinical state, quality of life, cognition, and biom…

    Stage

    Phase 2

    Ages

    21 and older

    Site

    McLean Hospital, Belmont, Massachusetts

    Run by

    Staci Gruber, Ph.D.

    See if you can join NCT03984565 on ClinicalTrials.gov

23. Optimizing Accelerated TMS for Chronic Pain With Thompson Sampling

    The purpose of this study is to evaluate the safety and efficacy of accelerated intermittent theta burst stimulation (aiTBS) targeting personalized nodes within the somato-cognitive action network (SCAN) and action motor network (AMN) for the treatment of chronic pain. The study will employ Thompso…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT07103135 on ClinicalTrials.gov

24. Mind Body Syndrome Therapy for Chronic Pain

    The goal of this study is to determine if a mind-body intervention can help people suffering from chronic back pain. The study is a randomized, partially blinded trial examining the effectiveness of a mind body intervention in reducing disability from back pain and alleviating back pain in particip…

    Stage

    Not phased

    Ages

    18 to 67

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT04689646 on ClinicalTrials.gov

25. Mind Body Intervention for Chronic Migraine Headaches

    The goal of this exploratory study is to test a mind-body interventional approach for the treatment of chronic migraines. The main goal is to obtain feasibility information on the protocol which has been used in other similar conditions. We will also evaluate multiple measurement tools in order to …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT06690060 on ClinicalTrials.gov